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Therapeutic Ultrasound pp 263–291Cite as

Sonoporation: Applications for Cancer Therapy

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 880))

Abstract

Therapeutic efficacy of both traditional chemotherapy and gene therapy in cancer is highly dependent on the ability to deliver drugs across natural barriers, such as the vessel wall or tumor cell membranes. In this regard, sonoporation induced by ultrasound-guided microbubble (USMB) destruction has been widely investigated in the enhancement of therapeutic drug delivery given it can help overcome these natural barriers, thereby increasing drug delivery into cancer. In this chapter we discuss challenges in current cancer therapy and how some of these challenges could be overcome using USMB-mediated drug delivery. We particularly focus on recent advances in delivery approaches that have been developed to further improve therapeutic efficiency and specificity of various cancer treatments. An example of clinical translation of USMB-mediated drug delivery is also shown.

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Authors and Affiliations

  1. Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, School of Medicine, Stanford, CA, USA

    Jiale Qin, Tzu-Yin Wang & Jürgen K. Willmann

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  1. Jiale Qin
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  2. Tzu-Yin Wang
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  3. Jürgen K. Willmann
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Correspondence to Jürgen K. Willmann .

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  1. Inserm U930 "Imagerie et Cerveau", Université François Rabelais de Tours - Faculté de Médecine, Tours Cedex 1, France

    Jean-Michel Escoffre

  2. Inserm U930 "Imagerie et Cerveau", Université François Rabelais de Tours - Faculté de Médecine, Tours Cedex 1, France

    Ayache Bouakaz

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Qin, J., Wang, TY., Willmann, J.K. (2016). Sonoporation: Applications for Cancer Therapy. In: Escoffre, JM., Bouakaz, A. (eds) Therapeutic Ultrasound. Advances in Experimental Medicine and Biology, vol 880. Springer, Cham. https://doi.org/10.1007/978-3-319-22536-4_15

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