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microRNA: Medical Evidence pp 291–305Cite as

microRNA and Wound Healing

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 888))

Abstract

microRNAs (miRNAs) are small noncoding RNA molecules which play pivotal roles in wound healing. The increased expression of certain genes and expression of some others represent a key component of the wound biology and are largely under the regulation of naturally occurring miRNAs. Understanding the dysregulated miRNAs in chronic wound biology will therefore enable the development of newer therapies. This chapter focuses on the miRNAs that can be potentially targeted for improving skin wound healing and the challenges in miRNA therapy, including considerations in miRNA target identification and delivery.

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Acknowledgement

Supported by NIH RO1 grants GM069589, GM077185, and NR013898 to Chandan K Sen and DK076566 to Sashwati Roy.

Author information

Authors and Affiliations

  1. Extremity Trauma and Regenerative Medicine Division, US Army Institute of Surgical Research, 3698 Chambers Pass, BHT-1, Joint Base-San Antonio, Fort Sam Houston, San Antonio, TX, 78234, USA

    Jaideep Banerjee

  2. The Ohio State University Wexner Medical Center, Davis Heart & Lung Research Institute, Comprehensive Wound Center, Center for Regenerative Medicine & Cell-Based Therapies, 473 West, 12th Avenue, Columbus, OH, 43210, USA

    Chandan K. Sen

Authors
  1. Jaideep Banerjee
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  2. Chandan K. Sen
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Correspondence to Jaideep Banerjee .

Editor information

Editors and Affiliations

  1. Columbia University Medical Center, New York, New York, USA

    Gaetano Santulli

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Banerjee, J., Sen, C.K. (2015). microRNA and Wound Healing. In: Santulli, G. (eds) microRNA: Medical Evidence. Advances in Experimental Medicine and Biology, vol 888. Springer, Cham. https://doi.org/10.1007/978-3-319-22671-2_15

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