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Personalized Oral Health Care pp 99–112Cite as

Personalized Medicine Approaches to the Prevention, Diagnosis, and Treatment of Chronic Periodontitis

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Abstract

Over the years, the multifactorial and interactive nature of periodontal disease challenged clinicians in an attempt to delineate a pattern for its destructive progression. Periodontal disease is caused by persistent inflammation of the periodontium in response to the colonization of microbes upon the tooth surface near the gingival margin and a subsequent biofilm formation resulting in irreversible attachment loss of marginal alveolar bone and associated periodontal ligament and migration of the junctional epithelium. In spite of the infectious nature of periodontal disease, identification of the oral microbiome and a complete understanding of its pathogenic pathway seem the most logical step toward the development of newer and effective approaches for periodontal therapy.

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References

  1. Albandar JM, Tinoco E. Global epidemiology of periodontal diseases in children and young persons. Periodontol 2000. 2002;29(1):153–76.

    Article  PubMed  Google Scholar 

  2. Eke P, Dye B, Wei L, Thornton-Evans G, Genco R. Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res. 2012;91(10):914–20.

    Article  PubMed  Google Scholar 

  3. Kinane D, Bouchard P. Periodontal diseases and health: consensus report of the sixth European workshop on periodontology. J Clin Periodontol. 2008;35(s8):333–7.

    Article  PubMed  Google Scholar 

  4. Schei O, Waerhaug J, Lovdal A, Arno A. Alveolar bone loss as related to oral hygiene and age. J Periodontol. 1959;30(1):7–16.

    Article  Google Scholar 

  5. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol. 1999;4(1):1–6.

    Article  PubMed  Google Scholar 

  6. Mombelli A, Meier C. On the symmetry of periodontal disease. J Clin Periodontol. 2001;28(8):741–5.

    Article  PubMed  Google Scholar 

  7. Armitage GC, Cullinan MP. Comparison of the clinical features of chronic and aggressive periodontitis. Periodontol 2000. 2010;53(1):12–27.

    Article  PubMed  Google Scholar 

  8. Lang N, Bartold PM, Cullinan M, Jeffcoat M, Mombelli A, Murakami S, et al. Consensus report: aggressive periodontitis. Ann Periodontol. 1999;4(1):53.

    Article  Google Scholar 

  9. Leech MT, Bartold P. The association between rheumatoid arthritis and periodontitis. Best Pract Res Clin Rheumatol. 2015;29:189–201.

    Google Scholar 

  10. Seymour G, Ford P, Cullinan M, Leishman S, Yamazaki K. Relationship between periodontal infections and systemic disease. Clin Microbiol Infect. 2007;13(s4):3–10.

    Article  PubMed  Google Scholar 

  11. Tonetti MS, Dyke TE. Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol. 2013;40(s14):S24–9.

    PubMed  Google Scholar 

  12. Krüger M, Hansen T, Kasaj A, Moergel M. The correlation between chronic periodontitis and oral cancer. Case Rep Dent. 2013;2013:262410.

    PubMed Central  PubMed  Google Scholar 

  13. Usher AK, Stockley RA. The link between chronic periodontitis and COPD: a common role for the neutrophil? BMC Med. 2013;11(1):241.

    Article  PubMed Central  PubMed  Google Scholar 

  14. Han Y, Houcken W, Loos B, Schenkein H, Tezal M. Periodontal disease, atherosclerosis, adverse pregnancy outcomes, and head-and-neck cancer. Adv Dent Res. 2014;26(1):47–55.

    Article  PubMed  Google Scholar 

  15. Ide M, Papapanou PN. Epidemiology of association between maternal periodontal disease and adverse pregnancy outcomes–systematic review. J Clin Periodontol. 2013;40(s14):S181–94.

    PubMed  Google Scholar 

  16. Socransky SS, Haffajee AD. The bacterial etiology of destructive periodontal disease: current concepts. J Periodontol. 1992;63(4s):322–31.

    Article  PubMed  Google Scholar 

  17. Lendenmann U, Grogan J, Oppenheim F. Saliva and dental pellicle-a review. Adv Dent Res. 2000;14(1):22–8.

    Article  PubMed  Google Scholar 

  18. Saxton C. Scanning electron microscope study of the formation of dental plaque. Caries Res. 1973;7(2):102–19.

    Article  PubMed  Google Scholar 

  19. Listgarten M. Formation of dental plaque and other oral biofilms. Dental plaque revisited: oral biofilms in health and disease. Cardiff: Bioline. 1999:187–210.

    Google Scholar 

  20. Finke M, Parker DM, Jandt KD. Influence of soft drinks on the thickness and morphology of in situ acquired pellicle layer on enamel. J Colloid Interface Sci. 2002;251(2):263–70.

