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Template Mapping Biopsies: An Overview of Technique and Results

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Interventional Urology

Abstract

Template prostate mapping biopsies are a highly accurate investigation of prostate cancer that can be applied to most men who are at risk of prostate cancer. They provide spatial information in the location and extent of diseased tissue which cannot be obtained via TRUS biopsy while confirming absence of the disease in the remaining prostate tissue. They are characteristically better in detection of anteriorly located tumors. It is also an ideal reference standard for validation studies.

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References

  1. Djulbegovic M, Beyth RJ, Neuberger MM, et al. Screening for prostate cancer: systematic review and meta-analysis of randomised controlled trials. BMJ. 2010;341:c4543. Epub 2010/09/17.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Andriole GL, Crawford ED, Grubb 3rd RL, et al. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med. 2009;360(13):1310–9. Epub 2009/03/20.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  3. Hugosson J, Carlsson S, Aus G, et al. Mortality results from the Goteborg randomised population-based prostate-cancer screening trial. Lancet Oncol. 2010;11(8):725–32. Epub 2010/07/06.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Schroder FH, Hugosson J, Roobol MJ, et al. Prostate-cancer mortality at 11 years of follow-up. N Engl J Med. 2012;366(11):981–90. Epub 2012/03/16.

    Article  PubMed  Google Scholar 

  5. Schroder FH, Hugosson J, Roobol MJ, et al. Screening and prostate-cancer mortality in a randomized European study. N Engl J Med. 2009;360(13):1320–8. Epub 2009/03/20.

    Article  PubMed  Google Scholar 

  6. Holmberg L, Bill-Axelson A, Steineck G, et al. Results from the Scandinavian Prostate Cancer Group Trial Number 4: a randomized controlled trial of radical prostatectomy versus watchful waiting. J Natl Cancer Inst Monogr. 2012;2012(45):230–3. Epub 2012/12/29.

    Article  PubMed Central  PubMed  Google Scholar 

  7. Wilt TJ. The Prostate Cancer Intervention Versus Observation Trial:VA/NCI/AHRQ Cooperative Studies Program #407 (PIVOT): Design and Baseline Results of a Randomized Controlled Trial Comparing Radical Prostatectomy With Watchful Waiting for Men With Clinically Localized Prostate Cancer. J Natl Cancer Inst Monogr. 2012;2012(45):184–90.

    Article  PubMed Central  PubMed  Google Scholar 

  8. Barry MJ. Screening for prostate cancer — the controversy that refuses to die. N Engl J Med. 2009;360(13):1351–4.

    Article  CAS  PubMed  Google Scholar 

  9. Parker C, Emberton M. Screening for prostate cancer appears to work, but at what cost? BJU Int. 2009;104(3):290–2. Epub 2009/06/25.

    Article  PubMed  Google Scholar 

  10. Cross T, McPhail S. Clinical guideline prostate cancer: diagnosis and treatment. An assessment of need. A report to the National Collaborating Centre for Cancer. 2008.

    Google Scholar 

  11. Bangma CH, Roemeling S, Schroder FH. Overdiagnosis and overtreatment of early detected prostate cancer. World J Urol. 2007;25(1):3–9. Epub 2007/03/17.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Thompson IM, Goodman PJ, Tangen CM, et al. The influence of finasteride on the development of prostate cancer. N Engl J Med. 2003;349(3):215–24. Epub 2003/06/26.

    Article  CAS  PubMed  Google Scholar 

  13. Djavan B, Ravery V, Zlotta A, et al. Prospective evaluation of prostate cancer detected on biopsies 1, 2, 3 and 4: when should we stop? J Urol. 2001;166(5):1679–83. Epub 2001/10/05.

    Article  CAS  PubMed  Google Scholar 

  14. Scattoni V, Zlotta A, Montironi R, Schulman C, Rigatti P, Montorsi F. Extended and saturation prostatic biopsy in the diagnosis and characterisation of prostate cancer: a critical analysis of the literature. Eur Urol. 2007;52(5):1309–22. Epub 2007/08/28.

