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The Ideal 7-Step Breast Cancer Diet, Lifestyle, and Dietary Supplements Program for Prevention/Recurrence: Heart Healthy = Breast Healthy!

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Integrative Medicine for Breast Cancer
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Abstract

The primary cause of mortality in the USA and in most developed countries is cardiovascular disease (CVD), and it is the primary or secondary cause of death in the largest clinical trials ever conducted for preventing or treating breast cancer. The overall risk of mortality needs to be placed into perspective, and it does not serve to belittle the seriousness of other common and not so common health conditions, but rather serves as an ideal nexus for health care professional and patient educational purposes. Heart healthy recommendations have been tantamount to overall breast health recommendations because there are simplistic correlations between heart health and breast specific diseases. Health care professionals working in the field of breast cancer need to motivate and provide a simplistic, realistic, and practical set of diet and lifestyle recommendations to patients in order to impact the more important statistic of health known as “all-cause morbidity and mortality.” A list of seven heart healthy recommendations are provided in this chapter to assist the clinician and patient in their discussions of practical, logical, and realistic changes that may not only be accomplished in a short time period, but should provide at least some type of tangible overall benefit for the individual concerned about her or his risk of breast cancer (prevention or recurrence). Additionally, a summary of many nutritional interventions and dietary supplements postulated to have anticancer effects is reviewed as well as methods to enhance compliance of proven heart healthy changes in your clinical practice.

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References

  1. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, et al., for the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics—2013 update: a report from the American Heart Association. Circulation 2013;127:e6–245.

    Google Scholar 

  2. World Heart Federation website. http://www.world-heart-federation.org. Accessed 20 Mar 2014.

  3. Eyre H, Kahn R, Robertson RM, Clark NG, Doyle C, Hong Y, et al., for the American Cancer Society; American Diabetes Association, and the American Heart Association. Preventing cancer, cardiovascular disease, and diabetes: a common agenda for the American Cancer Society, the American Diabetes Association, and the American Heart Association. Circulation 2004;109:3244–55.

    Google Scholar 

  4. Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, et al. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst. 1998;90:1371–88.

    Article  CAS  PubMed  Google Scholar 

  5. Vogel VG, Costatino JP, Wickerham DL, Cronin WM, Cecchini RS, Atkins JN, et al. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes. JAMA. 2006;295:2727–41.

    Article  CAS  PubMed  Google Scholar 

  6. Vogel VG, Costantino JP, Wickerham DL, Cronin WM, Cecchini RS, Atkins JN, et al. Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) P-2 Trial: preventing breast cancer. Cancer Prev Res. 2010;3:696–706.

    Article  CAS  Google Scholar 

  7. Cecchini RS, Costantino JP, Cauley JA, Cronin WM, Wickerham DL, Land SR, et al. Body mass index and risk of developing invasive breast cancer among high-risk women in NSABP P-1 and START breast cancer prevention trials. Cancer Prev Res (Phila). 2012;5:583–92.

    Article  CAS  Google Scholar 

  8. Thompson IM, Goodman PJ, Tangen CM, Lucia MS, Miller GS, Ford LG, et al. The influence of finasteride on the development of prostate cancer. N Engl J Med. 2003;349:215–24.

    Article  CAS  PubMed  Google Scholar 

  9. Scardino PT. The prevention of prostate cancer–the dilemma continues. N Engl J Med. 2003;349:297–9.

    Article  PubMed  Google Scholar 

  10. Kaplan SA, Roehrborn CG, Meehan AG, Liu KS, Carides AD, Binkowitz BS, et al. PCPT: Evidence that finasteride reduces risk of most frequently detected intermediate- and high-grade (Gleason score 6 and 7) cancer. Urology. 2009;73:935–9.

    Article  PubMed  Google Scholar 

  11. Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, et al. Calcium and vitamin D supplementation and the risk of fractures. N Engl J Med. 2006;354:669–83.

    Article  CAS  PubMed  Google Scholar 

  12. Cauley JA, Chlebowski RT, Wactawski-Wende J, Robbins JA, Rodabough RJ, Chen Z, et al. Calcium plus vitamin D supplementation and health outcomes five years after active intervention ended: the Women’s Health Initiative. J Womens Health (Larchmt). 2013;22(11):915–29.

    Article  Google Scholar 

  13. Hsia J, Heiss G, Ren H, Allison M, Dolan NC, Greenland P, et al. Calcium/vitamin D supplementation and cardiovascular events. Circulation. 2007;115:846–54.

    Article  CAS  PubMed  Google Scholar 

  14. Chlebowski RT, Johnson KC, Kooperberg C, Pettinger M, Wactawski-Wende J, Rohan T, et al. Calcium plus vitamin D supplementation and the risk of breast cancer. J Natl Cancer Inst. 2008;100:1581–91.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Lippman SM, Klein EA, Goodman PJ, Lucia MA, Thompson IM, Ford LG, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2009;301:39–51.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  16. Nash IS, Mosca L, Blumenthal RS, Davidson MH, Smith SC, Paternak RC. Contemporary awareness and understanding of cholesterol as a risk factor: results of an American Heart Association National Survey. Arch Intern Med. 2003;163:1597–600.

    Article  PubMed  Google Scholar 

  17. Choi EJ, Jekal Y, Kim S, Yoo JS, Kim HS, Oh EG, et al. Middle-aged women’s awareness of cholesterol as a risk factor: results from a national survey of Korean Middle-aged Women’s Health Awareness (KomWHA) study. Int J Nurs Stud. 2010;47:452–60.

    Article  PubMed  Google Scholar 

  18. Hickey A, O’Hanlon A, McGee H, Donnellan C, Shelley E, Horgan F, et al. Stroke awareness in the general population: knowledge of stroke risk factors and warning signs in older adults. BMC Geriatr. 2009;9:35.

    Article  PubMed Central  PubMed  Google Scholar 

  19. Jones SP, Jenkinson AJ, Leathley MJ, Watkins CL. Stroke knowledge and awareness: an integrative review of the evidence. Age Ageing. 2010;39:11–22.

    Article  PubMed  Google Scholar 

  20. Reiner Z, Sonicki Z, Tedeschi-Reiner E. The perception and knowledge of cardiovascular risk factors among medical students. Croat Med J. 2012;53:278–84.

    Article  PubMed Central  PubMed  Google Scholar 

  21. Rogers VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, et al. Heart disease and stroke statistics—2012 update: a report from the American Heart Association. Circulation. 2012;125:e2–220.

    Article  Google Scholar 

  22. Agency for Healthcare Research and Quality (2009). Cardiovascular disease and other chronic conditions in women: recent findings. www.ahrq.gov/research/womheart.htm. Accessed 1 June 2015.

  23. American Heart Association (2012). AHA 2020 Goal—2012 statistical fact sheet. www.heart.org/dc/groups/heart-public/@wcm/@sop/@smd/documents/downloadable/ucm_319831.pdf. Accessed 1 June 2015.

  24. The Expert Panel. Executive summary of the third report of the National Cholesterol Education Program (NCEP). Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285:2486–98.

    Article  Google Scholar 

  25. Grundy SM, Cleeman JI, Merz CN, Brewer Jr HB, Clark LT, Hunninghake DB, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. Circulation. 2004;110:227–39.

    Article  PubMed  Google Scholar 

  26. Centers for Disease Control and Prevention (CDC). Prevalence of abnormal lipid levels among youths—United States, 1999–2006. MMWR Morb Mortal Wkly Rep. 2010;59:29–33.

    Google Scholar 

  27. Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation. 2003;107:363–9.

    Article  PubMed  Google Scholar 

  28. Kraus WE, Houmard JA, Duscha BD, Knetzger KJ, Wharton MB, McCartney JS, et al. Effects of the amount and intensity of exercise on plasma lipoproteins. N Engl J Med. 2002;347:1483–92.

    Article  CAS  PubMed  Google Scholar 

  29. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo Jr JL, et al., for the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Hypertension 2003;42:1206–52.

    Google Scholar 

  30. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014;311:507–20.

    Article  CAS  PubMed  Google Scholar 

  31. Whelton SP, Chin A, Xin X, He J. Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials. Ann Intern Med. 2002;136:493–503.

    Article  PubMed  Google Scholar 

  32. Scoccianti C, Lauby-Secretan B, Bello PY, Chajes V, Romieu I. Female breast cancer and alcohol consumption: a review of the literature. Am J Prev Med. 2014;46(3 Suppl 1):S16–25.

    Article  PubMed  Google Scholar 

  33. Strijk JE, Proper KI, Klaver L, van der Beek AJ, van Mechelen W. Associations between VO2max and vitality in older workers: a cross-sectional study. BMC Public Health. 2010;10:684.

    Article  PubMed Central  PubMed  Google Scholar 

  34. Blair SN, Morris JN. Healthy hearts—and the universal benefits of being physically active: physical activity and health. Ann Epidemiol. 2009;19:253–6.

    Article  PubMed  Google Scholar 

  35. Baguet JP. Out-of-office blood pressure: from measurement to control. Integr Blood Press Control. 2012;5:27–34.

    Article  PubMed Central  PubMed  Google Scholar 

  36. AMA Wire. How a doctor quickly improved patients’ blood pressure readings. http://www.ama-assn.org/ama/ama-wire/post/doctor-quickly-improved-patients-blood-pressure-readings. Accessed 1 June 2015.

  37. Liao S, Li J, Wei W, Wang W, Zhang Y, Li J, et al. Association between diabetes mellitus and breast cancer risk: a meta-analysis of the literature. Asian Pac J Cancer Prev. 2011;12:1061–5.

    PubMed  Google Scholar 

  38. Salinas-Martinez AM, Flores-Cortes LI, Cardona-Chavarria JM, Hernandez-Guiterrez B, Abundis A, Vazquez-Lara J, et al. Prediabetes, diabetes, and risk of breast cancer: a case-control study. Arch Med Res. 2014;45:432–8.

    Article  PubMed  Google Scholar 

  39. Isidro ML. Sexual dysfunction in men with type 2 diabetes. Postgrad Med J. 2012;88:152–9.

    Article  CAS  PubMed  Google Scholar 

  40. Copeland KL, Brown JS, Creasman JM, Van Den Eeden SK, Subak LL, Thom DH, et al. Diabetes mellitus and sexual function in middle-aged and older women. Obstet Gynecol. 2012;120(2 Pt 1):331–40.

    Article  PubMed Central  PubMed  Google Scholar 

  41. Moyad MA. Current methods used for defining, measuring, and treating obesity. Semin Urol Oncol. 2001;19:247–56.

    CAS  PubMed  Google Scholar 

  42. Writing Group for the Women’s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA. 2002;288:321–33.

    Article  Google Scholar 

  43. Pischon T, Boeing H, Hoffmann K, Bergmann M, Schulze MB, Overvad K, et al. General and abdominal adiposity and risk of death in Europe. N Engl J Med. 2008;359:2105–20.

    Article  CAS  PubMed  Google Scholar 

  44. Jacobs EJ, Newton CC, Wang Y, Patel AV, McCullough ML, Campbell PT, et al. Waist circumference and all-cause mortality in a large US cohort. Arch Intern Med. 2010;170:1293–301.

    Article  PubMed  Google Scholar 

  45. Seidell JC. Waist circumference and waist/hip ratio in relation to all-cause mortality, cancer and sleep apnea. Eur J Clin Nutr. 2010;64:35–41.

    Article  CAS  PubMed  Google Scholar 

  46. Zhu S, Heymsfield SB, Toyoshima H, Wang Z, Pietrobelli A, Heshka S. Race-ethnicity-specific waist circumference cutoffs for identifying cardiovascular disease risk factors. Am J Clin Nutr. 2005;81:409–15.

    CAS  PubMed  Google Scholar 

  47. Chandramohan G, Kalantar-Zadeh K, Kermah D, Marie Go SC, Vaziri ND, Norris KC. Relationship between obesity and pulse pressure in children: results of the National Health and Nutrition Survey (NHANES) 1988–1994. J Am Soc Hypertens. 2012;6:277–83.

    Article  PubMed Central  PubMed  Google Scholar 

  48. Taylor EN, Stampfer MJ, Curhan GC. Obesity, weight gain, and the risk of kidney stones. JAMA. 2005;293:455–62.

    Article  CAS  PubMed  Google Scholar 

  49. Scales Jr CD, Smith AC, Hanley JM, Saigal CS, Urologic Diseases in America Project. Prevalence of kidney stones in the United States. Eur Urol. 2012;62:160–5.

    Article  PubMed Central  PubMed  Google Scholar 

  50. Moyad MA. Obesity, interrelated mechanisms, and exposures and kidney cancer. Semin Urol Oncol. 2001;19:270–9.

    CAS  PubMed  Google Scholar 

  51. Mathew A, George PS, Ildaphonse G. Obesity and kidney cancer risk in women: a meta-analysis (1992–2008). Asian Pac J Cancer Prev. 2009;10:471–8.

    PubMed  Google Scholar 

  52. Adams TD, Gress RE, Smith SC, Halverson RC, Simper SC, Rosamond WD, et al. Long-term mortality after gastric bypass surgery. N Engl J Med. 2007;357:753–61.

    Article  CAS  PubMed  Google Scholar 

  53. Sjostrom L, Narbro K, Sjostrom CD, Karason K, Larsson B, Wedel H, et al., for the Swedish Obese Subjects Study. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007;357:741–752.

    Google Scholar 

  54. Bray GA. The missing link-lose weight, live longer. N Engl J Med. 2007;357(8):818–9.

    Article  CAS  PubMed  Google Scholar 

  55. Sjostrom L, Peltonen M, Jacobson P, et al. Bariatric surgery and long-term cardiovascular events. JAMA. 2012;307:56–65.

    Article  PubMed  Google Scholar 

  56. Schauer PR, Kashyap SR, Wolski K, Brethauer SA, Kirwan JP, Pothier CE, et al. Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N Engl J Med. 2012;366:1567–76.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  57. Mingrone G, Panunzi S, De Gaetano A, Guidone C, Iaconelli A, Leccesi L, et al. Bariatric surgery versus conventional medical therapy for type 2 diabetes. N Engl J Med. 2012;366:1577–85.

    Article  CAS  PubMed  Google Scholar 

  58. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63:11–30.

    Article  PubMed  Google Scholar 

  59. Berube S, Lemiux J, Moore L, Maunsell E, Brisson J. Smoking at time of diagnosis and breast cancer-specific survival: new findings and systematic review with meta-analysis. Breast Cancer Res. 2014;16:R42.

    Article  PubMed Central  PubMed  Google Scholar 

  60. Aveyard P, Lycett D, Farley A. Managing smoking cessation-related weight gain. Pol Arch Med Wewn. 2012;122:494–8.

    PubMed  Google Scholar 

  61. Johnson KC, Miller AB, Collishaw NE, Palmer JR, Hammond SK, Salmon AG, et al. Active smoking and secondhand smoke increase breast cancer risk: the report of the Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk (2009). Tob Control. 2011;20(1):e2.

    Article  PubMed  Google Scholar 

  62. Lorinzi PD, Cardinal BJ, Winters-Stone K, Smit E, Loprinzi CL. Physical activity and the risk of breast cancer recurrence: a literature review. Oncol Nurs Forum. 2012;39:269–74.

    Article  Google Scholar 

  63. Chen X, Lu W, Zheng W, Gu K, Matthews CE, Chen Z, et al. Exercise after diagnosis of breast cancer in association with survival. Cancer Prev Res (Phila). 2011;4:1409–18.

    Article  Google Scholar 

  64. Pant S, Shapiro CL. Aromatase inhibitor-associated bone loss: clinical considerations. Drugs. 2008;68:2591–600.

    Article  CAS  PubMed  Google Scholar 

  65. Cormie P, Galvao DA, Spry N, Newton RU. Neither heavy nor light load resistance acutely exacerbates lymphedema in breast cancer survivor. Integr Cancer Ther. 2013;12:423–32.

    Article  PubMed  Google Scholar 

  66. Irwin ML, Cartmel B, Gross CP, Ercolano E, Li F, Yao X, et al. Randomized exercise trial of aromatase inhibitor-induced arthralgia in breast cancer survivors. J Clin Oncol. 2015;33:1104–11.

    Article  PubMed  Google Scholar 

  67. Ahmed HM, Blaha MJ, Nasir K, Rivera JJ, Blumenthal RS. Effects of physical activity on cardiovascular disease. Am J Cardiol. 2012;109:288–95.

    Article  PubMed  Google Scholar 

  68. Poehlman ET, Melby C. Resistance training and energy balance. Int J Sport Nutr. 1998;8:143–59.

    CAS  PubMed  Google Scholar 

  69. Braith RW, Stewart KJ. Resistance exercise training: its role in the prevention of cardiovascular disease. Circulation. 2006;113:2642–50.

    Article  PubMed  Google Scholar 

  70. Hurley BF, Roth SM. Strength training in the elderly. Sports Med. 2000;30:249–68.

    Article  CAS  PubMed  Google Scholar 

  71. Blake H, Mo P, Malik S, Thomas S. How effective are physical activity interventions for alleviating depressive symptoms in older people? A systematic review. Clin Rehabil. 2009;23:873–87.

    Article  CAS  PubMed  Google Scholar 

  72. Deslandes A, Moraes H, Ferreira C, Veiga H, Silveira H, Mouta R, et al. Exercise and mental health: many reasons to move. Neuropsychobiology. 2009;59:191–8.

    Article  PubMed  Google Scholar 

  73. Blumenthal JA, Babyak MA, Moore KA, Craighead WE, Herman S, Khatri P, et al. Effects of exercise training on older patients with major depression. Arch Intern Med. 1999;159:2349–56.

    Article  CAS  PubMed  Google Scholar 

  74. Babyak M, Blumenthal JA, Herman S, Khatri P, Doraiswamy M, Moore K, et al. Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months. Psychosom Med. 2000;62:633–8.

    Article  CAS  PubMed  Google Scholar 

  75. Blumenthal JA, Doralswamy PM. Exercise to combat depression. JAMA. 2014;312:2166–7.

    Article  PubMed  Google Scholar 

  76. Biedermann SV, Fuss J, Steinle J, Auer MK, Dormann C, Falfan-Melgoza C, et al. The hippocampus and exercise: histological correlates of MR-detected volume changes. Brain Struct Funct 2014, Epub ahead of print.

    Google Scholar 

  77. Blumenthal JA, Babyak MA, O’Connor C, Keteyian S, Landzberg J, Howlett J, et al. Effects of exercise training on depressive symptoms in patients with chronic heart failure: the HF-ACTION randomized trial. JAMA. 2012;308:465–74.

    PubMed Central  CAS  PubMed  Google Scholar 

  78. Barnes PM, Schoenborn CA. Trends in adults receiving a recommendation for exercise or other physical activity from a physician or other health professional. NCHS Data Brief. 2012;86:1–8.

    PubMed  Google Scholar 

  79. Moyad MA. Dr Moyad’s no bogus science health advice. Ann Arbor, MI: Ann Arbor Media Group; 2009.

    Google Scholar 

  80. Moyad MA. The supplement handbook. New York, NY: Rodale Publishing; 2014.

    Google Scholar 

  81. Yu JN, Cunningham JA, Rosenberg Thouin S, Gurvich T, Liu D. Hyperlipidemia. Prim Care. 2000;27:541–87.

    Article  CAS  PubMed  Google Scholar 

  82. Ornish D, Weidner G, Fair WR, Marlin R, Pettengill EB, Raisin CJ, et al. Intensive lifestyle changes may affect the progression of prostate cancer. J Urol. 2005;174:1065–9.

    Article  PubMed  Google Scholar 

  83. Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr. 2010;91:535–46.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  84. Yamagishi K, Iso H, Yatsuya H, Tanabe N, Date C, Kikuchi S, et al., for the JACC Study Group. Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) Study. Am J Clin Nutr 2010;92:759–65.

    Google Scholar 

  85. Mozaffarian D, Micha R, Wallace S. Effects of coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLoS Med. 2010;7:e1000252.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  86. Chiuve SE, Rimm EB, Sandhu RK, Bernstein AM, Rexrode KM, Manson JE, et al. Dietary fat quality and risk of sudden cardiac death in women. Am J Clin Nutr. 2012;96(3):498–507. Epub 1 Aug 2012.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  87. Chlebowski RT, Blackburn GL, Thomson CA, Nixon DW, Shapiro A, Hoy MK, et al. Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women’s Intervention Nutrition Study. J Natl Cancer Inst. 2006;98:1767–76.

    Article  PubMed  Google Scholar 

  88. Pierce JP, Natarajan L, Caan BJ, Parker BA, Greenberg ER, Flatt SW, et al. Influence of a diet very high in vegetables, fruit, and fiber and low in fat on prognosis following treatment for breast cancer: the Women’s Healthy Eating and Living (WHEL) randomized trial. JAMA. 2007;298:289–98.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  89. Villasenor A, Flatt SW, Marinac C, Natarajan L, Pierce JP, Patterson RE. Postdiagnosis C-reactive protein and breast cancer survivorship: findings from the WHEL study. Cancer Epidemiol Biomarkers Prev. 2014;23:189–99.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  90. Loftfield E, Harrigan M, Li F, Cartmel B, Zhou Y, Playdon M, et al. Lifestyle, exercise and nutrition study (LEAN). J Clin Oncol. 2014;32:5s. abstract number 1505 ASCO 2014 Annual Meeting.

    Article  CAS  Google Scholar 

  91. Johnstone BC, Kanters S, Bandayrel K. Comparison of weight loss among named diet programs in overweight and obese adults: a meta-analysis. JAMA. 2014;312:923.

    Article  CAS  Google Scholar 

  92. Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384:766–81.

    Article  PubMed  PubMed Central  Google Scholar 

  93. Giovannucci E. Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. J Natl Cancer Inst. 1999;91:317–31.

    Article  CAS  PubMed  Google Scholar 

  94. Moyad MA. The ABCs of nutrition and supplements for prostate cancer. Ann Arbor, MI: JW Edwards Publishing; 2000.

    Google Scholar 

  95. www.usda.gov. Accessed 25 Oct 2010.

  96. Clinton SK. Lycopene: chemistry, biology, and implications for human health and disease. Nutr Rev. 1998;56:35–51.

    Article  CAS  PubMed  Google Scholar 

  97. Mourvaki E, Gizzi S, Rossi R, Rufini S. Passionflower fruit—a “new” source of lycopene? J Med Food. 2005;8:104–6.

    Article  CAS  PubMed  Google Scholar 

  98. Ilic D, Forbes KM, Hassed C. Lycopene for the prevention of prostate cancer. Cochrane Database Syst Rev. 2011;11:CD008007.

    PubMed  Google Scholar 

  99. Ilic D, Misso M. Lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer: a systematic review. Maturitas. 2012;72:269–76.

    Article  CAS  PubMed  Google Scholar 

  100. Ried K, Fakler P. Protective effect of lycopene on serum cholesterol and blood pressure: meta-analyses of intervention trials. Maturitas. 2011;68:299–310.

    Article  CAS  PubMed  Google Scholar 

  101. Pantuck AJ, Leppert JT, Zomorodian N, Aronson W, Hong J, Barnard RJ, et al. Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clin Cancer Res. 2006;12(13):4018–26.

    Article  CAS  PubMed  Google Scholar 

  102. Forest CP, Padma-Nathan H, Liker HR. Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, cross-over study. Int J Impot Res. 2007;19:564–7.

    Article  CAS  PubMed  Google Scholar 

  103. Uno T, Yasui-Furukori N. Effect of grapefruit juice in relation to human pharmacokinetic study. Curr Clin Pharmacol. 2006;1:157–61.

    Article  CAS  PubMed  Google Scholar 

  104. Komperda KE. Potential interaction between pomegranate juice and warfarin. Pharmacotherapy. 2009;29:1002–6.

    Article  CAS  PubMed  Google Scholar 

  105. Jarvis S, Li C, Bogle RG. Possible interaction between pomegranate juice and warfarin. Emerg Med J. 2010;27:74–5.

    Article  CAS  PubMed  Google Scholar 

  106. Rocha A, Wang L, Penichet M, Martins-Green M. Pomegranate juice and specific components inhibit cell and molecular processes critical for metastasis of breast cancer. Breast Cancer Res Treat. 2012;136:647–58.

    Article  CAS  PubMed  Google Scholar 

  107. Aune D, Chan DS, Vieira AR, Rosenblatt DA, Vieira R, Greenwood DC, et al. Fruits, vegetables and breast cancer risk: a systematic review and meta-analysis of prospective studies. Breast Cancer Res Treat. 2012;134:479–93.

    Article  CAS  PubMed  Google Scholar 

  108. van Gils CH, Peeters PH, Bueno-de-Mesquita HB, Boshulzen HC, Lahmann PH, Clavel-Chapelon F, et al. Consumption of vegetables and fruits and risk of breast cancer. JAMA. 2005;293:183–93.

    Article  PubMed  Google Scholar 

  109. Walker C, Reamy BV. Diets for cardiovascular disease prevention: what is the evidence? Am Fam Physician. 2009;79:571–8.

    PubMed  Google Scholar 

  110. Duthie GG, Wood AD. Natural salicylates: foods, functions and disease prevention. Food Funct. 2011;2:515–20.

    Article  CAS  PubMed  Google Scholar 

  111. Boffetta P, Couto E, Wichmann J, Ferrari P, Trichopoulos D, Bueno-de-Mesquita HB, et al. Fruit and vegetable intake and overall cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst. 2010;102:529–37.

    Article  CAS  PubMed  Google Scholar 

  112. Bhupathiraju SN, Wedick NM, Pan A, Manson JE, Rexrode KM, Willet WC, et al. Quantity and variety in fruit and vegetable intake and risk of coronary heart disease. Am J Clin Nutr. 2013;98:1514–23.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  113. Oude Griep LM, Verschuren WM, Kromhout D, Ocke MC, Geleijnse JM. Variety of fruits and vegetable consumption and 10-year incidence of stroke. Public Health Nutr. 2012;15:2280–6.

    Article  PubMed  Google Scholar 

  114. Van Horn L. Fiber, lipids, and coronary heart disease. A statement for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation. 1997;95:2701–4.

    Article  PubMed  Google Scholar 

  115. Brown L, Rosner B, Willett WW, Sacks FM. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr. 1999;69:30–42.

    CAS  PubMed  Google Scholar 

  116. Anderson JW, Baird P, Davis Jr RH, Ferreri S, Knudtson M, Koraym A, et al. Health benefits of dietary fiber. Nutr Rev. 2009;67:188–205.

    Article  PubMed  Google Scholar 

  117. Slavin JL. Position of the American Dietetic Association: health implications of dietary fiber. J Am Diet Assoc. 2008;108:1716–31.

    Article  PubMed  Google Scholar 

  118. Pereira MA, O’Reilly E, Augustsson K, Fraser GE, Goldbourt U, Heitmann BL, et al. Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies. Arch Intern Med. 2004;164:370–6.

    Article  PubMed  Google Scholar 

  119. Pietinen P, Rimm EB, Korhonen P, Hartman AM, Willett WC, Albanes D, et al. Intake of dietary fiber and risk of coronary heart disease in a cohort of Finnish men: the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Circulation. 1996;94:2720–7.

    Article  CAS  PubMed  Google Scholar 

  120. Rimm EB, Ascherio A, Giovannucci E, Spiegelman D, Stampfer MJ, Willett WC. Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men. JAMA. 1996;275:447–51.

    Article  CAS  PubMed  Google Scholar 

  121. Park Y, Subar AF, Hollenbeck A, Schatzkin A. Dietary fiber intake and mortality in the NIH-AARP diet and health study. Arch Intern Med. 2011;171:1061–8.

    Article  PubMed Central  PubMed  Google Scholar 

  122. Eshak ES, Iso H, Date C, Kikuchi S, Watanabe Y, Wada Y, et al. Dietary fiber intake is associated with reduced risk of mortality from cardiovascular disease among Japanese men and women. J Nutr. 2010;140:1445–53.

    Article  CAS  PubMed  Google Scholar 

  123. Moreyra AE, Wilson AC, Koraym A. Effect of combining psyllium fiber with simvastatin in lowering cholesterol. Arch Intern Med. 2005;165:1161–6.

    Article  CAS  PubMed  Google Scholar 

  124. Agrawal AR, Tandon M, Sharma PL. Effect of combining viscous fibre with lovastatin on serum lipids in normal human subjects. Int J Clin Pract. 2007;61:1812–8.

    Article  CAS  PubMed  Google Scholar 

  125. Streppel MT, Arends LR, van’t Veer P, Grobbee DE, Geleijnse JM. Dietary fiber and blood pressure: a meta-analysis of randomized placebo-controlled trials. Arch Intern Med. 2005;165:150–6.

    Article  PubMed  Google Scholar 

  126. Vernay M, Aidara M, Salanave B, Deschamps V, Malon A, Oleko A, et al. Diet and blood pressure in 18–74 year old adults: the French Nutrition and Health Survey (ENNS, 2006–2007). J Hypertens. 2012;30(10):1920–7. Epub 12 July 2012.

    Article  CAS  PubMed  Google Scholar 

  127. Marlett JA, McBurney MI, Slavin JL, for the American Dietetic Association. Position of the American Dietetic Association: health implications of dietary fiber. J Am Diet Assoc 2002;102:993–1000.

    Google Scholar 

  128. Pan A, Yu D, Demark-Wahnefried W, Franco OH, Lin X. Meta-analysis of the effects of flaxseed interventions on blood lipids. Am J Clin Nutr. 2009;90:288–97.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  129. Rodriguez-Leyva D, Dupasquier CM, McCullough R, Pierce GN. The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acid. Can J Cardiol. 2010;26:489–96.

    Article  PubMed Central  PubMed  Google Scholar 

  130. Jin F, Nieman DC, Sha W, Xie G, Qiu Y, Jia W. Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. Plant Foods Hum Nutr. 2012;67:105–10.

    Article  CAS  PubMed  Google Scholar 

  131. Demark-Wahnefried W, Price DT, Polascik TJ, Robertson CN, Anderson EE, Paulson DF, et al. Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. Urology. 2001;58:47–52.

    Article  CAS  PubMed  Google Scholar 

  132. Demark-Wahnefried W, Robertson CN, Walther PJ, Polascik TJ, Paulson DF, Vollmer RT. Pilot study to explore effects of low-fat, flaxseed-supplemented diet on proliferation of benign prostatic epithelium and prostate-specific antigen. Urology. 2004;63:900–4.

    Article  PubMed  Google Scholar 

  133. Demark-Wahnefried W, Polascik TJ, George SL, Switzer BR, Madden JF, Ruffin 4th MT, et al. Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. Cancer Epidemiol Biomarkers Prev. 2008;17:3577–87.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  134. Zhang W, Wang X, Liu Y, Tian H, Flickinger B, Empie MW, et al. Effects of dietary flaxseed meric extract on symptoms of benign prostatic hyperplasia. J Med Food. 2008;11:207–14.

    Article  CAS  PubMed  Google Scholar 

  135. Thompson LU, Chen JM, Tong L, Strasser-Weippt K, Goss PE. Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer. Clin Cancer Res. 2005;11:3828–35.

    Article  CAS  PubMed  Google Scholar 

  136. McCann SE, Edge SB, Hicks DG, Thompson LU, Morrison CD, Fetterly G, et al. A pilot study comparing the effect of flaxseed, aromatase inhibitor, and the combination on breast tumor biomarkers. Nutr Cancer 2014;66:566–75.

    Google Scholar 

  137. Mason JK, Fu M, Chen J, Thompson LU. Flaxseed oil enhances the effectiveness of trastuzumab in reducing the growth of HER2-overexpressing human breast tumors (BT-474). J Nutr Biochem. 2015;26:16–23.

    Article  CAS  PubMed  Google Scholar 

  138. Aune D, Chan DS, Greenwood DC, Vieira AR, Rosenblatt DA, Vieira R, et al. Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies. Ann Oncol. 2012;23:1394–402.

    Article  CAS  PubMed  Google Scholar 

  139. Dong JY, He K, Wang P, Qin LQ. Dietary fiber intake and risk of breast cancer: a meta-analysis of prospective cohort studies. Am J Clin Nutr. 2011;94:900–5.

    Article  CAS  PubMed  Google Scholar 

  140. Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Wilson RS, et al. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol. 2003;60:940–6.

    Article  PubMed  Google Scholar 

  141. Morris MC. The role of nutrition in Alzheimer’s disease: epidemiological evidence. Eur J Neurol. 2009;16 Suppl 1:1–7.

    Article  PubMed Central  PubMed  Google Scholar 

  142. Moyad MA. An introduction to dietary/supplemental omega-3 fatty acids for general health and prevention: part I. Urol Oncol. 2005;23:28–35.

    Article  CAS  PubMed  Google Scholar 

  143. Moyad MA. An introduction to dietary/supplemental omega-3 fatty acids for general health and prevention: part II. Urol Oncol. 2005;23:36–48.

    Article  CAS  PubMed  Google Scholar 

  144. Bucher HC, Hengstler P, Schindler C, Meier G. N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med. 2002;112:298–304.

    Article  CAS  PubMed  Google Scholar 

  145. Kris-Etherton PM, Harris WS, Appel LJ, for the Nutrition Committee. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002;106:2747–57.

    Google Scholar 

  146. Harris WS. N-3 fatty acids and serum lipoproteins: human studies. Am J Clin Nutr. 1997;65(5 Suppl):1645S–54.

    CAS  PubMed  Google Scholar 

  147. Cabo J, Alonso R, Mata P. Omega-3 fatty acids and blood pressure. Br J Nutr. 2012;107 Suppl 2:S195–200.

    Article  CAS  PubMed  Google Scholar 

  148. Albert CM, Campos H, Stampfer MJ, Ridker PM, Manson JE, Willett WC, et al. Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med. 2002;346:1113–8.

    Article  CAS  PubMed  Google Scholar 

  149. Siener R, Jansen B, Watzer B, Hesse A. Effect of n-3 fatty acid supplementation on urinary risk factors for calcium oxalate stone formation. J Urol. 2011;185:719–24.

    Article  CAS  PubMed  Google Scholar 

  150. Yasui T, Suzuki S, Itoh Y, Tozawa K, Tokudome S, Kohri K. Eicosapentaenoic acid has a preventive effect on the recurrence of nephrolithiasis. Urol Int. 2008;81:135–8.

    Article  CAS  PubMed  Google Scholar 

  151. Guallar E, Sanz-Gallardo MI, van’t Veer P, Bode P, Aro A, Gomez-Aracena J, et al. Mercury, fish oils, and the risk of myocardial infarction. N Engl J Med. 2002;347:1747–54.

    Article  CAS  PubMed  Google Scholar 

  152. Yoshizawa K, Rimm EB, Morris JS, Spate VL, Hsieh CC, Spiegelman D, et al. Mercury and the risk of coronary heart disease in men. N Engl J Med. 2002;347:1755–60.

    Article  CAS  PubMed  Google Scholar 

  153. Virtanen JK, Laukkanen JA, Mursu J, Voutilainen S, Tuomainen TP. Serum long-chain n-3 polyunsaturated fatty acids, mercury, and risk of sudden cardiac death in men: a prospective population-based study. PLoS One. 2012;7:e41046.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  154. Weil M, Bressler J, Parsons P, Bolla K, Glass T, Schwartz B. Blood mercury levels and neurobehavioral function. JAMA. 2005;293:1875–82.

    Article  CAS  PubMed  Google Scholar 

  155. DeRouen TA, Martin MD, Leroux BG, Townes BD, Woods JS, Leitao J, et al. Neurobehavioral effects of dental amalgam in children: a randomized clinical trial. JAMA. 2006;295:1784–92.

    Article  CAS  PubMed  Google Scholar 

  156. Mozaffarian D, Shi P, Morris JS, Spiegelman D, Grandjean P, Siscovick DS, et al. Mercury exposure and risk of cardiovascular disease in two U.S. cohorts. N Engl J Med. 2011;364:1116–25.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  157. Kris-Etherton PM, Harris WS, Appel LJ, AHA Nutrition Committee. American Heart Association. Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association. Arterioscler Thromb Vasc Biol. 2003;23:151–2.

    Article  CAS  PubMed  Google Scholar 

  158. GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results from the GISSI-Prevenzione trial. Lancet. 1999;354:447–55.

    Article  Google Scholar 

  159. Marchioli R, Barzi F, Bomba E, Chieffo C, Di Gregorio D, Di Mascio R, et al. Early protection against sudden cardiac death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione. Circulation. 2002;105:1897–903.

    Article  CAS  PubMed  Google Scholar 

  160. Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomized open-label, blinded endpoint analysis. Lancet. 2007;369:1090–8.

    Article  CAS  PubMed  Google Scholar 

  161. Kwak SM, Myung SK, Lee YJ, Seo HG, et al., for the Korean Meta-Analysis Study Group. Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. Arch Intern Med 2012;172:686–94.

    Google Scholar 

  162. Mozaffarian D, Marchiolli R, Macchia A, Silletta MG, Ferrazzi P, Gardner TJ, et al. Fish oil and postoperative atrial fibrillation: the Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial. JAMA. 2012;308:2001–11.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  163. Risk and Prevention Study Collaborative Group. N-3 fatty acids in patients with multiple cardiovascular risk factors. N Engl J Med. 2013;368:1800–8.

    Article  CAS  Google Scholar 

  164. Age-Related Eye Disease Study 2 Research Group. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA. 2013;309:2005–15.

    Article  CAS  Google Scholar 

  165. Li D. Omega-3 polyunsaturated fatty acids and non-communicable diseases: meta-analysis based systematic review. Asia Pac J Clin Nutr. 2015;24:10–5.

    CAS  PubMed  Google Scholar 

  166. Zheng JS, Hu XJ, Zhao YM, Yang J, Li D. Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies. BMJ. 2013;346:f3706. Epub ahead of print.

    Article  PubMed  Google Scholar 

  167. Fabian CJ, Kimler BF, Hursting SD. Omega-3 fatty acids for breast cancer prevention and survivorship. Breast Cancer Res. 2015;17:62.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  168. Ghoreishi Z, Esfahani A, Djazayeri A, Djalali M, Golestan B, Ayromlou H, et al. Omega-3 fatty acids are protective against paclitaxel-induced peripheral neuropathy: a randomized double-blind placebo controlled trial. BMC Cancer. 2012;12:355.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  169. Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, et al. Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial. Am J Clin Nutr. 2011;93:402–12.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  170. Smith GI, Julliand S, Reeds DN, Sinacore DR, Klein S, Mittendorfer B. Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults. Am J Clin Nutr. 2015;102(1):115–22. Epub 20 May 2015.

    Article  CAS  PubMed  Google Scholar 

  171. Fracasso PM, Picus J, Wildi JD, Goodner SA, Creekmore AN, Gao F, et al. Phase 1 and pharmacokinetic study of weekly docosahexaenoic acid-paclitaxel, Taxoprexin, in resistant solid tumor malignancies. Cancer Chemother Pharmacol. 2009;63:451–8.

    Article  CAS  PubMed  Google Scholar 

  172. O’Neil CE, Keast DR, Nicklas TA, Fulgoni 3rd VL. Nut consumption is associated with decreased health risk factors for cardiovascular disease and metabolic syndrome in U.S. adults: NHANES 1999–2004. J Am Coll Nutr. 2011;30:502–10.

    Article  PubMed  Google Scholar 

  173. Albert CM, Gaziano JM, Willett WC, Manson JE. Nut consumption and decreased risk of sudden cardiac death in the physicians’ health study. Arch Intern Med. 2002;162:1382–7.

    Article  PubMed  Google Scholar 

  174. Ellsworth JL, Kushi LH, Folsom AR. Frequent nut intake and risk of death from coronary heart disease and all causes in postmenopausal women: the Iowa Women’s Health Study. Nutr Metab Cardiovasc Dis. 2001;11:372–7.

    CAS  PubMed  Google Scholar 

  175. Fraser GE, Shavlik DJ. Risk factors for all-cause and coronary heart disease mortality in the oldest-old: the Adventist Health Study. Arch Intern Med. 1997;157:2249–58.

    Article  CAS  PubMed  Google Scholar 

  176. Sabate J, Wien M. Nuts, blood lipids and cardiovascular disease. Asia Pac J Clin Nutr. 2010;19:131–6.

    CAS  PubMed  Google Scholar 

  177. Casas-Agustench P, Bullo M, Salas-Salvado J. Nuts, inflammation and insulin resistance. Asia Pac J Clin Nutr. 2010;19:124–30.

    CAS  PubMed  Google Scholar 

  178. Afshin A, Micha R, Khatibzadeh S, Mozaffarian D. Consumption of nuts and legumes and risk of incident heart disease, stroke, and diabetes: a systematic review and meta-analysis. Am J Clin Nutr. 2014;100:278–88.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  179. Yang Q, Cogswell ME, Flanders WD, Hong Y, Zhang Z, Loustalot F, et al. Trends in cardiovascular health metrics and associations with all-cause and CVD mortality among US adults. JAMA. 2012;307:1273–83.

    Article  CAS  PubMed  Google Scholar 

  180. Hu FB, Willett WC, Tricia L, Stampfer MJ, Colditz GA, Manson JE. Adiposity as compared with physical activity in predicting mortality among women. N Engl J Med. 2004;351(26):2694–703.

    Article  CAS  PubMed  Google Scholar 

  181. Ajani UA, Lotufo PA, Gaziano JM, Lee IM, Spelsberg A, Buring JE, et al. Body mass index and mortality among US male physicians. Ann Epidemiol. 2004;14:731–9.

    Article  PubMed  Google Scholar 

  182. Baik I, Ascherio A, Rimm EB, Giovannucci E, Spiegelman D, Stampfer MJ, et al. Adiposity and mortality in men. Am J Epidemiol. 2000;152:264–71.

    Article  CAS  PubMed  Google Scholar 

  183. Platz EA, Willet WC, Colditz GA, Rimm EB, Spiegelman D, Giovannucci E. Proportion of colon cancer risk that might be preventable in a cohort of middle-aged US men. Cancer Causes Control. 2000;11:579–88.

    Article  CAS  PubMed  Google Scholar 

  184. Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med. 2003;348:2599–608.

    Article  PubMed  Google Scholar 

  185. Mitrou PN, Kipnis V, Thiebaut AC, Reedy J, Subar AF, Wirfalt E, et al. Mediterranean dietary pattern and prediction of all-cause mortality in a U.S. population: results from the NIH-AARP Diet and Health Study. Arch Intern Med. 2007;167:2461–8.

    Article  PubMed  Google Scholar 

  186. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. on behalf of the INTERHEART Study Investigators. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 2004;364:937–52.

    Google Scholar 

  187. Joshi P, Islam S, Pais P, Reddy S, Dorairaj P, Kazmi K, et al. Risk factors for early myocardial infarction in South Asians compared with individuals in other countries. JAMA. 2007;297:286–94.

    Article  CAS  PubMed  Google Scholar 

  188. Wilcox BJ, He Q, Chen R, Yano K, Masaki KH, Grove JS, et al. Midlife risk factors and healthy survival in men. JAMA. 2006;296:2343–50.

    Article  Google Scholar 

  189. Yates LB, Djousse L, Kurth T, Buring JE, Gaziano JM. Exceptional longevity in men: modifiable factors associated with survival and function to age 90 years. Arch Intern Med. 2008;168:284–90.

    Article  PubMed  Google Scholar 

  190. Terry DF, Pencina MJ, Vasan RS, Murabito JM, Wolf PA, Hayes MK, et al. Cardiovascular risk factors predictive for survival and morbidity-free survival in the oldest-old Framingham Heart Study participants. J Am Geriatr Soc. 2005;53:1944–50.

    Article  PubMed  Google Scholar 

  191. Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997;336:1117–24.

    Article  CAS  PubMed  Google Scholar 

  192. Sacks FM, Svetkey LP, Vollmer WM, Appel LJ, Bray GA, Harsha D, et al. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group. N Engl J Med. 2001;344:3–10.

    Article  CAS  PubMed  Google Scholar 

  193. Karanja N, Erlinger TP, Pao-Hwa L, Miller ER, Bray GA. The DASH diet for high blood pressure: from clinical trial to dinner table. Cleve Clin J Med. 2004;71(9):745–53.

    Article  PubMed  Google Scholar 

  194. Taylor EN, Fung TT, Curhan GC. DASH-Style diet associates with reduced risk for kidney stones. J Am Soc Nephrol. 2009;20:2253–9.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  195. Rock CL. Multivitamin-multimineral supplements: who uses them? Am J Clin Nutr. 2007;85(Suppl):277S–9.

    CAS  PubMed  Google Scholar 

  196. Gahche J, Bailey R, Burt V, Hughes J, Yetley E, Dwyer J, et al. Dietary supplement use among U.S. adults has increased since NHANES III (1988–1994). NCHS Data Brief 2011;(61):1–8.

    Google Scholar 

  197. Barqawi A, Gamito E, O’Donnell C, Crawford ED. Herbal and vitamin supplement use in a prostate cancer screening population. Urology. 2004;63:288–92.

    Article  PubMed  Google Scholar 

  198. Kristal AR, Arnold KB, Schenk JM, Neuhouser ML, Goodman P, Penson DF, et al. Dietary patterns, supplement use, and the risk of symptomatic benign prostatic hyperplasia: results from the prostate cancer prevention trial. Am J Epidemiol. 2008;167:925–34.

    Article  PubMed  Google Scholar 

  199. Muntwyler J, Hennekens CH, Manson JE, Buring JE, Gaziano M. Vitamin supplement use in a low-risk population of US male physicians and subsequent cardiovascular mortality. Arch Intern Med. 2002;162:1472–6.

    Article  PubMed  Google Scholar 

  200. Shikany JM, Patterson RE, Agurs-Collins T, Anderson G. Antioxidant supplement use in Women’s Health Initiative participants. Prev Med. 2003;36:379–87.

    Article  PubMed  Google Scholar 

  201. Neuhouser ML, Wassertheil-Smoller S, Thomson C, Aragaki A, Anderson GL, Manson JE, et al. Multivitamin use and risk of cancer and cardiovascular disease in the Women’s Health Initiative cohorts. Arch Intern Med. 2009;169:294–304.

    Article  PubMed  Google Scholar 

  202. Giovannucci E, Chan AT. Role of vitamin and mineral supplementation and aspirin use in cancer survivors. J Clin Oncol. 2010;28:4081–5.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  203. Lawson KA, Wright ME, Subar A, Mouw T, Hollenbeck A, Schatzkin A, et al. Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study. J Natl Cancer Inst. 2007;99:754–64.

    Article  CAS  PubMed  Google Scholar 

  204. Stevens VL, McCullough ML, Diver WR, Rodriguez C, Jacobs EJ, Thun MJ, et al. Use of multivitamins and prostate cancer mortality in a large cohort of US men. Cancer Causes Control. 2005;16:643–50.

    Article  PubMed  Google Scholar 

  205. Neuhouser ML, Barnett MJ, Kristal AR, Ambrosone CB, King IB, Thornquist M, et al. Dietary supplement use and prostate cancer risk in the Carotene and Retinol Efficacy Trial. Cancer Epidemiol Biomarkers Prev. 2009;18:2202–6.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  206. Larsson SC, Akesson A, Bergkvist L, Wolk A. Multivitamin use and breast cancer incidence in a prospective cohort of Swedish women. Am J Clin Nutr. 2010;91:1268–72.

    Article  CAS  PubMed  Google Scholar 

  207. Berube S, Diorio C, Brisson J. Multivitamin-multimineral supplement use and mammographic breast density. Am J Clin Nutr. 2008;87:1400–4.

    CAS  PubMed  Google Scholar 

  208. Clarke R, Halsey J, Lewington S, Lonn E, Armitage J, Manson JE, et al. Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality. Arch Intern Med. 2010;170:1622–31.

    Article  CAS  PubMed  Google Scholar 

  209. Collin SM, Metcalfe C, Refsum H, Lewis SJ, Zuccolo L, Smith GD, et al. Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2010;19:1632–42.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  210. Ng K, Meyerhardt JA, Chan JA, Niedzwiecki D, Hollis DR, Saltz LB, et al. Multivitamin use is not associated with cancer recurrence or survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol. 2010;28:4354–63.

    Article  PubMed Central  PubMed  Google Scholar 

  211. Li Q, Chuang SC, Eluf-Neto J, Menezes A, Matos E, Koifman S, et al. Vitamin or mineral supplement intake and the risk of head and neck cancer: pooled analysis in the INHANCE consortium. Int J Cancer. 2012;131:1686–99.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  212. Hercberg S, Galan P, Preziosi P, Bertrais S, Mennen L, Malvy D, et al. The SU.VI.MAX study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med. 2004;164:2335–42.

    Article  CAS  PubMed  Google Scholar 

  213. Gaziano JM, Sesso HD, Christen WG, Bubes V, Smith JP, MacFadyen J, et al. Multivitamins in the prevention of cancer in men: the Physicians’ Health Study II randomized controlled trial. JAMA. 2012;308:1871–80.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  214. Sesso HD, Christen WG, Bubes V, Smith JP, MacFadyen J, Schvartz M, et al. Multivitamins in the prevention of cardiovascular disease in men: the Physicians’ Health Study II randomized controlled trial. JAMA. 2012;308:1751–60.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  215. Christen WG, Glynn RJ, Manson JE, MacFadyen J, Bubes V, Schvartz M, et al. Effects of multivitamin supplement on cataract and age-related macular degeneration in a randomized trial of male physicians. Ophthalmology. 2014;121:525–34.

    Article  PubMed Central  PubMed  Google Scholar 

  216. Milton RC, Sperduto RD, Clemons TE, Ferris 3rd FL, for the Age-Related Eye Disease Study Research Group. Centrum use and progression of age-related cataract in the Age-Related Eye Disease Study: a propensity score approach. AREDS report no. 21. Ophthalmology 2006;113:1264–70.

    Google Scholar 

  217. Clinical Trial of Nutritional Supplements and Age-Related Cataract Study Group. A randomized, double-masked, placebo-controlled clinical trial of multivitamin supplementation of age-related lens opacities. Clinical trial of nutritional supplements and age-related cataract report no. 3. Ophthalmology. 2008;115:599–607.

    Article  Google Scholar 

  218. Zhao LQ, Li M, Zhu H, for the epidemiological evidence-based eye disease study research group. The effect of multivitamin/mineral supplements on age-related cataracts: a systematic review and meta-analysis. Nutrients 2014;6:931–49.

    Google Scholar 

  219. Christen WG, Gaziano JM, Hennekens CH. Design of Physicians’ Health Study II—a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials. Ann Epidemiol. 2000;10:125–34.

    Article  CAS  PubMed  Google Scholar 

  220. Klein EA, Thompson Jr IM, Tangen CM, Crowley JJ, Lucia MS, Goodman PJ, et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E cancer prevention trial (SELECT). JAMA. 2011;306:1549–56.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  221. Sesso HD, Buring JE, Christen WG, Kurth T, Belanger C, MacFadyen J, et al. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians’ Health Study II randomized controlled trial. JAMA. 2008;300:2123–33.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  222. Kristal AR, Darke AK, Morris JS, Tangen CM, Goodman PJ, Thompson IM, et al. Baseline selenium status and effects of selenium and vitamin e supplementation on prostate cancer risk. J Natl Cancer Inst. 2014;106(3):djt456. Epub 22 Feb 2014.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  223. Kenfield SA, Van Blarigan EL, DuPre N, Stampfer MJ, Giovannucci L, Chan JM. Selenium supplementation and prostate cancer mortality. J Natl Cancer Inst. 2014;107:360.

    Article  PubMed  Google Scholar 

  224. Gontero P, Marra G, Soria F, Oderda M, Zitella A, Baratta F, et al. A randomized double-blind placebo controlled phase I–II study on clinical and molecular effects of dietary supplements in men with precancerous prostatic lesions. Chemoprevention or “chemopromotion”? Prostate. 2015;75(11):1177–86. Epub 20 Apr 2015.

    Article  CAS  PubMed  Google Scholar 

  225. Ordonez-Mena JM, Schottker B, Fedriko V, Jenab M, Olsen A, Halkjaer J, et al. Pre-diagnostic vitamin D concentrations and cancer risks in older individuals: an analysis of cohorts participating in the CHANCES consortium. Eur J Epidemiol 2015, Epub ahead of print.

    Google Scholar 

  226. Barnett CM, Beer TM. Prostate cancer and vitamin D: what does the evidence really suggest? Urol Clin North Am. 2011;38:333–42.

    Article  PubMed  Google Scholar 

  227. Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. Institute of Medicine of the National Academies. Dietary reference intakes for calcium and vitamin D. Washington, DC: National Academies Press; 2011.

    Google Scholar 

  228. Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, et al. Annual high-dose oral vitamin D and falls and fractures in older women. JAMA. 2010;303:1815–22.

    Article  CAS  PubMed  Google Scholar 

  229. Zerwekh JE. Blood biomarkers of vitamin D status. Am J Clin Nutr. 2008;87(Suppl):1087S–91.

    CAS  PubMed  Google Scholar 

  230. Isenor JE, Ensom MH. Is there a role for therapeutic drug monitoring of vitamin D level as a surrogate marker for fracture risk. Pharmacotherapy. 2010;30:254–64.

    Article  CAS  PubMed  Google Scholar 

  231. Ardawi MS, Siblany AM, Bakhsh TM, Qari MH, Maimani AA. High prevalence of vitamin D deficiency among healthy Saudi Arabian men: relationship to bone mineral density, parathyroid hormone, bone turnover markers, and lifestyle factors. Osteoporos Int. 2012;23:675–86.

    Article  CAS  PubMed  Google Scholar 

  232. Jaaskelainen T, Knekt P, Marniemi J, Sares-Jaske L, Mannisto S, Heliovaara M, et al. Vitamin D status is associated with sociodemographic factors, lifestyle and metabolic health. Eur J Nutr. 2013;52:513–25.

    Article  PubMed  CAS  Google Scholar 

  233. Waldron JL, Ashby HL, Comes MP, Bechervaise J, Razavi C, Thomas OL, et al. Vitamin D: a negative acute phase reactant. J Clin Pathol. 2013;66:620–2.

    Article  CAS  PubMed  Google Scholar 

  234. Moyad MA, Vogelzang NJ. Heart healthy equals prostate healthy and statins, aspirin, and/or metformin (S.A.M.) are the ideal recommendations for prostate cancer prevention. Asian J Androl 2015, Epub ahead of print.

    Google Scholar 

  235. Rothwell PM, Fowkes FG, Belch JK, Ogawa H, Warlow CP, Meade TW. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomized trials. Lancet. 2011;377:31–41.

    Article  CAS  PubMed  Google Scholar 

  236. Jalving M, Gietema JA, Lefrandt JD, de Jong S, Reyners AK, Gans RO, et al. Metformin: taking away the candy for cancer? Eur J Cancer. 2010;46:2369–80.

    Article  CAS  PubMed  Google Scholar 

  237. Diabetes Prevention Program Research Group. 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet. 2009;374:1677–86.

    Article  PubMed Central  Google Scholar 

  238. Platz EA, Till C, Goodman PJ, Parnes HL, Figg WD, Albanes D, et al. Men with low serum cholesterol have a lower risk of high-grade prostate cancer in the placebo arm of the Prostate Cancer Prevention Trial. Cancer Epidemiol Biomarkers Prev. 2009;18:2807–13.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  239. Moyad MA. Why a statin and/or another proven heart healthy agent should be utilized in the next major cancer chemoprevention trial: part I. Urol Oncol. 2004;22:466–71.

    Article  CAS  PubMed  Google Scholar 

  240. Moyad MA. Why a statin and/or another proven heart healthy agent should be utilized in the next major cancer chemoprevention trial: part II. Urol Oncol. 2004;22:472–7.

    Article  CAS  PubMed  Google Scholar 

  241. Moyad MA. Heart healthy equals prostate healthy equals statins: the next cancer chemoprevention trial: part I. Curr Opin Urol. 2005;15:1–6.

    Article  PubMed  Google Scholar 

  242. Moyad MA. Heart healthy equals prostate healthy equals statins: the next cancer chemoprevention trial: part II. Curr Opin Urol. 2005;15:7–12.

    Article  PubMed  Google Scholar 

  243. Goodwin PJ, Parulekar WR, Gelmon KA, Shepherd LE, Ligibel JA, Hershman DL, et al. Effect of metformin vs placebo on weight and metabolic factors in NCIC CTG MA.32. J Natl Cancer Inst 2015;107, Epub ahead of print.

    Google Scholar 

  244. De Berardis G, Lucisano G, D’Ettorre A, Pellegrini F, Lepore V, Tognoni G, et al. Association of aspirin use with major bleeding in patients with and without diabetes. JAMA. 2012;307:2286–94.

    Article  PubMed  Google Scholar 

  245. Dell’Aglio DM, Perino LJ, Kazzi Z, Abramson J, Schwartz MD, Morgan BW. Acute metformin overdose: examining pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: a systematic review of the literature. Ann Emerg Med. 2009;54:818–23.

    Article  PubMed  Google Scholar 

  246. Zaharan NL, Williams D, Bennett K. Statins and risk of treated incident diabetes in a primary care population. Br J Clin Pharmacol. 2013;75:1118–24.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  247. Barton DL, Liu H, Dakhil SR, Linquist B, Sloan JA, Nichols CR, et al. Wisconsin ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2. J Natl Cancer Inst. 2013;105(16):1230–8.

    Article  PubMed Central  PubMed  Google Scholar 

  248. Ryan JL, Heckler CE, Roscoe JA, Dakhil SR, Kirshner J, Flynn PJ, et al. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer. 2012;20:1479–89.

    Article  PubMed Central  PubMed  Google Scholar 

  249. Hansen MV, Andersen LT, Madsen MT, Hagerman I, Rasmussen LS, Bokmand S, et al. Effect of melatonin on depressive symptoms and anxiety in patients undergoing breast cancer surgery: a randomized, double-blind, placebo-controlled trial. Breast Cancer Res Treat. 2014;145:683–95.

    Article  CAS  PubMed  Google Scholar 

  250. Chen WY, Giobbie-Hurder A, Gantman K, Savoie J, Scheib R, Parker LM, et al. A randomized, placebo-controlled trial of melatonin on breast cancer survivors: impact on sleep, mood, and hot flashes. Breast Cancer Res Treat. 2014;145:381–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  251. Miller PE, Alexander DD, Perez V. Effects of whey protein and resistance exercise on body composition: a meta-analysis of randomized controlled trials. J Am Coll Nutr. 2014;33:163–75.

    Article  CAS  PubMed  Google Scholar 

  252. Moyad MA, Klotz LH. Statin clinical trial (REALITY) for prostate cancer: an over 15-year wait is finally over thanks to a dietary supplement. Urol Clin North Am. 2011;38:325–31.

    Article  PubMed  Google Scholar 

  253. Moyad MA. Complementary & alternative medicine for prostate and urologic health. New York: Springer Books; 2014.

    Book  Google Scholar 

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Moyad, M.A. (2016). The Ideal 7-Step Breast Cancer Diet, Lifestyle, and Dietary Supplements Program for Prevention/Recurrence: Heart Healthy = Breast Healthy!. In: Integrative Medicine for Breast Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-23422-9_3

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