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microRNA and NF-kappa B

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microRNA: Basic Science

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 887))

Abstract

Nuclear Factor kappa B (NF-κB) plays important roles in regulation of countless cellular functions, including cell cycle and apoptosis. As a versatile transcription factor, NF-κB is a target of a large amount of miRNAs. Abnormal NF-κB activity is frequently associated with an abnormal level of miRNAs, which is found to play critical roles in disease progression including cancer. While the expression and activity of NF-κB can be directly or indirectly up-regulated or downregulated by various miRNAs, NF-κB can also regulate the expression of many miRNAs. Intriguingly, reciprocal regulation between miRNAs and NF-κB, which exists in the form of positive and negative feedback loops, is often observed in various cancers. In this chapter, the mechanisms and roles of miRNA-regulated NF-κB and NF-κB-regulated miRNAs in a variety of cancers will be discussed. The potential therapeutic use of miRNAs that are up- and down-stream of NF-κB signaling pathways as targets for cancer treatment will also be accessed.

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Authors and Affiliations

  1. Edison Biotechnology Institute, Konneker Research Center, Ohio University, Athens, OH, 45701, USA

    Ye Yuan, Lingying Tong Ph.D. & Shiyong Wu Ph.D.

  2. Department of Chemistry and Biochemistry, Ohio University, Athens, OH, 45701, USA

    Ye Yuan & Shiyong Wu Ph.D.

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  1. Columbia University Medical Center, New York, New York, USA

    Gaetano Santulli

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Yuan, Y., Tong, L., Wu, S. (2015). microRNA and NF-kappa B. In: Santulli, G. (eds) microRNA: Basic Science. Advances in Experimental Medicine and Biology, vol 887. Springer, Cham. https://doi.org/10.1007/978-3-319-22380-3_9

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