Abstract
Tea, a product of the leaves and buds of the Camellia sinensis (Theaceae) plant, is one of the world’s most popular beverages. Tea can be broadly classified according to the production method as unfermented (green tea), half-fermented (oolong tea), fully fermented (black tea), or post-fermented (pu-erh tea). Green tea is mainly consumed in Japan and China, whereas black tea is primarily consumed in Western countries, India, and other parts of the world. The global production of green tea accounts for only 20 % of the total amount of tea produced, which is approximately one fourth of that of black tea [1]. However, green tea has been the primary target for investigations on health and nutrition among the various teas as indicated by a search conducted in the PubMed database in January 2015, which showed approximately 6020, 3340, 330, and 100 publications for the keywords “green tea,” “black tea,” “oolong tea,” and “pu-erh tea,” respectively. When combined with cancer, for example, the corresponding numbers of publications were approximately 2000, 670, 40, and 10, respectively.
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References
Thakur VS, Gupta K, Gupta S. The chemopreventive and chemotherapeutic potentials of tea polyphenols. Curr Pharm Biotechnol. 2012;13:191–9.
Carlson JR, Bauer BA, Vincent A, Limburg PJ, Wilson T. Reading the tea leaves: anticarcinogenic properties of (−)-epigallocatechin-3-gallate. Mayo Clin Proc. 2007;82:725–32.
Yang CS, Wang X, Lu G, Picinich SC. Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer. 2009;9:429–39.
Suzuki Y, Miyoshi N, Isemura M. Health-promoting effects of green tea. Proc Jpn Acad Ser B Phys Biol Sci. 2012;88:88–101.
Yang CS, Hong J. Prevention of chronic diseases by tea: possible mechanisms and human relevance. Annu Rev Nutr. 2013;33:161–81.
Weikel KA, Garber C, Baburins A, Taylor A. Nutritional modulation of cataract. Nutr Rev. 2014;72:30–47.
Sorice A, Guerriero E, Capone F, Colonna G, Castello G, Costantini S. Ascorbic acid: its role in immune system and chronic inflammation diseases. Mini Rev Med Chem. 2014;14:444–52.
Smith TJ. Green tea polyphenols in drug discovery – a success or failure? Expert Opin Drug Discov. 2011;6:589–95.
Shukla Y. Tea and cancer chemoprevention: a comprehensive review. Asian Pac J Cancer Prev. 2007;8:155–66.
Chow HH, Hakim IA. Pharmacokinetic and chemoprevention studies on tea in humans. Pharmacol Res. 2011;64:105–12.
Ishida H, Wakimoto T, Kitao Y, Tanaka S, Miyase T, Nukaya H. Quantitation of chafurosides A and B in tea leaves and isolation of prechafurosides A and B from oolong tea leaves. J Agric Food Chem. 2009;57:6779–86.
Shohin Test Hokoku (Commercial products test reports). Kochi Prefecture Consumer Center. 2000;35:1–17 (in Japanese)
Imai K, Suga K, Nakachi K. Cancer-preventive effects of drinking green tea among a Japanese population. Prev Med. 1997;26:769–75.
Vogiatzoglou A, Heuer T, Mulligan AA, Lentjes MA, Luben RN, Kuhnle GG. Estimated dietary intakes and sources of flavanols in the German population (German National Nutrition Survey II). Eur J Nutr. 2014;53:635–43.
Oguni I, Nasu K, Kanaya S, Ota Y, Yamamoto S, Komura T. Epidemiological and experimental studies on the antitumor activity by green tea extracts. Jpn J Nutr. 1989;47:93–102.
Tewes FJ, Koo LC, Meisgen TJ, Rylander R. Lung cancer risk and mutagenicity of tea. Environ Res. 1990;52:23–33.
Sasazuki S, Tamakoshi A, Matsuo K, et al. Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan. Green tea consumption and gastric cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol. 2012;42:335–46.
McCann SE, Yeh M, Rodabaugh K, Moysich KB. Higher regular coffee and tea consumption is associated with reduced endometrial cancer risk. Int J Cancer. 2009;124:1650–3.
Lee AH, Su D, Pasalich M, Binns CW. Tea consumption reduces ovarian cancer risk. Cancer Epidemiol. 2013;37:54–9.
Geybels MS, Verhage BA, Arts IC, van Schooten FJ, Goldbohm RA, van den Brandt PA. Dietary flavonoid intake, black tea consumption, and risk of overall and advanced stage prostate cancer. Am J Epidemiol. 2013;177:1388–98.
Yuan JM, Sun C, Butler LM. Tea and cancer prevention: epidemiological studies. Pharmacol Res. 2011;64:123–35.
