Skip to main content
SpringerLink
Log in

High-Intensity Focused Ultrasound for Prostate Cancer

  • Chapter
Interventional Urology

  • 1333 Accesses

Abstract

Prostate cancer is the most common cancer in males and the second-leading cancer-related cause of death in the Western world. Prostate-specific antigen (PSA) screening, and changes in the diagnostic pathway of prostate cancer, has resulted in proportionally more men being diagnosed with early stage prostate cancer still confined to the prostate. Patients are faced with an overwhelming choice of treatment options to treat their disease. Standard options include radical prostatectomy (RP) and external-beam radiotherapy (ERBT) which, although provide good long-term cancer control, are associated with significant side effects affecting the quality of life of these patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Murat F-JL, Gelet A. Current status of high-intensity focused ultrasound for prostate cancer: technology, clinical outcomes, and future. Curr Urol Rep. 2008;9:113–21.

    Article  PubMed  Google Scholar 

  2. Haar GT, Coussios C. High intensity focused ultrasound: physical principles and devices. Int J Hyperthermia. 2007;23:89–104.

    Article  PubMed  Google Scholar 

  3. Marberger M. Energy-based ablative therapy of prostate cancer: high-intensity focused ultrasound and cryoablation. Curr Opin Urol. 2007;17:194–9.

    Article  PubMed  Google Scholar 

  4. Dickinson L, et al. Image-directed, tissue-preserving focal therapy of prostate cancer: a feasibility study of a novel deformable magnetic resonance-ultrasound (MR-US) registration system. BJU Int. 2013;112:594–601.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Poissonnier L, et al. Control of prostate cancer by transrectal HIFU in 227 patients. Eur Urol. 2007;51:381–7.

    Article  CAS  PubMed  Google Scholar 

  6. Blana A, et al. Eight years’ experience with high-intensity focused ultrasonography for treatment of localized prostate cancer. Urology. 2008;72:1329–33; discussion 1333–4.

    Article  PubMed  Google Scholar 

  7. Crouzet S, et al. Multicentric oncologic outcomes of high-intensity focused ultrasound for localized prostate cancer in 803 patients. Int Braz J Urol. 2011;37:128.

    Article  Google Scholar 

  8. Crouzet S, et al. Whole-gland ablation of localized prostate cancer with high-intensity focused ultrasound: Oncologic outcomes and morbidity in 1002 patients. Eur Urol. 2014;65:907–14.

    Article  PubMed  Google Scholar 

  9. Ripert T, et al. Six years’ experience with high-intensity focused ultrasonography for prostate cancer: Oncological outcomes using the new “Stuttgart” definition for biochemical failure. BJU Int. 2011;107:1899–905.

    Article  PubMed  Google Scholar 

  10. Pfeiffer D, Berger J, Gross AJ. Single application of high-intensity focused ultrasound as a first-line therapy for clinically localized prostate cancer: 5-year outcomes. BJU Int. 2012;110:1702–8.

    Article  PubMed  Google Scholar 

  11. Thüroff S, Chaussy C. Evolution and outcomes of 3 MHz high intensity focused ultrasound therapy for localized prostate cancer during 15 years. J Urol. 2013;190:702–10.

    Article  PubMed  Google Scholar 

  12. Blana A, et al. First analysis of the long-term results with transrectal HIFU in patients with localised prostate cancer. Eur Urol. 2008;53:1194–203.

    Article  PubMed  Google Scholar 

  13. Blana A, et al. Complete high-intensity focused ultrasound in prostate cancer: outcome from the @-Registry. Prostate Cancer Prostatic Dis. 2012;15:256–9.

    Article  CAS  PubMed  Google Scholar 

  14. Uchida T, et al. Transrectal high-intensity focused ultrasound for the treatment of localized prostate cancer: eight-year experience. Int J Urol. 2009;16:881–6.

    Article  PubMed  Google Scholar 

  15. Shoji S, et al. Quality of life following high-intensity focused ultrasound for the treatment of localized prostate cancer: a prospective study. Int J Urol. 2010;17:715–9.

