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Augmented Reality Assisted Brain Tumor Extraction in Mice

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Augmented and Virtual Reality (AVR 2015)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 9254))

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Abstract

Computer assisted navigation is a widely adopted technique in neurosurgery and orthopedics. In general, the used tracking systems are applicable to multiple situations. However, these general-purpose devices are costly and in case of unusual laboratory applications, a dedicated solution often shows a better performance. In this paper, we propose a cost-effective 3D navigation system for the augmented reality assisted brain tumor extraction in mice, used for cancer research. Off-the-shelf camera 3D reconstruction algorithms are used to individually track a target and a surgical tool. Relative to its costs, the experiments showed an excellent navigation error of \(0.48\,\mathrm{mm} \pm {0.25}\,\mathrm{mm}\).

Simone E. Hieber and Philippe C. Cattin shared last authorship.

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References

  1. Arun, K.S., Huang, T.S., Blostein, S.D.: Least-squares fitting of two 3-d point sets. IEEE Trans. Pattern Anal. Mach. Intell. 5, 698–700 (1987)

    Article  Google Scholar 

  2. Broers, H., Jansing, N.: How precise is navigation for minimally invasive surgery? Int. Orthop. 31(1), 39–42 (2007)

    Article  Google Scholar 

  3. Gao, X.S., Hou, X.R., Tang, J., Cheng, H.F.: Complete solution classification for the perspective-three-point problem. IEEE Trans. Pattern Anal. Mach. Intell. 25(8), 930–943 (2003)

    Article  Google Scholar 

  4. Hartley, R., Zisserman, A.: Multiple view geometry in computer vision. Cambridge University Press, New York (2010)

    Google Scholar 

  5. Huynh, D.Q.: Metrics for 3D rotations: comparison and analysis. J. Math. Imag. Vis. 35(2), 155–164 (2009)

    Article  MathSciNet  Google Scholar 

  6. Krucker, T., Lang, A., Meyer, E.P.: New polyurethane-based material for vascular corrosion casting with improved physical and imaging characteristics. Microsc. Res. Tech. 69(2), 138–147 (2006). http://dx.doi.org/10.1002/jemt.20263

    Article  Google Scholar 

  7. Luhmann, T.: Precision potential of photogrammetric 6DOF pose estimation with a single camera. ISPRS J. Photogrammetry Remote Sens. 64(3), 275–284 (2009)

    Article  Google Scholar 

  8. Müller, B., Lang, S., Dominietto, M., Rudin, M., Schulz, G., Deyhle, H., Germann, M., Pfeiffer, F., David, C., Weitkamp, T.: High-resolution tomographic imaging of microvessels. Proc. SPIE - Int. Soc. Opt. Eng. 7078, 70780B-1–70780B-10 (2008). http://dx.doi.org/10.1117/12.794157

    Google Scholar 

  9. Onprasert, O., Suthakorn, J.: A novel method on tool tip calibration for biomedical application. In: Proceedings of the World Congress on Computer Science and Information Engineering, pp. 650–653 (2011)

    Google Scholar 

  10. Paganin, D., Mayo, S.C., Gureyev, T.E., Miller, P.R., Wilkins, S.W.: Simultaneous phase and amplitude extraction from a single defocused image of a homogeneous object. J. Microsc. 206(1), 33–40 (2002). http://dx.doi.org/10.1046/j.1365-2818.2002.01010.x

    Article  MathSciNet  Google Scholar 

  11. Thalmann, P., Hieber, S.E., Schulz, G., Deyhle, H., Khimchenko, A., Kurtcuoglu, V., Olgac, U., Marmaras, A., Kuo, W., Meyer, E.P., Beckmann, F., Herzen, J., Ehrbar, S., Müller, B.: Three-dimensional registration of synchrotron radiation-based micro-computed tomography images with advanced laboratory micro-computed tomography data from murine kidney casts. Am. J. Physiol. Heart Circ. Physiol. 9212, 92120Y-1–92120Y-9 (2014). http://dx.doi.org/10.1117/12.2060809

    Google Scholar 

  12. WHO: Research for patient safety (2008). http://www.who.int/patientsafety/information_centre/documents/ps_research_brochure_en.pdf

  13. Zhang, Z.: A flexible new technique for camera calibration. IEEE Trans. Pattern Anal. Mach. Intell. 22(11), 1330–1334 (2000)

    Article  Google Scholar 

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Acknowledgments

We would like to thank Bert Müller for his initiative and helpful discussions, Therese Bormann for her help in the container design and the 3D printing at the FHNW Muttenz, Mathias Griessen and Alex Seiler for their support in the software implementation, Sandra Burgi for preparing the murine brain, and Marco Dominietto for his useful feedback and the MRT measurements at the Animal Imaging Center of ETH Zurich.

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Correspondence to Adrian Schneider .

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Schneider, A., Thalmann, P., Pezold, S., Hieber, S.E., Cattin, P.C. (2015). Augmented Reality Assisted Brain Tumor Extraction in Mice. In: De Paolis, L., Mongelli, A. (eds) Augmented and Virtual Reality. AVR 2015. Lecture Notes in Computer Science(), vol 9254. Springer, Cham. https://doi.org/10.1007/978-3-319-22888-4_19

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  • DOI: https://doi.org/10.1007/978-3-319-22888-4_19

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-22887-7

  • Online ISBN: 978-3-319-22888-4

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