Zheng JS, Yang J, Fu YQ, Huang T, Huang YJ, Li D. Effects of green tea, black tea, and coffee consumption on the risk of esophageal cancer: a systematic review and meta-analysis of observational studies. Nutr Cancer. 2013;65:1–16.
Montague JA, Butler LM, Wu AH, et al. Green and black tea intake in relation to prostate cancer risk among Singapore Chinese. Cancer Causes Control. 2012;23:1635–41.
Shafique K, McLoone P, Qureshi K, Leung H, Hart C, Morrison DS. Tea consumption and the risk of overall and grade specific prostate cancer: a large prospective cohort study of Scottish men. Nutr Cancer. 2012;64:790–7.
Lu CM, Lan SJ, Lee YH, Huang JK, Huang CH, Hsieh CC. Tea consumption: fluid intake and bladder cancer risk in Southern Taiwan. Urology. 1999;54:823–8.
Yamane T. Clinical trial involving 8 patients with familial adenomatous polyposis. In: Isemura M, editor. Beneficial health effect of green tea. Kerala: Research Signpost; 2008. p. 105–12.
Shimizu M, Fukutomi Y, Ninomiya M, et al. Green tea extracts for the prevention of metachronous colorectal adenomas: a pilot study. Cancer Epidemiol Biomarkers Prev. 2008;17:3020–5.
Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res. 2006;66:1234–40.
Brausi M, Rizzi F, Bettuzzi S. Chemoprevention of human prostate cancer by green tea catechins: two years later. A follow-up update. Eur Urol. 2008;54:472–3.
Hara Y. Tea catechins and their applications as supplements and pharmaceutics. Pharmacol Res. 2011;64:100–4.
Gupta S, Hastak K, Ahmad N, Lewin JS, Mukhtar H. Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols. Proc Natl Acad Sci U S A. 2001;98:10350–5.
Tachibana H. Green tea polyphenol sensing. Proc Jpn Acad Ser B Phys Biol Sci. 2011;87:66–80.
Tsang WP, Kwok TT. Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells. J Nutr Biochem. 2010;21:140–6.
Chakrabarti M, Ai W, Banik NL, Ray SK. Overexpression of miR-7-1 increases efficacy of green tea polyphenols for induction of apoptosis in human malignant neuroblastoma SH-SY5Y and SK-N-DZ cells. Neurochem Res. 2013;38:420–32.
Pan MH, Lai CS, Wu JC, Ho CT. Epigenetic and disease targets by polyphenols. Curr Pharm Des. 2013;19:6156–85.
Hibasami H, Komiya T, Achiwa Y, et al. Black tea theaflavins induce programmed cell death in cultured human stomach cancer cells. Int J Mol Med. 1998;1:725–7.
Halder B, Das Gupta S, Gomes A. Black tea polyphenols induce human leukemic cell cycle arrest by inhibiting Akt signaling: possible involvement of Hsp90, Wnt/beta-catenin signaling and FOXO1. FEBS J. 2012;279:2876–91.
Lahiry L, Saha B, Chakraborty J, et al. Theaflavins target Fas/caspase-8 and Akt/pBad pathways to induce apoptosis in p53-mutated human breast cancer cells. Carcinogenesis. 2010;31:259–68.
Pan MH, Liang YC, Lin-Shiau SY, Zhu NQ, Ho CT, Lin JK. Induction of apoptosis by the oolong tea polyphenol theasinensin A through cytochrome c release and activation of caspase-9 and caspase-3 in human U937 cells. J Agric Food Chem. 2000;48:6337–46.
Chiang CT, Weng MS, Lin-Shiau SY, Kuo KL, Tsai YJ, Lin JK. Pu-erh tea supplementation suppresses fatty acid synthase expression in the rat liver through downregulating Akt and JNK signalings as demonstrated in human hepatoma HepG2 cells. Oncol Res. 2005;16:119–28.
Wang J, Hudson R, Sintim HO. Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs. Future Med Chem. 2012;4:1113–51.
Conney AH, Lu YP, Lou YR, Kawasumi M, Nghiem P. Mechanisms of caffeine-induced inhibition of UVB carcinogenesis. Front Oncol. 2013;3:144.
Miwa S, Sugimoto N, Yamamoto N, et al. Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-kappaB and MAPK pathways. Anticancer Res. 2012;32:3643–9.
Suzuki Y, Isemura M. Binding interaction between (−)-epigallocatechin gallate causes impaired spreading of cancer cells on fibrinogen. Biomed Res. 2013;34:301–8.
Brown AL, Lane J, Coverly J, et al. Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial. Br J Nutr. 2009;101:886–94.
