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ABC Importers

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ABC Transporters - 40 Years on

Abstract

Most ABC importers employ a soluble substrate-binding protein (SBP) to capture the ligand and donate the molecule to the translocator. The SBP can be a soluble periplasmic protein or tethered to the membrane via a lipid moiety or protein anchor or fused to the translocator. In the hybrid ABC transporters, multiple substrate-binding domains (SBDs) can be fused in tandem and provide several extracytoplasmic substrate-binding sites. The substrate is transferred from the SBP to the membrane domain, which translocates the substrate via alternating access of a membrane-embedded substrate-binding pocket. A subset of ABC transporters, known as the energy-coupling factor (ECF) transporters, employs a membrane-embedded S-component to capture the substrate. The S-component guided by the ECF module transports the substrate over the membrane via a so-called toppling mechanism. An overview of the mechanisms of transport by the different types of ABC importers is presented, together with structural information about the proteins.

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Authors and Affiliations

  1. Department of Biochemistry, University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, Nijenborgh 4, 9747, AG Groningen, The Netherlands

    Lotteke J. Y. M. Swier, Dirk-Jan Slotboom & Bert Poolman

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  1. Lotteke J. Y. M. Swier
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  2. Dirk-Jan Slotboom
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  3. Bert Poolman
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Correspondence to Bert Poolman .

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  1. School of Life Sciences, University of Technology, Sydney, Australia

    Anthony M. George

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Swier, L.J.Y.M., Slotboom, DJ., Poolman, B. (2016). ABC Importers. In: George, A. (eds) ABC Transporters - 40 Years on. Springer, Cham. https://doi.org/10.1007/978-3-319-23476-2_1

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