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Osteoporosis: Pathophysiology and Epidemiology

  • Chapter
The Duration and Safety of Osteoporosis Treatment

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Abstract

Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue resulting in increased bone fragility. Worldwide, there are nearly 9 million osteoporotic fractures each year, generating a massive burden both to individuals, in terms of associated morbidity and reduced survival, and to health services and wider economies. Furthermore, this burden is likely to increase globally as a result of urbanization of developing countries and an aging demographic across the majority of populations. In this chapter, we will review the pathophysiology and epidemiology of osteoporosis and fragility fracture, exploring mechanisms from cell biology to biomechanics and elucidating recent global secular trends in age- and sex-specific fracture rates.

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Notes

  1. 1.

    *Important References

    **Very important References

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Acknowledgments

We would like to thank Medical Research Council (UK), Arthritis Research UK, National Osteoporosis Society (UK), International Osteoporosis Foundation, and NIHR for funding this work.

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Authors and Affiliations

  1. MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK

    Rebecca J. Moon BSc, BM, MRCPCH, Cyrus Cooper OBE, FMedSci & Nicholas C. Harvey MA, MB, BChir, PhD, FRCP

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  2. Cyrus Cooper OBE, FMedSci
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  3. Nicholas C. Harvey MA, MB, BChir, PhD, FRCP
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Correspondence to Nicholas C. Harvey MA, MB, BChir, PhD, FRCP .

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Editors and Affiliations

  1. Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center; University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA

    Stuart Silverman

  2. Institute of Clinical Research; Department of Medicine, Holbæk, Denmark, University of Southern Denmark, Odense Patient Data Explorative Network; Holbæk Hospital, Odense, Denmark

    Bo Abrahamsen

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© 2016 Springer International Publishing Switzerland

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Moon, R.J., Cooper, C., Harvey, N.C. (2016). Osteoporosis: Pathophysiology and Epidemiology. In: Silverman, S., Abrahamsen, B. (eds) The Duration and Safety of Osteoporosis Treatment. Springer, Cham. https://doi.org/10.1007/978-3-319-23639-1_1

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  • DOI: https://doi.org/10.1007/978-3-319-23639-1_1

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-23638-4

  • Online ISBN: 978-3-319-23639-1

  • eBook Packages: MedicineMedicine (R0)

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