Abstract
This chapter presents an introduction to the microfluidics field and microfluidic biochips. We discuss the main fluid propulsion principles used by modern microfluidic platforms, with a focus on “digital” microfluidic biochips, which are the topic of this book. Digital microfluidic biochips manipulate the fluids as small “droplets” using electrokinetics, i.e., electrowetting-on-dielectric. Several application areas for biochips are discussed, and the motivation behind the work presented in this book is introduced. At the end of the chapter, we outline the structure of the book and an overview of the topics covered.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Advanced Liquid Logic: http://www.liquid-logic.com (2014). http://www.liquid-logic.com/technology.html
Chakrabarty, K.: Design automation and test solutions for digital microfluidic biochips. IEEE Trans. Circuits Syst. 57, 4–17 (2010)
Chakrabarty, K., Su, F.: Digital Microfluidic Biochips: Synthesis, Testing, and Reconfiguration Techniques. CRC Press, Boca Raton (2006)
Chakrabarty, K., Zeng, J.: Design Automation Methods and Tools for Microfluidics-Based Biochips. Springer, Dordrecht (2006)
Chakrabarty, K., Fair, R.B., Zeng, J.: Design tools for digital microfluidic biochips: towards functional diversification and more than Moore. Trans. Comput. Aided Des. Integr. Circuits Syst. 29(7), 1001–1017 (2010). DOI 10.1109/TCAD.2010.2049153
Dhar, S., Drezdon, S., Maftei, E.: Digital microfluidic biochip for malaria detection. Technical report, Duke University (2008)
Fair, R.B.: Digital microfluidics: is a true lab-on-a-chip possible? Microfluid. Nanofluid. 3(3), 245–281 (2007)
Fair, R.B., Khlystov, A., Tailor, T.D., Ivanov, V., Evans, R.D., Srinivasan, V., Pamula, V.K., Pollack, M.G., Griffin, P.B., Zhou, J.: Chemical and biological applications of digital-microfluidic devices. IEEE Des. Test Comput. 24(1), 10–24 (2007). DOI http://dx.doi.org/10.1109/ MDT.2007.8
Fouillet, Y., Jary, D., Chabrol, C., Claustre, P., Peponnet, C.: Digital microfluidic design and optimization of classic and new fluidic functions for lab on a chip systems. Microfluid. Nanofluid. 4(3), 159–165 (2008)
Hall, D.A., Ptacek, J., Snyder, M.: Protein microarray technology. Mech. Ageing Dev. 128, 161–167 (2006)
International Technology Roadmap for Semiconductors: http://www.itrs.net/Links/2007ITRS/Home2007.htm (2013)
Kopp, M.U., de Mello, A.J., Manz, A.: Chemical amplification: continuous-flow PCR on a chip. Science 280(5366), 1046–1048 (1998)
Luo, Y., Chakrabarty, K., Ho, T.Y.: Real-time error recovery in cyberphysical digital-microfluidic biochips using a compact dictionary. IEEE Trans. Comput. Aided Des. Integr. Circuits Syst. 32(12), 1839–1852 (2013)
Mark, D., Haeberle, S., Roth, G., von Stetten, F., Zengerle, R.: Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications. Chem. Soc. Rev. 39(3), 1153–1182 (2010)
Melin, J., Quake, S.R.: Microfluidic large-scale integration: the evolution of design rules for biological automation. Ann. Rev. Biophys. Biomol. Struct. 36, 213–231 (2007)
Moore, G.E.: Cramming more components onto integrated circuits. Electronics 38(8), 114–117 (1965)
Mukhopadhyay, R.: Microfluidics: on the slope of enlightenment. Anal. Chem. 81(11), 4169–4173 (2009)
Pamula, V.K., Srinivasan, V., Chakrapani, H., Fair, R.B., Toone, E.J.: A droplet-based lab-on-a-chip for colorimetric detection of nitroaromatic explosives. In: Proceedings of the Micro Electro Mechanical Systems Conference, pp. 722–725 (2005)
Pollack, M.G., Paik, P.Y., Shenderov, A.D., Pamula, V.K., Dietrich, F.S., Fair, R.B.: Investigation of electrowetting-based microfluidics for real-time pcr applications. In: Proceedings of the Micro Total Analysis Systems, μTAS, pp. 619–622 (2003)
Pollack, M.G., Shenderov, A.D., Fair, R.B.: Electrowetting-based actuation of droplets for integrated microfluidics. Lab Chip 2, 96–101 (2002)
Sista, R., Hua, Z., Thwar, P., Sudarsan, A., Srinivasan, V., Eckhardt, A., Pollack, M., Pamula, V.: Development of a digital microfluidic platform for point of care testing. Lab Chip 8(12), 2091–2104 (2008)
Sista, R.S., Eckhardt, A.E., Wang, T., Graham, C., Rouse, J.L., Norton, S.M., Srinivasan, V., Pollack, M.G., Tolun, A.A., Bali, D., et al.: Digital microfluidic platform for multiplexing enzyme assays: implications for lysosomal storage disease screening in newborns. Clin. Chem. 57(10), 1444–1451 (2011)
Srinivasan, V., Pamula, V.K., Fair, R.B.: An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids. Lab Chip 4, 310–315 (2004)
Stoughton, R.B.: Applications of DNA microarrays in biology. Ann. Rev. Biochem. 74, 53–82 (2005)
Thorsen, T., Maerkl, S., Quake, S.: Microfluidic largescale integration. Science 298, 580–584 (2002)
Wang, W., Li, Z.X., Yang, Y.J., Guo, Z.Y.: Droplet based micro oscillating flow-through PCR chip. In: Proceedings of the International Conference on Micro Electro Mechanical Systems Conference, pp. 280–283 (2004)
Yoshida, J.I.: Flash chemistry: flow microreactor synthesis based on high-resolution reaction time control. Chem. Rec. 10(5), 332–341 (2010)
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Pop, P., Alistar, M., Stuart, E., Madsen, J. (2016). Introduction. In: Fault-Tolerant Digital Microfluidic Biochips. Springer, Cham. https://doi.org/10.1007/978-3-319-23072-6_1
Download citation
DOI: https://doi.org/10.1007/978-3-319-23072-6_1
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-23071-9
Online ISBN: 978-3-319-23072-6
eBook Packages: EngineeringEngineering (R0)