Abstract
It is critical to keep in mind, especially in this chapter that multiple lifestyle options exists that can improve or actually not improve and even exacerbate side effects from cancer treatments. And there are many integrative medicines, especially dietary supplements that can improve, have no impact or actually cause a side effect from cancer treatment to become worse! The purpose of this chapter just like the rest of this book is to cover all of those integrative medicines that work, have no effect or are worthless for multiple cancer treatment side effects. When applicable prescription drug treatments are mentioned and reviewed. Still, this chapter and the book is not intended to provide a summary or exhaustive list of the conventional prescription treatment options for these side effects from A to Z because it would not only create an unreadable voluminous text, but this also would not serve the purpose of this text—to simply provide a non-biased and objective review of the medical research in the area of breast cancer and integrative medicines, especially in regard to lifestyle changes and dietary supplements. This is the area of oncology that appears to have arguably the greatest current needs for more objective and educational attention to this issue.
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References
Moyad MA. Promoting wellness: beyond hormone therapy. Ann Arbor, MI: Spry Publishing; 2013.
Strum SB, McDermed JE, Scholz MC, Johnson H, Tisman G. Anaemia associated with androgen deprivation in patients with prostate cancer receiving combined hormonal blockade. Br J Urol. 1997;79:933–41.
Moyad MA. The supplement handbook. New York, NY: Rodale Publishing; 2015.
Iyengar A, Sheppard D. A case of erythrocytosis in a patient treated with an aromatase inhibitor for breast cancer. Case Rep Hematol. 2013;2013:615198.
Wit JM, Hero M, Nunez SB. Aromatase inhibitors in pediatrics. Nat Rev Endocrinol. 2011;8:135–47.
Heidelbaugh JJ. Proton pump inhibitors and risk of vitamin and mineral deficiency: evidence and clinical implications. Ther Adv Drug Saf. 2013;4:125–33.
Alger E, Feldman A, Datz C. Obesity as an emerging risk factor for iron deficiency. Nutrients. 2014;6:3587–600.
Willis MS, Monaghan SA, Miller ML, McKenna RW, Perkins WD, Levinson BS, et al. Zinc-induced copper deficiency: a report of three cases initially recognized on bone marrow examination. Am J Clin Pathol. 2005;123:125–31.
Bar-Sela G, Tsalic M, Fried G, Goldberg H. Wheat grass juice may improve hematological toxicity related to chemotherapy in breast cancer patients: a pilot study. Nutr Cancer. 2007;58:43–8.
Ben-Arye E, Goldin E, Wengrower D, Stampfer A, Kohn R, Berry E. Wheat grass juice in the treatment of active distal ulcerative colitis: a randomized double-blind placebo-controlled trial. Scand J Gastroenterol. 2002;37:444–9.
Marawaha RK, Bansal D, Kaur S, Trehan A. Wheat grass juice reduces transfusion requirement in patients with thalassemia major: a pilot study. Indian Pediatr. 2004;41:716–20.
Pole SN. Wheat grass juice in thalassemia. Indian Pediatr. 2006;43:79–80.
Choudhary DR, Naithani R, Panigrahi I, Kumar R, Mahapatra M, Pati HP, et al. Effect of wheat grass therapy on transfusion requirement in beta-thalassemia major. Indian J Pediatr. 2009;76:375–6.
Singh K, Pannu MS, Singh P, Singh J. Effect of wheat grass tablets on the frequency of blood transfusions in Thalassemia Major. Indian J Pediatr. 2010;77:90–1.
Murphy CC, Bartholomew LK, Carpentier MY, Bluethmann SM, Vernon SW. Adherence to adjuvant hormonal therapy among breast cancer survivors in clinical practice: a systematic review. Breast Cancer Res Treat. 2012;134:459–78.
Irwin ML, Cartmel B, Gross CP, Ercolano E, Li F, Yao X, et al. Randomized exercise trial of aromatase inhibitor-induced arthralgia in breast cancer survivors. J Clin Oncol. 2015;33:1104–11.
DeNysschen CA, Burton H, Ademuyiwa F, Levine E, Tetewsky S, O’Connor T. Exercise intervention in breast cancer patients with aromatase inhibitor-associated arthralgia: a pilot study. Eur J Cancer Care (Engl). 2014;23:493–501.
Nyrop KA, Muss HB, Hackney B, Cleveland R, Altpeter M, Callahan LF. Feasibility and promise of a 6-week program to encourage physical activity and reduce joint symptoms among elderly breast cancer survivors on aromatase inhibitor therapy. J Geriatr Oncol. 2014;5:148–55.
Galantino ML, Desai K, Greene L, Demichele A, Stricker CT, Mao JJ. Impact of yoga on functional outcomes in breast cancer survivors with aromatase inhibitor-associated arthralgias. Integr Cancer Ther. 2012;11:313–20.
Crew KD, Capodice J, Greenlee H, Brafman L, Fuentes D, Awad D, et al. Randomized, blinded, sham-controlled trial of acupuncture for the management of aromatase inhibitor-associated joint symptoms in women with early stage breast cancer. J Clin Oncol. 2010;28:1154–60.
Oh B, Kimble B, Costa DS, Davis E, McLean A, Orme K, et al. Acupuncture for treatment of arthralgia secondary to aromatase inhibitor therapy in women with early breast cancer: pilot study. Acupunct Med. 2013;31:264–71.
Fransen M, Agailotis M, Nairn L, Votrubec M, Bridgett L, Su S, et al., for the LEGS study collaborative group. Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomized placebo-controlled clinical trial evaluating single and combination regimens. Ann Rheum Dis 2015;74:851–8.
Hochberg MC, Martel-Pelletier J, Monfort J, Moller I, Castillo JR, Arden N, et al., on behalf of the MOVES investigative group. Ann Rheum Dis 2015, Epub ahead of print.
Singh JA, Noorbaloochi S, MacDonald R, Maxwell LJ. Chondroitin for osteoarthritis. Cochrane Database Syst Rev. 2015;1:CD005614.
Clegg DO, Reda DJ, Harris CL, Klein MA, O’Dell JR, Hooper MM, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006;354:795–808.
Greenlee H, Crew KD, Shao T, Kranwinkel G, Kallinsky K, Mauer M, et al. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer. 2013;21:1077–87.
Goldberg RJ, Katz J. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain. 2007;129:210–23.
Hershman DL, Loprinzi C, Schneider BP. Symptoms: aromatase inhibitor induced arthralgias. Adv Exp Med Biol. 2015;862:89–100.
Hershman DL, Unger JM, Crew KD, Awad D, Dakhill SR, Gralow J, et al. Randomized multicenter placebo-controlled trial of omega-3 fatty acids for the control of aromatase inhibitor-induced musculoskeletal pain: SWOG S0927. J Clin Oncol. 2015;33:1910–7.
Niravath P. Aromatase inhibitor-induced arthralgia: a review. Ann Oncol. 2013;24:1443–9.
Khan QJ, Reddy PS, Kimier BF, Sharma P, Baxa SE, O’Dea AP, et al. Effect of vitamin D supplementation on serum 25-hydroxy vitamin D levels, joint pain, and fatigue in women starting adjuvant letrozole treatment for breast cancer. Breast Cancer Res Treat. 2010;119:111–8.
Khan Q, Kimler B, Reddy P, et al. Randomized trial of vitamin D3 to prevent worsening of musculoskeletal symptoms and fatigue in women with breast cancer starting adjuvant letrozole: the VITAL trial. J Clin Oncol 2012;30(Suppl; abstr 9000).
Shapiro AC, Adilis SA, Liang S, Robien K, Kirstein MN, Anderson E, et al. A randomized trial of vitamin D3 in aromatase inhibitor-associated musculoskeletal symptoms. J Clin Oncol 2015;33:(Suppl; abstract 9608).
Waldron JL, Ashby HL, Comes MP, Bechervaise J, Razavi C, Thomas OL, et al. Vitamin D: a negative acute phase reactant. J Clin Pathol. 2013;66:620–2.
Silva MC, Furlanetto TW. Does serum 25-hydroxyvitamin D decrease during acute-phase response? A systematic review. Nutr Res. 2015;35:91–6.
McAlindon T, LaValley M, Schneider E, Nuite M, Lee JY, Price LL, et al. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA. 2013;309:155–62.
Laslett LL, Jones G. Capsaicin for osteoarthritis pain. Prog Drug Res. 2014;68:277–91.
Snedecor SJ, Sudharshan L, Cappelleri JC, Sadosky A, Mehta S, Botteman M. Systemic review and meta-analysis of pharmacological therapies for painful diabetic peripheral neuropathy. Pain Pract. 2014;14:167–84.
Derry S, Sven-Rice A, Cole P, Tan T, Moore RA. Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2013;2:CD007393.
Watson CP, Evans RJ. The postmastectomy pain syndrome and topical capsaicin: a randomized trial. Pain. 1992;51:375–9.
Watson CP, Evans RJ, Watt VR. The post-mastectomy pain syndrome and the effect of topical capsaicin. Pain. 1989;38:177–86.
Diaz-Laviada I, Rodriguez-Henche N. The potential antitumor effects of capsaicin. Prog Drug Res. 2014;68:181–208.
Lugman S, Meena A, Marler LE, Kondratyuk TP, Pezzuto JM. Suppression of tumor necrosis factor-alpha-induced nuclear factor kB activation and aromatase activity by capsaicin and its analog capsazepine. J Med Food. 2011;14:1344–51.
Mao JJ, Stricker C, Bruner D, Xie S, Bowman MA, Farrar JT, et al. Patterns and risk factors associated with aromatase inhibitor-related arthralgia among breast cancer survivors. Cancer. 2009;115:3631–9.
Madhu K, Chanda K, Saji MJ. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. Inflammopharmacology. 2013;21:129–36.
Pinsomsak P, Niempoog S. The efficacy of Curcuma Longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized controlled trial. J Med Assoc Thai. 2012;95 Suppl 1:S51–8.
Bayet-Robert M, Kwiatkowski F, Leheurteur M, Gachon F, Pianchat E, Abrial C, et al. Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced metastatic breast cancer. Cancer Biol Ther. 2010;9:8–14.
Kumar P, Kadakol A, Shasthrula PK, Mundhe NA, Jamdade VS, Barua CC, et al. Curcumin as an adjuvant to breast cancer treatment. Anticancer Agents Med Chem. 2015;15:647–56.
Kanai M, Yoshimura K, Asada M, Imaizumi A, Suzuki C, Matsumoto S, et al. A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer. Cancer Chemother Pharmacol. 2011;68:157–64.
Epelbaum R, Schaffer M, Vizel B, Badmaev V, Bar-Sela G. Curcumin and gemcitabine in patients with advanced pancreatic cancer. Nutr Cancer. 2010;62:1137–41.
