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Dermatitis Herpetiformis

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Abstract

Dermatitis herpetiformis (DH) is the specific skin manifestation of celiac disease (CD) caused by the digestion of gluten in HLA-DQ2 or HLA-DQ8 individuals. DH is characterized by intensely pruritic polymorphic papulovesicular eruption on the extensor surfaces of the body. Both diseases are characterized by circulating IgA autoantibodies against tissue transglutaminase (tTG), which bind to the smooth muscle layer of the monkey esophagus causing the so-called EMA positivity. In addition, DH patients have another autoantibody population targeting the epidermal transglutaminase (eTG), the autoantigen of DH, which protein is highly homologous to tTG.

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Author information

Authors and Affiliations

  1. Department of Dermatology, Center for Blistering Diseases, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

    Barbara Horváth MD, PhD & Marcel F. Jonkman MD, PhD

Authors
  1. Barbara Horváth MD, PhD
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  2. Marcel F. Jonkman MD, PhD
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Corresponding author

Correspondence to Barbara Horváth MD, PhD .

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Editors and Affiliations

  1. Department of Dermatology, University Medical Center Groningen Center for Blistering Diseases, Groningen, The Netherlands

    Marcel F. Jonkman

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© 2016 Springer International Publishing Switzerland

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Horváth, B., Jonkman, M.F. (2016). Dermatitis Herpetiformis. In: Jonkman, M. (eds) Autoimmune Bullous Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-23754-1_20

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  • DOI: https://doi.org/10.1007/978-3-319-23754-1_20

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-23753-4

  • Online ISBN: 978-3-319-23754-1

  • eBook Packages: MedicineMedicine (R0)

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