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MRI-Guided HIFU Methods for the Ablation of Liver and Renal Cancers

  • Chapter
Therapeutic Ultrasound

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 880))

Abstract

MRI-guided High Intensity Focused Ultrasound (MRI-HIFU) is a promising method for the non-invasive ablation of pathological tissue in many organs, including mobile organs such as liver and kidney. The possibility to locally deposit thermal energy in a non-invasive way opens a path towards new therapeutic strategies with improved reliability and reduced associated trauma, leading to improved efficacy, reduced hospitalization and costs. Liver and kidney tumors represent a major health problem because not all patients are suitable for curative treatment with surgery. Currently, radio-frequency is the most used method for percutaneous ablation. The development of a completely non-invasive method based on MR guided high intensity focused ultrasound (HIFU) treatments is of particular interest due to the associated reduced burden for the patient, treatment related patient morbidity and complication rate. The objective of MR-guidance is hereby to control heat deposition with HIFU within the targeted pathological area, despite the physiological motion of these organs, in order to provide an effective treatment with a reduced duration and an increased level of patient safety. Regarding this, several technological challenges have to be addressed: Firstly, the anatomical location of both organs within the thoracic cage requires inter-costal ablation strategies, which preserve the therapeutic efficiency, but prevent undesired tissue damage to the ribs and the intercostal muscle. Secondly, both therapy guidance and energy deposition have to be rendered compatible with the continuous physiological motion of the abdomen.

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Authors and Affiliations

  1. Imaging Division, Department of UMCU, University Medical Center Utrecht, Utrecht, Netherlands

    Baudouin Denis de Senneville

  2. Mathematical Institute of Bordeaux, Department of CNRS, UMR 5251 CNRS/University of Bordeaux, Talence, 33400, France

    Baudouin Denis de Senneville, Chrit Moonen & Mario Ries

Authors
  1. Baudouin Denis de Senneville
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  2. Chrit Moonen
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  3. Mario Ries
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Correspondence to Baudouin Denis de Senneville .

Editor information

Editors and Affiliations

  1. Inserm U930 "Imagerie et Cerveau", Université François Rabelais de Tours - Faculté de Médecine, Tours Cedex 1, France

    Jean-Michel Escoffre

  2. Inserm U930 "Imagerie et Cerveau", Université François Rabelais de Tours - Faculté de Médecine, Tours Cedex 1, France

    Ayache Bouakaz

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de Senneville, B.D., Moonen, C., Ries, M. (2016). MRI-Guided HIFU Methods for the Ablation of Liver and Renal Cancers. In: Escoffre, JM., Bouakaz, A. (eds) Therapeutic Ultrasound. Advances in Experimental Medicine and Biology, vol 880. Springer, Cham. https://doi.org/10.1007/978-3-319-22536-4_3

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