Soeken KL, Lee W-L, Bausell B, Agelli M, Berman BM. Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis: a meta-analysis. J Fam Pract. 2002;51:425–30.
Ringdahl E, Pandit S. Treatment of knee osteoarthritis. Am Fam Physician. 2011;83:1287–92.
Sarkis KS, Pinheiro Mde M, Szejnfeld VL, Martini LA. High bone density and bone health. Endocrinol Nutr. 2012;59:207–14.
Zhang P, Peterson M, Su GL, Wang SC. Visceral adiposity is negatively associated with bone density and muscle attenuation. Am J Clin Nutr. 2015;101:337–43.
Mason C, Xiao L, Imayama I, Duggan CR, Bain C, Foster-Schubert KE, et al. Effects of weight loss on serum vitamin D in postmenopausal women. Am J Clin Nutr. 2011;94:95–103.
Winters-Stone KM, Dobek J, Nail L, Bennett JA, Leo MC, Naik A, et al. Strength training stops bone loss and builds muscle in postmenopausal breast cancer survivors: a randomized, controlled trial. Breast Cancer Res Treat. 2011;127:447–56.
Irwin ML, Alvarez-Reeves M, Cadmus L, Mierzejewski E, Mayne ST, Yu H, et al. Exercise improves body fat, lean mass, and bone mass in breast cancer survivors. Obesity (Silver Spring). 2009;17:1534–41.
Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006;354:669–83.
Prentice RL, Pettinger MB, Jackson RD, Wactawski-Wende J, Lacroix AZ, Anderson GL, et al. Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study. Osteoporos Int. 2013;24:567–80.
Martin-Herranz A, Salinas-Hernandez P. Vitamin D supplementation review and recommendations for women diagnosed with breast or ovary cancer in the context of bone health and cancer prognosis/risk. Crit Rev Oncol Hematol 2015, Epub ahead of print.
LeBlanc E, Chou R, Zakher B, Daeges M, Pappas M. Screening for vitamin D deficiency: systematic review for the U.S. Preventive Services Task Force Recommendation. Rockville, MD: Agency for Healthcare Research and Quality (US); Nov 2014. Report No.: 13-05183-EF-1.
LeBlanc ES, Zakher B, Daeges M, Pappas M, Chou R. Screening for vitamin D deficiency: a systematic review for the U.S. Preventive Services Task Force. Ann Intern Med. 2015;162:109–22.
Ellis GK, Bone HG, Chlebowski R, Paul D, Spadafora S, Smith J, et al. Randomized trial of denosumab in patients receiving adjuvant aromatase inhibitors for nonmetastatic breast cancer. J Clin Oncol. 2008;26:4875–82.
Stopeck AT, Lipton A, Body JJ, Steger GG, Tonkin K, de Boer RH, et al. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. J Clin Oncol. 2010;28:5132–9.
Thacher TD, Obadofin MO, O’Brien KO, Abrams SA. The effect of vitamin D2 and vitamin D3 on intestinal calcium absorption in Nigerian children with rickets. J Clin Endocrinol Metab. 2009;94:1314–21.
Biancuzzo RM, Clarke N, Reitz RE, Travison TG, Holick MF. Serum concentrations of 1,25-dihydroxyvitamin D2 and 1,250dihydroxyvitamin D3 in response to vitamin D2 and vitamin D3 supplementation. J Clin Endocrinol Metab. 2013;98:973–9.
Holick MF, Biancuzzo RM, Chen TC, Klein EK, Young A, Bibuld D, et al. Vitamin D2 is effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab. 2008;93:677–81.
Gordon CM, Williams AL, Feldman HA, May J, Sinclair L, Vasquez A, et al. Treatment of hypovitaminosis D in infants and toddlers. J Clin Endocrinol Metab. 2008;93:2716–21.
Gottschlich MM, Mayes T, Khoury J, Kagan RJ. Clinical trial of vitamin D2 vs D3 supplementation in critically ill pediatric burn patients. JPEN J Parenter Enteral Nutr 2015; Epub ahead of print.
Mangoo-Karim R, Da Silva Abreu J, Yanev GP, Perez NN, Stubbs JR, Wetmore JB. Ergocalciferol versus cholecalciferol for nutritional vitamin D replacement in CKD. Nephron 2015, Epub ahead of print.
Logan VF, Gray AR, Peddie MC, Harper MJ, Houghton LA. Long-term vitamin D3 supplementation is more effective than vitamin D2 in maintaining serum 25-hydroxyvitamin D status over the winter months. Br J Nutr. 2013;109:1082–8.
Osteoporosis-Part MA. Osteoporosis—Part II: Dietary and/or supplemental calcium and vitamin D. Urol Nurs. 2002;22:405–9.
Smith MR, Egerdie B, Harnandez Toriz N, Feldman R, Tammela TL, Saad F, et al., for the Denosumab HALT Prostate Cancer Study Group. Denosumab in men receiving androgen-deprivation therapy for prostate cancer. N Engl J Med 2009;361:745–55.
Kukuijan S, Nowson CA, Sanders KM, Nicholson GC, Seibel MJ, Salmon J, et al. Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: an 18-month factorial design randomized controlled trial. J Clin Endocrinol Metab. 2011;96:955–63.
Kemmler W, von Stengel S, Engelke K, Haberle L, Kalender WA. Exercise effects on bone mineral density, falls, coronary risk factors, and health care costs in older women: the randomized controlled senior fitness and prevention (SEFIB) study. Arch Intern Med. 2010;170:179–85.
Uusi-Rasi K, Patil R, Karinkanta S, Kannus P, Tokola K, Lamberg-Allardt C, et al. Exercise and vitamin D in fall prevention among older women: a randomized clinical trial. JAMA Intern Med. 2015;175:703–11.
Lau EM, Woo J, Leung PC, Swaminathan R, Leung D. The effects of calcium supplementation and exercise on bone density in elderly Chinese women. Osteoporos Int. 1992;2:168–73.
Slatkovska L, Alibhai S, Beyene J, et al. Effect of 12 months of whole-body vibration therapy on bone density and structure in postmenopausal women. Ann Intern Med. 2011;155:668–79.
Lam TP, Ng BK, Cheung LW, Lee KM, Qin L, Cheng JC, et al. Effect of whole body vibration (WBV) therapy on bone density and bone quality in osteopenic girls with adolescent idiopathic scoliosis: a randomized, controlled trial. Osteoporos Int. 2013;24:1623–36.
Van Ruymbeke B, Boone J, Coorevitis P, Vanderstraeten G, Bourgois J. Whole-body vibration in breast cancer survivors: a pilot study exploring its effects on muscle activity and subjectively perceived exertion. Int J Rehabil Res. 2014;37:371–4.
Reid IR. Efficacy, effectiveness and side effects of medications used to prevent fractures. J Intern Med. 2015;277:690–706.
Medicines and Healthcare Products Regulatory Agency (MHRA). Strontium ranelate (Protelos): risk of serious cardiac disorders-restricted indications, new contraindications, and warnings. Drug Saf Update. 2013;6:S1.
Wohl GR, Chettle DR, Pejovic-Millic A, Druchok C, Webber CE, Adachi JD, et al. Accumulation of bone strontium measured by in vivo XRF in rats supplemented with strontium citrate and strontium ranelate. Bone. 2013;52:63–9.
Guralp O, Erel CT. Effects of vitamin K in postmenopausal women: mini review. Maturitas. 2014;77:294–9.
Theuwissen E, Teunissen KJ, Spronk HM, Hamulyak K, Ten Café H, Shearer MJ, et al. Effect of low-dose supplements of menaquinone-7 (vitamin K2) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers. J Thromb Haemost. 2013;11:1085–92.
Miller PE, Alexander DD, Perez V. Effects of whey protein and resistance exercise on body composition: a meta-analysis of randomized controlled trials. J Am Coll Nutr. 2014;33:163–75.
Verreijen AM, Verlaan S, Engberink MF, Swinkels S, de Vogel-van den Bosch J, Weijs PJ, et al. A high whey protein-, leucine-, and vitamin D-enriched supplement preserves muscle mass during intentional weight loss in obese older adults: a double-blind randomized controlled trial. Am J Clin Nutr. 2015;101:279–86.
Pritchett K, Pritchett R. Chocolate milk: a post-exercise recovery beverage for endurance sports. Med Sports Sci. 2012;59:127–34.
Gualano B, Macedo AR, Alves CR, Roschel H, Benatti FB, Takayama L, et al. Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial. Exp Gerontol. 2014;53:7–15.
Devries MC, Phillips SM. Creatine supplementation during resistance training in older adults—a meta-analysis. Med Sci Sports Exerc. 2014;46:1194–203.
Cooney GM, Dwan K, Greig CA, Lawlor DA, Rimer J, Waugh FR, et al. Exercise for depression. Cochrane Database Syst Rev. 2013;9:CD004366.
Bluementhal JA, Doraiswamy PM. Exercise to combat depression. JAMA. 2014;312:2166–7.
Babyak M, Blumenthal JA, Herman S, Khatri P, Doraiswamy M, Moore K, et al. Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months. Psychosom Med. 2000;62:633–8.
Blumenthal JA, Sherwood A, Babyak MA, Watkins LL, Smith PJ, Hoffman BM, et al. Exercise and pharmacological treatment of depressive symptoms in patients with coronary heart disease: results from the UPBEAT (Understanding the Prognostic Benefits of Exercise and Antidepressant Therapy) study. J Am Coll Cardiol. 2012;60(12):1053–63.
Bluementhal JA, Babyak MA, Doraiswamy PM, Watkins L, Hoffman BM, Barbour KA, et al. Exercise and pharmacotherapy in the treatment of major depressive disorder. Psychosom Med. 2007;69:587–96.
Travier N, Velthuis MJ, Steins-Bisschop CN, van den Buijs B, Monninkhof EM, et al. Effect of an 18-week exercise programme started early during breast cancer treatment: a randomized controlled trial. BMC Med. 2015;13:121.
Schmidt ME, Wiskemann J, Armbrust P, Schneeweiss A, Ulrich CM, Steindorf K. Effects of resistance exercise on fatigue and quality of life in breast cancer patients undergoing adjuvant chemotherapy: a randomized controlled trial. Int J Cancer. 2015;137:471–80.
Battaglini CL, Mills RC, Phillips BL, Lee JT, Story CE, Nascimento MG, et al. Twenty-five years of research on the effects of exercise training in breast cancer survivors: a systematic review of the literature. World J Clin Oncol. 2014;5:177–90.
Papakostas GI. Evidence for S-adenosyl-l-methionine (SAM-e) for treatment of major depressive disorder. J Clin Psychiatry. 2009;70 Suppl 5:18–22.
Nahas R, Sheikh O. Complementary and alternative medicine for the treatment of major depressive disorder. Can Fam Physician. 2011;57:659–63.
