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Exploiting microRNA Specificity and Selectivity: Paving a Sustainable Path Towards Precision Medicine

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Book cover microRNA: Medical Evidence

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 888))

Abstract

In his State of the Union address before both chambers of the US Congress, President Barack Obama called for increased investment in US infrastructure and research and announced the launch of a new Precision Medicine Initiative, aiming to accelerate biomedical discovery. Due to their well-established selectivity and specificity, microRNAs can represent a useful tool, both in diagnosis and therapy, in forging the path towards the achievement of precision medicine. This introductory chapter represents a guide for the Reader in examining the functional roles of microRNAs in the most diverse aspects of clinical practice, which will be explored in this third volume of the microRNA trilogy.

The original version of this chapter was revised. The erratum to this chapter is available at: DOI 10.1007/978-3-319-22671-2_22

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References

  1. McCarthy M. Obama promises to defend health law and promote “precision medicine”. BMJ. 2015;350:h385.

    Article  PubMed  Google Scholar 

  2. Elwood TW. The usefulness of discerning patterns. J Allied Health. 2015;44:1.

    PubMed  Google Scholar 

  3. Collins FS, Varmus H. A new initiative on precision medicine. N Engl J Med. 2015;372:793–5.

    Article  CAS  PubMed  Google Scholar 

  4. Fox JL. Obama catapults patient-empowered Precision Medicine. Nat Biotechnol. 2015;33:325.

    Article  CAS  PubMed  Google Scholar 

  5. Lin AH, Timberlake N, Logg CR, Liu Y, Kamijima S, Diago O, et al. MicroRNA 142-3p attenuates spread of replicating retroviral vector in hematopoietic lineage-derived cells while maintaining an antiviral immune response. Hum Gene Ther. 2014;25:759–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Santulli G, Wronska A, Uryu K, Diacovo TG, Gao M, Marx SO, et al. A selective microRNA-based strategy inhibits restenosis while preserving endothelial function. J Clin Invest. 2014;124:4102–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Edwards JK, Pasqualini R, Arap W, Calin GA. MicroRNAs and ultraconserved genes as diagnostic markers and therapeutic targets in cancer and cardiovascular diseases. J Cardiovasc Transl Res. 2010;3:271–9.

    Article  PubMed  Google Scholar 

  8. Ristori E, Lopez-Ramirez MA, Narayanan A, Hill-Teran G, Moro A, Calvo CF, et al. A dicer-miR-107 interaction regulates biogenesis of specific miRNAs crucial for neurogenesis. Dev Cell. 2015;32:546–60.

    Article  CAS  PubMed  Google Scholar 

  9. Santulli G, Iaccarino G, De Luca N, Trimarco B, Condorelli G. Atrial fibrillation and microRNAs. Front Physiol. 2014;5:15.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Della Peruta M, Badar A, Rosales C, Chokshi S, Kia A, Nathwani D, et al. Preferential targeting of disseminated liver tumors using a recombinant adeno-associated viral vector. Hum Gene Ther. 2015;26:94–103.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Sardu C, Marfella R, Santulli G, Paolisso G. Functional role of miRNA in cardiac resynchronization therapy. Pharmacogenomics. 2014;15:1159–68.

    Article  CAS  PubMed  Google Scholar 

  12. Schratt GM, Tuebing F, Nigh EA, Kane CG, Sabatini ME, Kiebler M, et al. A brain-specific microRNA regulates dendritic spine development. Nature. 2006;439:283–9.

    Article  CAS  PubMed  Google Scholar 

  13. Taulli R, Pandolfi PP. “Snorkeling” for missing players in cancer. J Clin Invest. 2012;122:2765–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Wronska A, Kurkowska-Jastrzebska I, Santulli G. Application of microRNAs in diagnosis and treatment of cardiovascular disease. Acta Physiol (Oxf). 2015;213:60–83.

    Article  CAS  Google Scholar 

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Acknowledgements

Dr. Santulli is supported by the NIH (1K99DK107895).

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Correspondence to Gaetano Santulli M.D., Ph.D. .

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© 2015 Springer International Publishing Switzerland

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Santulli, G. (2015). Exploiting microRNA Specificity and Selectivity: Paving a Sustainable Path Towards Precision Medicine. In: Santulli, G. (eds) microRNA: Medical Evidence. Advances in Experimental Medicine and Biology, vol 888. Springer, Cham. https://doi.org/10.1007/978-3-319-22671-2_1

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