    Article  PubMed  Google Scholar 

  16. Inoue Y, Goto K, Hayashi T, Hayashi M. Transrectal high-intensity focused ultrasound for treatment of localized prostate cancer. Int J Urol. 2011;18:358–62.

    Article  PubMed  Google Scholar 

  17. Ahmed HU, et al. High-intensity-focused ultrasound in the treatment of primary prostate cancer: the first UK series. Br J Cancer. 2009;101:19–26.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  18. Madersbacher S, Pedevilla M, Vingers L, Susani M, Marberger M. Effect of high-intensity focused ultrasound on human prostate cancer in vivo. Cancer Res. 1995;55:3346–51.

    CAS  PubMed  Google Scholar 

  19. Beerlage HP, Thüroff S, Debruyne FM, Chaussy C, de la Rosette JJ. Transrectal high-intensity focused ultrasound using the Ablatherm device in the treatment of localized prostate carcinoma. Urology. 1999;54:273–7.

    Article  CAS  PubMed  Google Scholar 

  20. Muto S, et al. Focal therapy with high-intensity-focused ultrasound in the treatment of localized prostate cancer. Jpn J Clin Oncol. 2008;38:192–9.

    Article  PubMed  Google Scholar 

  21. Murat FJ, et al. 854 Focal Therapy of Prostate Cancer (PCA) with HIFU: influence on erectile dysfunction (ED). Eur Urol Suppl. 2009;8:334.

    Article  Google Scholar 

  22. Ahmed HU, et al. Focal therapy for localized prostate cancer: a phase I/II trial. J Urol. 2011;185:1246–54.

    Article  CAS  PubMed  Google Scholar 

  23. Ahmed HU, et al. Focal therapy for localised unifocal and multifocal prostate cancer: a prospective development study. Lancet Oncol. 2012;13:622–32.

    Article  PubMed Central  PubMed  Google Scholar 

  24. Ahmed HU, et al. Focal ablation targeted to the index lesion in multifocal localised prostate cancer: a Prospective Development Study. Eur. Urol. 2015. doi:10.1016/j.eururo.2015.01.030.

    Google Scholar 

  25. El Fegoun AB, et al. Focal therapy with high-intensity focused ultrasound for prostate cancer in the elderly. A feasibility study with 10 years follow-up. Int Braz J Urol. 2011;37:212–3.

    Google Scholar 

  26. Zelefsky MJ, Reuter VE, Fuks Z, Scardino P, Shippy A. Influence of local tumor control on distant metastases and cancer related mortality after external beam radiotherapy for prostate cancer. J Urol. 2008;179:1368–73; discussion 1373.

    Article  PubMed Central  PubMed  Google Scholar 

  27. Kuban DA, et al. Long-term multi-institutional analysis of stage T1-T2 prostate cancer treated with radiotherapy in the PSA era. Int J Radiat Oncol Biol Phys. 2003;57:915–28.

    Article  PubMed  Google Scholar 

  28. Agarwal PK, Sadetsky N, Konety BR, Resnick MI, Carroll PR. Treatment failure after primary and salvage therapy for prostate cancer: Likelihood, patterns of care, and outcomes. Cancer. 2008;112:307–14.

    Article  PubMed  Google Scholar 

  29. Lee WR, Hanks GE, Hanlon A. Increasing prostate-specific antigen profile following definitive radiation therapy for localized prostate cancer: clinical observations. J Clin Oncol. 1997;15:230–8.

    CAS  PubMed  Google Scholar 

  30. Murat FJ, et al. Mid-term results demonstrate salvage high-intensity focused ultrasound (HIFU) as an effective and acceptably morbid salvage treatment option for locally radiorecurrent prostate cancer. Eur Urol. 2009;55:640–9.

    Article  PubMed  Google Scholar 

  31. Zacharakis E, et al. The feasibility and safety of high-intensity focused ultrasound as salvage therapy for recurrent prostate cancer following external beam radiotherapy. BJU Int. 2008;102:786–92.

    Article  PubMed  Google Scholar 

  32. Gelet A, et al. Local recurrence of prostate cancer after external beam radiotherapy: early experience of salvage therapy using high-intensity focused ultrasonography. Urology. 2004;63:625–9.