Papakostas GI, Mischoulon D, Shyu I, Alpert JE, Fava M. S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial. Am J Psychiatry. 2010;167:942–8.
Mischoulon D, Price LH, Carpenter LL, Tyrka AR, Papakostas GI, Baer L, et al. A double-blind, randomized, placebo-controlled clinical trial of S-adenosyl-l-methionine (SAMe) versus escitalopram in major depressive disorder. J Clin Psychiatry. 2014;75:370–6.
Sarris J, Papakostas GI, Vitolo O, Fava M, Mischoulon D. S-adenosyl methionine (SAMe) versus escitalopram and placebo in major depression RCT: efficacy and effects of histamine and carnitine as moderators of response. J Affect Disord. 2014;164:76–81.
Sarris J, Price LH, Carpenter LL, Tyrka AR, Ng CH, Papakostas GI, et al. Is S-adenosyl methionine (SAMe) for depression only effective in males? A re-analysis of data from a randomized clinical trial. Pharmacopsychiatry. 2015;48(4–5):141–4. Epub 26 May 2015.
Mischoulon D, Alpert JE, Aming E, Bottiglieri T, Fava M, Papakostas GI. Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder. J Clin Psychiatry. 2012;73:843–8.
Dording CM, Mischoulon D, Shyu I, Alpert JE, Papakostas GI. SAMe and sexual functioning. Eur Psychiatry. 2012;27:451–4.
Rahimi R, Abdollahi M. An update on the ability of St. John’s wort to affect the metabolism of other drugs. Expert Opin Drug Metab Toxicol. 2012;8:691–708.
Linde K, Berner MM, Kriston L. St John’s wort for major depression. Cochrane Database Syst Rev. 2008;4:CD000448.
Luberto CM, White C, Sears RW, Cotton S. Integrative medicine for treating depression: an update on the latest evidence. Curr Psychiatry Rep. 2013;15:391.
Al-Akoum M, Maunsell E, Verreault R, Provencher L, Otis H, Dodin S. Effects of Hypericum perforatum (St. John’s wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. Menopause. 2009;16:307–14.
He SM, Yang AK, Li XT, Du YM, Zhou SF. Effects of herbal products on the metabolism and transport of anticancer agents. Expert Opin Drug Metab Toxicol. 2010;6:1195–213.
Bloch MH, Hannestad J. Omega-3 fatty acids for the treatment of depression: systematic review and meta-analysis. Mol Psychiatry. 2012;17:1272–82.
Mischoulon D, Nierenberg AA, Schettler PJ, Kinkead BL, Fehling K, Martinson MA, et al. A double-blind, randomized controlled clinical trial comparing eicosapentaenoic acid versus docosahexaenoic acid for depression. J Clin Psychiatry. 2015;76:54–61.
Gertsik L, Poland RE, Bresee C, Rapaport MH. Omega-3 fatty acid augmentation of citalopram treatment for patients with major depressive disorder. J Clin Psychopharmacol. 2012;32:61–4.
Zimmer R, Riemer T, Rauch B, Schneider S, Schiele R, Gohlke H, et al., for the OMEGA-Study Group. Effects of 1-year treatment with highly purified omega-3 fatty acids on depression after myocardial infarction: results form the OMEGA trial. J Clin Psychiatry 2013;74:e1037–45.
Cockayne NL, Duffy SL, Bonomally R, English A, Amminger PG, Mackinnon A, et al. The Beyond Ageing Project Phase 2—a double-blind, selective prevention, randomized, placebo-controlled trial of omega-3 fatty acids and sertraline in an older age cohort at risk for depression: study protocol for a randomized controlled trial. Trials. 2015;16:247.
Papakostas GI, Shelton RC, Zajecka JM, Etemand B, Rickels K, Clain A, et al. l-Methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials. Am J Psychiatry. 2012;169:1267–74.
Iovieno N, Dalton ED, Fava M, Mischoulon D. Second-tier natural antidepressants: review and critique. J Affect Disord. 2011;130:343–57.
Liu A, Ji J. Omega-3 essential fatty acids therapy for dry eye syndrome: a meta-analysis of randomized controlled studies. Med Sci Monit. 2014;20:1583–9.
Rosenberg ES, Asbell PA. Essential fatty acids in the treatment of dry eye. Ocul Surf. 2010;8:18–28.
Rashid S, Jin Y, Ecoiffier T, Barabino S, Schaumberg DA, Dana MR. Topical omega-3 and omega-6 fatty acids for treatment of dry eye. Arch Ophthalmol. 2008;126:219–25.
Al Mahmood AM, Al-Swailem SA. Essential fatty acids in the treatment of dry eye syndrome: a myth or reality? Saudi J Ophthalmol. 2014;28:195–7.
Jarvinen RL, Larmo PS, Setaia NL, Yang B, Engblom JR, Viltanen MH, Kallio HP. Effects of oral sea buckthorn oil on tear film fatty acids in individuals with dry eye. Cornea. 2011;30:1013–9.
Larmo PS, Jarvinen RL, Setaia NL, Tang B, Vitanen MH, Engblom JR, et al. Oral sea buckthorn oil attenuates tear film osmolarity and symptoms in individuals with dry eye. J Nutr. 2010;140:1462–8.
Kim EC, Choic JS, Joo CK. A comparison of vitamin a and cyclosporine a 0.05% drops for treatment of dry eye syndrome. Am J Ophthalmol. 2009;147:206–13.
Fraunfelder FW, Fraunfelder FT, Illingworth DR. Adverse ocular effects associated with niacin therapy. Br J Ophthalmol. 1995;79:54–6.
Turaka K, Nottage JM, Hammersmith KM, Nagra PK, Rapuano CJ. Dry eye syndrome in aromatase inhibitor users. Clin Experiment Ophthalmol. 2013;41:239–43.
Hutchinson CV, Walker JA, Davidson C. Oestrogen, ocular function and low-level vision: a review. J Endocrinol. 2014;223:R9–18.
Delli K, Spijkervet FK, Kroese FG, Bootsma H, Vissink A. Xerostomia. Monogr Oral Sci. 2014;24:109–25.
Hanchanale S, Adkinson L, Daniel S, Fleming M, Oxberry SG. Systematic literature review: xerostomia in advanced cancer patients. Support Care Cancer. 2015;23:861–8.
Bagheri H, Schmitt L, Berian M, Montasstruct JL. A comparative study of the effects of yohimbine and anetholtrithione on salivary secretion in depressed patients treated with psychotropic drugs. Eur J Clin Pharmacol. 1997;52:339–42.
Bagheri H, Schmitt L, Berian M, Montastruc JL. Effect of 3 weeks with yohimbine on salivary secretion in healthy volunteers and in depressed patients treated with tricyclic antidepressants. Br J Clin Pharmacol. 1992;34:555–8.
Cramp F, Byron-Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev. 2012;11:CD006145.
Ruddy KJ, Barton D, Loprinzi CL. Laying to rest psychostimulants for cancer-related fatigue? J Clin Oncol. 2014;32:1865–7.
Barton DL, Liu H, Dakhil SR, Linquist B, Sloan JA, Nichols CR, et al. Wisconsin ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2. J Natl Cancer Inst. 2013;105:1230–8.
Barton DL, Soori GS, Bauer BA, Sloan JA, Johnson PA, Figueras C, et al. Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA. Support Care Cancer. 2010;18:179–87.
Yennurajalingam S, Reddy A, Tannir NM, Chisholm GB, Lee RT, Lopez G, et al. High-dose Asian ginseng (Panax ginseng) for cancer-related fatigue: a preliminary report. Integr Cancer Ther 2015, Epub ahead of print.
Kennedy DO, Haskell CF, Robertson B, Reay J, Brewster-Maund C, Luedemann J, et al. Improved cognitive performance and mental fatigue following a multi-vitamin and mineral supplement with added guarana (Paullinia cupana). Appetite. 2008;50:506–13.
de Oliveira Campos MP, Riechelmann R, Martins LC, Hassan BJ, Casa FB, Del Giglio A. Guarana (Paullinia cupana) improves fatigue in breast cancer patients undergoing systemic chemotherapy. J Altern Complement Med. 2011;17:505–12.
da Costa Miranda V, Trufelli DC, Santos J, Campos MP, Nobuo M, da Costa Mirand M, et al. Effectiveness of guarana (Paullinia cupana) for postradiation fatigue and depression: results of a pilot double-blind randomized study. J Altern Complement Med. 2009;15:431–3.
Vidal-Alaball J, Butler CC, Cannings-John R, Goringe A, Hood K, McCaddon A, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2005;3:CD004655.
Masucci L, Goeree R. Vitamin B12 intramuscular injections versus oral supplements: a budget impact analysis. Ont Health Technol Assess Ser. 2013;13:1–24.
Zhang SM, Cook NR, Albert CM, Gaziano JM, Buring JE, Manson JE. Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial. JAMA. 2008;300:2012–21.
Christen WG, Glynn RJ, Chew EY, Albert CM, Manson JE. Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women’s Antioxidant and Folic Acid Cardiovascular Study. Arch Intern Med. 2009;169:335–41.
Lesser GJ, Case D, Stark N, Williford S, Giguere J, Garino LA, et al. A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer. J Support Oncol. 2013;11:31–42.
Parkinson Study Group QE3 Investigators. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. JAMA Neurol. 2014;71:543–52.
Teitelbaum JE, Johnson C, St Cyr J. The use of d-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med. 2006;12:857–62.
Kerksick C, Rasmussen C, Bowden R, Leutholtz B, Harvey T, Earnest C, et al. Effects of ribose supplementation prior to and during intense exercise on anaerobic capacity and metabolic markers. Int J Sport Nutr Exerc Metab. 2005;15:653–64.
Cruciani RA, Zhang JJ, Manola J, Cella D, Ansari B, Fisch MJ. l-Carnitine supplementation for the management of fatigue in patients with cancer: an eastern cooperative oncology group phase III, randomized, double-blind, placebo-controlled trial. J Clin Oncol. 2012;30:3864–9.
Cruciani RA, Revuelta M, Dvorkin E, Hormel P, Lesage P, Esteban-Cruciani N. l-Carnitine supplementation in patients with HIV/AIDS and fatigue: a double-blind, placebo-controlled pilot study. HIV AIDS (Auckl). 2015;7:65–73.
Mantovani G, Maccio A, Madeddu C, Serpe R, Massa E, Dessi M, et al. Randomized phase III clinical trial of five different arms of treatment in 332 patients with cancer cachexia. Oncologist. 2010;15:200–11.
Maccio A, Madeddu C, Gramignano G, Mulas C, Floris C, Sanna E, et al. A randomized phase III clinical trial of a combined treatment for cachexia in patients with gynecological cancers: evaluating the impact on metabolic and inflammatory profiles and quality of life. Gynecol Oncol. 2012;124:417–25.
Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore powder of Ganoderma lucidum improves cancer-related fatigue in breast cancer patients undergoing endocrine therapy: a pilot clinical trial. Evid Based Complement Alternat Med. 2012;2012:809614.
Mucke M, Mochamat S, Cuhls H, Peuckmann-Post V, Minton O, Stone P, et al. Pharmacological treatments for fatigue associated with palliative care. Cochrane Database Syst Rev. 2015;5:CD006788.
Walcott FL, Land SR, Constantino JP, Midthune D, Dunn BK. Vasomotor symptoms, BMI, and adherence to tamoxifen in the National Surgical Adjuvant Breast and Bowel Project (NSABP) Breast Cancer Prevention Trial (P-1). J Clin Oncol 2015;33(Suppl; abstr 1501).
Da Fonesca AM, Bagnoli VR, Suza MA, Azevedo RS, Couto Ede Jr B, Soares Jr JM, et al. Impact of age and body mass on the intensity of menopausal symptoms in 5968 Brazilian women. Gynecol Endocrinol. 2013;29:116–8.
Herber-Gast GC, Mishra GD, van der Schouw YT, Brown WJ, Dobson AJ. Risk factors for night sweats and hot flushes in midlife: results from a prospective cohort study. Menopause. 2013;20:953–9.
Huang AJ, Subak LL, Wing R, West DS, Hernandez AL, Macer J, et al. An intensive behavioral weight loss intervention and hot flushes in women. Arch Intern Med. 2010;170:1161–7.
Ryu KJ, Park HT, Kwon DH, Yang KS, Kim YJ, Yi KW, et al. Vasomotor symptoms and metabolic syndrome in Korean postmenopausal women. Menopause 2015, Epub head of print.
Blumel JE, Chedraui P, Aedo S, Fica J, Mezones-Holquin E, Baron G, et al. Obesity and its relation to depressive symptoms and sedentary lifestyle in middle-aged women. Maturitas. 2015;80:100–5.
Imayama I, Alfano CM, Neuhouser ML, George SM, Wilder Smith A, Baumgartner RN, et al. Weight, inflammation, cancer-related symptoms and health related quality of life among breast cancer survivors. Breast Cancer Res Treat. 2013;140:159–76.
Daley A, Stokes-Lampard H, Thomas A, MacArthur C. Exercise for vasomotor menopausal symptoms. Cochrane Database Syst Rev. 2014;11:CD006108.
Newton KM, Reed SD, Guthrie KA, Sherman KJ, Booth-LaForce C, Caan B, et al. Efficacy of yoga for vasomotor symptoms: a randomized controlled trial. Menopause. 2014;21:339–46.
Sternfeld B, Guthrie KA, Ensrud KE, LaCroix AZ, Larson JC, Dunn AL, et al. Efficacy of exercise for menopausal symptoms: a randomized controlled trial. Menopause. 2014;21:330–8.
Duijts SF, van Beurden M, Oldenburg HS, Hunter MS, Kieffer JM, Stuvier MM, et al. Efficacy of cognitive behavioral therapy and physical exercise in alleviating treatment-induced menopausal symptoms in patients with breast cancer: results of a randomized, controlled, multicenter trial. J Clin Oncol. 2012;30:4124–33.
Carpenter JS, Burns DS, Wu J, Otte JL, Schneider B, Ryker K, et al. Paced respiration for vasomotor and other menopausal symptoms: a randomized, controlled trial. J Gen Intern Med. 2013;28:193–200.
Sood R, Sood A, Wolf SL, Linquist BM, Liu H, Sloan JA, et al. Paced breathing compared to usual breathing for hot flashes. Menopause. 2013;20:179–84.
Chandwani KD, Heckler CE, Mohile SG, Mustian KM, Janeisins M, Peppone LJ, et al. Hot flashes severity, complementary and alternative medicine use, and self-rated health in women with breast cancer. Explore (NY). 2014;10:241–7.
Chiu HY, Shyu YK, Chang PC, Tsai PS. Effects of acupuncture on menopause-related symptoms in breast cancer survivors: a meta-analysis of randomized controlled trials. Cancer Nurs 2015, Epub ahead of print.
Garcia MK, McQuade J, Haddad R, Patel S, Lee R, Yang P, et al. Systematic review of acupuncture in cancer care: a synthesis of the evidence. J Clin Oncol. 2013;31:952–60.
Dodin S, Blanchet C, Marc I, Ernst E, Wu T, Valliancourt C, et al. Acupuncture for menopausal symptoms. Cochrane Database Syst Rev. 2013;7:CD007410.
Pockaj BA, Gallagher JG, Loprinzi CL, Stella PJ, Barton DL, Sloan JA, et al. Phase III double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG Trial N01CC1. J Clin Oncol. 2006;24:2836–41.
Pruthi S, Qin R, Terstreip SA, Liu H, Loprinzi CL, Shah TR, et al. A phase III, randomized, placebo-controlled, double-blind trial of flaxseed for the treatment of hot flashes: North Central Cancer Treatment Group N08C7. Menopause. 2012;19:48–53.
Pan A, Yu D, Demark-Wahnefried W, Franco OH, Lin X. Meta-analysis of the effects of flaxseed interventions on blood lipids. Am J Clin Nutr. 2009;90:288–97.
Anderson JW, Bush HM. Soy protein effects on serum lipoproteins: a quality assessment and meta-analysis of randomized, controlled studies. J Am Coll Nutr. 2011;30:79–91.
Park H, Qin R, Smith TJ, Atherton PJ, Barton DL, Sturtz K, et al. North Central Cancer Treatment Group N10C2 (Alliance): a double-blind placebo-controlled study of magnesium supplements to reduce menopausal hot flashes. Menopause. 2015;22:627–32.
Park H, Parker GL, Boardman CH, Morris MM, Smith TJ. A pilot phase II trial of magnesium supplements to reduce menopausal hot flashes in breast cancer patients. Support Care Cancer. 2011;19:859–63.
Herrada J, Gupta A, Campos-Gines AF, et al. Oral magnesium oxide for treatment of hot flashes in women undergoing treatment for breast cancer: a pilot study [Abstract]. In: 2010 ASCO annual meeting, Chicago, IL, 2010.
Cohen LS, Joffe H, Guthrie KA, Ensrud KE, Freeman M, Carpenter JS, et al. Efficacy of omega-3 for vasomotor symptoms treatment: a randomized controlled trial. Menopause. 2014;21:347–54.
Lethaby A, Marjoribanks J, Kronenberg F, Roberts H, Eden J, Brown J. Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database Syst Rev. 2013;12:CD001395.
Fritz H, Seely D, Flower G, Skidmore B, Fernandes R, Vadeboncoeur S, et al. Soy, red clover, and isoflavones and breast cancer: a systematic review. PLoS One. 2013;28:e81968.
del Giorno C, Fonesca AM, Bagnoli VR, Assis JS, Soares Jr JM, Baracat EC. Effects of Trifolium pratense on the climacteric and sexual symptoms in postmenopausal women. Rev Assoc Med Bras. 2010;56:558–62.
Geller SE, Shulman LP, van Breeman RB, Banuvar S, Zhou Y, Epstein G, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause. 2009;16:1156–66.
Bommer S, Klein P, Suter A. First time proof of sage’s tolerability and efficacy in menopausal women with hot flashes. Adv Ther. 2011;28:490–500.
Quella SK, Loprinzi CL, Barton DL, Knost JA, Sloan JA, LaVasseur BI, et al. Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: a North Central Cancer Treatment Group trial. J Clin Oncol. 2000;18:1068–74.
Barton DL, Loprinzi CL, Quella SK, Sloan JA, Veeder MH, Egner JR, et al. Prospective evaluation of vitamin E for hot flashes in breast cancer survivors. J Clin Oncol. 1998;16:495–500.
Scheffers CS, Armsrong S, Cantineau AE, Farquhar C, Jordan V, et al. Dehydroepiandrosterone for women in the peri- or postmenopausal phase. Cochrane Database Syst Rev. 2015;1:CD011066.
Wu WH, Kang YP, Wang NH, Jou HJ, Wang TA. Sesame ingestion affects sex hormones, antioxidant status, and blood lipids in postmenopausal women. J Nutr. 2006;136:1270–5.
Coulman KD, Liu Z, Hum WQ, Michaelides J, Thompson LU. Whole sesame seed is as rich a source of mammalian lignin precursors as whole flaxseed. Nutr Cancer. 2005;52:156–65.
Alipoor B, Haghighian MK, Sadat BE, Asghari M. Effect of sesame seed on lipid profile and redox status in hyperlipidemic patients. Int J Food Sci Nutr. 2012;63:674–8.
Florentino L, Ancoli-Israel S. Insomnia and its treatment in women with breast cancer. Sleep Med Rev. 2006;10:419–29.
Lis CG, Gupta D, Grutsch JF. The relationship between insomnia and patient satisfaction with quality of life in cancer. Support Care Cancer. 2008;16:261–6.
Courneya KS, Segal RJ, Mackey JR, Gelmon K, Friedenreich CM, Yasui Y, et al. Effects of exercise dose and type on sleep quality in breast cancer patients receiving chemotherapy: a multicenter randomized trial. Breast Cancer Res Treat. 2014;144:361–9.
Sprod LK, Palesh OG, Janelsins MC, Peppone LJ, Heckler CE, Adams MJ, et al. Exercise, sleep quality, and mediators of sleep in breast and prostate cancer patients receiving radiation therapy. Community Oncol. 2010;7:463–71.
Mustian KM, Sprod LK, Janelsins M, Peppone LJ, Chandwani K, Heckler C, et al. Multicenter, randomized controlled trial of yoga for sleep quality among cancer survivors. J Clin Oncol. 2013;31:3233–41.
FDA Drug Safety Communication: FDA warns of next-day impairment with sleep aid Lunesta (eszopiclone) and lowers recommended dose. www.fda.gov/Drugs/DrugSafety/ucm397260.htm. Accessed 15 June 2015.
Paulozzi LJ. Prescription drug overdoses: a review. J Safety Res. 2012;43:283–9.
Cardinali DP, Srinivasan V, Brzezinski A, Brown GM. Melatonin and its analogs in insomnia and depression. J Pineal Res. 2012;52:365–75.
Olde Rikkert MG, Rigaud AS. Melatonin in elderly patients with insomnia. A systematic review. Z Gerontol Geriatr. 2001;34:491–7.
Davis MP, Goforth HW. Long-term and short-term effects of insomnia in cancer and effective interventions. Cancer J. 2014;20:330–44.
Vural EM, van Munster BC, de Rooij SE. Optimal dosages for melatonin supplementation therapy in older adults: a systematic review of current literature. Drugs Aging. 2014;31:441–51.