Hino A, Adachi H, Enomoto M, et al. Habitual coffee but not green tea consumption is inversely associated with metabolic syndrome: an epidemiological study in a general Japanese population. Diabetes Res Clin Pract. 2007;76:383–9.
Takami H, Nakamoto M, Uemura H, et al. Inverse correlation between coffee consumption and prevalence of metabolic syndrome: baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima. Jpn J Epidemiol. 2013;23:12–20.
Vernarelli JA, Lambert JD. Tea consumption is inversely associated with weight status and other markers for metabolic syndrome in US adults. Eur J Nutr. 2013;52:1039–48.
Basu A, Sanchez K, Leyva MJ, et al. Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome. J Am Coll Nutr. 2010;29:31–40.
Vieira Senger AE, Schwanke CH, Gomes I, Valle Gottlieb MG. Effect of green tea (Camellia sinensis) consumption on the components of metabolic syndrome in elderly. J Nutr Health Aging. 2012;16:738–42.
Nagao T, Hase T, Tokimitsu I. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity. 2007;15:1473–83.
Kubota K, Sumi S, Tojo H, et al. Improvements of mean body mass index and body weight in preobese and overweight Japanese adults with black Chinese tea (Pu-Erh) water extract. Nutr Res. 2011;31:421–8.
Yuda N, Tanaka M, Suzuki M, Asano Y, Ochi H, Iwatsuki K. Polyphenols extracted from black tea (Camellia sinensis) residue by hot-compressed water and their inhibitory effect on pancreatic lipase in vitro. J Food Sci. 2012;77:H254–61.
Grove KA, Sae-tan S, Kennett MJ, Lambert JD. (−)-Epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice. Obesity. 2012;20:2311–3.
Murase T, Nagasawa A, Suzuki J, Hase T, Tokimitsu I. Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver. Int J Obes Relat Metab Disord. 2002;26:1459–64.
Yeh CW, Chen WJ, Chiang CT, Lin-Shiau SY, Lin JK. Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects. Pharmacogenomics J. 2003;3:267–76.
Huang HC, Lin JK. Pu-erh tea, green tea, and black tea suppresses hyperlipidemia, hyperleptinemia and fatty acid synthase through activating AMPK in rats fed a high-fructose diet. Food Funct. 2012;3:170–7.
Gardner EJ, Ruxton CH, Leeds AR. Black tea--helpful or harmful? A review of the evidence. Eur J Clin Nutr. 2007;61:3–18.
Larsson SC. Coffee, tea, and cocoa and risk of stroke. Stroke. 2014;45:309–14.
Larsson SC, Virtamo J, Wolk A. Black tea consumption and risk of stroke in women and men. Ann Epidemiol. 2013;23:157–60.
Hou Y, Shao W, Xiao R, et al. Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model. Exp Gerontol. 2009;44:434–9.
Liu G, Mi XN, Zheng XX, Xu YL, Lu J, Huang XH. Effects of tea intake on blood pressure: a meta-analysis of randomised controlled trials. Br J Nutr. 2014;112:1043–54.
Greyling A, Ras RT, Zock PL, et al. The effect of black tea on blood pressure: a systematic review with meta-analysis of randomized controlled trials. PLoS One. 2014;9:e103247.
Iso H, Date C, Wakai K, Fukui M, Tamakoshi A, JACC Study Group. The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults. Ann Intern Med. 2006;144:554–62.
van Woudenbergh GJ, Kuijsten A, Drogan D, et al. Tea consumption and incidence of type 2 diabetes in Europe: the EPIC-InterAct case-cohort study. PLoS One. 2012;7:e36910.
Huang H, Guo Q, Qiu C, et al. Associations of green tea and rock tea consumption with risk of impaired fasting glucose and impaired glucose tolerance in Chinese men and women. PLoS One. 2013;8:e79214.
Beresniak A, Duru G, Berger G, Bremond-Gignac D. Relationships between black tea consumption and key health indicators in the world: an ecological study. BMJ Open. 2012;2:e000648.
Maruyama K, Iso H, Sasaki S, Fukino Y. The association between concentrations of green tea and blood glucose levels. J Clin Biochem Nutr. 2009;44:41–5.
Nagao T, Meguro S, Hase T, et al. A catechin-rich beverage improves obesity and blood glucose control in patients with type 2 diabetes. Obesity. 2009;17:310–7.
Boggs DA, Rosenberg L, Ruiz-Narvaez EA, Palmer JR. Coffee, tea, and alcohol intake in relation to risk of type 2 diabetes in African American women. Am J Clin Nutr. 2010;92:960–6.