    Article  PubMed  Google Scholar 

  33. Crouzet S, et al. Locally recurrent prostate cancer after initial radiation therapy: early salvage high-intensity focused ultrasound improves oncologic outcomes. Radiother Oncol. 2012;105:198–202.

    Article  PubMed  Google Scholar 

  34. Song W, et al. High-intensity focused ultrasound as salvage therapy for patients with recurrent prostate cancer after radiotherapy. Korean J Urol. 2014;55:91–6.

    Article  PubMed Central  PubMed  Google Scholar 

  35. Ahmed HU, et al. Focal salvage therapy for localized prostate cancer recurrence after external beam radiotherapy: a pilot study. Cancer. 2012;118:4148–55.

    Article  PubMed  Google Scholar 

  36. Baco E, et al. Hemi salvage high-intensity focused ultrasound (HIFU) in unilateral radiorecurrent prostate cancer: a prospective two-centre study. BJU Int. 2014. doi:10.1111/bju.12545.

    Google Scholar 

  37. Gerber GS, et al. Results of radical prostatectomy in men with clinically localized prostate cancer. JAMA. 1996;276:615–9.

    Article  CAS  PubMed  Google Scholar 

  38. Chun FK-H, et al. Anatomic radical retropubic prostatectomy-long-term recurrence-free survival rates for localized prostate cancer. World J Urol. 2006;24:273–80.

    Article  PubMed  Google Scholar 

  39. Asimakopoulos AD, Miano R, Virgili G, Vespasiani G, Finazzi Agrò E. HIFU as salvage first-line treatment for palpable, TRUS-evidenced, biopsy-proven locally recurrent prostate cancer after radical prostatectomy: a pilot study. Urol Oncol. 2012;30:577–83.

    Article  PubMed  Google Scholar 

  40. Hayashi M, Shinmei S, Asano K. Transrectal high-intensity focused ultrasound for treatment for patients with biochemical failure after radical prostatectomy. Int J Urol. 2007;14:1048–50.

    Article  PubMed  Google Scholar 

  41. Potters L, et al. 12-year outcomes following permanent prostate brachytherapy in patients with clinically localized prostate cancer. J Urol. 2005;173:1562–6.

    Article  PubMed  Google Scholar 

  42. Yutkin V, et al. Salvage high-intensity focused ultrasound for patients with recurrent prostate cancer after brachytherapy. Urology. 2014;84:1157–62.

    Article  PubMed  Google Scholar 

  43. Chen JC, et al. Prostate cancer: MR imaging and thermometry during microwave thermal ablation-initial experience. Radiology. 2000;214:290–7.

    Article  CAS  PubMed  Google Scholar 

  44. Hazle JD, et al. MRI-guided thermal therapy of transplanted tumors in the canine prostate using a directional transurethral ultrasound applicator. J Magn Reson Imaging. 2002;15:409–17.

    Article  PubMed  Google Scholar 

  45. Germain D, Chevallier P, Laurent A, Saint-Jalmes H. MR monitoring of tumour thermal therapy. MAGMA. 2001;13:47–59.

    Article  CAS  PubMed  Google Scholar 

  46. Ross AB, et al. Highly directional transurethral ultrasound applicators with rotational control for MRI-guided prostatic thermal therapy. Phys Med Biol. 2004;49:189–204.

    Article  PubMed  Google Scholar 

  47. Lafon C, Koszek L, Chesnais S, Theillère Y, Cathignol D. Feasibility of a transurethral ultrasound applicator for coagulation in prostate. Ultrasound Med Biol. 2004;30:113–22.

    Article  PubMed  Google Scholar 

  48. Partanen A, et al. Magnetic resonance imaging (MRI)-guided transurethral ultrasound therapy of the prostate: a preclinical study with radiological and pathological correlation using customised MRI-based moulds. BJU Int. 2013;112:508–16.

    Article  PubMed  Google Scholar 

  49. Chopra R, et al. MRI-compatible transurethral ultrasound system for the treatment of localized prostate cancer using rotational control. Med Phys. 2008;35:1346–57.

