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Testis and Testicular Adnexa

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Essentials of Anatomic Pathology

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Abstract

Nonneoplastic lesions of the testis include cryptorchidism, torsion, orchiepididymitis, granulomatous orchitis, and hypospermatogenesis. Intratubular germ cell neoplasia, unclassified type (ICGNU), is the precursor of both seminomatous and most nonseminomatous germ cell tumors in postpubertal patients. Distended tubules may have either intratubular seminoma or intratubular embryonal carcinoma cells. Most nonseminomatous tumors contain a mixture of tumor types, which are reviewed here. Morphology, aided by a panel of immunostains, can determine the presence and percent of embryonal carcinoma, yolk sac tumor, choriocarcinoma, or teratoma in such tumors. Up to 5% of testicular neoplasms may require immunostains. Occasionally, sex cord-stromal tumors, hematolymphoid tumors, and epididymal adenomatoid tumors enter the differential diagnosis of germ cell neoplasms.

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Author information

Authors and Affiliations

  1. Department of Pathology/Medical College of Wisconsin, 9200 W. Wisconsin Ave, Milwaukee, WI, 53226, USA

    Kenneth A. Iczkowski MD

  2. Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, 350 W. 11th Street, Room 4014, Indianapolis, IN, 46202, USA

    Thomas M. Ulbright MD

Authors
  1. Kenneth A. Iczkowski MD
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  2. Thomas M. Ulbright MD
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Correspondence to Kenneth A. Iczkowski MD .

Editor information

Editors and Affiliations

  1. Indiana University School of Medicine, Indianapolis, Indiana, USA

    Liang Cheng

  2. Granger Diagnostics, A Division of Granger Genetics, North Chesterfield, Virginia, USA

    David G. Bostwick

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Iczkowski, K.A., Ulbright, T.M. (2016). Testis and Testicular Adnexa. In: Cheng, L., Bostwick, D. (eds) Essentials of Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-23380-2_39

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  • DOI: https://doi.org/10.1007/978-3-319-23380-2_39

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-23379-6

  • Online ISBN: 978-3-319-23380-2

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