Abstract
This chapter explores how protein sequencing – a technique enabling the determination of the fine structure of protein chains – circulated across different biomedical fields in Spain during the last third of the twentieth century. By focusing on three individual scientists, I argue that protein sequencing had three distinct Spanish lives and was inextricably linked to the biographies of its users. Between 1967 and 1995, protein sequencing shifted from an aid to prevent agrarian plagues in Franco’s dictatorship to a promising diagnostic tool in the transition towards democracy and, finally, an out-of-fashion technique overshadowed by the emergence of recombinant DNA methods. My proposed three lives challenge over-simplistic comparative frameworks and suggest that the local configuration of a new scientific technique should not be sought in its similarities or idiosyncratic differences with a given ‘global’. Protein sequencing in Spain was rather shaped by the researchers’ will of constructing a professional space of their own and achieving a complex equilibrium between the fulfilment of local demands and the engagement with what was considered international and cutting-edge at each historical time.
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Notes
- 1.
As two out of my three subject scientists are deceased, I reconstructed each life by combining uncatalogued personal and institutional archives, published scientific literature and oral histories with relatives and colleagues.
- 2.
On the scientific component of the Development Plans, see reports of the Comisión Asesora de Investigación Científica y Técnica (Madrid, President’s Office, 1964–1986). On the possibility to create a “protected space” for scientific research and the national variations of generic governance, see Gläser, Laudel and Lettkemann (Chap. 2).
- 3.
For Martín-Municio’s correspondence with EMBO and syllabi of the first editions of the course see Personal Archive of A. Martín-Municio, Faculty of Chemistry, Universidad Complutense de Madrid (Spain), uncatalogued file on EMBO.
- 4.
For a discussion of a related case (how Chagas disease and the associated parasite ‘Trypanosoma cruzi’ have been addressed as a scientific problem), see Kreimer (Chap. 10).
- 5.
Personal Archive of A. Martín-Municio, Faculty of Chemistry, Universidad Complutense de Madrid (Spain), uncatalogued file on NSF. From the late-1950s onwards, the US Administration had seen in Franco’s regime a potential ally against Communism, which had resulted in institutions devoted to cultural, educational and scientific exchange. This collaboration boosted the international diplomacy of the dictatorship and was complemented with other initiatives focused on the European front, such as the Spanish membership of EMBO or its previous integration in CERN.
- 6.
R. Manso, J. Ávila, M. Salas and A. Sánchez, interviews with author, Universidad Autónoma de Madrid and Central Headquarters of CSIC, 2009, 2010 and 2011.
- 7.
B. Frangione, phone interview with author, 2009, and personal communication, 2012. Annual reports of the Department of Pathology, NYU Medical Center, Archives of New York University, 1963–1973.
- 8.
On the importance of place in emerging scientific spaces see Meyer and Molyneux-Hodgson (Chap. 4).
- 9.
Personal Archive of A. Martín-Municio, Faculty of Chemistry, Universidad Complutense de Madrid (Spain), uncatalogued folder on NSF. J. Gavilanes and R. Rodríguez, interview with author, Faculty of Chemistry, Universidad Complutense de Madrid, 2009 and 2012.
- 10.
CBM, Memoria, 1975–1978. F. Soriano, interview with author, Centro de Ciencias Humanas y Sociales (CSIC), 2011.
- 11.
Newspaper Archive of the Spanish Biblioteca Nacional, June 2011. Search of keywords ‘Hospital Ramón y Cajal’ with chronological restriction 1965–1985.
- 12.
E. Rodríguez Ocaña and T. Ortiz: “Medical research in Franco’s Spain: an overview”, paper delivered at the conference Science, Scientists and Totalitarian Systems: Spanish Science during Francoism, Universidad Pompeu Fabra, Barcelona, 2008. J.M. Sancho Rof, interview with author, Hospital Ramón y Cajal, 2010. Hospital Ramón y Cajal, Memoria Anual, years 1977–1979.
- 13.
On the importance of specialised techniques and training spaces see Sormani (Chap. 13).
- 14.
Hospital Ramón y Cajal, Memoria Anual, years 1980–1994. In 1992, the format of the reports changed and Méndez’s laboratory features only under the section “Research Activity”.
- 15.
Quote from Ley 13/1986, de 14 de abril, de Fomento y Coordinación General de la Investigación Científica y Técnica, section “Exposición de motivos”. Available at http://www.boe.es/buscar/doc.php?id=BOE-A-1986-9479 (last accessed March 2014).
- 16.
CBM, Memoria, 1981–1985.
- 17.
C. López-Otín, J. Ávila and M. Salas, interviews with author, phone and CBM, 2008 and 2009.
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Acknowledgements
Special thanks are given to M.J. Santesmases, A. Romero, E. Muñoz and other researchers at the Instituto de Filosofía (CSIC), as well as to the editors of this volume. J. Baines thoroughly polished my English prior to publication. The scientists I interviewed – and their PAs – kindly accommodated me in their busy schedules. One of them, A. Sánchez Álvarez-Insúa, died shortly after the interview and this chapter is a tribute to his memory. E. Méndez’s widow, Pilar, provided both valuable memories and records. Other people who helped me at different stages of my work are: X. Calvó, A. Nieto-Galán, A. Presas, J. Guillem, J.R. Bertomeu, D. Teira, J. Bunde, A. Lee, R. Gutiérrez, V. Olmedo and P. Martínez. The research for this chapter was funded by the projects HUM2006-04939/FISO, FFI2009-07522 and FFI2012-34076, awarded by the Spanish National R&D Programme, and by two contracts within the schemes JAE-Doc and Juan de la Cierva, awarded by CSIC and the Spanish Government.
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García-Sancho, M. (2016). Recasting the Local and the Global: The Three Lives of Protein Sequencing in Spanish Biomedical Research (1967–1995). In: Merz, M., Sormani, P. (eds) The Local Configuration of New Research Fields. Sociology of the Sciences Yearbook, vol 29. Springer, Cham. https://doi.org/10.1007/978-3-319-22683-5_12
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