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Epstein Barr Virus Volume 1 pp 267–285Cite as

Burkitt’s Lymphoma

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 390))

Abstract

Endemic Burkitt’s lymphoma (BL) remains the most prevalent pediatric cancer in sub-Saharan Africa even though it was the first human cancer with a viral etiology described over 50 years ago. Epstein–Barr virus (EBV) was discovered in a BL tumor in 1964 and has since been implicated in other malignancies. The etiology of endemic BL has been linked to EBV and Plasmodium falciparum malaria co-infection. While epidemiologic studies have yielded insight into EBV infection and the etiology of endemic BL, the modulation of viral persistence in children by malaria and deficits in EBV immunosurveillance has more recently been reified. Renewed efforts to design prophylactic and therapeutic EBV vaccines provide hope of preventing EBV-associated BL as well as increasing the ability to cure this cancer.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY, USA

    Rosemary Rochford

  2. Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA, 01605, USA

    Ann M. Moormann

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  1. Rosemary Rochford
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Correspondence to Ann M. Moormann .

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  1. Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland

    Christian Münz

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Rochford, R., Moormann, A.M. (2015). Burkitt’s Lymphoma. In: Münz, C. (eds) Epstein Barr Virus Volume 1. Current Topics in Microbiology and Immunology, vol 390. Springer, Cham. https://doi.org/10.1007/978-3-319-22822-8_11

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