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Demyelinating Diseases: Multiple Sclerosis and Neuromyelitis Optica

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Atlas of Sellar and Parasellar Lesions

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Abstract

Multiple sclerosis (MS) is a demyelinating disease that more commonly affects women; its occurrence is partially determined by ancestral background.

In patients with classic MS, hyperactivity of the hypothalamic-pituitary-adrenal axis and a chronically activated corticotropin-releasing hormone (CRH) system have been shown.

Neuromyelitis optica (NMO) spectrum disorder, also known as Devic’s disease, is a group of related demyelinating conditions with common manifestations in the suprasellar region and spinal cord. The optic chiasm, nerves, hypothalamus, and infundibulum are frequently affected. The spectrum of disease includes classic NMO, optic neuritis, Asian opticospinal MS, NMO with endocrinopathies, and other subtypes.

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Authors and Affiliations

  1. Department of Neurological Surgery, Keck School of Medicine, University of Southern California, 1200 N State Street, #3300, Los Angeles, CA, 90033, USA

    Gabriel Zada MD, MS

  2. Department of Pathology (Neuropathology), University of Virginia School of Medicine, 1215 Lee Street, Room 3060–HEP, Charlottesville, VA, 22908, USA

    M. Beatriz S. Lopes MD, PhD

  3. Department of Radiology, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA, 02115, USA

    Srinivasan Mukundan Jr. PhD, MD

  4. Department of Neurosurgery, Brigham and Women’s Hospital, 15 Francis Street, Boston, MA, 02115, USA

    Edward Laws Jr. MD

Authors
  1. Gabriel Zada MD, MS
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  2. M. Beatriz S. Lopes MD, PhD
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  3. Srinivasan Mukundan Jr. PhD, MD
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  4. Edward Laws Jr. MD
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Corresponding author

Correspondence to Gabriel Zada MD, MS .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, University of Southern California, LOS ANGELES, California, USA

    Gabriel Zada

  2. Department of Pathology, University of Virginia, CHARLOTTESVILLE, Virginia, USA

    M. Beatriz S. Lopes

  3. Department of Radiology, Brigham and Women's Hospital, BOSTON, Massachusetts, USA

    Srinivasan Mukundan Jr.

  4. Department of Neurosurgery, Brigham and Women’s Hospital, BOSTON, Massachusetts, USA

    Edward R. Laws Jr.

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© 2016 Springer International Publishing Switzerland

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Zada, G., Lopes, M.B.S., Mukundan, S., Laws, E. (2016). Demyelinating Diseases: Multiple Sclerosis and Neuromyelitis Optica. In: Zada, G., Lopes, M., Mukundan Jr., S., Laws Jr., E. (eds) Atlas of Sellar and Parasellar Lesions. Springer, Cham. https://doi.org/10.1007/978-3-319-22855-6_58

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  • DOI: https://doi.org/10.1007/978-3-319-22855-6_58

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-22854-9

  • Online ISBN: 978-3-319-22855-6

  • eBook Packages: MedicineMedicine (R0)

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