Hayashino Y, Fukuhara S, Okamura T, Tanaka T, Ueshima H. High oolong tea consumption predicts future risk of diabetes among Japanese male workers: a prospective cohort study. Diabet Med. 2011;28:805–10.
Pham NM, Nanri A, Kochi T, et al. Coffee and green tea consumption is associated with insulin resistance in Japanese adults. Metabolism. 2014;63:400–8.
Oba S, Nagata C, Nakamura K, et al. Consumption of coffee, green tea, oolong tea, black tea, chocolate snacks and the caffeine content in relation to risk of diabetes in Japanese men and women. Br J Nutr. 2010;103:453–9.
Williamson G. Possible effects of dietary polyphenols on sugar absorption and digestion. Mol Nutr Food Res. 2013;57:48–57.
Anderson RA, Polansky MM. Tea enhances insulin activity. J Agric Food Chem. 2002;50:7182–6.
Han MK. Epigallocatechin gallate, a constituent of green tea, suppresses cytokine-induced pancreatic beta-cell damage. Exp Mol Med. 2003;35:136–9.
Wolfram S, Raederstorff D, Preller M, et al. Epigallocatechin gallate supplementation alleviates diabetes in rodents. J Nutr. 2006;136:2512–8.
Abe K, Ijiri M, Suzuki T, Taguchi K, Koyama Y, Isemura M. Green tea with a high catechin content suppresses inflammatory cytokine expression in the galactosamine-injured rat liver. Biomed Res. 2005;26:187–92.
Bharrhan S, Koul A, Chopra K, Rishi P. Catechin suppresses an array of signalling molecules and modulates alcohol-induced endotoxin mediated liver injury in a rat model. PLoS One. 2011;6:e20635.
Cunha CA, Lira FS, Rosa Neto JC, et al. Green tea extract supplementation induces the lipolytic pathway, attenuates obesity, and reduces low-grade inflammation in mice fed a high-fat diet. Mediators Inflamm. 2013;2013:635470.
Abe K, Suzuki T, Ijiri M, Koyama Y, Isemura M, Kinae N. The anti-fibrotic effect of green tea with a high catechin content in the galactosamine-injured rat liver. Biomed Res. 2007;28:43–8.
Kochi T, Shimizu M, Terakura D, et al. Non-alcoholic steatohepatitis and preneoplastic lesions develop in the liver of obese and hypertensive rats: suppressing effects of EGCG on the development of liver lesions. Cancer Lett. 2014;342:60–9.
Sameshima Y, Ishida Y, Ono Y, Hujita M, Kuriki Y. Green tea powder enhances the safety and efficacy of interferon α-2b plus ribavirin combination therapy in chronic hepatitis C patients with a very high genotype 1 HCV load. In: Isemura M, editor. Beneficial health effect of green tea. Kerala: Research Signpost; 2008. p. 113–9.
Mandel SA, Youdim MB. In the rush for green gold: can green tea delay age-progressive brain neurodegeneration? Recent Pat CNS Drug Discov. 2012;7:205–17.
Mazzanti G, Menniti-Ippolito F, Moro PA, et al. Hepatotoxicity from green tea: a review of the literature and two unpublished cases. Eur J Clin Pharmacol. 2009;65:331–41.
Tsubono Y, Nishino Y, Komatsu S, et al. Green tea and the risk of gastric cancer in Japan. N Engl J Med. 2001;344:632–6.
Shirai T, Sato A, Chida K, et al. Epigallocatechin gallate-induced histamine release in patients with green tea-induced asthma. Ann Allergy Asthma Immunol. 1997;79:65–9.
Otera H, Tada K, Sakurai T, Hashimoto K, Ikeda A. Hypersensitivity pneumonitis associated with inhalation of catechin-rich green tea extracts. Respiration. 2011;82:388–92.
Pisters KM, Newman RA, Coldman B, et al. Phase I trial of oral green tea extract in adult patients with solid tumor. J Clin Oncol. 2001;19:1830–8.
Kuriyama S, Shimazu T, Ohmori K, et al. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study. JAMA. 2006;296:1255–65.
Qiu L, Sautter J, Gu D. Associations between frequency of tea consumption and health and mortality: evidence from old Chinese. Br J Nutr. 2012;108:1686–97.
Gardener H, Rundek T, Wright CB, Elkind MS, Sacco RL. Coffee and tea consumption are inversely associated with mortality in a multiethnic urban population. J Nutr. 2013;143:1299–308.
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Suzuki, T., Miyoshi, N., Hayakawa, S., Imai, S., Isemura, M., Nakamura, Y. (2016). Health Benefits of Tea Consumption. In: Wilson, T., Temple, N. (eds) Beverage Impacts on Health and Nutrition. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-319-23672-8_4
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