Abstract
Endoscopic retrograde cholangiopancreatography (ERCP) is used to diagnose and intervene on a variety of pancreaticobiliary pathologies. It is a mainstay of therapy for cholangitis, choledocholithiasis, initial treatment of pancreatic and biliary strictures, and several post-cholecystectomy indications. Advances in technique and equipment now enable targeted biopsies and stone treatment under direct endoscopic visualization. ERCP can be safely performed in patients with altered foregut anatomy by skilled teams using modified equipment and techniques, including transgastric approaches in patients after roux-en-y gastric bypass. Despite expanding indications and increased procedural sophistication, operators should remain mindful of the underlying principles of careful endoscopic access, controlled cannulation and sphincterotomy, and image-guided intervention. Procedural risks, most notably post-ERCP pancreatitis, should be carefully weighed against the numerous potential benefits of ERCP for minimally invasive diagnosis and treatment of disorders of the hepatobiliary and pancreatic ductal systems.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
McCune WS, Shorb PE, Moscovitz H. Endoscopic cannulation of the ampulla of vater: a preliminary report. Ann Surg. 1968;167(5):752–6.
Classen M, Demling L. Endoscopic sphincterotomy of the papilla of vater and extraction of stones from the choledochal duct (author’s transl). Dtsch Med Wochenschr. 1974;99(11):496–7. doi:10.1055/s-0028-1107790.
Cotton PB, Blumgart LH, Davies GT, Pierce JW, Salmon PR, Burwood RJ, et al. Cannulation of papilla of vater via fiber-duodenoscope. Assessment of retrograde cholangiopancreatography in 60 patients. Lancet. 1972;1(7741):53–8.
Cotton PB, Beales JS. Clinical relevance of endoscopic retrograde cholangio-pancreatography. Gut. 1972;13(10):851.
Varadarajulu S, Kilgore ML, Wilcox CM, Eloubeidi MA. Relationship among hospital ERCP volume, length of stay, and technical outcomes. Gastrointest Endosc. 2006;64(3):338–47. doi:10.1016/j.gie.2005.05.016.
Cote GA, Imler TD, Xu H, Teal E, French DD, Imperiale TF, et al. Lower provider volume is associated with higher failure rates for endoscopic retrograde cholangiopancreatography. Med Care. 2013;51(12):1040–7. doi:10.1097/MLR.0b013e3182a502dc.
Kapral C, Duller C, Wewalka F, Kerstan E, Vogel W, Schreiber F. Case volume and outcome of endoscopic retrograde cholangiopancreatography: results of a nationwide Austrian benchmarking project. Endoscopy. 2008;40(8):625–30. doi:10.1055/s-2008-1077461.
Kochar B, Akshintala VS, Afghani E, Elmunzer BJ, Kim KJ, Lennon AM, et al. Incidence, severity, and mortality of post-ERCP pancreatitis: a systematic review by using randomized, controlled trials. Gastrointest Endosc. 2014. doi:10.1016/j.gie.2014.06.045.
Cohen S, Bacon BR, Berlin JA, Fleischer D, Hecht GA, Loehrer Sr PJ, et al. National Institutes of Health State-of-the-Science Conference Statement: ERCP for diagnosis and therapy, January 14–16, 2002. Gastrointest Endosc. 2002;56(6):803–9. doi:10.1067/mge.2002.129875.
Tanaka M. Intraductal papillary mucinous neoplasm of the pancreas: diagnosis and treatment. Pancreas. 2004;28(3):282–8.
Dasari BV, Tan CJ, Gurusamy KS, Martin DJ, Kirk G, McKie L, et al. Surgical versus endoscopic treatment of bile duct stones. Cochrane Database Syst Rev. 2013;12, CD003327. doi:10.1002/14651858.CD003327.pub4.
Ingraham AM, Cohen ME, Ko CY, Hall BL. A current profile and assessment of north american cholecystectomy: results from the American College of Surgeons National Surgical Quality Improvement Program. J Am Coll Surg. 2010;211(2):176–86. doi:10.1016/j.jamcollsurg.2010.04.003.
Rogers SJ, Cello JP, Horn JK, Siperstein AE, Schecter WP, Campbell AR, et al. Prospective randomized trial of LC + LCBDE vs ERCP/S + LC for common bile duct stone disease. Arch Surg. 2010;145(1):28–33. doi:10.1001/archsurg.2009.226.