    Article  PubMed  Google Scholar 

  21. Lie T. Early dental plaque morphogenesis. J Periodontal Res. 1977;12(2):73–89.

    Article  PubMed  Google Scholar 

  22. Desanctis M, Murphy KG. The role of resective periodontal surgery in the treatment of furcation defects. Periodontol 2000. 2000;22(1):154–68.

    Article  PubMed  Google Scholar 

  23. Bartold PM, Van Dyke TE. Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts. Periodontol 2000. 2013;62(1):203–17.

    Article  PubMed  Google Scholar 

  24. Laine ML, Crielaard W, Loos BG. Genetic susceptibility to periodontitis. Periodontol 2000. 2012;58(1):37–68.

    Article  PubMed  Google Scholar 

  25. Offenbacher S, Barros SP, Beck JD. Rethinking periodontal inflammation. J Periodontol. 2008;79(8S):1577–84.

    Article  PubMed  Google Scholar 

  26. Johnson GK, Guthmiller JM. The impact of cigarette smoking on periodontal disease and treatment. Periodontol 2000. 2007;44(1):178–94.

    Article  PubMed  Google Scholar 

  27. Tomar SL, Asma S. Smoking-attributable periodontitis in the United States: findings from NHANES III. J Periodontol. 2000;71(5):743–51.

    Article  PubMed  Google Scholar 

  28. Phipps KR, Chan BK, Jennings-Holt M, Geurs NC, Reddy MS, Lewis CE, et al. Periodontal health of older men: the MrOS dental study. Gerodontology. 2009;26(2):122–9.

    Article  PubMed  Google Scholar 

  29. Kibayashi M, Tanaka M, Nishida N, Kuboniwa M, Kataoka K, Nagata H, et al. Longitudinal study of the association between smoking as a periodontitis risk and salivary biomarkers related to periodontitis. J Periodontol. 2007;78(5):859–67.

    Article  PubMed  Google Scholar 

  30. Rosa GM, Lucas GQ, Lucas ON. Cigarette smoking and alveolar bone in young adults: a study using digitized radiographs. J Periodontol. 2008;79(2):232–44.

    Article  PubMed  Google Scholar 

  31. Hugoson A, Rolandsson M. Periodontal disease in relation to smoking and the use of Swedish snus: epidemiological studies covering 20 years (1983–2003). J Clin Periodontol. 2011;38(9):809–16.

    Article  PubMed  Google Scholar 

  32. Preber H, Bergström J. Occurrence of gingival bleeding in smoker and non-smoker patients. Acta Odontol. 1985;43(5):315–20.

    Article  Google Scholar 

  33. Apatzidou D, Riggio M, Kinane D. Impact of smoking on the clinical, microbiological and immunological parameters of adult patients with periodontitis. J Clin Periodontol. 2005;32(9):973–83.

    Article  PubMed  Google Scholar 

  34. Vouros I, Kalpidis C, Chadjipantelis T, Konstantinidis A. Cigarette smoking associated with advanced periodontal destruction in a Greek sample population of patients with periodontal disease. J Int Acad Periodontol. 2009;11(4):250–7.

    PubMed  Google Scholar 

  35. Nociti FH, Casati MZ, Duarte PM. Current perspective of the impact of smoking on the progression and treatment of periodontitis. Periodontol 2000. 2015;67(1):187–210.

    Article  PubMed  Google Scholar 

  36. Ryder MI, Fujitaki R, Lebus S, Mahboub M, Faia B, Muhaimin D, et al. Alterations of neutrophil L-selection and CD18 expression by tobacco smoke: implications for periodontal diseases. J Periodontal Res. 1998;33(6):359–68.

    Article  PubMed  Google Scholar 

  37. Ryder MI, Wu TC, Kallaos SS, Hyun W. Alterations of neutrophil f-actin kinetics by tobacco smoke: implications for periodontal diseases. J Periodontal Res. 2002;37(4):286–92.

    Article  PubMed  Google Scholar 

  38. Zhang W, Song F, Windsor L. Cigarette smoke condensate affects the collagen-degrading ability of human gingival fibroblasts. J Periodontal Res. 2009;44(6):704–13.

    Article  PubMed  Google Scholar 

  39. Zhang W, Fang M, Song F, Windsor LJ. Effects of cigarette smoke condensate and nicotine on human gingival fibroblast-mediated collagen degradation. J Periodontol. 2011;82(7):1071–9.

    Article  PubMed  Google Scholar 

  40. Katono T, Kawato T, Tanabe N, Tanaka H, Suzuki N, Kitami S, et al. Effects of nicotine and lipopolysaccharide on the expression of matrix metalloproteinases, plasminogen activators, and their inhibitors in human osteoblasts. Arch Oral Biol. 2009;54(2):146–55.

    Article  PubMed  Google Scholar 

  41. Semlali A, Chakir J, Goulet JP, Chmielewski W, Rouabhia M. Whole cigarette smoke promotes human gingival epithelial cell apoptosis and inhibits cell repair processes. J Periodontal Res. 2011;46(5):533–41.

