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The Rise and Fall of Oogonial Stem Cells Within the Historical Context of Adult Stem Cells

  • Shweta Nayak
  • Yu Ren
  • Aleksandar Rajkovic

Abstract

For decades, it has been believed that adult human female reproductive potential was determined by a finite number of primordial follicles, which are established in the embryonic gonad. The rise of adult stem cells in other organs inevitably led to investigations that searched for stem cells in various organs of the reproductive tract, including ovaries, endometrium, and uterus. Within ovaries, somatic stem cells that drive granulosa cell proliferation and provide an essential support environment for differentiating oocytes have been characterized with little controversy. No adult stem cell claim has stirred as much controversy as the one that oogonial stem cells exist and can give rise to neo-oogenesis. Such a finding would render women, previously believed to have a nonrenewable gamete supply, remarkably more like men, who are able to replenish their germ cells. We review the rise and fall of oogonial stem cells in the historical context of the general concept of adult stem cells.

Keywords

Ovary Stem cell Biology Oocyte Ovarian reserve 

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of Obstetrics, Gynecology, and Reproductive SciencesMagee-Womens Research Institute, University of PittsburghPittsburghUSA

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