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Therapeutic Ultrasound pp 331–338Cite as

Drug and Gene Delivery using Sonoporation for Cardiovascular Disease

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 880))

Abstract

Using the improvements made in diagnostic contrast enhanced ultrasound, researchers have made significant progress in the field of ultrasound-mediated sonoporation for drug delivery. Many programs take advantage of commercial products; both ultrasound imaging systems and contrast agents to better enable translation from preclinical to first-in-man studies (Kotopoulis et al., Med Phys 40:072902, 2013). Particularly well-suited targets for this novel therapy are diseases of the cardiovascular system. This chapter will highlight several recent studies addressing treatment of both acute and chronic conditions.

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References

  • AIM-HIGH Investigators; Boden WE, Probstfield JL, Anderson T, Chaitman BR, Desvignes-Nickens P, Koprowicz K, McBride R, Teo K, Weintraub W (2011) Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med 365:2255–2267

    Google Scholar 

  • Ason B, Castro-Perez J, Tep S, Stefanni A, Tadin-Strapps M, Roddy T, Hankemeier T, Hubbard B, Sachs AB, Michael Flanagan W, Kublin NA, Mitnaul LJ (2011) ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5). Lipids 46:991–1003

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Black DM, Delmas PD, Eastell R, Reid R, Boonen S, Cauley JA, Cosman F, Lakatos P, Leung PC, Man Z, Mautalen C, Mesenbrink P, Hu H, Caminis J, Tong K, Rosario-Jansen T, Krasnow J, Hue TF, Sellmeyer D, Eriken EF, Cummings SR, HORIZON Pivotal Fracture Trial (2007) Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 356:1809–1822

    Article  CAS  PubMed  Google Scholar 

  • Castle J, Butts M, Healey A, Kent K, Marino M, Feinstein SB (2013) Ultrasound-mediated targeted drug delivery: recent success and remaining challenges. Am J Physiol Heart Circ Physiol 304:H350–H357

    Article  CAS  PubMed  Google Scholar 

  • Castle J, Roberts J, Feinstein SB (2014) Localized gene delivery for the elevation of HDL. Paper presented at the 29th annual advances in contrast ultrasound – ICUS Bubble conference, Chicago, 17–19 Sept 2014

    Google Scholar 

  • Chen ZY, Lin Y, Yang F, Jiang L, Ge SP (2013) Gene therapy for cardiovascular disease mediated by ultrasound and microbubbles. Cardiovasc Ultrasound 11:11

    Article  PubMed Central  PubMed  Google Scholar 

  • Chiesa G, Monteggia E, Marchesi M, Lorenzon P, Laucello M, Lorusso V, Di Mario C, Karvouni E, Newton RS, Bisgaier CL, Franceschini G, Sirtori CR (2002) Recombinant apolipoprotein A-I(Milano) infusion into rabbit carotid artery rapidly removes lipid from fatty streaks. Circ Res 90:974–980

    Article  CAS  PubMed  Google Scholar 

  • Culp WC, Porter TR, Xie F, Goertzen TC, McCowan TC, Vonk BN, Baxter BT (2001) Microbubble potentiated ultrasound as a method of declotting thrombosed dialysis grafts: experimental study in dogs. Cardiovasc Intervent Radiol 24:407–412

    Article  CAS  PubMed  Google Scholar 

  • Darge K, Papadopoulou F, Ntoulia A, Bulas DI, Coley BD, Fordham LA, Paltiel HJ, McCarville B, Volberg FM, Cosgrove DO, Goldberg BB, Wilson SR, Feinstein SB (2013) Safety of contrast-enhanced ultrasound in children for non-cardiac applications: a review by the Society for Pediatric Radiology (SPR) and the International Contrast Ultrasound Society (ICUS). Pediatr Radiol 43:1063–1073

    Article  PubMed  Google Scholar 

  • Deeks ED, Perry CM (2008) Zoledronic acid: a review of its use in the treatment of osteoporosis. Drugs Aging 25:963–986

    Article  CAS  PubMed  Google Scholar 

  • Deng CX, Sieling E, Pan H, Cui J (2004) Ultrasound-induced cell membrane porosity. Ultrasound Med Biol 30:519–526

    Article  PubMed  Google Scholar 

  • Fishbein I, Chorny M, Levy RJ (2010) Site-specific gene therapy for cardiovascular disease. Curr Opin Drug Discov Devel 13:203–213

    PubMed Central  CAS  PubMed  Google Scholar 

  • Fisher EA, Feig JE, Hewing B, Hazen SL, Smith JD (2012) High-density lipoprotein function, dysfunction, and reverse cholesterol transport. Arterioscler Thromb Vasc Biol 32:2813–2820

