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Chikungunya

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Emerging Infectious Uveitis

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Abstract

Chikungunya virus is a single-stranded RNA virus belongs tothe family Togaviridae. It is transmitted to humans by the bite of infected mosquitoes, Aedes aegypti and Aedes albopictus. In addition to systemic fever, it can cause ocular manifestations such as anterior uveitis, retinitis and optic neuritis. This article will highlight thechikungunya infection with ocular manifestations.

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References

  1. Calisher CH, Shope RE, Brandt W et al (1980) Proposed antigenic classification of registered arboviruses I (Togaviridae, Alphavirus). Intervirology 14:229–232

    Article  CAS  PubMed  Google Scholar 

  2. Robinson MC (1955) An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–53. I. Clinical features. Trans R Soc Trop Med Hyg 49:28–32

    Article  CAS  PubMed  Google Scholar 

  3. Lumsden WH (1955) An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–53; II. General description and epidemiology. Trans Royal Society Trop Med Hyg 49:33–57

    Article  CAS  Google Scholar 

  4. Pialoux G, Gaüzère BA, Jauréguiberry S, Strobel M (2007) Chikungunya, an epidemic arbovirosis. Lancet Infect Dis 7:319–327

    Article  PubMed  Google Scholar 

  5. World Health Organization (2009) Guidelines for prevention and control of chikungunya fever. World Health Organization, Regional Office for South-East Asia, New Delhi

    Google Scholar 

  6. Centers for Disease Control and Prevention (2005–2006) Chikungunya fever diagnosed among international travelers – United States. MMWR Morb Mortal Wkly Rep 55:1040–1042

    Google Scholar 

  7. Rezza G, Nicoletti L, Angelini R, Romi R, Finarelli AC, Panning M et al (2007) Infection with chikungunya virus in Italy: an outbreak in a temperate region. Lancet 370:1840–1846

    Article  CAS  PubMed  Google Scholar 

  8. Pistone T, Ezzedine K, Schuffenecker I, Receveur MC, Malvy D (2009) An imported case of chikungunya fever from Madagascar: use of the sentinel traveller for detecting emerging arboviral infections in tropical and European countries. Travel Med Infect Dis 7:52–54

    Article  PubMed  Google Scholar 

  9. Rougeron V, Sam IC, Caron M, Nkoghe D, Leroy E, Roques P (2014) Chikungunya, a paradigm of neglected tropical disease that emerged to be a new health global risk. J Clin Virol. Oct 22. pii: S1386–6532(14)00371–0

    Google Scholar 

  10. Her Z, Malleret B, Chan M, Ong EK, Wong SC, Kwek DJ et al (2010) Active infection of human blood monocytes by Chikungunya virus triggers an innate immune response. J Immunol 184:5903–5913

    Article  CAS  PubMed  Google Scholar 

  11. Das T, Jaffar-Bandjee MC, Hoarau JJ, Krejbich Trotot P, Denizot M, Lee-Pat-Yuen G et al (2010) Chikungunya fever: CNS infection and pathologies of a re-emerging arbovirus. Prog Neurobiol 91:121–129

    Article  CAS  PubMed  Google Scholar 

  12. Tang BL (2012) The cell biology of chikungunya virus infection. Cell Microbiol Sep 14(9):1354–1363

    Article  CAS  Google Scholar 

  13. Wauquier N, Becquart P, Nkoghe D, Padilla C, Ndjoyi-Mbiguino A, Leroy EM (2011) The acute phase of chikungunya virus infection in humans is associated with strong innate immunity and T CD8 cell activation. J Infect Dis 204(1):115–123

    Article  CAS  PubMed  Google Scholar 

  14. Jaffar-Bandjee MC, Gasque P (2012) Physiopathology of chronic arthritis following chikungunya infection in man. Med Trop (Mars) 72(Spec No):86–87

    Google Scholar 

  15. Couderc T, Gangneux N, Chrétien F, Caro V, Le Luong T, Ducloux B, Tolou H, Lecuit M, Grandadam M (2012) Chikungunya virus infection of corneal grafts. J Infect Dis 206(6):851–859 15

    Article  CAS  PubMed  Google Scholar 

  16. Powers AM, Logue CH (2007) Changing patterns of chikungunya virus: reemergence of a zoonotic arbovirus. J Gen Virol 88:2363–2377

    Article  CAS  PubMed  Google Scholar 

  17. Mahendradas P (2009) Chikungunya in uveitis: text & imaging, 1st edn. Jaypee Brothers, New Delhi, pp. 706–712

    Google Scholar 

  18. Simon F, Savini H, Parola P (2008) Chikungunya: a paradigm of emergence and globalization of vector- borne diseases. Med Clin North Am 92:1323–1343

    Article  PubMed  Google Scholar 

  19. Powers AM, Logue CH (2007) Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus. J Gen Virol 88:2363–2377

    Article  CAS  PubMed  Google Scholar 

  20. Ribéra A, Degasne I, Jaffar Bandjee MC, Gasque P (2012) Chronic rheumatic manifestations following chikungunya virus infection: clinical description and therapeutic considerations. Med Trop (Mars) 72(Spec No):83–5.