Yachimski P, Poulose BK. ERCP vs laparoscopic common bile duct exploration for common bile duct stones: are the 2 techniques truly equivalent? Arch Surg. 2010;145(8):795, author reply 795–6. doi:10.1001/archsurg.2010.126.
Poulose BK, Speroff T, Holzman MD. Optimizing choledocholithiasis management: a cost-effectiveness analysis. Arch Surg. 2007;142(1):43–8, discussion 9. doi:10.1001/archsurg.142.1.43.
Poulose BK, Phillips S, Nealon W, Shelton J, Kummerow K, Penson D, et al. Choledocholithiasis management in rural America: health disparity or health opportunity? J Surg Res. 2011;170(2):214–9. doi:10.1016/j.jss.2011.03.040.
ASGE Standards of Practice Committee, Maple JT, Ben-Menachem T, Anderson MA, Appalaneni V, Banerjee S, et al. The role of endoscopy in the evaluation of suspected choledocholithiasis. Gastrointest Endosc. 2010;71(1):1–9. doi:10.1016/j.gie.2009.09.041.
Lee JG. Diagnosis and management of acute cholangitis. Nat Rev Gastroenterol Hepatol. 2009;6(9):533–41. doi:10.1038/nrgastro.2009.126.
Adler DG, Baron TH, Davila RE, Egan J, Hirota WK, Leighton JA, et al. ASGE guideline: the role of ERCP in diseases of the biliary tract and the pancreas. Gastrointest Endosc. 2005;62(1):1–8. doi:10.1016/j.gie.2005.04.015.
Monga A, Ramchandani M, Reddy DN. Per-oral cholangioscopy. J Interv Gastroenterol. 2011;1(2):70–7. doi:10.4161/jig.1.2.15352.
Vitale GC, Tran TC, Davis BR, Vitale M, Vitale D, Larson G. Endoscopic management of postcholecystectomy bile duct strictures. J Am Coll Surg. 2008;206(5):918–23, discussion 24–5. doi:10.1016/j.jamcollsurg.2008.01.064.
Wu YV, Linehan DC. Bile duct injuries in the era of laparoscopic cholecystectomies. Surg Clin North Am. 2010;90(4):787–802. doi:10.1016/j.suc.2010.04.019.
Rehman A, Affronti J, Rao S. Sphincter of Oddi dysfunction: an evidence-based review. Expert Rev Gastroenterol Hepatol. 2013;7(8):713–22. doi:10.1586/17474124.2013.849197.
Fan ST, Lai EC, Mok FP, Lo CM, Zheng SS, Wong J. Early treatment of acute biliary pancreatitis by endoscopic papillotomy. N Engl J Med. 1993;328(4):228–32. doi:10.1056/NEJM199301283280402.
Tse F, Yuan Y. Early routine endoscopic retrograde cholangiopancreatography strategy versus early conservative management strategy in acute gallstone pancreatitis. Cochrane Database Syst Rev. 2012;5, CD009779. doi:10.1002/14651858.CD009779.pub2.
Cahen DL, Gouma DJ, Nio Y, Rauws EA, Boermeester MA, Busch OR, et al. Endoscopic versus surgical drainage of the pancreatic duct in chronic pancreatitis. N Engl J Med. 2007;356(7):676–84. doi:10.1056/NEJMoa060610.
Dite P, Ruzicka M, Zboril V, Novotny I. A prospective, randomized trial comparing endoscopic and surgical therapy for chronic pancreatitis. Endoscopy. 2003;35(7):553–8. doi:10.1055/s-2003-40237.
Geenen JE, Hogan WJ, Dodds WJ, Toouli J, Venu RP. The efficacy of endoscopic sphincterotomy after cholecystectomy in patients with sphincter-of-Oddi dysfunction. N Engl J Med. 1989;320(2):82–7. doi:10.1056/NEJM198901123200203.
Toouli J, Roberts-Thomson IC, Kellow J, Dowsett J, Saccone GT, Evans P, et al. Manometry based randomised trial of endoscopic sphincterotomy for sphincter of Oddi dysfunction. Gut. 2000;46(1):98–102.
Cotton PB, Durkalski V, Romagnuolo J, Pauls Q, Fogel E, Tarnasky P, et al. Effect of endoscopic sphincterotomy for suspected sphincter of Oddi dysfunction on pain-related disability following cholecystectomy: the EPISOD randomized clinical trial. JAMA. 2014;311(20):2101–9. doi:10.1001/jama.2014.5220.
