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Craniopharyngioma: Pathological and Molecular Aspects

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Book cover Diagnosis and Management of Craniopharyngiomas

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Abstract

Craniopharyngioma (CP) (ICD-O 9350/1) is defined as a benign, partly cystic, epithelial tumour presumably derived from the Rathke’s pouch epithelium. CPs are classified in two forms with distinct morphological and molecular features: adamantinous (ACP) (ICD-O 9351/1) and papillary CP (PCP) (ICD-O 9352/1). Both ACP and PCP are regarded as grade I lesions by the World Health Organisation (WHO) Classification of Tumours of the Central Nervous System (CNS) (Rushing et al., Craniopharyngioma. In: Louis DN, Ohgaki H, Wiestler OD, Webster KC (eds) WHO classification of tumours of the central nervous system, 3rd edn. World Health Organization Press, Geneva, Switzerland, pp. 238–240, 2007). Rare tumours with mixed features of ACP and PCP have been described (Okada et al. 2010; Prieto and Pascual 2013). In this chapter, the pathological features of craniopharyngiomas as well as the latest results of molecular studies will be discussed.

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References

  • Ackland FM, Stanhope R, Preece MA (1987) Cushing’s disease and craniopharyngioma. Arch Dis Child 62:1077–1078

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Adamson TE, Wiestler OD, Kleihues P, Yasargil MG (1990) Correlation of clinical and pathological features in surgically treated craniopharyngiomas. J Neurosurg 73:12–17

    Article  CAS  PubMed  Google Scholar 

  • Agozzino L, Ferraraccio F, Accardo M et al (2006) Morphological and ultrastructural findings of prognostic impact in craniopharyngiomas. Ultrastruct Pathol 30(3):143–150

    Article  PubMed  Google Scholar 

  • Akachi K et al (1987) Malignant changes in a craniopharyngioma. No Shinkei Geka 15(8):843–848

    CAS  PubMed  Google Scholar 

  • Alison MR, Murphy G, Leedham S (2008) Stem cells and cancer: a deadly mix. Cell Tissue Res 331(1):109–124

    Article  PubMed  Google Scholar 

  • Alomari AK, Kelley BJ, Damisah E et al (2015) Craniopharyngioma arising in a Rathke’s cleft cyst: case report. J Neurosurg Pediatr 15(3):250–254

    Article  PubMed  Google Scholar 

  • Alvarez-Medina R, Le Dreau G, Ros M, Marti E (2009) Hedgehog activation is required upstream of Wnt signalling to control neural progenitor proliferation. Development 136(19):3301–3309

    Article  CAS  PubMed  Google Scholar 

  • Andoniadou CL, Signore M, Sajedi E et al (2007) Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain. Development 134(8):1499–1508

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Andoniadou CL, Gaston-Massuet C, Reddy R, Schneider RP, Blasco MA, Le Tissier P, Jacques TS, Pevny LH, Dattani MT, Martinez-Barbera JP (2012) Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma. Acta Neuropathol 124(2):259–271

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Andoniadou CL, Matsushima D, Mousavy Gharavy SN et al (2013) Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential. Cell Stem Cell 13(4):433–445

    Article  CAS  PubMed  Google Scholar 

  • Aquilina K, O’Brien DF, Farrell MA et al (2006) Primary cerebellopontine angle craniopharyngioma in a patient with Gardner syndrome. Case report and review of the literature. J Neurosurg 105(2):330–333

    Article  PubMed  Google Scholar 

  • Aquilina K, Merchant TE, Rodriguez-Galindo C et al (2010) Malignant transformation of irradiated craniopharyngioma in children: report of 2 cases. J Neurosurg Pediatr 5(2):155–161

    Article  PubMed  Google Scholar 

  • Asa SL, Kovacs K, Bilbao JM et al (1981) Immunohistochemical localization of keratin in craniopharyngiomas and squamous cell nests of the human pituitary. Acta Neuropathol 54(3):257–260

    Article  CAS  PubMed  Google Scholar 

  • Asari J, Yamanobe K, Sasaki T et al (1987) A case of prolactinoma associated with craniopharyngioma. No Shinkei Geka 15:1313–1318

    CAS  PubMed  Google Scholar 

  • Banczerowski P, Bálint K, Sipos L (2007) Temporal extradural ectopic craniopharyngioma. Case report. J Neurosurg 107(1):178–180

    Article  PubMed  Google Scholar 

  • Barbounis V, Goutas N, Efremidis A (2013) Coexistence of intracranial germ cell tumor and craniopharyngioma in an adolescent: case report and review of the literature. Int J Clin Exp Med 6(3):211–218

    PubMed  PubMed Central  Google Scholar 

  • Barker N, Ridgway RA, van Es JH et al (2009) Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457(7229):608–611

    Article  CAS  PubMed  Google Scholar 

  • Barkhoudarian G, Laws ER (2013) Craniopharyngioma: history. Pituitary 16(1):1–8