    Article  PubMed  Google Scholar 

  50. Chopra R, et al. MR imaging-controlled transurethral ultrasound therapy for conformal treatment of prostate tissue: initial feasibility in humans. Radiology. 2012;265:303–13.

    Article  PubMed  Google Scholar 

  51. Blana A, et al. High-intensity focused ultrasound for prostate cancer: comparative definitions of biochemical failure. BJU Int. 2009;104:1058–62.

    Article  CAS  PubMed  Google Scholar 

  52. Blana A, et al. Morbidity associated with repeated transrectal high-intensity focused ultrasound treatment of localized prostate cancer. World J Urol. 2006;24:585–90.

    Article  PubMed  Google Scholar 

  53. Ben Cheikh A, et al. MR detection of local prostate cancer recurrence after transrectal high-intensity focused US treatment: preliminary results. J Radiol. 2008;89:571–7.

    Article  CAS  PubMed  Google Scholar 

  54. Rouvière O, et al. Prostate cancer transrectal HIFU ablation: detection of local recurrences using T2-weighted and dynamic contrast-enhanced MRI. Eur Radiol. 2010;20:48–55.

    Article  PubMed  Google Scholar 

  55. Rouvière O, et al. MRI appearance of prostate following transrectal HIFU ablation of localized cancer. Eur Urol. 2001;40:265–74.

    Article  PubMed  Google Scholar 

  56. Susani M, Madersbacher S, Kratzik C, Vingers L, Marberger M. Morphology of tissue destruction induced by focused ultrasound. Eur Urol. 1993;23 Suppl 1:34–8.

    PubMed  Google Scholar 

  57. Rouvière O, Gelet A, Crouzet S, Chapelon J-Y. Prostate focused ultrasound focal therapy—imaging for the future. Nat Rev Clin Oncol. 2012. doi:10.1038/nrclinonc.2012.136.

    PubMed  Google Scholar 

  58. Tsakiris P, Thüroff S, de la Rosette J, Chaussy C. Transrectal high-intensity focused ultrasound devices: a critical appraisal of the available evidence. J Endourol. 2008;22:221–9.

    Article  PubMed  Google Scholar 

  59. Ahmed HU, et al. Rectal fistulae after salvage high-intensity focused ultrasound for recurrent prostate cancer after combined brachytherapy and external beam radiotherapy. BJU Int. 2009;103:321–3.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Surgery and Interventional Science, University College London, London, UK

    Stephanie Guillaumier MD, MRCS, DipABRSM & Hashim Uddin Ahmed PhD, FRCS(Urol), BM, BCh, BA

  2. Division of Surgery and Interventional Sciences, University College London Hospital, London, UK

    Mark Emberton MD, FRCS (Urol), FRCS, MBBS, BSc

  3. Department of Urology, University College London Hospital NHS Foundation Trust, London, UK

    Hashim Uddin Ahmed PhD, FRCS(Urol), BM, BCh, BA

Authors
  1. Stephanie Guillaumier MD, MRCS, DipABRSM
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mark Emberton MD, FRCS (Urol), FRCS, MBBS, BSc
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hashim Uddin Ahmed PhD, FRCS(Urol), BM, BCh, BA
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mark Emberton MD, FRCS (Urol), FRCS, MBBS, BSc .

Editor information

Editors and Affiliations

  1. Focal Therapy and Interventional Urologic Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

    Ardeshir R. Rastinehad

  2. Department of Radiology, Hofstra North Shore LIJ School of Medici Department of Radiology, New Hyde Park, New York, USA

    David N. Siegel

  3. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    Peter A. Pinto

  4. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    Bradford J. Wood

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Guillaumier, S., Emberton, M., Ahmed, H.U. (2016). High-Intensity Focused Ultrasound for Prostate Cancer. In: Rastinehad, A., Siegel, D., Pinto, P., Wood, B. (eds) Interventional Urology. Springer, Cham. https://doi.org/10.1007/978-3-319-23464-9_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-23464-9_10

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-23463-2

  • Online ISBN: 978-3-319-23464-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation