Abstract
Introduction: The Zika virus (ZIKV), an emerging mosquito-borne pathogen, reached epidemic proportions due to its rapid spread within the Americas after an outbreak in Brazil. An association between the ZIKV infection during pregnancy and microcephaly in newborns was first suspected from 6 months after the onset of the ZIKV outbreak in Brazil. Manifestations that extend beyond the central nervous system which include ophthalmologic abnormalities have been described as part of congenital Zika syndrome (CZS). Diagnosis and Ocular Features: The main ophthalmologic findings in infants with suspected ZIKV-related microcephaly are focal pigment mottling, chorioretinal atrophy, optic nerve hypoplasia, and/or increased cup-to-disc ratio. It’s necessary to rule out other congenital infections such as toxoplasmosis, rubella, cytomegalovirus, herpes simplex virus, syphilis, and human immunodeficiency virus. Conclusions and Relevance: All children with microcephaly of mothers presumably infected with the ZIKV during pregnancy should undergo at least one ocular examination since the exposure could be associated with vision-threatening findings.
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References
Dick GW, Kitchen SF, Haddow AJ (1952) Zika virus. I: isolations and serological specificity. Trans R Soc Trop Med Hyg 46:509–520
Dick GW (1952) Zika virus, II: pathogenicity and physical properties. Trans R Soc Trop Med Hyg 46:521–534
Foy BD, Kobylinski KC, Chilson Foy JL et al (2011) Probable non-vector-borne transmission of Zika virus, Colorado, USA. Emerg Infect Dis 17:880–882
Besnard M, Lastère S, Teissier A, Cao-Lormeau V, Musso D (2014) Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014. Euro Surveill 19:20751
Lanciotti RS, Kosoy OL, Laven JJ et al (2008) Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis 14:1232–1239
Musso D, Roche C, Nhan TX, Robin E, Teissier A, Cao-Lormeau VM (2015) Detection of Zika virus in saliva. J Clin Virol 68:53–55
Gourinat AC, O’Connor O, Calvez E, Goarant C, Dupont-Rouzeyrol M (2015) Detection of Zika virus in urine. Emerg Infect Dis 21:84–86
EB H (2009) Zika virus outside Africa. Emerg Infect Dis 15:1347–1350
Cao-Lormeau V-M (2014) Zika Virus, French Polynesia, South Pacific, 2013. Emerg Infect Dis 20:1960
Zanluca C, de Melo VC, Mosimann AL, Dos Santos GI, Dos Santos CN, Luz K (2015) First report of autochthonous transmission of Zika virus in Brazil. Mem Inst Oswaldo Cruz 110:569–572
Yakob L, Walter T (2016) Zika virus outbreak in the Americas: the need for novel mosquito control methods. Lancet Glob Health 4(3):e148–e149
World Health Organization (WHO) WHO director-general summarizes the outcome of the emergency committee regarding clusters of microcephaly and Guillain-Barré syndrome. http://www.who.int/mediacentre/news/statements/2016/emergency-committee-zika-microcephaly/en/. Accessed 1 Feb 2016
Fauci AS, Morens DM (2016) Zika virus in the Americas – yet another arbovirus threat. N Engl J Med 374:601–604
Schuler-Faccini L, Ribeiro EM, Feitosa IM et al (2016) Possible association between Zika virus infection and microcephaly – Brazil, 2015. MMWR Morb Mortal Wkly Rep 65:59–62
Centro de Operações de Emergências em Saúde Pública sobre Microcefalias Monitoramento dos casos de microcefalias no Brasil. http://portalsaude.saude.gov.br/images/pdf/2015/novembro/30/coes-microcefalias---informe-epidemiol--gico---se-47.pdf. Accessed 26 Dec 2015
Ministério da Saúde Microcefalia: 3174 casos são investigados em 20 estados e no Distrito Federal. http://portalsaude.saude.gov.br/index.php/o-ministerio/principal/secretarias/job/webradio/21527-microcefalia-3174-casos-sao-investigados-em-20-estados-e-no-distrito-federal. Accessed 9 Jan 2016
Centro de Operações de Emergências em Saúde Pública sobre Microcefalias (COES) Monitoramento dos casos de microcefalia no Brasil até a Semana Epidemiológica 47. Informe Epidemiológico – Semana Epidemiológica 47. 2015. http://portalsaude.saude.gov.br/images/pdf/2015/novembro/30/coes-microcefalias---informe-epidemiol—gico—se-47.pdf. Accessed 9 Jan 2016
Brasil P, Pereira JP Jr, Raja Gabaglia C, et al (2016) Zika virus infection in pregnant women in Rio de Janeiro – preliminary report. N Engl J Med 375(24):2321–2334
Mlakar J, Korva M, Tul N et al (2016) Zika virus associated with microcephaly. N Engl J Med 374(10):951–958
Costa F, Sarno M, Khouri R et al (2016) Emergence of congenital Zika syndrome: viewpoint from the front lines. Ann Intern Med 164(10):689–691
Ventura CV, Maia M, Bravo-Filho V, Gois AL, Belfort R Jr (2016) Zika virus in Brazil and macular atrophy in a child with microcephaly. Lancet 387:228
Ventura CV, Maia M, Ventura BV et al (2016) Ophthalmologic assessment of ten infants with microcephaly and presumable intra-uterus zika virus infection. Arq Bras Oftalmol 79:1–3
de Paula Freitas B, de Oliveira Dias JR, Prazeres J, et al (2016) Ocular findings in infants with microcephaly associated with presumed Zika virus congenital infection in Salvador, Brazil. JAMA Ophthalmol
CDC (2015) Chikungunya virus: clinical evaluation & disease. US Department of Health and Human Services, CDC, Atlanta. www.cdc.gov/chikungunya/hc/clinicalevaluation.html. Accessed 9 Jan 2016
World Health Organization (2009) Dengue: guidelines for diagnosis, treatment, prevention and control. World Health Organization, Geneva/Switzerland. http://apps.who.int/iris/bitstream/10665/ 44188/1/9789241547871_eng.pdf. Accessed 9 Jan 2016
Barreto ML, Barral-Netto M, Stabeli R et al (2016) Zika virus and microcephaly in Brazil: a scientific agenda. Lancet 387(10022):919–921
Oduyebo T, Petersen EE, Rasmussen SA et al (2016) Update: Interim guidelines for health care providers caring for pregnant women and women of reproductive age with possible Zika virus exposure – United States, 2016. MMWR Morb Mortal Wkly Rep 65:122–127
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Maia, M., Prazeres, J., de Paula Freitas, B., de Oliveira Dias, J.R., Ventura, C.V., Belfort, R. (2017). The Zika Virus: Review of Ocular Findings. In: Chee, SP., Khairallah, M. (eds) Emerging Infectious Uveitis. Springer, Cham. https://doi.org/10.1007/978-3-319-23416-8_21
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DOI: https://doi.org/10.1007/978-3-319-23416-8_21
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