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Molecular Pathways in Growth and Survival: Epigenomics

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Waldenström’s Macroglobulinemia

Abstract

Epigenetics refers to those heritable changes in gene expression that are not induced by DNA sequence aberrations. One of the most well-defined epigenetic markers is histone acetylation which has been shown to be deregulated in clonal disorders, including both solid tumors and B-cell malignancies, such as Waldenstrom’s Macroglobulinemia (WM). Importantly, recent evidences have suggested that WM cells present with an aberrant histone acetylation status, and this may be due to deregulated microRNA profiling within the WM tumor clone, thus providing the preclinical support for using miRNA-based therapies in this disease.

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Author information

Authors and Affiliations

  1. Centro per la Ricerca Emato-oncologica AIL (CREA), ASST Spedali Civili di Brescia, Brescia, BS, 25123, Italy

    Antonio Sacco & Irene M. Ghobrial

  2. Department of Medical Oncology, Dana-Farber Cancer Institute, 02215, Boston, MA, USA

    Michele Moschetta & Salomon Manier

  3. Department of Hematology, ASST Spedali Civili di Brescia, 25123, Brescia, BS, Italy

    Giuseppe Rossi & Aldo M. Roccaro MD, PhD

Authors
  1. Antonio Sacco
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  2. Michele Moschetta
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  3. Salomon Manier
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  4. Giuseppe Rossi
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  5. Irene M. Ghobrial
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  6. Aldo M. Roccaro MD, PhD
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Corresponding author

Correspondence to Aldo M. Roccaro MD, PhD .

Editor information

Editors and Affiliations

  1. Haematology, Hôpital Pitié-Salpêtriêre, Paris, France

    Véronique Leblond

  2. Dana Farber Cancer Institute, Boston, Massachusetts, USA

    Steve Treon

  3. School of Medicine, University of Athens, Athens, Greece

    Meletios Dimoploulos

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© 2017 Springer International Publishing Switzerland

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Sacco, A., Moschetta, M., Manier, S., Rossi, G., Ghobrial, I.M., Roccaro, A.M. (2017). Molecular Pathways in Growth and Survival: Epigenomics. In: Leblond, V., Treon, S., Dimoploulos, M. (eds) Waldenström’s Macroglobulinemia. Springer, Cham. https://doi.org/10.1007/978-3-319-22584-5_6

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  • DOI: https://doi.org/10.1007/978-3-319-22584-5_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-22583-8

  • Online ISBN: 978-3-319-22584-5

  • eBook Packages: MedicineMedicine (R0)

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