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Atlas of Sellar and Parasellar Lesions pp 343–346Cite as

Lymphoma

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Abstract

Sellar region lymphoma may arise as primary CNS lymphoma (PCNSL) or systemic lymphoma (often non-Hodgkin’s lymphoma) metastasizing to the pituitary gland. (See Metastases to the Pituitary Gland, below.)

Overall, PCNSL accounts for approximately 1 % of all intracranial neoplasms.

This entity is more common in men and can occur in immunocompromised or immunocompetent individuals. The mean age in immunocompetent patients is 60–70 years, compared with 30–40 years in immunocompromised individuals.

PCNSL develops more commonly in immunocompromised individuals, especially those with HIV/AIDS, although the incidence of this disease has declined in the past decade.

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References

  1. Megan Ogilvie C, Payne S, Evanson J, Lister TA, Grossman AB. Lymphoma metastasizing to the pituitary: an unusual presentation of a treatable disease. Pituitary. 2005;8:139–46.

    Article  CAS  PubMed  Google Scholar 

  2. Da Silva AN, Lopes MB, Schiff D. Rare pathological variants and presentations of primary central nervous system lymphomas. Neurosurg Focus. 2006;21(5), E7.

    Article  PubMed  Google Scholar 

  3. Kaufmann TJ, Lopes MB, Laws Jr ER, Lipper MH. Primary sellar lymphoma: radiologic and pathologic findings in two patients. AJNR Am J Neuroradiol. 2002;23:364–7.

    PubMed  Google Scholar 

  4. Liu JK, Sayama C, Chin SS, Couldwell WT. Extranodal NK/T-cell lymphoma presenting as a pituitary mass. Case report and review of the literature. J Neurosurg. 2007;107:660–5.

    Article  PubMed  Google Scholar 

  5. Giustina A, Gola M, Doga M, Rosei EA. Clinical review 136: primary lymphoma of the pituitary: an emerging clinical entity. J Clin Endocrinol Metab. 2001;86:4567–75.

    Article  CAS  PubMed  Google Scholar 

  6. Yasuda M, Akiyama N, Miyamoto S, Warabi M, Takahama Y, Kitamura M, et al. Primary sellar lymphoma: intravascular large B-cell lymphoma diagnosed as a double cancer and improved with chemotherapy, and literature review of primary parasellar lymphoma. Pituitary. 2010;13:39–47.

    Article  PubMed  Google Scholar 

  7. Rizek P, Seitelbach M, Alturkustani M, Leung A, Fraser JA. Sellar and parasellar intravascular lymphoma mimicking pituitary apoplexy. J Neuroophthalmol. 2012;32:33–7.

    Article  PubMed  Google Scholar 

  8. Saeger W, Ludecke DK, Buchfelder M, Fahlbusch R, Quabbe HJ, Petersenn S. Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry. Eur J Endocrinol. 2007;156:203–16.

    Article  CAS  PubMed  Google Scholar 

  9. Freda PU, Post KD. Differential diagnosis of sellar masses. Endocrinol Metab Clin North Am. 1999;28:81–117.

    Article  CAS  PubMed  Google Scholar 

  10. Robison NJ, Prabhu SP, Sun P, Chi SN, Kieran MW, Manley PE, et al. Predictors of neoplastic disease in children with isolated pituitary stalk thickening. Pediatr Blood Cancer. 2013;60:1630–5.

    Article  PubMed  Google Scholar 

  11. Zheng WL, Zhang GS, Tan CL, Shen JK, Yang JJ, Zhong HY. Diabetes insipidus as main presentation of non-Hodgkin’s lymphoma with hypophyseal involvement: two case reports. Leuk Res. 2010;34:e32–4.

    Article  PubMed  Google Scholar 

  12. Soussan M, Wartski M, Ezra J, Glaisner S, Pecking AP, Alberini JL. Non-Hodgkin lymphoma localization in the pituitary gland: diagnosis by FDG-PET/CT. Clin Nucl Med. 2008;33:111–2.

