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Novel Mechanisms of Memory pp 99–117Cite as

Inverse Synaptic Tagging by Arc

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Abstract

Long-term synaptic plasticity and memory formation require activity-dependent gene expression. However, it remains unknown how such activity-induced gene products are targeted to proper cellular compartments including synapses. Investigation of the targeting of the memory related-protein Arc from the soma to the synapses have elucidated a novel “inverse” synaptic tagging mechanism that enables Arc to specifically target the un-potentiated synapses. The findings provide new mechanistic insights into how the contrast between strong and weak synapses is maintained during long-term synaptic plasticity. Furthermore, they facilitate a better understanding of the molecular basis of biochemical memory at individual synapses and ultimately learning and memory.

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Authors and Affiliations

  1. Medical Innovation Center, Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan

    Hiroyuki Okuno Ph.D., Anna Araki M.Sc. & Keiichiro Minatohara Ph.D.

Authors
  1. Hiroyuki Okuno Ph.D.
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  2. Anna Araki M.Sc.
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  3. Keiichiro Minatohara Ph.D.
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Correspondence to Hiroyuki Okuno Ph.D. .

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Editors and Affiliations

  1. Institute of Psychiatry Cellular Basis of Behaviour, King's College London, London, United Kingdom

    Karl Peter Giese

  2. Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland

    Kasia Radwanska

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Okuno, H., Araki, A., Minatohara, K. (2016). Inverse Synaptic Tagging by Arc. In: Giese, K., Radwanska, K. (eds) Novel Mechanisms of Memory. Springer, Cham. https://doi.org/10.1007/978-3-319-24364-1_6

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