    Article  PubMed  Google Scholar 

  15. Lecornet E, Ahmed HU, Hu Y, et al. The accuracy of different biopsy strategies for the detection of clinically important prostate cancer: a computer simulation. J Urol. 2012;188(3):974–80.

    Article  PubMed  Google Scholar 

  16. Barzell WE, Melamed MR, Cathcart P, Moore CM, Ahmed HU, Emberton M. Identifying candidates for active surveillance: an evaluation of the repeat biopsy strategy for men with favorable risk prostate cancer. J Urol. 2012;188(3):762–8.

    Article  PubMed  Google Scholar 

  17. Onik G, Miessau M, Bostwick DG. Three-dimensional prostate mapping biopsy has a potentially significant impact on prostate cancer management. J Clin Oncol. United States 2009;27(26):4321–6. Epub 2009/08/05.

    Google Scholar 

  18. Crawford ED, Wilson SS, Torkko KC, et al. Clinical staging of prostate cancer: a computer-simulated study of transperineal prostate biopsy. BJU Int. 2005;96(7):999–1004.

    Article  PubMed  Google Scholar 

  19. Kulkarni GS, Al-Azab R, Lockwood G, et al. Evidence for a biopsy derived grade artifact among larger prostate glands. J Urol. 2006;175(2):505–9. Epub 2006/01/13.

    Article  PubMed  Google Scholar 

  20. Barzell WE, Melamed MR. Appropriate patient selection in the focal treatment of prostate cancer: the role of transperineal 3-dimensional pathologic mapping of the prostate—a 4-year experience. Urology. 2007;70(6):S27–35.

    Article  Google Scholar 

  21. Onik G, Barzell W. Transperineal 3D mapping biopsy of the prostate: an essential tool in selecting patients for focal prostate cancer therapy. Urol Oncol. 2008;26(5):506–10. Epub 2008/09/09.

    Article  PubMed  Google Scholar 

  22. Taira AV, Merrick GS, Galbreath RW, et al. Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting. Prostate Cancer Prostatic Dis. 2010;13(1):71–7.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  23. Barzell W, Whitmore W, Andriole G. How to perform transperineal saturation prostate biopsy: technique addresses diagnostic, therapeutic dilemmas that arise following TRUS biopsies. Urol Times. 2003;31:41.

    Google Scholar 

  24. Crawford ED, Rove KO, Barqawi AB, et al. Clinical-pathologic correlation between transperineal mapping biopsies of the prostate and three-dimensional reconstruction of prostatectomy specimens. Prostate. 2013;73(7):778–87. Epub 2012/11/22.

    Article  PubMed Central  PubMed  Google Scholar 

  25. El-Shater Bosaily A, Parker C, Brown LC, et al. PROMIS - Prostate MR imaging study: A paired validating cohort study evaluating the role of multi-parametric MRI in men with clinical suspicion of prostate cancer. Contemp Clin Trials. 2015. Epub 2015/03/10.

    Google Scholar 

  26. Merrick GS, Taubenslag W, Andreini H, et al. The morbidity of transperineal template-guided prostate mapping biopsy. BJU Int. 2008;101(12):1524–9. Epub 2008/03/08.

    Article  PubMed  Google Scholar 

  27. Buskirk SJ, Pinkstaff DM, Petrou SP, et al. Acute urinary retention after transperineal template-guided prostate biopsy. Int J Radiat Oncol Biol Phys. 2004;59(5):1360–6. Epub 2004/07/28.

    Article  PubMed  Google Scholar 

  28. Miller J, Perumalla C, Heap G. Complications of transrectal versus transperineal prostate biopsy. ANZ J Surg. 2005;75(1–2):48–50. Epub 2005/03/03.