    Article  PubMed  Google Scholar 

  13. Mathiasen RA, Jarrahy R, Cha ST, Kovacs K, Herman VS, Ginsberg E, Shahinian HK. Pituitary lymphoma: a case report and literature review. Pituitary. 2000;2:283–7.

    Article  CAS  PubMed  Google Scholar 

  14. Wiens AL, Hagen MC, Bonnin JM, Rizzo KA. T-cell lymphoblastic lymphoma/leukemia presenting as a pituitary mass lesion: a case report and review of the literature. Neuropathology. 2012;32:668–74.

    Article  PubMed  Google Scholar 

  15. Huang YY, Lin SF, Dunn P, Wai YY, Hsueh C, Tsai JS. Primary pituitary lymphoma presenting as hypophysitis. Endocr J. 2005;52:543–9.

    Article  PubMed  Google Scholar 

  16. Moshkin O, Muller P, Scheithauer BW, Juco J, Horvath E, Patterson BJ, et al. Primary pituitary lymphoma: a histological, immunohistochemical, and ultrastructural study with literature review. Endocr Pathol. 2009;20:46–9.

    Article  PubMed  Google Scholar 

  17. Deangelis LM. Current management of primary central nervous system lymphoma. Oncology (Williston Park). 1995;9:63–71; discussion 71, 75–6, 78.

    CAS  Google Scholar 

  18. Schultz C, Scott C, Sherman W, Donahue B, Fields J, Murray K, et al. Preirradiation chemotherapy with cyclophosphamide, doxorubicin, vincristine, and dexamethasone for primary CNS lymphomas: initial report of Radiation Therapy Oncology Group protocol 88–06. J Clin Oncol. 1996;14:556–64.

    CAS  PubMed  Google Scholar 

  19. Omuro AM, Abrey LE. Chemotherapy for primary central nervous system lymphoma. Neurosurg Focus. 2006;21(5):E12.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neurological Surgery, Keck School of Medicine, University of Southern California, 1200 N State Street, #3300, Los Angeles, CA, 90033, USA

    Gabriel Zada MD, MS

  2. Department of Pathology (Neuropathology), University of Virginia School of Medicine, 1215 Lee Street, Room 3060–HEP, Charlottesville, VA, 22908, USA

    M. Beatriz S. Lopes MD, PhD

  3. Department of Radiology, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA, 02115, USA

    Srinivasan Mukundan Jr. PhD, MD

  4. Department of Neurosurgery, Brigham and Women’s Hospital, 15 Francis Street, Boston, MA, 02115, USA

    Edward Laws Jr. MD

Authors
  1. Gabriel Zada MD, MS
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  2. M. Beatriz S. Lopes MD, PhD
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  3. Srinivasan Mukundan Jr. PhD, MD
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  4. Edward Laws Jr. MD
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Corresponding author

Correspondence to Gabriel Zada MD, MS .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, University of Southern California, LOS ANGELES, California, USA

    Gabriel Zada

  2. Department of Pathology, University of Virginia, CHARLOTTESVILLE, Virginia, USA

    M. Beatriz S. Lopes

  3. Department of Radiology, Brigham and Women's Hospital, BOSTON, Massachusetts, USA

    Srinivasan Mukundan Jr.

  4. Department of Neurosurgery, Brigham and Women’s Hospital, BOSTON, Massachusetts, USA

    Edward R. Laws Jr.

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© 2016 Springer International Publishing Switzerland

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Zada, G., Lopes, M.B.S., Mukundan, S., Laws, E. (2016). Lymphoma. In: Zada, G., Lopes, M., Mukundan Jr., S., Laws Jr., E. (eds) Atlas of Sellar and Parasellar Lesions. Springer, Cham. https://doi.org/10.1007/978-3-319-22855-6_41

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  • DOI: https://doi.org/10.1007/978-3-319-22855-6_41

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-22854-9

  • Online ISBN: 978-3-319-22855-6

  • eBook Packages: MedicineMedicine (R0)

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