Skip to main content
SpringerLink
Log in

Spindle Cell Oncocytoma

  • Chapter
Atlas of Sellar and Parasellar Lesions

  • 2877 Accesses

Abstract

Spindle cell oncocytoma (SCO) is an exceedingly rare, nonfunctioning, nonadenomatous tumor that arises in the pituitary gland. In 2007, it was classified as a separate pathological entity by the WHO.

SCOs are thought to arise from folliculostellate cells.

In many cases, an SCO may mimic a nonfunctioning pituitary adenoma. As nonadenomatous sellar lesions, however, SCOs also require differentiation from pituicytomas or granular cell tumors.

SCOs typically present with visual loss, hypopituitarism, and headaches.

The mean age at diagnosis is 61 years.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Roncaroli F, Scheithauer BW. Papillary tumor of the pineal region and spindle cell oncocytoma of the pituitary: new tumor entities in the 2007 WHO Classification. Brain Pathol. 2007;17:314–8.

    Article  PubMed  Google Scholar 

  2. Roncaroli F, Scheithauer BW, Cenacchi G, Horvath E, Kovacs K, Lloyd RV, et al. ‘Spindle cell oncocytoma’ of the adenohypophysis: a tumor of folliculostellate cells? Am J Surg Pathol. 2002;26:1048–55.

    Article  PubMed  Google Scholar 

  3. Covington MF, Chin SS, Osborn AG. Pituicytoma, spindle cell oncocytoma, and granular cell tumor: clarification and meta-analysis of the world literature since 1893. AJNR Am J Neuroradiol. 2011;32:2067–72.

    Article  CAS  PubMed  Google Scholar 

  4. Ogiwara H, Dubner S, Shafizadeh S, Raizer J, Chandler JP. Spindle cell oncocytoma of the pituitary and pituicytoma: two tumors mimicking pituitary adenoma. Surg Neurol Int. 2011;2:116.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Matyja E, Maksymowicz M, Grajkowska W, Olszewski W, Zielinski G, Bonicki W. Spindle cell oncocytoma of the adenohypophysis – a clinicopathological and ultrastructural study of two cases. Folia Neuropathol. 2010;48:175–84.

    PubMed  Google Scholar 

  6. Borges MT, Lillehei KO, Kleinschmidt-DeMasters BK. Spindle cell oncocytoma with late recurrence and unique neuroimaging characteristics due to recurrent subclinical intratumoral bleeding. J Neurooncol. 2011;101:145–54.

    Article  PubMed  Google Scholar 

  7. Vajtai I, Beck J, Kappeler A, Hewer E. Spindle cell oncocytoma of the pituitary gland with follicle-like component: organotypic differentiation to support its origin from folliculo-stellate cells. Acta Neuropathol. 2011;122:253–8.

    Article  PubMed  Google Scholar 

  8. Kloub O, Perry A, Tu PH, Lipper M, Lopes MB. Spindle cell oncocytoma of the adenohypophysis: report of two recurrent cases. Am J Surg Pathol. 2005;29:247–53.

    Article  PubMed  Google Scholar 

  9. Alexandrescu S, Brown RE, Tandon N, Bhattacharjee MB. Neuron precursor features of spindle cell oncocytoma of adenohypophysis. Ann Clin Lab Sci. 2012;42:123–9.

    PubMed  Google Scholar 

  10. Fujisawa H, Tohma Y, Muramatsu N, Kida S, Kaisaki Y, Tamamura H. Spindle cell oncocytoma of the adenohypophysis with marked hypervascularity. Case report. Neurol Med Chir (Tokyo). 2012;52:594–8.

    Article  Google Scholar 

  11. Borota OC, Scheithauer BW, Fougner SL, Hald JK, Ramm-Pettersen J, Bollerslev J. Spindle cell oncocytoma of the adenohypophysis: report of a case with marked cellular atypia and recurrence despite adjuvant treatment. Clin Neuropathol. 2009;28:91–5.

    Article  PubMed  Google Scholar 

  12. Coiré CI, Horvath E, Smyth HS, Kovacs K. Rapidly recurring folliculostellate cell tumor of the adenohypophysis with the morphology of a spindle cell oncocytoma: case report with electron microscopic studies. Clin Neuropathol. 2009;28:303–8.

    Article  PubMed  Google Scholar 

  13. Demssie YN, Joseph J, Dawson T, Roberts G, de Carpentier J, Howell S. Recurrent spindle cell oncocytoma of the pituitary, a case report and review of literature. Pituitary. 2011;14:367–70.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurological Surgery, Keck School of Medicine, University of Southern California, 1200 N State Street, #3300, Los Angeles, CA, 90033, USA

    Gabriel Zada MD, MS

  2. Department of Pathology (Neuropathology), University of Virginia School of Medicine, 1215 Lee Street, Room 3060–HEP, Charlottesville, VA, 22908, USA

    M. Beatriz S. Lopes MD, PhD

  3. Department of Radiology, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA, 02115, USA

    Srinivasan Mukundan Jr. PhD, MD

  4. Department of Neurosurgery, Brigham and Women’s Hospital, 15 Francis Street, Boston, MA, 02115, USA

    Edward Laws Jr. MD

Authors
  1. Gabriel Zada MD, MS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Beatriz S. Lopes MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Srinivasan Mukundan Jr. PhD, MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Edward Laws Jr. MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gabriel Zada MD, MS .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, University of Southern California, LOS ANGELES, California, USA

    Gabriel Zada

  2. Department of Pathology, University of Virginia, CHARLOTTESVILLE, Virginia, USA

    M. Beatriz S. Lopes

  3. Department of Radiology, Brigham and Women's Hospital, BOSTON, Massachusetts, USA

    Srinivasan Mukundan Jr.

  4. Department of Neurosurgery, Brigham and Women’s Hospital, BOSTON, Massachusetts, USA

    Edward R. Laws Jr.

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Zada, G., Lopes, M.B.S., Mukundan, S., Laws, E. (2016). Spindle Cell Oncocytoma. In: Zada, G., Lopes, M., Mukundan Jr., S., Laws Jr., E. (eds) Atlas of Sellar and Parasellar Lesions. Springer, Cham. https://doi.org/10.1007/978-3-319-22855-6_43

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-22855-6_43

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-22854-9

  • Online ISBN: 978-3-319-22855-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation