Abstract
Current recommendations are that all patients with cirrhosis be screened for varices using upper endoscopy. However, this scope all approach is the most expensive and we need to better define which patients are at risk for variceal bleeding and then screen selectively. There is increasing data that noninvasive tests can predict which patients are most at risk for having varices; however, how this helps with predicting who is going to bleed is less clear. Unfortunately, there are few studies that have examined the cost-effectiveness of these newer tests as compared to upper endoscopy. When these studies have been performed, upper endoscopy is the least cost-effective approach to screening for varices. Using platelet counts or imaging is more cost-effective than is endoscopy and is noninvasive. Comparison of upper endoscopy to elastography on a cost-effectiveness basis needs to be performed to better understand how we should be using these new technologies in the management of the cirrhotic. Guidelines need to contain cost-sensitive recommendations as to screening for varices.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W, and the Practice Guidelines Committee of the American Association for the Study of Liver Diseases (2007) Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology 46:922–938
Berzigotti A, Bosch J, Boyer TD (2014) Use of noninvasive markers of portal hypertension and timing of screening endoscopy for gastroesophageal varices in patients with chronic liver disease. Hepatology 59:729–731
Groszmann RJ, Garcia-Tsao G, Bosch J, Grace ND, Burroughs AK, Planas R et al (2005) Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis. N Engl J Med 353:2254–2261
Merkel C, Marin R, Angeli P, Zanella P, Felder M, Bernardinello E et al (2004) A placebo-controlled clinical trial of nadolol in the prophylaxis of growth of small esophageal varices in cirrhosis. Gastroenterology 127:476–484
Spiegel BMR, Targownik L, Dulai GS, Karsan HA, Gralnek IM (2003) Endoscopic screening for esophageal varices in cirrhosis: is it ever cost effective? Hepatology 37:366–377
Arguedas MR, Heudebert GR, Eloubeidi MA, Abrams GA, Fallow MB (2002) Cost-effectiveness of screening, surveillance, and primary prophylaxis strategies for esophageal varices. Am J Gastroenterol 97:2441–2452
Berzigotti A, Seijo S, Arena U, Abraldes JG, Vizzutti F, Garcia-Pagan JC et al (2013) Elastography, spleen size, and platelet count identify portal hypertension in patients with compensated cirrhosis. Gastroenterology 144:102–111
Chalasani N, Imperiale TF, Ismail A, Sood G, Carey M, Wilcox M et al (1999) Predictors of large esophageal varices in patients with cirrhosis. Am J Gastroenterol 94:3285–3291
Bosch J, Garcia-Pagan JC (2003) Prevention of variceal rebleeding. Lancet 361:952–954
D’Amico G, Garcia-Pagan JC, Luca A, Bosch J (2006) Hepatic vein pressure gradient reduction and prevention of variceal bleeding in cirrhosis: a systematic review. Gastroenterology 131:1611–1624
Di Pascoli L, Buja A, Bolognesi M, Montagnese S, Gatta A, Gregori D et al (2014) Cost-effectiveness analysis of beta-blockers vs endoscopic surveillance in patients with cirrhosis and small varices. World J Gastroenterol 20:10464–10469
Perri RE, Chiorean MV, Fidler JL, Fletcher JG, Talwalker JA, Stadheim L et al (2008) A prospective evaluation of computerized tomographic (CT) scanning as a screening modality for esophageal varices. Hepatology 47:1587–1594
Lotfipour AK, Douek M, Shimoga SV, Sayer JW, Han SB, Jutabha R, Lu DSK (2014) The cost of screening esophageal varices: traditional endoscopy versus computed tomography. J Comput Assist Tomogr 38:963–967
Elrazek A, Elrazek A, Eid KA, El-Sherif AEA, El Al UMA, El-Sherbiny SM, Bilasy SE (2015) Screening esophagus during routine ultrasound: medical and cost benefits. Eur J Gastroent Hepatol 27:8–12
White CM, Kilgore ML (2009) PillCam ESO versus esophagogastroduodenoscopy in esophageal variceal screening. A decision analysis. J Clin Gastroenterol 43:975–981
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this paper
Cite this paper
Boyer, T.D. (2016). Cost Considerations. In: de Franchis, R. (eds) Portal Hypertension VI. Springer, Cham. https://doi.org/10.1007/978-3-319-23018-4_8
Download citation
DOI: https://doi.org/10.1007/978-3-319-23018-4_8
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-23017-7
Online ISBN: 978-3-319-23018-4
eBook Packages: MedicineMedicine (R0)