    PubMed  Google Scholar 

  42. Bulmanski Z, Brady M, Stoute D, Lallier TE. Cigarette smoke extract induces select matrix metalloproteinases and integrin expression in periodontal ligament fibroblasts. J Periodontol. 2012;83(6):787–96.

    Article  PubMed  Google Scholar 

  43. Nociti Jr FH, Nogueira-Filho GR, Primo MT, Machado MA, Tramontina VA, Barros SP, et al. The influence of nicotine on the bone loss rate in ligature-induced periodontitis. A histometric study in rats. J Periodontol. 2000;71(9):1460–4.

    Article  PubMed  Google Scholar 

  44. Neto JBC, de Souza AP, Barbieri D, Moreno Jr H, Sallum EA, Nociti Jr FH. Matrix metalloproteinase-2 may be involved with increased bone loss associated with experimental periodontitis and smoking: a study in rats. J Periodontol. 2004;75(7):995–1000.

    Article  Google Scholar 

  45. Milanezi de Almeida J, Bosco AF, Bonfante S, Theodoro LH, Nagata MJH, Garcia VG. Nicotine-induced damage affects gingival fibroblasts in the gingival tissue of rats. J Periodontol. 2011;82(8):1206–11.

    Article  PubMed  Google Scholar 

  46. Benatti BB, César-Neto JB, Gonçalves PF, Sallum EA, Nociti FH. Smoking affects the self-healing capacity of periodontal tissues. A histological study in the rat. Eur J Oral Sci. 2005;113(5):400–3.

    Article  PubMed  Google Scholar 

  47. Grossi SG, Goodson JM, Gunsolley JC, Otomo-Corgel J, Bland PS, Doherty F, et al. Mechanical therapy with adjunctive minocycline microspheres reduces red-complex bacteria in smokers. J Periodontol. 2007;78(9):1741–50.

    Article  PubMed  Google Scholar 

  48. Heasman L, Stacey F, Preshaw P, McCracken G, Hepburn S, Heasman P. The effect of smoking on periodontal treatment response: a review of clinical evidence. J Clin Periodontol. 2006;33(4):241–53.

    Article  PubMed  Google Scholar 

  49. Wan CP, Leung WK, Wong M, Wong R, Wan P, Lo E, et al. Effects of smoking on healing response to non-surgical periodontal therapy: a multilevel modelling analysis. J Clin Periodontol. 2009;36(3):229–39.

    Article  PubMed  Google Scholar 

  50. Angaji M, Gelskey S, Nogueira-Filho G, Brothwell D. A systematic review of clinical efficacy of adjunctive antibiotics in the treatment of smokers with periodontitis. J Periodontol. 2010;81(11):1518–28.

    Article  PubMed  Google Scholar 

  51. Alberti K, Zimmet PF. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15:539–53.

    Article  PubMed  Google Scholar 

  52. Nathan DM. Long-term complications of diabetes mellitus. N Engl J Med. 1993;328(23):1676–85.

    Article  PubMed  Google Scholar 

  53. Taylor GW. Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective. Ann Periodontol. 2001;6(1):99–112.

    Article  PubMed  Google Scholar 

  54. Löe H. Periodontal disease: the sixth complication of diabetes mellitus. Diabet Care. 1993;16(1):329–34.

    Article  Google Scholar 

  55. Genco RJ, Borgnakke WS. Risk factors for periodontal disease. Periodontol 2000. 2013;62(1):59–94.

    Article  PubMed  Google Scholar 

  56. Emrich LJ, Shlossman M, Genco RJ. Periodontal disease in non-insulin-dependent diabetes mellitus. J Periodontol. 1991;62(2):123–31.

    Article  PubMed  Google Scholar 

  57. Shlossman M, Knowler WC, Pettitt DJ, Genco RJ. Type 2 diabetes mellitus and periodontal disease. J Am Dent Assoc. 1990;121(4):532–6.

    Article  PubMed  Google Scholar 

  58. Taylor GW, Burt BA, Becker MP, Genco RJ, Shlossman M. Glycemic control and alveolar bone loss progression in type 2 diabetes. Ann Periodontol. 1998;3(1):30–9.

    Article  PubMed  Google Scholar 

  59. Chávarry N, Vettore MV, Sansone C, Sheiham A. The relationship between diabetes mellitus and destructive periodontal disease: a meta-analysis. Oral Health Prev Dent. 2009;7(2):107–27.

    PubMed  Google Scholar 

  60. Bandyopadhyay D, Marlow NM, Fernandes JK, Leite RS. Periodontal disease progression and glycaemic control among Gullah African Americans with type-2 diabetes. J Clin Periodontol. 2010;37(6):501–9.