    Article  PubMed  Google Scholar 

  • Beaty NB, Ahn E (2014) Images in clinical medicine. Adamantinomatous craniopharyngioma containing teeth. N Engl J Med 370(9):860

    Article  PubMed  Google Scholar 

  • Belza J (1966) Double midline intracranial tumors of vestigial origin: contiguous intrasellar chordoma and suprasellar craniopharyngioma. Case report. J Neurosurg 25:199–204

    Article  CAS  PubMed  Google Scholar 

  • Bernstein ML, Buchino JJ. (1983) The histologic similarity between craniopharyngioma and odontogenic lesions: a reappraisal. Oral Surg Oral Med Oral Pathol. 56(5):502–11. PubMed PMID: 6196702

    Google Scholar 

  • Bhattacharjee MB, Armstrong DD, Vogel H, Cooley LD (1997) Cytogenetic analysis of 120 primary pediatric brain tumors and literature review. Cancer Genet Cytogenet 97(1):39–53

    Article  CAS  PubMed  Google Scholar 

  • Bijlsma MF, Roelink H (2010) Non-cell-autonomous signaling by Shh in tumors: challenges and opportunities for therapeutic targets. Expert Opin Ther Targets 14(7):693–702

    Article  CAS  PubMed  Google Scholar 

  • Bikmaz K, Guerrero CA, Dammers R et al (2009) Ectopic recurrence of craniopharyngiomas: case report. Neurosurgery 64(2):E382–E383

    Article  PubMed  Google Scholar 

  • Boongird A, Laothamatas J, Larbcharoensub N, Phudhichareonrat S (2009) Malignant craniopharyngioma: case report and review of the literature. Neuropathology 29(5):591–596

    Article  PubMed  Google Scholar 

  • Bozbuga M, Turan Suslu H, Hicdonmez T, Bayindir C (2011) Primary cerebellopontine angle craniopharyngioma in a patient with Gardner syndrome. J Clin Neurosci 18(2):300–301

    Article  PubMed  Google Scholar 

  • Brastianos PK, Taylor-Weiner A, Manley PE et al (2014) Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nat Genet 46(2):161–165

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Broggi G, Franzini A, Cajola L, Pluchino F (1994) Cell kinetic investigations in craniopharyngioma: preliminary results and considerations. Pediatr Neurosurg 21(Suppl 1):21–23

    Article  PubMed  Google Scholar 

  • Burghaus S, Holsken A, Buchfelder M et al (2010) A tumor-specific cellular environment at the brain invasion border of adamantinomatous craniopharyngiomas. Virchows Arch 456:287–300

    Article  PubMed  Google Scholar 

  • Buslei R, Nolde M, Hofmann B et al (2005) Common mutations of beta-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region. Acta Neuropathol 109(6):589–597

    Article  CAS  PubMed  Google Scholar 

  • Buslei R, Holsken A, Hofmann B et al (2007) Nuclear beta-catenin accumulation associates with epithelial morphogenesis in craniopharyngiomas. Acta Neuropathol 113(5):585–590

    Article  CAS  PubMed  Google Scholar 

  • Caceres A, Reitman AJ, Tomita T (2005) Craniopharyngioma and Cushing disease: case report. J Neurosurg 102:318–321

    Article  PubMed  Google Scholar 

  • Campanini ML, Colli LM, Paixao BM et al (2010) CTNNB1 gene mutations, pituitary transcription factors, and MicroRNA expression involvement in the pathogenesis of adamantinomatous craniopharyngiomas. Horm Cancer 1(4):187–196

    Article  CAS  PubMed  Google Scholar 

  • Cao J, Lin JP, Yang LX, Chen K, Huang ZS (2010) Expression of aberrant beta-catenin and impaired p63 in craniopharyngiomas. Br J Neurosurg 24(3):249–256

    Article  CAS  PubMed  Google Scholar 

  • Caretti V, Sewing AC, Lagerweij T et al (2014) Human pontine glioma cells can induce murine tumors. Acta Neuropathol 127(6):897–909

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Castinetti F, Davis SW, Brue T, Camper SA (2011) Pituitary stem cell update and potential implications for treating hypopituitarism. Endocr Rev 32(4):453–471

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen H, Zhou L, Luo L et al (2013) Giant cranionasal and cystic-solid craniopharyngioma associated with extensive bone erosion and ossification. J Craniofac Surg 24(4):e398–e401

    Article  PubMed  Google Scholar 

  • Clarke MF, Fuller M (2006) Stem cells and cancer: two faces of eve. Cell 124(6):1111–1115

    Article  CAS  PubMed  Google Scholar 

  • Critchley M & Ironside RN (1926) The pituitary adenamantinomata 49(4):437–481

    Google Scholar 

  • Crotty TB, Scheithauer BW, Young WF Jr et al (1995) Papillary craniopharyngioma: a clinicopathological study of 48 cases. J Neurosurg 83(2):206–214