Garewal D, Waikar P. Propofol sedation for ERCP procedures: a dilemna? Observations from an anesthesia perspective. Diagn Ther Endosc. 2012;2012:639190. doi:10.1155/2012/639190.
ASGE Standards of Practice Committee, Banerjee S, Shen B, Baron TH, Nelson DB, Anderson MA, et al. Antibiotic prophylaxis for GI endoscopy. Gastrointest Endosc. 2008;67(6):791–8. doi:10.1016/j.gie.2008.02.068.
ASGE Technology Committee, Varadarajulu S, Banerjee S, Barth BA, Desilets DJ, Kaul V, et al. GI endoscopes. Gastrointest Endosc. 2011;74(1):1–6.e6. doi:10.1016/j.gie.2011.01.061.
ASGE Technology Committee, Shah RJ, Adler DG, Conway JD, Diehl DL, Farraye FA, et al. Cholangiopancreatoscopy. Gastrointest Endosc. 2008;68(3):411–21. doi:10.1016/j.gie.2008.02.033.
Tse F, Yuan Y, Moayyedi P, Leontiadis GI. Guidewire-assisted cannulation of the common bile duct for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Cochrane Database Syst Rev. 2012;12, CD009662. doi:10.1002/14651858.CD009662.pub2.
Bourke MJ, Costamagna G, Freeman ML. Biliary cannulation during endoscopic retrograde cholangiopancreatography: core technique and recent innovations. Endoscopy. 2009;41(7):612–7. doi:10.1055/s-0029-1214859.
Binmoeller KF, Schafer TW. Endoscopic management of bile duct stones. J Clin Gastroenterol. 2001;32(2):106–18.
Disario JA, Freeman ML, Bjorkman DJ, Macmathuna P, Petersen BT, Jaffe PE, et al. Endoscopic balloon dilation compared with sphincterotomy for extraction of bile duct stones. Gastroenterology. 2004;127(5):1291–9.
Zhao HC, He L, Zhou DC, Geng XP, Pan FM. Meta-analysis comparison of endoscopic papillary balloon dilatation and endoscopic sphincteropapillotomy. World J Gastroenterol. 2013;19(24):3883–91. doi:10.3748/wjg.v19.i24.3883.
Madhoun MF, Wani S, Hong S, Tierney WM, Maple JT. Endoscopic papillary large balloon dilation reduces the need for mechanical lithotripsy in patients with large bile duct stones: a systematic review and meta-analysis. Diagn Ther Endosc. 2014;2014:309618. doi:10.1155/2014/309618.
Bernhoft RA, Pellegrini CA, Motson RW, Way LW. Composition and morphologic and clinical features of common duct stones. Am J Surg. 1984;148(1):77–85.
Vennes JA. Management of calculi in the common duct. Semin Liver Dis. 1983;3(2):162–71. doi:10.1055/s-2008-1040682.
ASGE Standards of Practice Committee, Maple JT, Ikenberry SO, Anderson MA, Appalaneni V, Decker GA, et al. The role of endoscopy in the management of choledocholithiasis. Gastrointest Endosc. 2011;74(4):731–44. doi:10.1016/j.gie.2011.04.012.
Neuhaus H, Zillinger C, Born P, Ott R, Allescher H, Rosch T, et al. Randomized study of intracorporeal laser lithotripsy versus extracorporeal shock-wave lithotripsy for difficult bile duct stones. Gastrointest Endosc. 1998;47(5):327–34.
Jakobs R, Adamek HE, Maier M, Kromer M, Benz C, Martin WR, et al. Fluoroscopically guided laser lithotripsy versus extracorporeal shock wave lithotripsy for retained bile duct stones: a prospective randomised study. Gut. 1997;40(5):678–82.
Adamek HE, Maier M, Jakobs R, Wessbecher FR, Neuhauser T, Riemann JF. Management of retained bile duct stones: a prospective open trial comparing extracorporeal and intracorporeal lithotripsy. Gastrointest Endosc. 1996;44(1):40–7.
Dumonceau JM, Tringali A, Blero D, Deviere J, Laugiers R, Heresbach D, et al. Biliary stenting: indications, choice of stents and results: European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline. Endoscopy. 2012;44(3):277–98. doi:10.1055/s-0031-1291633.
Mavrogiannis C, Liatsos C, Papanikolaou IS, Karagiannis S, Galanis P, Romanos A. Biliary stenting alone versus biliary stenting plus sphincterotomy for the treatment of post-laparoscopic cholecystectomy biliary leaks: a prospective randomized study. Eur J Gastroenterol Hepatol. 2006;18(4):405–9.
