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Novel Mechanisms of Memory pp 89–98Cite as

An Alternative Mechanism for Long-Term Memory Formation

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Abstract

Long-term memory (LTM) formation has been linked with functional strengthening of existing synapses as well as other processes including de novo synaptogenesis. However, it is unclear whether synaptogenesis can contribute to LTM formation. Using alpha-calcium/calmodulin kinase II autophosphorylation-deficient (T286A) mutants, we demonstrate that when functional strengthening is severely impaired contextual LTM formation is linked with training-induced PSD95 upregulation followed by persistent generation of multiinnervated spines (MIS), a type of synapse that is characterized by several presynaptic terminals contacting the same postsynaptic spine. In the chapter, the molecular processes involved in generation of MIS and properties of MIS-dependent memory will be discussed.

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Author information

Authors and Affiliations

  1. Department of Molecular and Cellular Neuroscience, Nencki Institute of Experimental Biology, Ul. L. Pasteura 3, Warsaw, 02-093, Poland

    Kasia Radwanska

  2. Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King’s College London, London, SE5 9NU, UK

    Karl Peter Giese

Authors
  1. Kasia Radwanska
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  2. Karl Peter Giese
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Correspondence to Kasia Radwanska .

Editor information

Editors and Affiliations

  1. Institute of Psychiatry Cellular Basis of Behaviour, King's College London, London, United Kingdom

    Karl Peter Giese

  2. Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland

    Kasia Radwanska

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Radwanska, K., Giese, K.P. (2016). An Alternative Mechanism for Long-Term Memory Formation. In: Giese, K., Radwanska, K. (eds) Novel Mechanisms of Memory. Springer, Cham. https://doi.org/10.1007/978-3-319-24364-1_5

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