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Engineering Mineralized and Load Bearing Tissues pp 129–142Cite as

Dentin Matrix Proteins in Bone Tissue Engineering

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 881))

Abstract

Dentin and bone are mineralized tissue matrices comprised of collagen fibrils and reinforced with oriented crystalline hydroxyapatite. Although both tissues perform different functionalities, they are assembled and orchestrated by mesenchymal cells that synthesize both collagenous and noncollagenous proteins albeit in different proportions. The dentin matrix proteins (DMPs) have been studied in great detail in recent years due to its inherent calcium binding properties in the extracellular matrix resulting in tissue calcification. Recent studies have shown that these proteins can serve both as intracellular signaling proteins leading to induction of stem cell differentiation and also function as nucleating proteins in the extracellular matrix. These properties make the DMPs attractive candidates for bone and dentin tissue regeneration. This chapter will provide an overview of the DMPs, their functionality and their proven and possible applications with respect to bone tissue engineering.

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Acknowledgements

We are pleased to acknowledge the long-term support from the National Institutes of Health, DE 19633 and DE 11657 for financial support of our own contributions in this area.

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Authors and Affiliations

  1. Brodie Tooth Development Genetics & Regenerative Medicine Research Laboratory Department of Oral Biology, University of Illinois at Chicago, Chicago, IL, 60612, USA

    Sriram Ravindran & Anne George Ph.D.

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  1. Sriram Ravindran
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  2. Anne George Ph.D.
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Correspondence to Anne George Ph.D. .

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Editors and Affiliations

  1. Center for Regenerative Medicine, Oregon Health and Science University, Portland, Oregon, USA

    Luiz E. Bertassoni

  2. Department of Biomaterials and Biomimetics, New York University, New York, New York, USA

    Paulo G. Coelho

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Ravindran, S., George, A. (2015). Dentin Matrix Proteins in Bone Tissue Engineering. In: Bertassoni, L., Coelho, P. (eds) Engineering Mineralized and Load Bearing Tissues. Advances in Experimental Medicine and Biology, vol 881. Springer, Cham. https://doi.org/10.1007/978-3-319-22345-2_8

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