Perri V, Familiari P, Tringali A, Boskoski I, Costamagna G. Plastic biliary stents for benign biliary diseases. Gastrointest Endosc Clin N Am. 2011;21(3):405–33, viii. doi:10.1016/j.giec.2011.04.012.
Costamagna G, Tringali A, Mutignani M, Perri V, Spada C, Pandolfi M, et al. Endotherapy of postoperative biliary strictures with multiple stents: results after more than 10 years of follow-up. Gastrointest Endosc. 2010;72(3):551–7. doi:10.1016/j.gie.2010.04.052.
Bakhru MR, Kahaleh M. Expandable metal stents for benign biliary disease. Gastrointest Endosc Clin N Am. 2011;21(3):447–62, viii. doi:10.1016/j.giec.2011.04.007.
Kaffes AJ, Liu K. Fully covered self-expandable metal stents for treatment of benign biliary strictures. Gastrointest Endosc. 2013;78(1):13–21. doi:10.1016/j.gie.2013.02.019.
Vakil N. Expandable metal stents: principles and tissue responses. Gastrointest Endosc Clin N Am. 2011;21(3):351–7, vii. doi:10.1016/j.giec.2011.04.008.
Gerges C, Schumacher B, Terheggen G, Neuhaus H. Expandable metal stents for malignant hilar biliary obstruction. Gastrointest Endosc Clin N Am. 2011;21(3):481–97, ix. doi:10.1016/j.giec.2011.04.004.
Lee JH. Self-expandable metal stents for malignant distal biliary strictures. Gastrointest Endosc Clin N Am. 2011;21(3):463–80, viii–ix. doi:10.1016/j.giec.2011.04.009.
Siegel JH, Guelrud M. Endoscopic cholangiopancreatoplasty: hydrostatic balloon dilation in the bile duct and pancreas. Gastrointest Endosc. 1983;29(2):99–103.
Huibregtse K, Schneider B, Vrij AA, Tytgat GN. Endoscopic pancreatic drainage in chronic pancreatitis. Gastrointest Endosc. 1988;34(1):9–15.
Williamson RC. Pancreatic sphincteroplasty: indications and outcome. Ann R Coll Surg Engl. 1988;70(4):205–11.
Siegel JH, Cohen SA, Kasmin FE, Veerappan A. Stent-guided sphincterotomy. Gastrointest Endosc. 1994;40(5):567–72.
Costamagna G, Bulajic M, Tringali A, Pandolfi M, Gabbrielli A, Spada C, et al. Multiple stenting of refractory pancreatic duct strictures in severe chronic pancreatitis: long-term results. Endoscopy. 2006;38(3):254–9. doi:10.1055/s-2005-921069.
Sauer B, Talreja J, Ellen K, Ku J, Shami VM, Kahaleh M. Temporary placement of a fully covered self-expandable metal stent in the pancreatic duct for management of symptomatic refractory chronic pancreatitis: preliminary data (with videos). Gastrointest Endosc. 2008;68(6):1173–8. doi:10.1016/j.gie.2008.06.011.
Park do H, Kim MH, Moon SH, Lee SS, Seo DW, Lee SK. Feasibility and safety of placement of a newly designed, fully covered self-expandable metal stent for refractory benign pancreatic ductal strictures: a pilot study (with video). Gastrointest Endosc. 2008;68(6):1182–9. doi:10.1016/j.gie.2008.07.027.
Deviere J. Pancreatic stents. Gastrointest Endosc Clin N Am. 2011;21(3):499–510, ix. doi:10.1016/j.giec.2011.04.011.
Singh P, Das A, Isenberg G, Wong RC, Sivak Jr MV, Agrawal D, et al. Does prophylactic pancreatic stent placement reduce the risk of post-ERCP acute pancreatitis? A meta-analysis of controlled trials. Gastrointest Endosc. 2004;60(4):544–50.
Mazaki T, Masuda H, Takayama T. Prophylactic pancreatic stent placement and post-ERCP pancreatitis: a systematic review and meta-analysis. Endoscopy. 2010;42(10):842–53. doi:10.1055/s-0030-1255781.
Matsushita M, Shimatani M, Takaoka M, Okazaki K. Double-balloon enteroscopy for ERCP in patients with altered GI anatomy: front-viewing, a drawback for biliary cannulation? Gastrointest Endosc. 2009;70(3):601, author reply 601–2. doi:10.1016/j.gie.2008.12.244.