    Article  PubMed Central  PubMed  Google Scholar 

  61. Lalla E, Papapanou PN. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nat Rev Endocrinol. 2011;7(12):738–48.

    Article  PubMed  Google Scholar 

  62. Grossi SG, Genco RJ. Periodontal disease and diabetes mellitus: a two-way relationship. Ann Periodontol. 1998;3(1):51–61.

    Article  PubMed  Google Scholar 

  63. Genco RJ, Grossi SG, Ho A, Nishimura F, Murayama Y. A proposed model linking inflammation to obesity, diabetes, and periodontal infections. J Periodontol. 2005;76(11-s):2075–84.

    Article  PubMed  Google Scholar 

  64. Taylor GW, Borgnakke W. Periodontal disease: associations with diabetes, glycemic control and complications. Oral Dis. 2008;14(3):191–203.

    Article  PubMed  Google Scholar 

  65. Kiran M, Arpak N, Ünsal E, Erdoğan MF. The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus. J Clin Periodontol. 2005;32(3):266–72.

    Article  PubMed  Google Scholar 

  66. Jones JA, Miller DR, Wehler CJ, Rich SE, Krall-Kaye EA, McCoy LC, et al. Does periodontal care improve glycemic control? The department of veterans affairs dental diabetes study. J Clin Periodontol. 2007;34(1):46–52.

    Article  PubMed  Google Scholar 

  67. Darré L, Vergnes J-N, Gourdy P, Sixou M. Efficacy of periodontal treatment on glycaemic control in diabetic patients: a meta-analysis of interventional studies. Diabet Metab. 2008;34(5):497–506.

    Article  Google Scholar 

  68. Salvi GE, Carollo-Bittel B, Lang NP. Effects of diabetes mellitus on periodontal and peri-implant conditions: update on associations and risks. J Clin Periodontol. 2008;35(s8):398–409.

    Article  PubMed  Google Scholar 

  69. Darby IA, Bisucci T, Hewitson TD, MacLellan DG. Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice. Int J Biochem Cell Biol. 1997;29(1):191–200.

    Article  PubMed  Google Scholar 

  70. Graves DT, Liu R, Oates TW. Diabetes-enhanced inflammation and apoptosis–impact on periodontal pathosis. Periodontol 2000. 2007;45(1):128–37.

    Article  PubMed  Google Scholar 

  71. Liu R, Desta T, He H, Graves DT. Diabetes alters the response to bacteria by enhancing fibroblast apoptosis. Endocrinology. 2004;145(6):2997–3003.

    Article  PubMed  Google Scholar 

  72. Michalowicz BS, Aeppli D, Virag JG, Klump DG, Hinrichs E, Segal NL, et al. Periodontal findings in adult twins. J Periodontol. 1991;62(5):293–9.

    Article  PubMed  Google Scholar 

  73. Michalowicz BS, Diehl SR, Gunsolley JC, Sparks BS, Brooks CN, Koertge TE, et al. Evidence of a substantial genetic basis for risk of adult periodontitis. J Periodontol. 2000;71(11):1699–707.

    Article  PubMed  Google Scholar 

  74. Marazita ML, Burmeister JA, Gunsolley JC, Koertge TE, Lake K, Schenkein HA. Evidence for autosomal dominant inheritance and race-specific heterogeneity in early-onset periodontitis. J Periodontol. 1994;65(6):623–30.

    Article  PubMed  Google Scholar 

  75. Meng H, Ren X, Tian Y, Feng X, Xu L, Zhang L, et al. Genetic study of families affected with aggressive periodontitis. Periodontol 2000. 2011;56(1):87–101.

    Article  PubMed  Google Scholar 

  76. Shearer DM, Thomson WM, Caspi A, Moffitt TE, Broadbent JM, Poulton R. Inter-generational continuity in periodontal health: findings from the Dunedin Family History Study. J Clin Periodontol. 2011;38(4):301–9.

    Article  PubMed Central  PubMed  Google Scholar 

  77. Divaris K, Monda KL, North KE, Olshan AF, Reynolds LM, Hsueh W-C, et al. Exploring the genetic basis of chronic periodontitis: a genome-wide association study. Hum Mol Genet. 2013;22(11):2312–24.

    Article  PubMed Central  PubMed  Google Scholar 

  78. Kornman KS, Crane A, Wang HY, di Giovine FS, Newman MG, Pirk FW, et al. The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol. 1997;24(1):72–7. PubMed.

    Article  PubMed  Google Scholar 

  79. Karimbux NY, Saraiya VM, Elangovan S, Allareddy V, Kinnunen T, Kornman KS, et al. Interleukin-1 gene polymorphisms and chronic periodontitis in adult whites: a systematic review and meta-analysis. J Periodontol. 2012;83(11):1407–19.

    Article  PubMed  Google Scholar 

  80. Taylor JJ, Preshaw PM, Donaldson PT. Cytokine gene polymorphism and immunoregulation in periodontal disease. Periodontol 2000. 2004;35(1):158–82.

    Article  PubMed  Google Scholar 

  81. Schröder N, Meister D, Wolff V, Christan C, Kaner D, Haban V, et al. Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human TLR-4 gene. Genes Immun. 2005;6(5):448–51.

    Article  PubMed  Google Scholar 

  82. Zhang HY, Feng L, Wu H, Xie XD. The association of IL-6 and IL-6R gene polymorphisms with chronic periodontitis in a Chinese population. Oral Dis. 2014;20(1):69–75.

    Article  PubMed  Google Scholar 

  83. Vaithilingam R, Safii S, Baharuddin N, Ng C, Cheong S, Bartold P, et al. Moving into a new era of periodontal genetic studies: relevance of large case–control samples using severe phenotypes for genome-wide association studies. J Periodontal Res. 2014;49(6):683–95.

    Article  PubMed  Google Scholar 

  84. Schaefer AS, Bochenek G, Manke T, Nothnagel M, Graetz C, Thien A, et al. Validation of reported genetic risk factors for periodontitis in a large-scale replication study. J Clin Periodontol. 2013;40(6):563–72.

    Article  PubMed  Google Scholar 

  85. Schaefer AS, Richter GM, Nothnagel M, Manke T, Dommisch H, Jacobs G, et al. A genome-wide association study identifies GLT6D1 as a susceptibility locus for periodontitis. Hum Mol Genet. 2009:ddp508.

    Google Scholar 

  86. Hashim NT, Linden GJ, Ibrahim ME, Gismalla BG, Lundy FT, Hughes FJ, et al. Replication of the association of GLT6D1 with aggressive periodontitis in a Sudanese population. J Clin Periodontol. 2015;42(4):319–24.

    Article  PubMed  Google Scholar 

  87. Larsson L, Castilho RM, Giannobile WV. Epigenetics and its role in periodontal diseases: a state-of-the-art review. J Periodontol. 2015;86(4):556–68. PubMed.

    Article  PubMed  Google Scholar 

  88. Zhang S, Barros SP, Moretti AJ, Yu N, Zhou J, Preisser JS, et al. Epigenetic regulation of TNFA expression in periodontal disease. J Periodontol. 2013;84(11):1606–16. PubMed Pubmed Central PMCID: 3986590.

    PubMed Central  PubMed  Google Scholar 

  89. Uehara O, Abiko Y, Saitoh M, Miyakawa H, Nakazawa F. Lipopolysaccharide extracted from Porphyromonas gingivalis induces DNA hypermethylation of runt-related transcription factor 2 in human periodontal fibroblasts. J Microbiol Immunol Infect. 2014;47(3):176–81. PubMed.

    Article  PubMed  Google Scholar 

  90. Larsson L, Thorbert-Mros S, Rymo L, Berglundh T. Influence of epigenetic modifications of the interleukin-10 promoter on IL10 gene expression. Eur J Oral Sci. 2012;120(1):14–20. PubMed.

    Article  PubMed  Google Scholar 

  91. Van Dyke TE, Sheilesh D. Risk factors for periodontitis. J Int Acad Periodontol. 2005;7(1):3–7. PubMed Pubmed Central PMCID: 1351013.

    PubMed Central  PubMed  Google Scholar 

  92. Johnson BD, Engel D. Acute necrotizing ulcerative gingivitis. A review of diagnosis, etiology and treatment. J Periodontol. 1986;57(3):141–50. PubMed.

    Article  PubMed  Google Scholar 

  93. Chrousos GP. Stress and disorders of the stress system. Nat Rev Endocrinol. 2009;5(7):374–81.

    Article  PubMed  Google Scholar 

  94. Halawany H, Abraham N, Jacob V, Al Amri M, Patil S. Is psychological stress a possible risk factor for periodontal disease. A systematic review. J Psychiatry. 2015;18(217):2.

    Google Scholar 

  95. Genco RJ, Ho AW, Grossi SG, Dunford R, Tedesco L. Relationship of stress, distress, and inadequate coping behaviors to periodontal disease. J Periodontol. 1999;70(7):711–23.

    Article  PubMed  Google Scholar 

  96. Moss ME, Beck JD, Kaplan BH, Offenbacher S, Weintraub JA, Koch GG, et al. Exploratory case-control analysis of psychosocial factors and adult periodontitis. J Periodontol. 1996;67(10s):1060–9.

    Article  PubMed  Google Scholar 

  97. Padgett DA, Glaser R. How stress influences the immune response. Trends Immunol. 2003;24(8):444–8.

    Article  PubMed  Google Scholar 

  98. Glaser R, Kiecolt-Glaser JK. Stress-induced immune dysfunction: implications for health. Nat Rev Immunol. 2005;5(3):243–51.