Wade AF, Farmer M, Harari G, Fund N, Laudon M, Nir T, et al. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer’s disease: a 6-month, randomized, placebo-controlled, multicenter trial. Clin Interv Aging. 2014;9:947–61.
Rossignol DA, Frye RE. Melatonin in autism spectrum disorders: a systematic review and meta-analysis. Dev Med Child Neurol. 2011;53:783–92.
Schernhammer ES, Giobbie-Hurder A, Gantman K, Savoie J, Scheib R, Parker LM, et al. A randomized, controlled trial of oral melatonin supplementation and breast cancer biomarkers. Cancer Causes Control. 2012;23:609–16.
Chen WY, Giobbie-Hurder A, Gantman K, Savoie J, Scheib R, Parker LM, et al. A randomized, placebo-controlled trial of melatonin on breast cancer survivors: impact on sleep, mood, and hot flashes. Breast Cancer Res Treat. 2014;145(2):381–8.
Seely D, Wu P, Fritz H, Kennedy DA, Tsui T, Seely AJ, et al. Melatonin as adjuvant cancer care with and without chemotherapy: a systematic review and meta-analysis of randomized trials. Integr Cancer Ther. 2012;11:293–303.
Grossman E, Laudon M, Ylacin R, Zengil H, Peleg E, Sharabi Y, et al. Melatonin reduces night blood pressure in patients with nocturnal hypertension. Am J Med. 2006;119:898–902.
Cagnacci A, Cannoletta M, Renzi A, Baldassari F, Arangino S, Volpe A. Prolonged melatonin administration decreases nocturnal blood pressure in women. Am J Hpertens. 2005;18(12 Pt 1):1614–8.
Lusardi P, Piazza E, Fogari R. Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study. Br J Clin Pharmacol. 2000;49:423–7.
Grossman E, Laudon M, Zisapel N. Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials. Vasc Health Risk Manag. 2011;7:577–84.
Khezri MB, Merate H. The effects of melatonin on anxiety and pain scores of patients, intraocular pressure, and operating conditions during cataract surgery under topical anesthesia. Indian J Ophthalmol. 2013;61:319–24.
Cook JS, Saunder CL, Ray CA. Melatonin differently affects vascular blood flow in humans. Am J Physiol Heart Circ Physiol. 2011;300:H670–4.
Kelber O, Nieber K, Kraft K. Valerian: no evidence for clinically relevant interactions. Evid Based Complement Alternat Med. 2014;2014:879396.
Fernandez-San-Martin MI, Masa-Font R, Palacios-Soler L, Sancho-Gomez P, Calbo-Caldentey C, Flores-Mateo G. Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials. Sleep Med. 2010;11:505–11.
Barton DL, Atherton PJ, Bauer BA, Moore DF, Mattar BI, LaVasseur BI, et al. The use of Valeriana officinalis (Valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study (NCCTG Trial, N01C5). J Support Oncol. 2011;9(1):24–31.
Taavoni S, Ekbatani N, Kashaniyan M. Effect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trial. Menopause. 2011;18:951–5.
Kashani F, Kashani P. The effect of massage therapy on quality of sleep in breast cancer patients. Iran J Nurs Midwifery Res. 2014;19:113–8.
Wyatt RJ, Engelman K, Kupfer DJ, Fram DH, Sjoerdsma A, Snyder F. Effects of l-tryptophan (a natural sedative) on human sleep. Lancet. 1970;2(7678):842–6.
Wyatt RJ, Zarcone V, Engelman K, Dement WC, Snyder F, Sjoerdsma A. Effects of 5-hydroxytryptophan on the sleep of normal human subjects. Electroencephalogr Clin Neurophysiol. 1971;30:505–9.
Das YT, Bagchi M, Bagchi D, Preuss HG. Safety of 5-hydroxy-l-tryptophan. Toxicol Lett. 2004;150:111–22.
Fernstrom JD. Effects and side effects associated with the non-nutritional use of tryptophan by humans. J Nutr. 2012;142:2236S–44.
Loh SY, Musa AN. Methods to improve rehabilitation of patients following breast cancer surgery: a review of systematic reviews. Breast Cancer (Dov Med Press). 2015;7:81–98.
Shaitelman SF, Cromwell KD, Rasmussen JC, Stout NL, Armer JM, Lasinski BB, et al. Recent progress in the treatment and prevention cancer-related lymphedema. CA Cancer J Clin. 2015;65:55–81.
Fu MR. Breast cancer-related lymphedema: symptoms, diagnosis, risk reduction, and management. World J Clin Oncol. 2014;5:241–7.
Perera N, Liolitsa D, Iype S, Croxford A, Yassin M, Lang P, et al. Phlepotonic for haemorrhoids. Cochrane Database Syst Rev. 2012;8:CD004322.
Katsenis K. Micronized purified flavonoid fraction (MPFF): a review of its pharmacological effects, therapeutic efficacy and benefits in the management of chronic venous insufficiency. Curr Vasc Pharmacol. 2005;3:1–9.
Allaert FA. Meta-analysis of the impact of the principal venoactive drugs agents on malleolar venous edema. Int Angiol. 2012;31:310–5.
Bogucka-Kocka A, Wozniak M, Feldo M, Kockic J, Szewczyk K. Diosmin-isolation techniques, determination in plant material and pharmaceutical formulations, and clinical use. Nat Prod Commun. 2013;8:545–50.
Badger C, Preston N, Seers K, Mortimer P. Benzo-pyrones for reducing and controlling lypmhoedema of the limbs. Cochrane Database Syst Rev. 2004;2:CD003140.
Olszewski W. Clinical efficacy of micronized purified flavonoid fraction (MPFF) in edema. Angiology. 2000;51:25–9.
Pecking AP, Fevrier B, Wargon C, Pillion G. Efficacy of Daflon 500 mg in the treatment of lymphedema (secondary to conventional therapy of breast cancer). Angiology. 1997;48:93–8.
Pecking AP. Evaluation by lymphoscintigraphy of the effect of a micronized flavonoid fraction (Daflon 500 mg) in the treatment of upper limb lymphedema. Int Angiol. 1995;14(3 Suppl 1):39–43.
Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev. 2012;11:CD003230.
Horse Chestnut Seed Extract for Lymphedema. www.clinicaltrials.gov/ct2/show/NCT00213928. Accessed 20 June 2015.
Hutson PR, Love RR, Cleary JF, Anderson SA, Vanummersen L, Morgan-Meadows SL, et al. Horse chestnut seed extract for the treatment of arm lymphedema. J Clin Oncol. 2004;22(14S(July 15 Suppl)):8095.
Wadsworth AN, Faulds D. Hydroxyethylrutosides. A review of their pharmacology and therapeutic efficacy in venous insufficiency and related disorders. Drugs. 1992;44:1013–32.
Kiesewetter H, Koscieiny J, Kalus U, Vix JM, Peil H, Petrini O, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I–II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung. 2000;50:109–17.
Rabe E, Stucker M, Esperester A, Schafer E, Otillinger B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency-results of a double-blind placebo-controlled study. Eur J Vasc Endovasc Surg. 2011;41:540–7.
Piller NB, Morgan RG, Casley Smith JR. A double-blind, cross-over trial of O-(beta-hydroxyethyl)-rutosides (Benzo-pyrones) in the treatment of lymphedema of the arms and legs. Br J Plast Surg. 1988;41:20–7.
Taylor HM, Rose KE, Twycross RG. A double-blind clinical trial of hydroxyethylrutosides in obstructive arm lymphedema. Phlebology. 1993;8 Suppl 1:22–8.
Pronk LC, van Putten WL, van Beurden V, de Boer-Dennert M, Stoter G, Verweii J. The venotonic drug hydroxyethylrutosiden does not prevent or reduce docetaxel-induced fluid retention: results of a comparative study. Cancer Chemother Pharmacol. 1999;43:173–7.
Schoonees A, Visser J, Musekiwa A, Volmink J. Pycnogenol (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane Database Syst Rev. 2012;4:CD008294.
Dennert G, Homeber M. Selenium for alleviating the side effects of chemotherapy, radiotherapy and surgery in cancer patients. Cochrane Database Syst Rev. 2006;3:CD005037.
Duffield-Lillico AJ, Slate EH, Reid ME, Turnbull BW, Wilkins PA, Combs Jr GF, et al., for the Nutritional Prevention of Cancer Study Group. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst 2003;95:1477–81.
Stranges S, Marshall JR, Natarajan R, Donahue RP, Trevisan M, Combs GF, et al. Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Ann Intern Med. 2007;147:217–23.
Gontero P, Marra G, Soria F, Oderda M, Zitella A, Baratta F, et al. A randomized double-blind placebo controlled phase I–II study on clinical and molecular effects of dietary supplements in men with precancerous prostatic lesions. Chemopreventon or “chemopromotion”? Prostate. 2015;75:1177–86.
Kenfield SA, Van Blarigan EL, DuPre N, Stampfer MJ, Giovannucci E, Chan JM. Selenium supplementation and prostate cancer mortality. J Natl Cancer Inst. 2014;107:360.
Kristal AR, Darke AK, Morris JS, Tangen CM, Goodman PJ, Thompson IM, et al. Baseline selenium status and effects of selenium and vitamin e supplementation on prostate cancer risk. J Natl Cancer Inst. 2014;106:djt456.
Suh EE. The effects of P6 acupressure and nurse-provided counseling on chemotherapy-induced nausea and vomiting in patients with breast cancer. Oncol Nurs Forum. 2012;39:E1–9.
Lee J, Dodd M, Dibbie S, Abrams D. Review of acupressure studies for chemotherapy-induced nausea and vomiting. J Pain Symptom Manage. 2008;36:529–44.
Chao LF, Zhang AL, Liu HE, Cheng MH, Lam HB, Lo SK. The efficacy of acupoint stimulation for the management of therapy-related adverse events in patients with breast cancer: a systematic review. Breast Cancer Res Treat. 2009;118:255–67.
Ryan JL, Heckler CE, Roscoe JA, Dakhil SR, Kirshner J, Flynn PJ, et al. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer. 2012;20:1479–89.
Zindol® for chemotherapy induced nausea and vomiting. http://www.aphios.com/products/therapeutic-product-pipeline/oncology/zindol.html. Accessed 1 June 2015.
Zindol® DS. http://www.aphioshwc.com/products/zindol-ds.html. Accessed 1 June 2015.
Zick SM, Ruffin MT, Lee J, Normolle DP, Siden R, Alrawi S, et al. Phase II trial of encapsulated ginger as treatment for chemotherapy-induced nausea and vomiting. Support Care Cancer. 2009;17:563–72.
Lua PL, Sailhah N, Mazlan N. Effects of inhaled ginger aromatherapy on chemotherapy-induced nausea and vomiting and health-related quality of life in women with breast cancer. Complement Ther Med. 2015;23:396–404.
