Abstract
Cerebral arterial time constant (τ) estimates how quickly the cerebral arterial bed distal to the point of insonation is filled with arterial blood following a cardiac contraction. It is not known how τ behaves in different vascular territories in the brain. We therefore investigated the differences in τ of two cerebral arteries: the posterior inferior cerebellar artery (PICA) and the middle cerebral artery (MCA).
Transcranial Doppler cerebral blood flow velocity (CBFV) in the PICA and left MCA along with Finapres arterial blood pressure (ABP) were simultaneously recorded in 35 young healthy volunteers. τ was estimated using mathematical transformations of pulse waveforms of ABP and the CBFV of the MCA and the PICA. Since τ is independent from the vessel radius, its comparison in different cerebral arteries was feasible. Mean ABP was 76.1 ± 9.6 mmHg. The CBFV of the MCA was higher than that of the PICA (59.7 ± 7.7 vs. 41.0 ± 4.5 cm/s; p < 0.000001). τ of the PICA was shorter than that of the MCA (0.15 ± 0.03 vs. 0.18 ± 0.03 s; p < 0.000001). The MCA-supplied vascular bed has a longer distal average length, measured from the place of insonation up to the small arterioles, than the PICA-supplied vascular bed. Therefore, a longer time is needed to fill it with arterial blood volume. This study thus confirms the physiological validity of the τ concept.
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References
Aaslid R, Markwalder TM, Nornes H (1982) Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 57(6):769–774
Czosnyka M, Richards HK, Reinhard M, Steiner LA, Budohoski K, Smielewski P et al (2012) Cerebrovascular time constant: dependence on cerebral perfusion pressure and end-tidal carbon dioxide concentration. Neurol Res 34(1):17–24
Kasprowicz M, Diedler J, Reinhard M, Carrera E, Steiner LA, Smielewski P et al (2012) Time constant of the cerebral arterial bed in normal subjects. Ultrasound Med Biol 38(7):1129–1137
Kasprowicz M, Diedler J, Reinhard M, Carrera E, Smielewski P, Budohoski KP et al (2012) Time constant of the cerebral arterial bed. Acta Neurochir Suppl 114:17–21
Kasprowicz M, Czosnyka M, Soehle M, Smielewski P, Kirkpatrick PJ, Pickard JD et al (2012) Vasospasm shortens cerebral arterial time constant. Neurocrit Care 16(2):213–218
Ito H, Kanno I, Takahashi K, Ibaraki M, Miura S (2003) Regional distribution of human cerebral vascular mean transit time measured by positron emission tomography. Neuroimage 19(3):1163–1169
Chen Y, Wang DJ, Detre JA (2012) Comparison of arterial transit times estimated using arterial spin labeling. MAGMA 25(2):135–144
Reinhard M, Schork J, Allignol A, Weiller C, Kaube H (2012) Cerebellar and cerebral autoregulation in migraine. Stroke 43(4):987–993
Czosnyka M, Richards H, Pickard JD, Harris N, Iyer V (1994) Frequency-dependent properties of cerebral blood transport--an experimental study in anaesthetized rabbits. Ultrasound Med Biol 20(4):391–399
Kim DJ, Kasprowicz M, Carrera E, Castellani G, Zweifel C, Lavinio A et al (2009) The monitoring of relative changes in compartmental compliances of brain. Physiol Meas 30(7):647–659
Kontos HA (1989) Validity of cerebral arterial blood flow calculations from velocity measurements. Stroke 20(1):1–3
Aaslid R, Newell DW, Stooss R, Sorteberg W, Lindegaard KF (1991) Assessment of cerebral autoregulation dynamics from simultaneous arterial and venous transcranial Doppler recordings in humans. Stroke 22(9):1148–1154
Carrera E, Kim DJ, Castellani G, Zweifel C, Smielewski P, Pickard JD et al (2011) Effect of hyper- and hypocapnia on cerebral arterial compliance in normal subjects. J Neuroimaging 21(2):121–125
Panerai RB, Coughtrey H, Rennie JM, Evans DH (1993) A model of the instantaneous pressure–velocity relationships of the neonatal cerebral circulation. Physiol Meas 14(4):411–418
Avezaat CJ, van Eijndhoven JH (1986) The role of the pulsatile pressure variations in intracranial pressure monitoring. Neurosurg Rev 9(1–2):113–120
Ito H, Yokoyama I, Iida H, Kinoshita T, Hatazawa J, Shimosegawa E et al (2000) Regional differences in cerebral vascular response to PaCO2 changes in humans measured by positron emission tomography. J Cereb Blood Flow Metab 20(8):1264–1270
de Riva N, Budohoski KP, Smielewski P, Kasprowicz M, Zweifel C, Steiner LA et al (2012) Transcranial Doppler pulsatility index: what it is and what it isn’t. Neurocrit Care 17(1):58–66
Czosnyka M, Richards HK, Whitehouse HE, Pickard JD (1996) Relationship between transcranial Doppler-determined pulsatility index and cerebrovascular resistance: an experimental study. J Neurosurg 84(1):79–84
Reinhard M, Waldkircher Z, Timmer J, Weiller C, Hetzel A (2008) Cerebellar autoregulation dynamics in humans. J Cereb Blood Flow Metab 28(9):1605–1612
Haubrich C, Wendt A, Diehl RR, Klotzsch C (2004) Dynamic autoregulation testing in the posterior cerebral artery. Stroke 35(4):848–852
Grants
MK was supported by the Ministry of Polish Science and Higher Education.
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ICM+ (www.neurosurg.cam.ac.uk/icmplus) is licensed by the University of Cambridge, UK. MC has an interest in part of the licensing fee.
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Kasprowicz, M., Czosnyka, M., Poplawska, K., Reinhard, M. (2016). Cerebral Arterial Time Constant Recorded from the MCA and PICA in Normal Subjects. In: Ang, BT. (eds) Intracranial Pressure and Brain Monitoring XV. Acta Neurochirurgica Supplement, vol 122. Springer, Cham. https://doi.org/10.1007/978-3-319-22533-3_42
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DOI: https://doi.org/10.1007/978-3-319-22533-3_42
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