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Gomaraschi M, Ossoli A, Favari E, Adorni MP, Sinagra G, Cattin L, Veglia F, Bernini F, Franceschini G, Calabresi L (2013) Inflammation impairs eNOS activation by HDL in patients with acute coronary syndrome. Cardiovasc Res 100:36–43

    Article  CAS  PubMed  Google Scholar 

  • Hacein-Bey-Abina S, von Kalle C, Schmidt M, Le Deist F, Wulffraat N, McIntyre E, Radford I, Villeval JL, Fraser CC, Cavazzana-Calvo M, Fischer A (2003a) A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 348:255–256

    Article  PubMed  Google Scholar 

  • Hacein-Bey-Abina S, von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, de Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, McIntytre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A, Cavazzana-Calvo M (2003b) LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302:415–419

    Article  CAS  PubMed  Google Scholar 

  • HPS2-THRIVE Collaborative Group; Landray MJ, Haynes R, Hopewell JC Parish S, Aung T, Tomson J, Wallendszus K, Craig M Jiang L, Collins R, Armitage J (2014) Effects of extended-release niacin with laropiprant in high-risk patients. N Engl J Med 371:203–212

    Google Scholar 

  • Ishihara K (1993) Administering anticancer drugs to specific locations in human bodies. USA Patent US 5190766 A

    Google Scholar 

  • Juffermans LJ, van Dijk A, Jongenelen CA, Drukarch B, Reijerkerk A, de Vries HE, Kamp O, Musters RJ (2009) Ultrasound and microbubble-induced intra- and intercellular bioeffects in primary endothelial cells. Ultrasound Med Biol 35:1917–1927

    Article  PubMed  Google Scholar 

  • Kotopoulis S, Dimcevski G, Gilja OH, Hoem D, Postema M (2013) Treatment of human pancreatic cancer using combined ultrasound, microbubbles, and gemcitabine: a clinical case study. Med Phys 40:072902

    Article  PubMed  Google Scholar 

  • Lambrinoudaki I, Vlachou S, Galapi F, Papadimitriou D, Papadias K (2008) Once-yearly zoledronic acid in the prevention of osteoporotic bone fractures in postmenopausal women. Clin Interv Aging 3:445–451

    PubMed Central  CAS  PubMed  Google Scholar 

  • Liu F, Zhu J, Huang Y, Guo W, Rui M, Xu Y, Hu B (2013) Hypolipidemic effect of SR-BI gene delivery by combining cationic liposomal microbubbles and ultrasound in hypercholesterolemic rats. Mol Med Rep 7:1965–1969

    CAS  PubMed  Google Scholar 

  • Mathias W, Kamp O and Porter T (2014) Sonothrombolysis the SAMI study. Paper presented at the 29th annual advances in contrast ultrasound – ICUS Bubble conference. Chicago, 1719 Sept 2014

    Google Scholar 

  • Merrick A (2008) How Walgreen changed its prescription for growth. Wall Street J, p. B1

    Google Scholar 

  • Nicholls SJ, Tuzcu EM, Sipahi I, Schoenhagen P, Crowe T, Kapadia S, Nissen SE (2006) Relationship between atheroma regression and change in lumen size after infusion of apolipoprotein A-I Milano. J Am Coll Cardiol 47:992–997

    Article  CAS  PubMed  Google Scholar 

  • Nissen SE, Tardif JC, Nicholls SJ, Revkin JH, Shear CL, Duggan WT, Ruzyllo W, Bachinsky WB, Lasala GP, Tuzcu E, ILLUSTRATE Investigators (2007) Effect of torcetrapib on the progression of coronary atherosclerosis. N Engl J Med 356:1304–1316

    Article  CAS  PubMed  Google Scholar 

  • Pan H, Zhou Y, Sieling F, Shi J, Cui J, Deng C (2004) Sonoporation of cells for drug and gene delivery. Conf Proc IEEE Eng Med Biol Soc 5:3531–3534

    CAS  PubMed  Google Scholar 

  • Pollack A (2012) New drugs for lipids set off race. New York Times. November 5, 2012 page B1

    Google Scholar 

  • Rader DJ, deGoma EM (2014) Future of cholesteryl ester transfer protein inhibitors. Annu Rev Med 65:385–403

    Article  CAS  PubMed  Google Scholar 

  • Reis ED, Roque M, Dansky H, Fallon JT, Badimon JJ, Cordon-Cardo C, Shiff SJ, Fisher EA (2000) Sulindac inhibits neointimal formation after arterial injury in wild-type and apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A 97:12764–12769

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Rubiera M, Ribo M, Delgado-Mederos R, Santamarina E, Maisterra O, Delgado P, Montaner J, Alvarez-Sabin J, Molina CA (2008) Do bubble characteristics affect recanalization in stroke patients treated with microbubble-enhanced sonothrombolysis? Ultrasound Med Biol 34:1573–1577