Pillai AK, Sharma KK, Gupta YK, Bakhshi S. Anti-emetic effect of ginger powder versus placebo as an add-on therapy in children and young adults receiving high emetogenic chemotherapy. Pediatr Blood Cancer. 2011;56:234–8.
Marx W, Kiss N, Isenring L. Is ginger beneficial for nausea and vomiting? An update of the literature. Curr Opin Support Palliat Care. 2015;9:189–95.
Tan PC, Omar SZ. Contemporary approaches to hyperemesis during pregnancy. Curr Opin Obstet Gynecol. 2011;23:87–93.
ACOG Practice Bulletin. Clinical management guidelines for obstetrician-gynecologists. Number 52 (April), 2004;103:803–15.
Ensiyeh J, Sakineh MA. Comparing ginger and vitamin B6 for the treatment of nausea and vomiting in pregnancy: a randomized controlled trial. Midwifery. 2009;25:649–53.
Herrell HE. Nausea and vomiting in pregnancy. Am Fam Physician. 2014;89:965–70.
Persaud N, Chin J, Walker M. Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy? J Obstet Gynecol Can. 2014;36:343–8.
Matthews A, Haas DM, O’Mathuna DP, Dowswell T, Doyle M. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2014;3:CD007575.
You Q, Yu H, Wu D, Zhang Y, Zheng J, Peng C. Vitamin B6 points PC6 injection during acupuncture can relieve nausea and vomiting in patients with ovarian cancer. Int J Gynecol Cancer. 2009;19:567–71.
Ghavanini AA, Kimpinski K. Revisiting the evidence for neuropathy caused by pyridoxine deficiency and excess. J Clin Neuromuscul Dis. 2014;16:25–31.
Levine ME, Gillis MG, Koch SY, Voss AC, Stern RM, et al. Protein and ginger for the treatment of chemotherapy-induced delayed nausea. J Altern Complement Med. 2008;14:545–51.
Jednak MA, Shadigian EM, Kim MS, Woods ML, Hooper FG, Owyang C, et al. Protein meals reduce nausea and gastric slow wave dysrhythmic activity in first trimester pregnancy. Am J Physiol. 1999;277(4 Pt 1):G855–61.
Paddon-Jones D, Short KR, Campbell WW, Volpi E, Wolfe RR. Role of dietary protein in the sarcopenia of aging. Am J Clin Nutr. 2008;87:1562S–6.
Fallon MT. Neuropathic pain in cancer. Br J Anaesth. 2013;111:105–11.
Bril V, England J, Franklin GM, Backonja M, Cohen J, Toro D, et al. Evidence-based guideline: Treatment of painful diabetic neuropathy: report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. PM R. 2011;3:345–52.
Qutenza (capsaicin) 8% patch. www.qutenza.com. Accessed 15 June 2015.
Wagner T, Roth-Daniek A, Sell A, England J, Kern KU. Capsaicin 8% patch for peripheral neuropathic pain: review of treatment best practice from real-world clinical experience. Pain Manag. 2012;2:239–50.
Observation of the use of Qutenza in standard clinical practice (ASCEND). www.clinicaltrials.gov/ct2/show/NCT01737294. Accessed 15 June 2015.
Ziegler D, Low PA, Litchy WJ, Boulton AJ, Vinik AI, Freeman R, et al. Efficacy and safety of antioxidant treatment with alpha-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Diabetes Care. 2011;34:2054–60.
Minhout GS, Kollen BJ, Alkhalaf A, Kleefstra N, Bilo HJ. Alpha lipoic acid for symptomatic peripheral neuropathy in patients with diabetes: a meta-analysis of randomized controlled trials. Int J Endocrinol. 2012;2012:456279.
Papanas N, Ziegler D. Efficacy of alpha-lipoic acid in diabetic neuropathy. Expert Opin Pharmacother. 2014;15:2721–31.
Gullo D, Evans JL, Sortino G, Goldfine ID, Vigneri R. Insulin autoimmune syndrome (Hirata Disease) in European Caucasians taking alpha-lipoic acid. Clin Endocrinol (Oxf). 2014;81:204–9.
Gedlicka C, Scheithauer W, Schull B, Kornek GV. Effective treatment of oxaliplatin-induced cumulative polyneuropathy with alpha-lipoic acid. J Clin Oncol. 2002;20:3359–61.
Guo Y, Jones D, Palmer JL, Forman A, Dakhil SR, Velasco MR, et al. Oral alpha-lipoic acid to prevent chemotherapy-induced peripheral neuropathy: a randomized, double-blind, placebo-controlled trial. Support Care Cancer. 2014;22:1223–31.
Koufaki M. Therapeutic applications of lipoic acid: a patent review (2011–2014). Expert Opin Ther Pat. 2014;24:993–1005.
de Aquiar Pastore Silva J, Emilia de Souza Fabre M, Waitzberg DL. Omega-3 supplements for patients in chemotherapy and/or radiotherapy: a systematic review. Clin Nutr. 2015;34:359–66.
Ghoreishi Z, Esfahani A, Djazayeri A, Djalali M, Golestan B, Ayromlou H, et al. Omega-3 fatty acids are protective against paclitaxel-induced peripheral neuropathy: a randomized double-blind placebo controlled trial. BMC Cancer. 2012;12:355.
Okuda Y, Mizutani M, Ogawa M, Sone H, Asano M, Asakura Y, et al. Long-term effects of eicosapentaenoic acid on diabetic peripheral neuropathy and serum lipids in patients with type II diabetes mellitus. J Diabetes Complications. 1996;10:280–7.
Fracasso PM, Picus J, Wildi JD, Goodner SA, Creekmore AN, Gao F, et al. Phase 1 and pharmacokinetic study of weekly docosahexaenoic acid-paclitaxel, Taxoprexin, in resistant solid tumor malignancies. Cancer Chemother Pharmacol. 2009;63:451–8.
Omega Swirl: Smoothie Taste & Texture. www.barleans.com/omega-swirl.asp. Accessed 15 June 2015.
Hershman DL, Unger JM, Crew KD, Minasian LM, Awad D, Moinpour CM, et al. Randomized double-blind placebo-controlled trial of acetyl-l-carnitine for the prevention of taxane-induced neuropathy in women undergoing adjuvant breast cancer therapy. J Clin Oncol. 2013;31:2627–33.
Campone M, Berton-Rigaud D, Joly-Lobbedez F, Baurain JF, Rolland F, Stenzi A, et al. A double-blind, randomized phase II study to evaluate the safety and efficacy of acetyl-l-carnitine in the prevention of sagopilone-induced peripheral neuropathy. Oncologist. 2013;18:1190–1.
Callander N, Markovina S, Eickhoff J, Hutson P, Campbell T, Hematti P, et al. Acetyl-l-carnitine (ALCAR) for the prevention of chemotherapy-induced peripheral neuropathy in patients with relapsed or refractory multiple myeloma treated with bortezomib, doxorubicin and low-dose dexamethasone: a study from the Wisconsin Oncology Network. Cancer Chemother Pharmacol. 2014;74:875–82.
Berger JR, Singhai D. The neurologic complications of bariatric surgery. Handb Clin Neurol. 2014;120:587–94.
Chopra K, Tiwari V. Alcoholic neuropathy: possible mechanisms and future treatment possibilities. Br J Clin Pharmacol. 2012;73:348–62.
Pacal L, Kuricova K, Kankova K. Evidence for altered thiamine metabolism in diabetes: is there a potential to oppose gluco- and lipotoxicity by rational supplementation. World J Diabetes. 2014;15:288–95.
Javed S, Petropoulos IN, Alam U, Malik RA. Treatment of painful diabetic neuropathy. Ther Adv Chronic Dis. 2015;6:15–28.
Ko SH, Ko SH, Ahn YB, Song KH, Han KD, Park YM, et al. Association of vitamin B12 deficiency and metformin use in patients with type 2 diabetes. J Korean Med Sci. 2014;29:965–72.
Gdynia HJ, Muller T, Sperfeld AD, Kuhnlein P, Otto M, Kassubek J, et al. Severe sensorimotor neuropathy after intake of highest dosages of vitamin B6. Neuromuscul Disord. 2008;18:156–8.
Loven D, Levavi H, Sabach G, Zart R, Andras M, Fishman A, et al. Long-term glutamate supplementation failed to protect against peripheral neurotoxicity of paclitaxel. Eur J Cancer Care (Engl). 2009;18(1):78–83.
Kottschade LA, Sloan JA, Mazurczak MA, Johnson DB, Murphy BP, Rowland KM, et al. The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase III clinical trial. Support Care Cancer. 2011;19:1769–77.
Franconi G, Manni L, Schroder S, Marchetti P, Robinson N. A systematic review of experimental and clinical acupuncture in chemotherapy-induced peripheral neuropathy. Evid Based Complement Alternat Med. 2013;2013:516918.
Rostock M, Jaroslawski K, Guethlin C, Ludtke R, Schroder S, Bartsch HH. Chemotherapy-induced peripheral neuropathy in cancer patients: a four-arm randomized trial on the effectiveness of electroacupuncture. Evid Based Complement Alternat Med. 2013;2013:349653.
Schloss JM, Colosimo M, Airey C, Masci PP, Linnane AW, Vitetta L. Nutraceuticals and chemotherapy induced peripheral neuropathy (CIPN): a systematic review. Clin Nutr. 2013;32:888–93.
Eum S, Choi HD, Chang MJ, Choi HC, Ko YJ, Ahn JS, et al. Protective effects of vitamin E on chemotherapy-induced peripheral neuropathy: a meta-analysis of randomized controlled trials. Int J Vitam Nutr Res. 2013;83:101–11.
Moyad MA. Complementary and alternative medicine for prostate and urologic health. New York, NY: Springer Publishing; 2014.
Boquiren VM, Esplen MJ, Wong J, Toner B, Warner E, Malik N. Sexual functioning in breast cancer survivors experiencing body image disturbance. Psychooncology 2015, Epub ahead of print.
Lee M, Kim YH, Jeon MJ. Risk factors for negative impacts on sexual activity and function in younger breast cancer survivors. Psychooncology 2015, Epub ahead of print.
Schover LR, Baum GP, Fuson LA, Brewster A, Melhem-Bertrandt A. Sexual problems during the first 2 years of adjuvant treatment with aromatase inhibitors. J Sex Med. 2014;11:3102–11.
Bartula I, Sherman KA. The female sexual functioning index (FSFI): evaluation of acceptability, reliability, and validity in women with breast cancer. Support Care Cancer. 2015;23(9):2633–41. Epub 12 Feb 2015.
Taylor S, Harley C, Ziegler L, Brown J, Velikova G. Interventions for sexual problems following treatment for breast cancer: a systematic review. Breast Cancer Res Treat. 2011;130:711–24.
