Abstract
The discovery of a hybridoma technology to generate monoclonal antibodies from immunized mice was first reported by George Köhler and César Milstein in 1975. To make this discovery, they developed a lymphocyte fusion technique that allowed selection of monoclonal antibodies of refined specificity and affinity. They received a Noble Prize in Physiology or Medicine in 1984 for this breakthrough innovation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Stevens MW, Henry RL, Owens SM, et al (2014) First human study of a chimeric anti-methamphetamine monoclonal antibody in healthy volunteers. MAbs 6:1649–1656. doi:10.4161/19420862.2014.976431
Valentine JL, Owens SM (1996) Antiphencyclidine monoclonal antibody therapy significantly changes phencyclidine concentrations in brain and other tissues in rats. J Pharmacol Exp Ther 278:717–724.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Owens, S.M. (2016). Monoclonal Antibodies. In: Montoya, I. (eds) Biologics to Treat Substance Use Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-23150-1_7
Download citation
DOI: https://doi.org/10.1007/978-3-319-23150-1_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-23149-5
Online ISBN: 978-3-319-23150-1
eBook Packages: MedicineMedicine (R0)