    Article  PubMed  Google Scholar 

  99. Guo S, DiPietro LA. Factors affecting wound healing. J Dent Res. 2010;89(3):219–29.

    Article  PubMed Central  PubMed  Google Scholar 

  100. Hilgert J, Hugo F, Bandeira D, Bozzetti M. Stress, cortisol, and periodontitis in a population aged 50 years and over. J Dent Res. 2006;85(4):324–8.

    Article  PubMed  Google Scholar 

  101. Boyapati L, Wang HL. The role of stress in periodontal disease and wound healing. Periodontol 2000. 2007;44(1):195–210.

    Article  PubMed  Google Scholar 

  102. Dimsdale JE, Moss J. Plasma catecholamines in stress and exercise. JAMA. 1980;243(4):340–2.

    Article  PubMed  Google Scholar 

  103. Peruzzo DC, Benatti BB, Ambrosano GM, Nogueira-Filho GR, Sallum EA, Casati MZ, et al. A systematic review of stress and psychological factors as possible risk factors for periodontal disease. J Periodontol. 2007;78(8):1491–504.

    Article  PubMed  Google Scholar 

  104. Anerud A, Loe H, Boysen H, Smith M. The natural history of periodontal disease in man. Changes in gingival health and oral hygiene before 40 years of age. J Periodontal Res. 1979;14(6):526–40. PubMed.

    Article  PubMed  Google Scholar 

  105. Loe H, Anerud A, Boysen H, Smith M. The natural history of periodontal disease in man. Study design and baseline data. J Periodontal Res. 1978;13(6):550–62. PubMed.

    Article  PubMed  Google Scholar 

  106. Loe H, Anerud A, Boysen H, Smith M. The natural history of periodontal disease in man. The rate of periodontal destruction before 40 years of age. J Periodontol. 1978;49(12):607–20. PubMed.

    Article  PubMed  Google Scholar 

  107. Loe H, Anerud A, Boysen H, Smith M. The natural history of periodontal disease in man. Tooth mortality rates before 40 years of age. J Periodontal Res. 1978;13(6):563–72. PubMed.

    Article  PubMed  Google Scholar 

  108. Loe H, Anerud A, Boysen H, Morrison E. Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age. J Clin Periodontol. 1986;13(5):431–45. PubMed.

    Article  PubMed  Google Scholar 

  109. Goodson JM, Tanner AC, Haffajee AD, Sornberger GC, Socransky SS. Patterns of progression and regression of advanced destructive periodontal disease. J Clin Periodontol. 1982;9(6):472–81. PubMed.

    Article  PubMed  Google Scholar 

  110. Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent Jr RL. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998;25(2):134–44. PubMed.

    Article  PubMed  Google Scholar 

  111. Kolenbrander PE, London J. Adhere today, here tomorrow: oral bacterial adherence. J Bacteriol. 1993;175(11):3247–52. PubMed Pubmed Central PMCID: 204720.

    PubMed Central  PubMed  Google Scholar 

  112. Slots J, Mashimo P, Levine MJ, Genco RJ. Periodontal therapy in humans. I. Microbiological and clinical effects of a single course of periodontal scaling and root planing, and of adjunctive tetracycline therapy. J Periodontol. 1979;50(10):495–509. PubMed.

    Article  PubMed  Google Scholar 

  113. Loesche WJ, Giordano JR, Hujoel P, Schwarcz J, Smith BA. Metronidazole in periodontitis: reduced need for surgery. J Clin Periodontol. 1992;19(2):103–12. PubMed.

    Article  PubMed  Google Scholar 

  114. Kumar PS, Mason MR, Brooker MR, O’Brien K. Pyrosequencing reveals unique microbial signatures associated with healthy and failing dental implants. J Clin Periodontol. 2012;39(5):425–33. PubMed Pubmed Central PMCID: 3323747.

    Article  PubMed Central  PubMed  Google Scholar 

  115. Dabdoub SM, Tsigarida AA, Kumar PS. Patient-specific analysis of periodontal and peri-implant microbiomes. J Dent Res. 2013;92(12 Suppl):168S–75. PubMed Pubmed Central PMCID: 3827621.

    Article  PubMed Central  PubMed  Google Scholar 

  116. Perez-Chaparro PJ, Goncalves C, Figueiredo LC, Faveri M, Lobao E, Tamashiro N, et al. Newly identified pathogens associated with periodontitis: a systematic review. J Dent Res. 2014;93(9):846–58. PubMed.

    Article  PubMed Central  PubMed  Google Scholar 

  117. Ding T, Schloss PD. Dynamics and associations of microbial community types across the human body. Nature. 2014;509(7500):357–60. PubMed Pubmed Central PMCID: 4139711.

    Article  PubMed Central  PubMed  Google Scholar 

  118. Yu X, Graves DT. Fibroblasts, mononuclear phagocytes, and endothelial cells express monocyte chemoattractant protein-1 (MCP-1) in inflamed human gingiva. J Periodontol. 1995;66(1):80–8. PubMed.