Esposito K, Ciotola M, Giugliano F, Schisano B, Autorino R, Iuliano S, et al. Mediterranean diet improves sexual function in women with the metabolic syndrome. Int J Impot Res. 2007;19:486–91.
Giugliano F, Maiorino MI, Di Palo C, Autorino R, De Sio M, Giugliano D, et al. Adherence to Mediterranean diet and sexual function in women with type 2 diabetes. J Sex Med. 2010;7:1883–90.
Esposito K, Giugliano F, Maiorino MI, Giugliano D. Dietary factors, Mediterranean diet and erectile dysfunction. J Sex Med. 2010;7:2338–45.
Esposito K, Giugliano F, Ciotola M, De Sio M, Armiento MD, Giugliano D. Obesity and sexual dysfunction, male and female. Int J Impot Res. 2008;20:358–65.
Aversa A, Bruzziches R, Francomano D, Greco EA, Violl F, Lenzi A, et al. Weight loss by multidisciplinary intervention improves endothelial and sexual function. J Sex Med. 2013;10(4):1024–33. Epub 24 Jan 2013.
Esposito K, Ciotola M, Malorino MI, Giugliano F, Autorino R, De Sio M, et al. Hyperlipidemia and sexual function in premenopausal women. J Sex Med. 2009;6:1696–703.
Veronelli A, Mauri C, Zecchini B, Peca MG, Turri O, Valitutti MT, et al. Sexual dysfunction is frequent in premenopausal women with diabetes, obesity, and hypothyroidism, and correlates with markers of increased cardiovascular risk. A preliminary report. J Sex Med. 2009;6:1561–8.
Alexander J, Crosby M, Ferguson D, Singh G, Steidle C, Weimiller M. Randomized, placebo-controlled, double-blind, crossover design trial of the efficacy and safety of Zestra for women in women with and without female sexual arousal disorder. J Sex Marital Ther. 2003;29 Suppl 1:33–44.
Pitel S, Raccah D, Gerbi A, Pieroni G, Vague P, Coste TC. At low doses, a gamma-linolenic acid-lipoic acid conjugate is more effective than docosahexaenoic acid-enriched phispholipids in preventing neuropathy in diabetic rats. J Nutr. 2007;137:368–72.
Hornych A, Oravec S, Girault F, Forette B, Horrobin DF. The effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandin synthesis in older subjects. Bratisl Lek Listy. 2002;103:101–7.
Belch JJ, Shaw B, O’Dowd A, Saniabadi A, Leiberman P, Sturrock RD, et al. Evening primrose oil (Efamol) in the treatment of Raynaud’s phenomenon: a double blind study. Thromb Haemost. 1985;54:490–4.
Herbenick D, Reece M, Hensel D, Sanders S, Jozkowski K, Fortenberry JD. Association of lubricant use with women’s sexual pleasure, sexual satisfaction, and genital symptoms: a prospective daily diary study. J Sex Med. 2011;8:202–12.
Sutton KS, Boyer SC, Goldfinger C, Ezer P, Pukall CF. To lube or not to lube: experiences and perceptions of lubricant use in women with and without dyspareunia. J Sex Med. 2012;9:240–50.
Herbenick D, Reece M, Sanders SA, Dodge B, Ghassemi A, Fortenberry JD. Women’s vibrator use in sexual partnerships: results from a nationally representative survey in the United States. J Sex Marital Ther. 2010;36:49–65.
Juraskova I, Jarvis S, Mok K, Peate M, Meiser B, Cheah BC, et al. The acceptability, feasibility, and efficacy (phase I/II study) of the OVERcome (Olive Oil, Vaginal Exercise, and MoisturizeR) intervention to improve dyspareunia and alleviate sexual problems in women with breast cancer. J Sex Med. 2013;10:2549–58.
Kim S-O, Kim MK, Lee H-S, Park JK, Park K. The effect of Korean red ginseng extract on the relaxation response in isolated rabbit vaginal tissue and its mechanism. J Sex Med. 2008;5:2079–84.
Lee H-S, Lee MN, Hwang IS, Kim SO, Ahn K, Park K. Effect of Korean red ginseng on vaginal blood flow and structure in hypercholesterolemic female rats. Kor J Androl. 2005;23:159–64.
Kim S-O, Kim MK, Chae MJ, Kim HY, Park JK, Park K. Effect of Korean red ginseng on the relaxation of clitoral corpus cavernosum in rabbit. Kor J Androl. 2006;24:29–34.
Oh K-J, Chae M-J, Lee H-S, Hong H-D, Park K. Effects of Korean red ginseng on sexual arousal in menopausal women: placebo-controlled, double-blind crossover clinical study. J Sex Med. 2010;7:1469–77.
Bottari A, Belcaro G, Ledda A, Luzzi R, Cesarone MR, Dugall M. Lady Prelox® improves sexual function in generally healthy women of reproductive age. Minerva Ginecol. 2013;65:435–44.
Bottari A, Belcaro G, Ledda A, Cesarone MR, Vinciguerra G, Di Renzo A, et al. Lady Prelox® improves sexual function in post-menopausal women. Panminerva Med. 2012;54(1 Suppl 4):3–9.
Cormio L, De Slati M, Lorusso F, Selvaggio O, Mirabella L, Sanquedolce F, et al. Oral l-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology. 2011;77:119–22.
Meston CM, Worcel M. The effects of yohimbine plus l-arginine glutamate on sexual arousal in postmenopausal women with sexual arousal disorder. Arch Sex Behav. 2002;31:323–32.
Lentz AC, Carson III CC, Marson L. Does the new herbal supplement “Maca” enhance erectile function or female sexual function. Sem Prev Alt Med. 2006;2:85–90.
Gonzales GF, Gonzales C, Gonzales-Castaneda C. Lepidium meyenii (Maca): a plant from the highlands of Peru—from tradition to science. Forsch Komplementmed. 2009;16:373–80.
Gonzales GF, Cordova A, Vega K, Chung A, Villena A, Gonez C, et al. Effect of Lepidium meyenii (Maca) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia. 2002;34:367–72.
Zenico T, Cicero AF, Valmorri L, Mercuriali M, Bercovich E. Subjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: a randomized, double-blind clinical trial. Andrologia. 2009;41:95–9.
Dording CM, Fisher L, Papakostas G, Farabaugh A, Sonawalla S, Fava M, et al. A double-blind, randomized, pilot dose-finding study of maca root (L. meyenii) for the management of SSRI-induced sexual dysfunction. CNS Neurosci Ther. 2008;14:182–91.
Shin BC, Lee MS, Yang EJ, Lim HS, Ernst E. Maca (L. meyenii) for improving sexual function: a systematic review. BMC Complement Altern Med. 2010;10:44.
Dording CM, Schetter PJ, Dalton ED, Parkin SR, Walker RS, Fehling KB, et al. A double-blind placebo-controlled trial of maca root as treatment for antidepressant-induced sexual dysfunction. Evid Based Complement Alternat Med. 2015;2015:949036.
Zheng BL, He K, Kim CH, Rogers L, Shao Y, Huang ZY, et al. Effect of a lipidic extract from Lepidium meyenii on sexual behavior in mice and rats. Urology. 2000;55:598–602.
McCollom MM, Villinski JR, McPhail KL, Craker LE, Gafner S. Analysis of macamides in samples of Maca (Lepidium meyenii) by HPLC-UV-MS/MS. Phytochem Anal. 2005;16:463–9.
Ganzera M, Zhao J, Muhammad I, Khan IA. Chemical profiling and standardization of Lepidium meyenii (Maca) by reversed phase high performance liquid chromatography. Chem Pharm Bull (Tokyo). 2002;50:988–91.
Gonzales GF. Ethnobiology and ethnopharmacology of Lepidium meyenii (Maca), a plant from the Peruvian Highlands. Evid Based Complement Alternat Med. 2012;2012:193496.
Ito TY, Trant AS, Polan ML. A double-blind placebo-controlled study of ArginMax, a nutritional supplement for enhancement of female sexual function. J Sex Marital Ther. 2001;27:541–9.
Ito TY, Polan ML, Whipple B, Trant AS. The enhancement of female sexual function with ArginMax, a nutritional supplement, among women differing in menopausal status. J Sex Marital Ther. 2006;32:369–78.
Greven KM, Case LD, Nycum LR, Zekan PJ, Hurd DD, Balcueva EP, et al. Effect of ArginMax on sexual functioning and quality of life among female cancer survivors: results of the WFU CCOP Research Base Protocol 97106. J Community Support Oncol. 2015;13(3):87–94.
Kornblut Anne E, Wilson D. How one pill escaped place on steroid list. The New York Times, Sunday, 17 Apr 2005, p. 1, 20.
Brown GA, Vukovich M, King DS. Testosterone prohormone supplements. Med Sci Sports Exerc. 2006;38:1451–61.
Leder BZ, Longcope C, Catlin DH, Ahrens B, Schoenfeld DA, Finkelstein JS. Oral androstenedione administration and serum testosterone concentrations in young men. JAMA. 2000;283:779–82.
King DS, Sharp RL, Vukovich MD, Brown GA, Reifenrath TA, Uhl NL, et al. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men: a randomized controlled trial. JAMA. 1999;281:2020–8.
Ritter RH, Cryar AK, Hermans MR. Oral androstenedione-induced impotence and severe oligospermia. Fertil Steril. 2005;84:217.
Broeder CE, Quindry J, Brittingham K, Panton L, Thomson J, Appakondu S, et al. The Andro Project: physiological and hormonal influences of androstenedione in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med. 2000;160:3093–104.
Leder BZ, Leblanc KM, Longcope C, Lee H, Catlin DH, Finkelstein JS. Effects of oral androstenedione administration on serum testosterone and estradiol levels in postmenopausal women. J Clin Endocrinol Metab. 2002;87:5449–54.
Moyad MA. Dr. Moyad’s guide to male sexual health: what works and what’s worthless? Ann Arbor, MI: Spry Publishing; 2012.
Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychological correlates results of the Massachusetts Male Aging Study. J Urol. 1994;151:54–61.
Reiter WJ, Pycha A, Schatzi G, Klingler HC, Mark I, Auterith A, et al. Serum dehydroepiandrosterone sulfate concentrations in men with erectile dysfunction. Urology. 2000;55:755–8.
Traish AM, Kang P, Saad F, Guay AT. Dehydroepiandrosterone (DHEA)—a precursor steroid or an active hormone in human physiology. J Sex Med. 2011;8:2960–82.
Reiter WJ, Schatzi G, Mark I, Zeiner A, Pycha A, Marberger M. Dehydroepiandrosterone in the treatment of erectile dysfunction in patients with different organic etiologies. Urol Res. 2001;29:278–81.
