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Precancerous Lesions of Ovarian Clear Cell and Endometrioid Carcinomas

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Precancerous Lesions of the Gynecologic Tract

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Abstract

Precancers are lesions that precede the development of invasive cancers. Nowadays, based on clinical, histopathological, and genetic evidence that will be reviewed herein, endometriosis is identified as the most likely precursor lesion for endometrioid or clear cell ovarian lesions. A strong epidemiological link with endometriosis has been reported in up to 40 % of endometrioid cancers and 50–90 % ovarian clear cell carcinoma; an association with adenofibromatous lesions is also known for both cancers. In this chapter, the author will attempt a comprehensive review of the precancerous lesions of ovarian clear cell and endometrioid carcinomas and review new advances including an attempt to explain most ovarian cancers with an origin outside the ovary, in particular the fallopian tube.

If a man will begin with certainties, he shall end in doubts; but if he will be content to begin with doubts he shall end in certainties.

Sir Francis Bacon. The Advancement of Learning (1605)

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  1. Department of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Avenue, L2, Cleveland, OH, 44195, USA

    Andres A. Roma MD

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    Oluwole Fadare

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Roma, A.A. (2016). Precancerous Lesions of Ovarian Clear Cell and Endometrioid Carcinomas. In: Fadare, O. (eds) Precancerous Lesions of the Gynecologic Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-22509-8_3

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