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Dimeric Sesquiterpenoids

  • Chapter
Progress in the Chemistry of Organic Natural Products 101

Part of the book series: Progress in the Chemistry of Organic Natural Products ((POGRCHEM,volume 101))

Abstract

It is widely accepted that a large number of proteins that are responsible for cellular function exist as dimers or need to be activated by dimerization before mediating certain signaling pathways. Simultaneously targeting both monomeric moieties of the dimeric proteins has shown potential in the development of various therapeutic agents. As dimeric molecules might be able to act on both moieties of a dimeric protein, dimeric sesquiterpenoids (DSs), which are generated biogenetically from coupling of two sesquiterpenoid molecules, are in essence potential biologically active molecules, and have attracted in recent years great attention for their peculiar structures and biological activities. In fact, a number of DSs are more potent than their monomeric precursors for some activities such as anti-inflammatory, anti-tumor, immunosuppressive, potassium channel blocking, antimalarial, anti-virus, and neurotrophic activities.

The complex and diversified structures of DSs also attracted attention of chemists in their isolation, structural elucidation, and synthetic construction.

In the contribution, a general view of the classification and distribution of DSs will be provided. Strategies for the structural elucidation of DSs and their analogues is presented. Chemical strategies for the convergence of the two sesquiterpenoid units is reviewed. Biological activities are discussed under each type of activity.

The original version of this chapter was revised as the affiliation of J.-M. Yue was incorrect. The erratum to this chapter is available at DOI 10.1007/978-3-319-22692-7_3.

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-22692-7_3

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Acknowledgments

The authors would like to express their gratitude to Dr. Zha-Jun Zhan for his kind help in literature discussions and to Dr. Neng-Lin Zhang for her help in reference editing.

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Authors and Affiliations

  1. School of Pharmacy, Guizhou Medical University, Zhangjiang Hi-Tech Park, Shanghai, 201203, People’s Republic of China

    Shang-Gao Liao

  2. Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), School of Pharmacy, Guizhou Medical University, Guizhou, 550004, People’s Republic of China

    Shang-Gao Liao

  3. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhangjiang Hi-Tech Park, Shanghai, 201203, People’s Republic of China

    Jian-Min Yue

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  1. Shang-Gao Liao
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Editors and Affiliations

  1. Div. Medicinal Chemistry & Pharmacognosy, The Ohio State University College of Pharmacy, Columbus, Ohio, USA

    A. Douglas Kinghorn

  2. Linz, Austria

    Heinz Falk

  3. Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, London, United Kingdom

    Simon Gibbons

  4. Graduate School of Pharmaceutical Scienc, Hokkaido University, Sapporo, Japan

    Jun'ichi Kobayashi

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Liao, SG., Yue, JM. (2016). Dimeric Sesquiterpenoids. In: Kinghorn, A., Falk, H., Gibbons, S., Kobayashi, J. (eds) Progress in the Chemistry of Organic Natural Products 101. Progress in the Chemistry of Organic Natural Products, vol 101. Springer, Cham. https://doi.org/10.1007/978-3-319-22692-7_1

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