    Article  PubMed  Google Scholar 

  29. Andrea Losa GMG, Massimo Lazzeri, Giovanni Lughezzani, Giampiero Cardone, Massimo Freschi, Giuliana Lista, Alessandro Larcher, Luciano Dante Nava, Giorgio Guazzoni. Complications and Quality of Life After Template-assisted Transperineal Prostate Biopsy in Patients Eligible for Focal Therapy. 2013;81(6):1291–6.

    Google Scholar 

  30. Bittner N, Merrick GS, Bennett A, et al. Diagnostic Performance of Initial Transperineal Template-guided Mapping Biopsy of the Prostate Gland. Am J Clin Oncol. 2013. Epub 2013/06/15.

    Google Scholar 

  31. Symons JL, Huo A, Yuen CL, et al. Outcomes of transperineal template-guided prostate biopsy in 409 patients. BJU Int. 2013;112(5):585–93. Epub 2013/04/05.

    Article  CAS  PubMed  Google Scholar 

  32. Mabjeesh NJ, Lidawi G, Chen J, German L, Matzkin H. High detection rate of significant prostate tumours in anterior zones using transperineal ultrasound-guided template saturation biopsy. BJU Int. 2012;110(7):993–7. Epub 2012/03/08.

    Article  PubMed  Google Scholar 

  33. Nafie S, Pal RP, Dormer JP, Khan MA. Transperineal template prostate biopsies in men with raised PSA despite two previous sets of negative TRUS-guided prostate biopsies. World J Urol. 2014;32(4):971–5. Epub 2013/12/18.

    Article  PubMed  Google Scholar 

  34. Ekwueme K, Simpson H, Zakhour H, Parr NJ. Transperineal template-guided saturation biopsy using a modified technique: outcome of 270 cases requiring repeat prostate biopsy. BJU Int. 2013;111(8):E365–73. Epub 2013/05/30.

    Article  PubMed  Google Scholar 

  35. Ayres BE, Montgomery BS, Barber NJ, et al. The role of transperineal template prostate biopsies in restaging men with prostate cancer managed by active surveillance. BJU Int. 2012;109(8):1170–6. Epub 2011/08/23.

    Article  PubMed  Google Scholar 

  36. Ahmed HU, Hu Y, Carter T, et al. Characterizing clinically significant prostate cancer using template prostate mapping biopsy. J Urol. 2011;186(2):458–64. Epub 2011/06/18.

    Article  PubMed  Google Scholar 

  37. Hu Y, Ahmed HU, Carter T, et al. A biopsy simulation study to assess the accuracy of several transrectal ultrasonography (TRUS)-biopsy strategies compared with template prostate mapping biopsies in patients who have undergone radical prostatectomy. BJU Int. 2012;110(6):812–20. Epub 2012/03/08.

    Article  PubMed  Google Scholar 

  38. Katz DJ, Pinochet R, Richards KA, et al. Comparison of transperineal mapping biopsy results with whole-mount radical prostatectomy pathology in patients with localized prostate cancer. Prostate Cancer. 2014;2014:781438. Epub 2014/06/06.

    Article  PubMed Central  PubMed  Google Scholar 

  39. Ong WL, Weerakoon M, Huang S, et al. Transperineal biopsy prostate cancer detection in first biopsy and post-negative TRUS biopsy settings: The Victorian Transperineal Biopsy Collaboration experience. BJU Int. 2015. Epub 2015/01/07.

    Google Scholar 

  40. Huo AS, Hossack T, Symons JL, et al. Accuracy of primary systematic template guided transperineal biopsy of the prostate for locating prostate cancer: a comparison with radical prostatectomy specimens. J Urol. United States: Inc. Published by Elsevier Inc; 2012. p. 2044–9.

    Google Scholar 

  41. Nafie S, Mellon JK, Dormer JP, Khan MA. The role of transperineal template prostate biopsies in prostate cancer diagnosis in biopsy naive men with PSA less than 20 ng ml(-1.). Prostate Cancer Prostatic Dis. 2014;17(2):170–3. Epub 2014/03/05.