    Article  PubMed  Google Scholar 

  • Shaw JA, Bobik A, Murphy A, Kanellakis P, Blombery P, Mukhamedova N, Woollard K, Lyon S, Sviridov D, Dart AM (2008) Infusion of reconstituted high-density lipoprotein leads to acute changes in human atherosclerotic plaque. Circ Res 103:1084–1091

    Article  CAS  PubMed  Google Scholar 

  • Sirsi SR, Borden MA (2012) Advances in ultrasound mediated gene therapy using microbubble contrast agents. Theranostics 2:1208–1222

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Slikkerveer J, Kleijn SA, Appelman Y, Porter TR, Veen G, van Rossum AC, Kamp O (2012) Ultrasound enhanced prehospital thrombolysis using microbubbles infusion in patients with acute ST elevation myocardial infarction: pilot of the Sonolysis study. Ultrasound Med Biol 38:247–252

    Article  PubMed  Google Scholar 

  • Staub D, Schinkel AFL, Coll B, Coli S, van der Steen AF, Reed JD, Krueger C, Thomenius KE, Adam D, Sijbrands EJ, ten Cate FJ, Feinstein SB (2010) Contrast-enhanced ultrasound imaging of the vasa vasorum from early atherosclerosis to the identification of unstable plaques. JACC Cardiovasc Imaging 3:761–771

    Article  PubMed  Google Scholar 

  • Suzuki J, Ogawa M, Takayama K, Taniyama Y, Morishita R, Hirata Y, Nagai R, Isobe M (2010) Ultrasound-microbubble–mediated intercellular adhesion molecule-1 small interfering ribonucleic acid transfection attenuates neointimal formation after arterial injury in mice. J Am Coll Cardiol 55:904–913

    Article  CAS  PubMed  Google Scholar 

  • Tadin-Strapps M, Peterson LB, Cumiskey AM, Rosa RL, Mendoza VH, Castro-Perez J, Puig O, Zhang L, Strapps WR, Yendluri S, Andrews L, Pickering V, Rice J, Luo L, Chen Z, Tep S, Ason B, Somers EP, Sachs AB, Bartz SR, Tian J, Chin J, Hubbard BK, Wong KK, Mitnaul LJ (2011) SiRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids. J Lipid Res 52:1084–1097

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Tsutsui JM, Feng X, Johanning J, Lof J, Cory B, He A, Thomas L, Matsunaga T, Unger E, Porter TR (2006) Treatment of deeply located acute intravascular thrombi with therapeutic ultrasound guided by diagnostic ultrasound and intravenous microbubbles. J Ultrasound Med 25:1161–1168

    PubMed  Google Scholar 

  • Wang W, Li W, Ma N, Steinhoff G (2013) Non-viral gene delivery methods. Curr Pharm Biotechnol 14:46–60

    CAS  PubMed  Google Scholar 

  • Yamamoto S, Yancey PG, Ikizler TA, Jerome WG, Kaseda R, Cox B, Bian A, Shintani A, Fogo AB, Linton MF, Fazio S, Kon V (2012) Dysfunctional high-density lipoprotein in patients on chronic hemodialysis. J Am Coll Cardiol 60:2372–2379

    Article  CAS  PubMed  Google Scholar 

  • Zheng C, Aikawa M (2013) High-density lipoproteins: from function to therapy. J Am Coll Cardiol 60:2380–2383

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Translational Sciences Lab, GE Global Research, Niskayuna, NY, USA

    Jason Castle

  2. SonoGene LLC, Glen Ellyn, IL, USA

    Steven B. Feinstein

  3. Section of Cardiology, Rush University Medical Center, Chicago, IL, USA

    Steven B. Feinstein

Authors
  1. Jason Castle
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  2. Steven B. Feinstein
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Corresponding author

Correspondence to Steven B. Feinstein .

Editor information

Editors and Affiliations

  1. Inserm U930 "Imagerie et Cerveau", Université François Rabelais de Tours - Faculté de Médecine, Tours Cedex 1, France

    Jean-Michel Escoffre

  2. Inserm U930 "Imagerie et Cerveau", Université François Rabelais de Tours - Faculté de Médecine, Tours Cedex 1, France

    Ayache Bouakaz

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Castle, J., Feinstein, S.B. (2016). Drug and Gene Delivery using Sonoporation for Cardiovascular Disease. In: Escoffre, JM., Bouakaz, A. (eds) Therapeutic Ultrasound. Advances in Experimental Medicine and Biology, vol 880. Springer, Cham. https://doi.org/10.1007/978-3-319-22536-4_18

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