    Article  PubMed  Google Scholar 

  119. Seymour GJ, Powell RN, Aitken JF. Experimental gingivitis in humans. A clinical and histologic investigation. J Periodontol. 1983;54(9):522–8. PubMed.

    Article  PubMed  Google Scholar 

  120. Page RC, Schroeder HE. Pathogenesis of inflammatory periodontal disease. A summary of current work. Lab Invest. 1976;34(3):235–49. PubMed.

    PubMed  Google Scholar 

  121. Theill LE, Boyle WJ, Penninger JM. RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol. 2002;20:795–823. PubMed.

    Article  PubMed  Google Scholar 

  122. Ross AB, Bateman TA, Kostenuik PJ, Ferguson VL, Lacey DL, Dunstan CR, et al. The effects of osteoprotegerin on the mechanical properties of rat bone. J Mater Sci Mater Med. 2001;12(7):583–8. PubMed.

    Article  PubMed  Google Scholar 

  123. Kostenuik PJ, Shalhoub V. Osteoprotegerin: a physiological and pharmacological inhibitor of bone resorption. Curr Pharm Des. 2001;7(8):613–35. PubMed.

    Article  PubMed  Google Scholar 

  124. Parameter on periodontal maintenance. American Academy of Periodontology. J Periodontol. 2000;71(5 Suppl):849–50. PubMed.

    Google Scholar 

  125. Stambaugh RV, Dragoo M, Smith DM, Carasali L. The limits of subgingival scaling. Int J Periodontics Restorative Dent. 1981;1(5):30–41. PubMed.

    PubMed  Google Scholar 

  126. Waerhaug J. The infrabony pocket and its relationship to trauma from occlusion and subgingival plaque. J Periodontol. 1979;50(7):355–65. PubMed.

    Article  PubMed  Google Scholar 

  127. Garrett S, Adams DF, Bogle G, Donly K, Drisko CH, Hallmon WW, et al. The effect of locally delivered controlled-release doxycycline or scaling and root planing on periodontal maintenance patients over 9 months. J Periodontol. 2000;71(1):22–30. PubMed.

    Article  PubMed  Google Scholar 

  128. Caton JG, Ciancio SG, Blieden TM, Bradshaw M, Crout RJ, Hefti AF, et al. Subantimicrobial dose doxycycline as an adjunct to scaling and root planing: post-treatment effects. J Clin Periodontol. 2001;28(8):782–9. PubMed.

    Article  PubMed  Google Scholar 

  129. Heasman PA, Heasman L, Stacey F, McCracken GI. Local delivery of chlorhexidine gluconate (PerioChip) in periodontal maintenance patients. J Clin Periodontol. 2001;28(1):90–5. PubMed.

    Article  PubMed  Google Scholar 

  130. Leiknes T, Leknes KN, Boe OE, Skavland RJ, Lie T. Topical use of a metronidazole gel in the treatment of sites with symptoms of recurring chronic inflammation. J Periodontol. 2007;78(8):1538–44. PubMed.

    Article  PubMed  Google Scholar 

  131. Ochsenbein C. A primer for osseous surgery. Int J Periodontics Restorative Dent. 1986;6(1):8–47. PubMed.

    PubMed  Google Scholar 

  132. Tibbetts Jr LS, Ochsenbein C, Loughlin DM. Rationale for the lingual approach to mandibular osseous surgery. Dent Clin North Am. 1976;20(1):61–78. PubMed.

    PubMed  Google Scholar 

  133. Cortellini P, Tonetti MS. Focus on intrabony defects: guided tissue regeneration. Periodontol 2000. 2000;22:104–32. PubMed.

    Article  PubMed  Google Scholar 

  134. Nyman S, Lindhe J, Rosling B. Periodontal surgery in plaque-infected dentitions. J Clin Periodontol. 1977;4(4):240–9. PubMed.

    Article  PubMed  Google Scholar 

  135. DeVore CH, Duckworth JE, Beck FM, Hicks MJ, Brumfield FW, Horton JE. Bone loss following periodontal therapy in subjects without frequent periodontal maintenance. J Periodontol. 1986;57(6):354–9. PubMed.

    Article  PubMed  Google Scholar 

  136. Knowles JW, Burgett FG, Nissle RR, Shick RA, Morrison EC, Ramfjord SP. Results of periodontal treatment related to pocket depth and attachment level. Eight years. J Periodontol. 1979;50(5):225–33. PubMed.

    Article  PubMed  Google Scholar 

  137. Lindhe J, Nyman S. Long-term maintenance of patients treated for advanced periodontal disease. J Clin Periodontol. 1984;11(8):504–14. PubMed.

    Article  PubMed  Google Scholar 

  138. Rosling B, Serino G, Hellstrom MK, Socransky SS, Lindhe J. Longitudinal periodontal tissue alterations during supportive therapy. Findings from subjects with normal and high susceptibility to periodontal disease. J Clin Periodontol. 2001;28(3):241–9. PubMed.