Hinojosa MW, Varela JE, Parikh D, Smith BR, Nguyen XM, Nguyen NT. National trends in use and outcome of laparoscopic adjustable gastric banding. Surg Obes Relat Dis. 2009;5(2):150–5. doi:10.1016/j.soard.2008.08.006.
Skinner M, Popa D, Neumann H, Wilcox CM, Monkemuller K. ERCP with the overtube-assisted enteroscopy technique: a systematic review. Endoscopy. 2014;46(7):560–72. doi:10.1055/s-0034-1365698.
Ahmed AR, Husain S, Saad N, Patel NC, Waldman DL, O’Malley W. Accessing the common bile duct after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2007;3(6):640–3. doi:10.1016/j.soard.2007.06.004.
Grover BT, Kothari SN. Biliary issues in the bariatric population. Surg Clin North Am. 2014;94(2):413–25. doi:10.1016/j.suc.2014.01.003.
Cotton PB, Garrow DA, Gallagher J, Romagnuolo J. Risk factors for complications after ERCP: a multivariate analysis of 11,497 procedures over 12 years. Gastrointest Endosc. 2009;70(1):80–8. doi:10.1016/j.gie.2008.10.039.
Testoni PA, Mariani A, Giussani A, Vailati C, Masci E, Macarri G, et al. Risk factors for post-ERCP pancreatitis in high- and low-volume centers and among expert and non-expert operators: a prospective multicenter study. Am J Gastroenterol. 2010;105(8):1753–61. doi:10.1038/ajg.2010.136.
Wang P, Li ZS, Liu F, Ren X, Lu NH, Fan ZN, et al. Risk factors for ERCP-related complications: a prospective multicenter study. Am J Gastroenterol. 2009;104(1):31–40. doi:10.1038/ajg.2008.5.
Cheng CL, Sherman S, Watkins JL, Barnett J, Freeman M, Geenen J, et al. Risk factors for post-ERCP pancreatitis: a prospective multicenter study. Am J Gastroenterol. 2006;101(1):139–47. doi:10.1111/j.1572-0241.2006.00380.x.
Testoni PA. Why the incidence of post-ERCP pancreatitis varies considerably? Factors affecting the diagnosis and the incidence of this complication. JOP. 2002;3(6):195–201.
Cotton PB, Lehman G, Vennes J, Geenen JE, Russell RC, Meyers WC, et al. Endoscopic sphincterotomy complications and their management: an attempt at consensus. Gastrointest Endosc. 1991;37(3):383–93.
Elmunzer BJ, Scheiman JM, Lehman GA, Chak A, Mosler P, Higgins PD, et al. A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis. N Engl J Med. 2012;366(15):1414–22. doi:10.1056/NEJMoa1111103.
Puig I, Calvet X, Baylina M, Isava A, Sort P, Llao J, et al. How and when should NSAIDs be used for preventing post-ERCP pancreatitis? A systematic review and meta-analysis. PLoS One. 2014;9(3):e92922. doi:10.1371/journal.pone.0092922.
Williams EJ, Taylor S, Fairclough P, Hamlyn A, Logan RF, Martin D, et al. Risk factors for complication following ERCP; results of a large-scale, prospective multicenter study. Endoscopy. 2007;39(9):793–801. doi:10.1055/s-2007-966723.
Debenedet AT, Elta GH. Post-sphincterotomy bleeding: fully-covered metal stents for hemostasis. F1000Res. 2013;2:171. doi:10.12688/f1000research.2-171.v1.
Vandervoort J, Soetikno RM, Tham TC, Wong RC, Ferrari Jr AP, Montes H, et al. Risk factors for complications after performance of ERCP. Gastrointest Endosc. 2002;56(5):652–6. doi:10.1067/mge.2002.129086.
Author information
Authors and Affiliations
Corresponding authors
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 SAGES
About this chapter
Cite this chapter
Kummerow, K.L., Poulose, B.K. (2016). Endoscopic Retrograde Cholangiopancreatography (ERCP). In: Kroh, M., Reavis, K. (eds) The SAGES Manual Operating Through the Endoscope. Springer, Cham. https://doi.org/10.1007/978-3-319-24145-6_19
Download citation
DOI: https://doi.org/10.1007/978-3-319-24145-6_19
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-24143-2
Online ISBN: 978-3-319-24145-6
eBook Packages: MedicineMedicine (R0)