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Measuring Lipid Bilayer Permeability with Biomimetic Membranes

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Carbon Nanomaterials for Biomedical Applications

Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 5))

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Abstract

While there are numerous active mechanisms controlling which molecules cross a cell’s plasma membrane to enter the cytoplasm, these are not the only routes by which molecules can enter cells. In fact, transport by passive diffusion across the lipid bilayer of the plasma membrane represents a nearly universal mechanism of molecular entry. Passive transport represents a key route by which both drugs and environmental toxins can cross biological barriers. Understanding the barrier properties of the lipid bilayer and what molecular characteristics control its permeability is therefore of fundamental interest to toxicology and drug development. Methods of measuring and predicting this permeability have been the topics of research for decades. Today, sophisticated biomimetic cell membranes, coupled with advanced analytical tools and computer modeling, allow new insight into this important biological property.

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Authors and Affiliations

  1. Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, USA

    Kristina Runas & Noah Malmstadt

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  1. Kristina Runas
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  2. Noah Malmstadt
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Correspondence to Noah Malmstadt .

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Editors and Affiliations

  1. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA

    Mei Zhang

  2. Soft Matter Materials Branch, Air Force Research Laboratory, Dayton, Ohio, USA

    Rajesh R. Naik

  3. Department of Macromolecular Science, Case Western Reserve University, Cleveland, Ohio, USA

    Liming Dai

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Runas, K., Malmstadt, N. (2016). Measuring Lipid Bilayer Permeability with Biomimetic Membranes. In: Zhang, M., Naik, R., Dai, L. (eds) Carbon Nanomaterials for Biomedical Applications. Springer Series in Biomaterials Science and Engineering, vol 5. Springer, Cham. https://doi.org/10.1007/978-3-319-22861-7_16

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