    Google Scholar 

  42. Pepe P, Dibenedetto G, Pennisi M, Fraggetta F, Colecchia M, Aragona F. Detection rate of anterior prostate cancer in 226 patients submitted to initial and repeat transperineal biopsy. Urol Int. 2014;93(2):189–92. Epub 2014/04/30.

    Google Scholar 

  43. Klatte T, Swietek N, Schatzl G, Waldert M. Transperineal template-guided biopsy for diagnosis of prostate cancer in patients with at least two prior negative biopsies. Wien Klin Wochenschr. 2013;125(21-22):669–73. Epub 2013/09/26.

    Google Scholar 

  44. Vyas L, Acher P, Kinsella J, et al. Indications, results and safety profile of transperineal sector biopsies (TPSB) of the prostate: a single centre experience of 634 cases. BJU Int. 2014;114(1):32–7. Epub 2013/09/24.

    Google Scholar 

  45. Gershman B, Zietman AL, Feldman AS, McDougal WS. Transperineal template-guided prostate biopsy for patients with persistently elevated PSA and multiple prior negative biopsies. Urol Oncol. 2013;31(7):1093–7. Epub 2012/02/07.

    Google Scholar 

  46. Krughoff K, Eid K, Phillips J, et al. The accuracy of prostate cancer localization diagnosed on transrectal ultrasound-guided biopsy compared to 3-dimensional transperineal approach. Adv Urol. 2013;2013:249080. Epub 2014/01/29.

    Google Scholar 

  47. Takeshita H, Numao N, Kijima T, et al. Diagnostic performance of initial transperineal 14-core prostate biopsy to detect significant cancer. Int Urol Nephrol. 2013;45(3):645–52. Epub 2013/03/27.

    Google Scholar 

  48. Bittner N, Merrick GS, Butler WM, Bennett A, Galbreath RW. Incidence and pathological features of prostate cancer detected on transperineal template guided mapping biopsy after negative transrectal ultrasound guided biopsy. J Urol. 2013;190(2):509–14. Epub 2013/02/19.

    Google Scholar 

  49. Dimmen M, Vlatkovic L, Hole K-H, Nesland JM, Brennhovd B, Axcrona K. Transperineal prostate biopsy detects significant cancer in patients with elevated prostate-specific antigen (PSA) levels and previous negative transrectal biopsies.

    Google Scholar 

  50. Pal RP, Elmussareh M, Chanawani M, Khan MA. The role of a standardized 36 core template-assisted transperineal prostate biopsy technique in patients with previously negative transrectal ultrasonography-guided prostate biopsies.

    Google Scholar 

  51. Barqawi AB, Rove KO, Gholizadeh S, O’Donnell CI, Koul H, Crawford ED. The role of 3-dimensional mapping biopsy in decision making for treatment of apparent early stage prostate cancer. J Urol. United States: Inc. Published by Elsevier Inc; 2011. p. 80–5.

    Google Scholar 

  52. Abdollah F, Novara G, Briganti A, et al. Trans-rectal versus trans-perineal saturation rebiopsy of the prostate: is there a difference in cancer detection rate? Urology. United States: 2011 Elsevier Inc; 2011. p. 921–5.

    Google Scholar 

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Correspondence to Hashim U. Ahmed PhD, FRCS(Urol), BM, BCh, BA .

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El-Shater Bosaily, A., Ahmed, H.U. (2016). Template Mapping Biopsies: An Overview of Technique and Results. In: Rastinehad, A., Siegel, D., Pinto, P., Wood, B. (eds) Interventional Urology. Springer, Cham. https://doi.org/10.1007/978-3-319-23464-9_8

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  • DOI: https://doi.org/10.1007/978-3-319-23464-9_8

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-23463-2

  • Online ISBN: 978-3-319-23464-9

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