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Vitamin D, Autoimmune Diseases, and Systemic Lupus Erythematosus

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Connective Tissue Disease

Part of the book series: Rare Diseases of the Immune System ((RDIS))

Abstract

Vitamin D is a steroid hormone that influences glucocorticoids and gonadal hormones, interfering with the immune system and estrogen-modulated cells. Therefore vitamin D deficiency is thought as a risk factor for several chronic inflammatory and autoimmune conditions.

A possible synergism between 1,25(OH)D3 and glucocorticoids could represent a new approach for the management of chronic autoimmune diseases.

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Conflicts of Interest

The authors declare no conflicts of interest with the contents of the present manuscript.

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Authors and Affiliations

  1. Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV 6, Genoa, 16132, Italy

    Sabrina Paolino, Carmen Pizzorni, Bruno Seriolo, Alberto Sulli & Maurizio Cutolo

  2. Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium

    Vanessa Smith

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  1. Sabrina Paolino
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  2. Vanessa Smith
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  3. Carmen Pizzorni
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  4. Bruno Seriolo
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  5. Alberto Sulli
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  6. Maurizio Cutolo
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Correspondence to Maurizio Cutolo .

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Editors and Affiliations

  1. Giovanni Bosco Hospital, Center of Immunopathology/Rare Dise, Torino, Torino, Italy

    Dario Roccatello

  2. University of Florence, Florence, Italy

    Lorenzo Emmi

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Paolino, S., Smith, V., Pizzorni, C., Seriolo, B., Sulli, A., Cutolo, M. (2016). Vitamin D, Autoimmune Diseases, and Systemic Lupus Erythematosus. In: Roccatello, D., Emmi, L. (eds) Connective Tissue Disease. Rare Diseases of the Immune System. Springer, Cham. https://doi.org/10.1007/978-3-319-24535-5_12

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  • DOI: https://doi.org/10.1007/978-3-319-24535-5_12

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