Abstract
This paper describes the use of minute-by-minute monitoring data to determine continuous optimal cerebral perfusion pressure (CPP) recommendations based on the autoregulatory status of pediatric patients with traumatic brain injury. Data from 79 children were retrospectively studied. Optimal CPP recommendations were obtained for the majority of the first 72 h of monitoring time. Actual CPP close to recommended CPP values was significantly associated with better outcome and was a significant independent predictor of better outcome when considering IMPACT model covariates in multivariate logistic regression.
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Acknowledgments
This study was supported by the Foundation for Scientific Research Flanders (FWO) (Research project G. 0904.11). Geert Meyfroidt receives funding from FWO as senior clinical investigator (1846113 N). Greet Van den Berghe receives long-term structural research financing via the Methusalem program funded by the Flemish Government (METH/08/07). We would like to acknowledge I.R. Chambers, P.A. Jones, T.Y.M. Lo, R.J. Forsyth, B. Fulton, P.J.D. Andrews, A.D. Mendelow, and R.A. Minns who designed the original study resulting in the pediatric database used here.
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The authors declare that they have no conflict of interest.
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Güiza, F., Meyfroidt, G., Lo, TY.M., Jones, P.A., Van den Berghe, G., Depreitere, B. (2016). Continuous Optimal CPP Based on Minute-by-Minute Monitoring Data: A Study of a Pediatric Population. In: Ang, BT. (eds) Intracranial Pressure and Brain Monitoring XV. Acta Neurochirurgica Supplement, vol 122. Springer, Cham. https://doi.org/10.1007/978-3-319-22533-3_38
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DOI: https://doi.org/10.1007/978-3-319-22533-3_38
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