    Article  PubMed  Google Scholar 

  139. Ramfjord SP, Morrison EC, Burgett FG, Nissle RR, Shick RA, Zann GJ, et al. Oral hygiene and maintenance of periodontal support. J Periodontol. 1982;53(1):26–30. PubMed.

    Article  PubMed  Google Scholar 

  140. Rosen B, Olavi G, Badersten A, Ronstrom A, Soderholm G, Egelberg J. Effect of different frequencies of preventive maintenance treatment on periodontal conditions. 5-Year observations in general dentistry patients. J Clin Periodontol. 1999;26(4):225–33. PubMed.

    Article  PubMed  Google Scholar 

  141. Giannobile WV, Braun TM, Caplis AK, Doucette-Stamm L, Duff GW, Kornman KS. Patient stratification for preventive care in dentistry. J Dent Res. 2013;92(8):694–701. PubMed Pubmed Central PMCID: 3711568.

    Article  PubMed Central  PubMed  Google Scholar 

  142. Ramseier CA, Kinney JS, Herr AE, Braun T, Sugai JV, Shelburne CA, et al. Identification of pathogen and host-response markers correlated with periodontal disease. J Periodontol. 2009;80(3):436–46. PubMed.

    Article  PubMed  Google Scholar 

  143. Syndergaard B, Al-Sabbagh M, Kryscio RJ, Xi J, Ding X, Ebersole JL, et al. Salivary biomarkers associated with gingivitis and response to therapy. J Periodontol. 2014;85(8):e295–303. PubMed.

    Article  PubMed Central  PubMed  Google Scholar 

  144. Sexton WM, Lin Y, Kryscio RJ, Dawson 3rd DR, Ebersole JL, Miller CS. Salivary biomarkers of periodontal disease in response to treatment. J Clin Periodontol. 2011;38(5):434–41. PubMed Pubmed Central PMCID: 3095429.

    Article  PubMed Central  PubMed  Google Scholar 

  145. Kinney JS, Morelli T, Oh M, Braun TM, Ramseier CA, Sugai JV, et al. Crevicular fluid biomarkers and periodontal disease progression. J Clin Periodontol. 2014;41(2):113–20. PubMed.

    Article  PubMed Central  PubMed  Google Scholar 

  146. Giannobile WV, Beikler T, Kinney JS, Ramseier CA, Morelli T, Wong DT. Saliva as a diagnostic tool for periodontal disease: current state and future directions. Periodontol 2000. 2009;50:52–64. PubMed.

    Article  PubMed  Google Scholar 

  147. Agrawal P, Sanikop S, Patil S. New developments in tools for periodontal diagnosis. Int Dent J. 2012;62(2):57–64. PubMed.

    Article  PubMed  Google Scholar 

  148. Giannobile WV. Salivary diagnostics for periodontal diseases. J Am Dent Assoc. 2012;143(10 Suppl):6S–11. PubMed.

    Article  PubMed  Google Scholar 

  149. Yager P, Edwards T, Fu E, Helton K, Nelson K, Tam MR, et al. Microfluidic diagnostic technologies for global public health. Nature. 2006;442(7101):412–8. PubMed.

    Article  PubMed  Google Scholar 

  150. Giannobile WV, McDevitt JT, Niedbala RS, Malamud D. Translational and clinical applications of salivary diagnostics. Adv Dent Res. 2011;23(4):375–80. PubMed Pubmed Central PMCID: 3172998.

    Article  PubMed Central  PubMed  Google Scholar 

  151. Kebschull M, Demmer RT, Grun B, Guarnieri P, Pavlidis P, Papapanou PN. Gingival tissue transcriptomes identify distinct periodontitis phenotypes. J Dent Res. 2014;93(5):459–68. PubMed Pubmed Central PMCID: 3988627.

    Article  PubMed Central  PubMed  Google Scholar 

  152. Ivanov M, Barragan I, Ingelman-Sundberg M. Epigenetic mechanisms of importance for drug treatment. Trends Pharmacol Sci. 2014;35(8):384–96. PubMed.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA

    Carlos Garaicoa-Pazmino DDS, Ann M. Decker DMD & Peter J. Polverini DDS, DMSc

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  1. Carlos Garaicoa-Pazmino DDS
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  2. Ann M. Decker DMD
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  3. Peter J. Polverini DDS, DMSc
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Correspondence to Carlos Garaicoa-Pazmino DDS .

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  1. School of Dentistry, The University of Michigan, Ann Arbor, Michigan, USA

    Peter J. Polverini

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Garaicoa-Pazmino, C., Decker, A.M., Polverini, P.J. (2015). Personalized Medicine Approaches to the Prevention, Diagnosis, and Treatment of Chronic Periodontitis. In: Polverini, P. (eds) Personalized Oral Health Care. Springer, Cham. https://doi.org/10.1007/978-3-319-23297-3_8

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