Reiter WJ, Pycha A, Schatzi G, Pokorny A, Gruber DM, Huber JC, et al. DHEA in the treatment of erectile dysfunction: a prospective, double-blind, randomized, placebo-controlled study. Urology. 1999;53:590–4.
Hellbronn LK, de Jonge L, Frisard MI, DeLany JP, Larson-Meyer DE, Rood J, et al., for the Pennington CALERIE Team. Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA 2006;295:1539–48.
Niskanen L, Laaksonen DE, Punnonen K, Mustajoki P, Kaukua J, Rissanen A. Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome. Diabetes Obes Metab. 2004;6:208–15.
Ernst B, Wilms B, Thurnheer M, Schultes B. Reduced circulating androgen levels after gastric bypass surgery in severely obese women. Obes Surg. 2013;23:602–7.
Voznesensky M, Walsh S, Dauser D, Brindisi J, Kenny AM. The association between dehydroepiandosterone and frailty in older men and women. Age Ageing. 2009;38:401–6.
Panjari M, Bell RJ, Jane F, Wolfe R, Adams J, Morrow C, et al. A randomized trial of oral DHEA treatment for sexual function, well-being, and menopausal symptoms in postmenopausal women with low libido. J Sex Med. 2009;6:2579–90.
Panjari M, Davis SR. DHEA for postmenopausal women: a review of the evidence. Maturitas. 2010;66:172–9.
Panjari M, Bell RJ, Jane F, Adams J, Morrow C, Davis SR. The safety of 52 weeks of oral DHEA therapy for postmenopausal women. Maturitas. 2009;63:240–5.
Hackbert L, Helman JR. Acute dehydroepiandrosterone (DHEA) effects on sexual arousal in postmenopausal women. J Womens Health Gend Based Med. 2002;11:155–62.
Mortola JF, Yen SS. The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women. J Clin Endocrinol Metab. 1990;71:696–704.
Panjari M, Davis SR. DHEA therapy for women: effect on sexual function and wellbeing. Hum Reprod Update. 2007;13:239–48.
Munarriz R, Talakoub L, Flaherty E, Giola M, Hoag L, Kim NN, et al. Androgen replacement therapy with dehydroepiandrosterone for androgen insufficiency and female sexual dysfunction: androgen and questionnaire results. J Sex Marital Ther. 2002;28 Suppl 1:165–73.
Davis SR, Panjari M, Stanczyk FZ. Clinical review: DHEA replacement for postmenopausal women. J Clin Endocrinol Metab. 2011;96:1642–53.
Arlt W, Callies F, van Villjmen JC, Koehler I, Reincke M, Bidlingmaier M, et al. Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med. 1999;341:1013–20.
Allollo B, Arlt W, Hahner S. DHEA: why, when, and how much—DHEA replacement in adrenal insufficiency. Ann Endocrinol (Paris). 2007;68:268–73.
Alkatib AA, Cosma M, Elamin MB, Erickson D, Swigio BA, Erwin PJ, et al. A systematic and meta-analysis of randomized placebo-controlled trials of DHEA treatment effects of quality of life in women with adrenal insufficiency. J Clin Endocrinol Metab. 2009;94:3676–81.
Nair KS, Rizza RA, O’Brien P, Dhatariya K, Short KR, Nehra A, et al. DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med. 2006;355:1647–59.
Parasrampuria J, Schwartz K, Petesch R. Quality control of dehydroepiandrosterone dietary supplement products. JAMA. 1998;280:1565.
Baker WL, Karan S, Kenny AM. Effect of dehydroepiandrosterone on muscle strength and physical function in older adults: a systematic review. J Am Geriatr Soc. 2011;59:997–1002.
Weiss EP, Shah K, Fontana L, Lambert CP, Holloszy JO, Villareal DT. Dehydroepiandrosterone replacement in older adults: 1- and 2-y effects on bone. Am J Clin Nutr. 2009;89:1459–67.
Labrie F, Archer D, Bouchard C, Fortier M, Cusan L, Gomez JL, et al. Effect of intravaginal dehydroepiandrosterone (Prasterone) on libido and sexual dysfunction in postmenopausal women. Menopause. 2009;16:923–31.
Panjari M, Davis SR. Vaginal DHEA to treat menopause related atrophy: a review of the evidence. Maturitas. 2011;70:22–5.
Labrie F, Martel C, Berube R, Cote I, Labrie C, Cusan L, et al. Intravaginal prasterone (DHEA) provides local action without clinically significant changes in serum concentrations of estrogens or androgens. J Steroid Biochem Mol Biol. 2013;138:359–67.
Mishra SI, Scherer RW, Geige PM, Berlanstein DR, Topalogiu O, Gotay CC, et al. Exercise interventions on health-related quality of life for caner survivors. Cochrane Database Syst Rev. 2012;8:CD007566.
Cramer H, Lange S, Klose P, Paul A, Dobos G. Yoga for breast cancer patients and survivors: a systematic review and meta-analysis. BMC Cancer. 2012;12:412.
Galantino ML, Callens ML, Cardena GJ, Piela NL, Mao JJ. Tai chi for well-being of breast cancer survivors with aromatase inhibitor-associated arthralgias: a feasibility study. Altern Ther Health Med. 2013;19:38–44.
Kim YH, Kim HJ, Ahn SD, Seo YJ, Kim SH. Effects of meditation on anxiety, depression, fatigue, and quality of life of women undergoing radiation therapy for breast cancer. Complement Ther Med. 2013;21:379–87.
Drackley NL, Degnim AC, Jakub JW, Cutshall SM, Thomley BS, Brodt JK, et al. Effect of massage therapy for postsurgical mastectomy recipients. Clin J Oncol Nurs. 2012;16:121–4.
Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983;24:385–96.
Kongkeaw C, Dilokthornsakul P, Thanarangsarit P, Limpeanchob N, Norman Scholfield C. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol. 2014;151:528–35.
Sarris J, McIntyre E, Camfield DA. Plant-based medicines for anxiety disorders: Part 2—A review of clinical studies with supporting preclinical evidence. CNS Drugs. 2013;27:301–19.
Ernst E. Herbal remedies for anxiety—a systematic review of controlled clinical trials. Phytomedicine. 2006;13:205–8.
Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effect of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 2008;14:707–13.
Sathyanarayanan V, Thomas T, Einother SJ, Dobriyal R, Joshi MK, Krishnamachari S. Brahmi for the better? New findings challenging cognition and anti-anxiety effects of Brahmi (Bacopa monniera) in healthy adults. Psychopharmacology (Berl). 2013;227:299–306.
BacoMind. www.bacomind.com. Accessed 15 June 2015.
KeenMind. www.keenmind.info. Accessed 15 June 2015.
PhamaGABA. www.natural-pharmagaba.com. Accessed 15 June 2015.
Weeks BS. Formulations of dietary supplement and herbal extracts for relaxation and anxiolytic action: Relarian. Med Sci Monit. 2009;15:RA256–62.
Abdou AM, Higashiguchi S, Horie K, Kim M, Hatta H, Yokogoshi H. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA). Biofactors. 2006;36:201–8.
Yoto A, Murao S, Motoki M, Yokoyama Y, Horie N, Takeshima K, et al. Oral intake of gamma-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks. Amino Acids. 2012;43:1331–7.
Head KA, Kelly GS. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep. Altern Med Rev. 2009;14:114–40.
Nakamura H, Takishima T, Kometani T, Yokogoshi H. Psychological stress-reducing effect of chocolate enriched with gamma-aminobutyric acid (GABA) in human: assessment of stress using heart rate variability and salivary chromogranin A. Int J Food Sci Nutr. 2009;60 Suppl 5:106–13.
Mu W, Zhang T, Jiang B. An overview of biological production of l-theanine. Biotechnol Adv. 2015;33:335–42.
Rao TP, Ozeki M, Juneja LR. In search of a safe natural sleep aid. J Am Coll Nutr. 2015;11:1–12.
Camfield DA, Stough C, Farrimond J, Scholey AB. Acute effects of tea constituents l-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis. Nutr Rev. 2014;72:507–22.
Vuong QV, Bowyer MC, Roach PD. l-Theanine: properties, synthesis and isolation from tea. J Sci Food Agric. 2011;91:1931–9.
Suntheanine. www.suntheanine.com. Accessed 15 June 2015.
Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. 2010;17:481–93.
Ishaque S, Shamseer L, Bukutu C, Vohra S. Rhodiola rosea for physical and mental fatigue: a systematic review. BMC Complement Altern Med. 2012;12:70.
Hung SK, Perry R, Ernst E. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine. 2011;18:235–44.
Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med. 2008;14:175–80.
Buchorntavakul C, Reddy KR. Review article: herbal and dietary supplement hepatotoxicity. Aliment Pharmacol Ther. 2013;37:3–17.
Sarris J, LaPorte E, Schweitzer I. Kava: a comprehensive review of efficacy, safety, and psychopharmacology. Aust N Z J Psychiatry. 2011;45:27–35.
Teschke R. Kava hepatotoxicity—a clinical review. Ann Heaptol. 2010;9:251–65.
Behl M, Nyska A, Chhabra RS, Travlos GS, Fomby LM, Sparrow BR, et al. Liver toxicity and carcinogenicity in F344/N rats and B6C3F1 mice exposed to Kava Kava. Food Chem Toxicol. 2011;49:2820–9.
Milburn DS, Myers CW. Tryptophan toxicity: a pharmacoepidemiologic review of eosinophilia-myalgia syndrome. DICP. 1991;25:1259–62.
Biddiss E, Knibbe TJ, McPherson A. The effectiveness aimed at reducing anxiety in health care waiting spaces: a systematic review of randomized and nonrandomized trials. Anesth Analg. 2014;119:433–48.
Errington-Evans N. Acupuncture for anxiety. CNS Neurosci Ther. 2012;18:277–84.
Boehm K, Bussing A, Ostermann T. Aromatherapy as an adjuvant treatment in cancer care—a descriptive systematic review. Afr J Tradit Complement Altern Med. 2012;9:503–18.
Ma Y, Olendzki BC, Wang J, Persuitte GM, Li W, Fang H, et al. Single-component versus multicomponent dietary goals for the metabolic syndrome: a randomized trial. Ann Intern Med. 2015;162:248–57.
Schwartz K, Chang HT, Nikolai M, Pernicone J, Rhee S, Olson K, et al. Treatment of glioma patients with ketogenic diets: report of two cases treated with an IRB-approved energy-restricted ketogenic diet protocol and review of the literature. Cancer Metab. 2015;3:3.
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Moyad, M.A. (2016). Rapid Review of Breast Cancer Treatment Side Effects and Dietary Supplement/Integrative Options from A to Z: What Helps, Harms, or Does Nothing?. In: Integrative Medicine for Breast Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-23422-9_7
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DOI: https://doi.org/10.1007/978-3-319-23422-9_7
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