Abstract
Gangliocytomas originating in the posterior pituitary are rare.
The majority of gangliocytomas of the neurohypophysis are actually a composite tumor with gangliocytic and pituitary adenomatous elements, forming so-called mixed gangliocytoma-pituitary adenomas.
The term “pituitary adenoma with adenohypophyseal neuronal choristoma” (PANCH) has also been used by some investigators, but it is discouraged by the current WHO classification.
Mixed gangliocytoma-pituitary adenomas are estimated to correspond to 0.5–1.25 % of all sellar region tumors.
Clinically, gangliocytomas present with hormonal oversecretion syndromes in 74 % of reported cases. These tumors are associated with neuroendocrine disorders, mainly acromegaly, although fewer cases with Cushing’s disease and hyperprolactinemia have been described.
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Zada, G., Lopes, M.B.S., Mukundan, S., Laws, E. (2016). Gangliocytoma and Ganglioglioma. In: Zada, G., Lopes, M., Mukundan Jr., S., Laws Jr., E. (eds) Atlas of Sellar and Parasellar Lesions. Springer, Cham. https://doi.org/10.1007/978-3-319-22855-6_42
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