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Therapeutic Ultrasound pp 243–261Cite as

Bubble-Assisted Ultrasound: Application in Immunotherapy and Vaccination

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 880))

Abstract

Bubble-assisted ultrasound is a versatile technology with great potential in immunotherapy and vaccination. This technology involves the exposure of immune cells (i.e., dendritic cells, lymphocytes) in-vitro or diseased tissues (i.e., brain, tumor) in-vivo to ultrasound treatment with gas bubbles. Bubble destruction leads to physical forces that induce the direct delivery of weakly permeant immuno-stimulatory molecules either into the cytoplasm of immune cells, or through the endothelial barrier of diseased tissues. Hence, therapeutic antibodies (i.e., antibody-based immunotherapy) and cytokine-encoding nucleic acids (i.e., cytokine gene therapy) can be successfully delivered into diseased tissues, thus improving immune responses. In addition, protein antigens, as well as antigen-encoding nucleic acids (pDNA, mRNA), can be delivered into dendritic cells (i.e., dendritic cell-based vaccines), thus leading to a long-lasting prophylactic or therapeutic immunization. This chapter focuses on the state-of-the-art of bubble-assisted ultrasound in the field of immunotherapy and vaccination.

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Notes

  1. 1.

    PRF pulse repetition frequency.

  2. 2.

    DC duty cycle.

  3. 3.

    PNP peak negative pressure.

  4. 4.

    MI mechanical index.

  5. 5.

    PRP pulse repetition period.

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Authors and Affiliations

  1. Imaging Division, University Medical Center Utrecht, Utrecht, The Netherlands

    Jean-Michel Escoffre, Roel Deckers, Clemens Bos & Chrit Moonen

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  1. Jean-Michel Escoffre
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  2. Roel Deckers
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  3. Clemens Bos
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  4. Chrit Moonen
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Corresponding authors

Correspondence to Jean-Michel Escoffre or Clemens Bos .

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Editors and Affiliations

  1. Inserm U930 "Imagerie et Cerveau", Université François Rabelais de Tours - Faculté de Médecine, Tours Cedex 1, France

    Jean-Michel Escoffre

  2. Inserm U930 "Imagerie et Cerveau", Université François Rabelais de Tours - Faculté de Médecine, Tours Cedex 1, France

    Ayache Bouakaz

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Escoffre, JM., Deckers, R., Bos, C., Moonen, C. (2016). Bubble-Assisted Ultrasound: Application in Immunotherapy and Vaccination. In: Escoffre, JM., Bouakaz, A. (eds) Therapeutic Ultrasound. Advances in Experimental Medicine and Biology, vol 880. Springer, Cham. https://doi.org/10.1007/978-3-319-22536-4_14

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