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Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System

  • Chapter
Therapeutic Ultrasound

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 880))

Abstract

The blood-brain barrier is a serious impediment to the delivery of pharmaceutical treatments for brain diseases, including cancer, neurodegenerative and neuropsychatric diseases. Focused ultrasound, when combined with microbubbles, has emerged as an effective method to transiently and locally open the blood-brain barrier to promote drug delivery to the brain. Focused ultrasound has been used to successfully deliver a wide variety of therapeutic agents to pre-clinical disease models. The requirement for clinical translation of focused ultrasound technology is considered.

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Authors and Affiliations

  1. Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada

    Alison Burgess & Kullervo Hynynen

  2. Medical Biophysics, University of Toronto, Toronto, ON, Canada

    Kullervo Hynynen

Authors
  1. Alison Burgess
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  2. Kullervo Hynynen
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Correspondence to Kullervo Hynynen .

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  1. Inserm U930 "Imagerie et Cerveau", Université François Rabelais de Tours - Faculté de Médecine, Tours Cedex 1, France

    Jean-Michel Escoffre

  2. Inserm U930 "Imagerie et Cerveau", Université François Rabelais de Tours - Faculté de Médecine, Tours Cedex 1, France

    Ayache Bouakaz

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© 2016 Springer International Publishing Switzerland

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Burgess, A., Hynynen, K. (2016). Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System. In: Escoffre, JM., Bouakaz, A. (eds) Therapeutic Ultrasound. Advances in Experimental Medicine and Biology, vol 880. Springer, Cham. https://doi.org/10.1007/978-3-319-22536-4_16

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