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CREB-Mediated Memory Enhancement

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Novel Mechanisms of Memory

Abstract

CREB-responsive transcription is a conserved, important mechanism employed during memory formation. In both Drosophila and mice, overexpression of the activator isoform can enhance this process. However, in both systems, some conflicting data exists, providing a lingering doubt about its universality. In this review, we consider how molecular, cellular and systems parameters affect the fly dCREB2 gene during memory formation. This multi-level analysis provides plausible explanations for some of the discrepant data that exists in the fly system, and perhaps can inform mouse behavioral analysis as well.

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Authors and Affiliations

  1. Department of Embryology, Carnegie Institution for Science, 3250 San Martin Drive, Baltimore, MD, 21218, USA

    Anne Tanenhaus

  2. Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First St., SW, Gonda Bldg, 19th Floor, Rochester, MN, 55905, USA

    Jiabin Zhang

  3. Laboratory of Genetics, University of Wisconsin, Madison, 3434 Genetics/Biotech, 425 Henry Mall, Madison, WI, 53706, USA

    Jerry C. P. Yin

Authors
  1. Anne Tanenhaus
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  2. Jiabin Zhang
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  3. Jerry C. P. Yin
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Correspondence to Anne Tanenhaus .

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Editors and Affiliations

  1. Institute of Psychiatry Cellular Basis of Behaviour, King's College London, London, United Kingdom

    Karl Peter Giese

  2. Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland

    Kasia Radwanska

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Tanenhaus, A., Zhang, J., Yin, J.C.P. (2016). CREB-Mediated Memory Enhancement. In: Giese, K., Radwanska, K. (eds) Novel Mechanisms of Memory. Springer, Cham. https://doi.org/10.1007/978-3-319-24364-1_7

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