Abstract
Silent ACTH tumors are a unique subgroup of nonfunctioning tumors that demonstrate strong immunoreactivity for ACTH, yet rarely cause hormonal excess of cortisol (Cushing’s disease).
The serum ACTH may be normal or mildly elevated.
These tumors are more common in female patients.
Their clinical presentation is similar to the presentation of macroadenomas, including headache, visual loss, panhypopituitarism, and amenorrhea/galactorrhea.
A relatively high proportion of hemorrhagic infarction (33 %) has been reported.
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Zada, G., Lopes, M.B.S., Mukundan, S., Laws, E. (2016). Silent Corticotroph (ACTH) Adenomas. In: Zada, G., Lopes, M., Mukundan Jr., S., Laws Jr., E. (eds) Atlas of Sellar and Parasellar Lesions. Springer, Cham. https://doi.org/10.1007/978-3-319-22855-6_14
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DOI: https://doi.org/10.1007/978-3-319-22855-6_14
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