    Google Scholar 

  21. Schuffenecker I, Iteman I, Michault A, Murri S, Frangeul L, Vaney MC et al (2006) Genome microevolution of chikungunya viruses causing the Indian Ocean outbreak. PLoS Med 3:e263

    Article  PubMed  PubMed Central  Google Scholar 

  22. Mourya DT, Mishra AC (2006) Chikungunya fever. Lancet 368:186–187

    Article  CAS  PubMed  Google Scholar 

  23. Parola P, de Lamballerie X, Jourdan J et al (2006) Novel chikungunya virus variant in travelers returning from Indian Ocean islands. Emerg Infect Dis 12:1493–1499

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Mahendradas P, Ranganna SK, Shetty R, Balu R, Narayana KM, Babu RB, Shetty BK (2008) Ocular manifestations associated with chikungunya. Ophthalmology 115(2):287–291

    Article  PubMed  Google Scholar 

  25. Lalitha P, Rathinam S, Banushree K, Maheshkumar S, Vijayakumar R, Sathe P (2007) Ocular involvement associated with an epidemic outbreak of chikungunya virus infection. Am J Ophthalmol 144(4):552–556

    Article  PubMed  Google Scholar 

  26. Mittal A, Mittal S, Bharathi JM, Ramakrishnan R, Sathe PS (2007) Uveitis during outbreak of chikungunya fever. Ophthalmology 114(9):1798

    Article  PubMed  Google Scholar 

  27. Babu K, Kini R, Philips M, Subbakrishna DK (2014) Clinical profile of isolated viral anterior uveitis in a South Indian patient population. Ocul Immunol Inflamm 22(5):356–359

    Article  PubMed  Google Scholar 

  28. Mahendradas P, Avadhani K, Shetty R (2013) Chikungunya and the eye: a review. J Ophthalmic Inflamm Infect 3:35. doi:10.1186/1869-5760-3-35

    Article  PubMed  PubMed Central  Google Scholar 

  29. Vishwanath S, Badami K, Sriprakash KS, Sujatha BL, Shashidhar SD, Shilpa YD (2014) Post-fever retinitis: a single center experience from south India. Int Ophthalmol 34(4):851–857

    Article  PubMed  Google Scholar 

  30. Chanana B, Azad RV, Nair S (2007) Bilateral macular choroiditis following chikungunya virus infection. Eye 21(7):1020–1021

    Article  CAS  PubMed  Google Scholar 

  31. Mittal A, Mittal S, Bharati MJ, Ramakrishnan R, Saravanan S, Sathe PS (2007) Optic neuritis associated with chikungunya virus infection in South India. Arch Ophthalmol 125(10):1381–1386

    Article  PubMed  Google Scholar 

  32. Rose N, Anoop TM, John AP, Jabbar PK, George KC (2011) Acute optic neuritis following infection with chikungunya virus in southern rural India. Int J Infect Dis 15(2):e147–e150

    Article  PubMed  Google Scholar 

  33. Mahendradas P, Shetty R, Malathi J, Madhavan HN (2010) Chikungunya virus iridocyclitis in Fuchs’ heterochromic iridocyclitis. Indian J Ophthalmol 58(6):545–547

    Article  PubMed  PubMed Central  Google Scholar 

  34. Babu K, Murthy GJ (2012) Chikungunya virus iridocyclitis in Fuchs’ heterochromic iridocyclitis. Indian J Ophthalmol 60(1):73–74

    Article  PubMed  PubMed Central  Google Scholar 

  35. Mahendradas P, Avadhani K (2013) Chikungunya retinitis: spectral-domain optical coherence tomography imaging of the eye. Elsevier, a division of Reed Elsevier India Private Limited, New Delhi, pp. 415–417

    Google Scholar 

  36. Pastorino B, Bessaud M, Grandadam M, Murri S, Tolou HJ, Peyrefitte CN (2005) Development of a TaqMan RT-PCR assay without RNA extraction step for the detection and quantification of African chikungunya viruses. J Virol Methods 124:65–71

    Article  CAS  PubMed  Google Scholar 

  37. Lakshmi V, Neeraja M, Subbalaxmi MV, Parida MM, Dash PK, Santhosh SR et al (2005) Clinical features and molecular diagnosis of chikungunya fever from South India. Clin Infect Dis 46:1436–1442

    Article  Google Scholar 

  38. Couderc T, Khandoudi N, Grandadam M et al (2008) Prophylaxis and therapy for chikungunya virus infection. J Infect Dis 200:516–523

    Article  Google Scholar 

  39. Brighton SW (1984) Chloroquine phosphate treatment of chronic chikungunya arthritis. An open pilot study. S Afr Med J 66:217–218

    CAS  PubMed  Google Scholar 

  40. Bouquillard E, Combe B (2009) A report of 21 cases of rheumatoid arthritis following chikungunya fever. A mean follow-up of 2 years. Joint Bone Spine 76:654–657

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, India

    Padmamalini Mahendradas

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  1. Padmamalini Mahendradas
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Correspondence to Padmamalini Mahendradas .

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Editors and Affiliations

  1. Singapore National Eye Center, Singapore, Singapore

    Soon-Phaik Chee

  2. Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, Monastir, Tunisia

    Moncef Khairallah

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Mahendradas, P. (2017). Chikungunya. In: Chee, SP., Khairallah, M. (eds) Emerging Infectious Uveitis. Springer, Cham. https://doi.org/10.1007/978-3-319-23416-8_12

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  • DOI: https://doi.org/10.1007/978-3-319-23416-8_12

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-23415-1

  • Online ISBN: 978-3-319-23416-8

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