    Article  CAS  PubMed  Google Scholar 

  • Cushing H (1932) Intracranial tumors. Charles C Thomas, Baltimore

    Google Scholar 

  • Cusimano MD, Kovacs K, Bilbao JM et al (1988) Suprasellar craniopharyngioma associated with hyperprolactinemia, pituitary lactotroph hyperplasia, and microprolactinoma. Case report. J Neurosurg 69:620–623

    Article  CAS  PubMed  Google Scholar 

  • Davis SW, Mortensen AH, Camper SA (2011) Birthdating studies reshape models for pituitary gland cell specification. Dev Biol 352(2):215–227

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • de Almeida JP, Sherman JH, Salvatori R, Quinones-Hinojosa A (2010) Pituitary stem cells: review of the literature and current understanding. Neurosurgery 67(3):770–780

    Article  PubMed  Google Scholar 

  • Demehri S, Turkoz A, Kopan R (2009) Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell 16(1):55–66

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Deschene ER, Myung P, Rompolas P et al (2014) β-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche. Science 343(6177):1353–1356

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dietrich S, Glimm H, Andrulis M et al (2012) BRAF inhibition in refractory hairy-cell leukemia. N Engl J Med 366:2038–2040

    Article  PubMed  Google Scholar 

  • Duò D, Gasverde S, Benech F et al (2003) MIB-1 immunoreactivity in craniopharyngiomas: a clinico-pathological analysis. Clin Neuropathol 22(5):229–234

    PubMed  Google Scholar 

  • Ebrahimi A, Honegger J, Schluesener H, Schittenhelm J (2013) Osteonectin expression in surrounding stroma of craniopharyngiomas: association with recurrence rate and brain infiltration. Int J Surg Pathol 21(6):591–598

    Article  PubMed  Google Scholar 

  • Elmaci L, Kurtkaya-Yapicier O, Ekinci G et al (2002) Metastatic papillary craniopharyngioma: case study and study of tumor angiogenesis. Neuro Oncol 4(2):123–128

    PubMed  PubMed Central  Google Scholar 

  • Erfurth EM, Holmer H, Fjalldal SB (2013) Mortality and morbidity in adult craniopharyngioma. Pituitary 16:46–55

    Article  PubMed  Google Scholar 

  • Fauquier T, Rizzoti K, Dattani M et al (2008) SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland. Proc Natl Acad Sci U S A 105(8):2907–2912

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Finzi G, Cerati M, Marando A et al (2014) Mixed pituitary adenoma/craniopharyngioma: clinical, morphological, immunohistochemical and ultrastructural study of a case, review of the literature, and pathogenetic and nosological considerations. Pituitary 17(1):53–59

    Article  CAS  PubMed  Google Scholar 

  • Florio T (2011) Adult pituitary stem cells: from pituitary plasticity to adenoma development. Neuroendocrinology 94(4):256–277

    Article  CAS  Google Scholar 

  • Frangou EM, Tynan JR, Robinson CA et al (2009) Metastatic craniopharyngioma: case report and literature review. Childs Nerv Syst 25(9):1143–1147

    Article  PubMed  Google Scholar 

  • Frazier CH, Alpers BJ (1931) Adamantinoma of the craniopharyngeal duct. Arch Neurol Psychiatry 26:905–965

    Article  Google Scholar 

  • Gao S, Shi X, Wang Y, Qian H, Liu C (2011) Malignant transformation of craniopharyngioma: case report and review of the literature. J Neurooncol 103(3):719–725

    Article  PubMed  Google Scholar 

  • Garcia-Lavandeira M, Quereda V, Flores I et al (2009) A GRFa2/Prop1/stem (GPS) cell niche in the pituitary. PLoS One 4(3):e4815

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Garcia-Lavandeira M, Saez C, Diaz-Rodriguez E et al (2012) Craniopharyngiomas express embryonic stem cell markers (SOX2, OCT4, KLF4, and SOX9) as pituitary stem cells but do not coexpress RET/GFRA3 receptors. J Clin Endocrinol Metab 97(1):E80–E87

    Article  CAS  PubMed  Google Scholar 

  • Gaston-Massuet C, Andoniadou CL, Signore M et al (2011) Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans. Proc Natl Acad Sci U S A 108(28):11482–11487

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gautier A, Godbout A, Grosheny C et al (2012) Markers of recurrence and long-term morbidity in craniopharyngioma: a systematic analysis of 171 patients. J Clin Endocrinol Metab 97(4):1258–1267

    Article  CAS  PubMed  Google Scholar 

  • Ghatak NR, Hirano A, Zimmerman HM (1971) Ultrastructure of a craniopharyngioma. Cancer 27:1465–1475

    Article  CAS  PubMed  Google Scholar 

  • Giangaspero F, Burger PC, Osborne DR (1984) Suprasellar papillary squamous epithelioma (“papillary craniopharyngioma”). Am J Surg Pathol 8:57–64

    Article  CAS  PubMed  Google Scholar 

  • Gibson P, Tong Y, Robinson G et al (2010) Subtypes of medulloblastoma have distinct developmental origins. Nature 468(7327):1095–1099

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gleiberman AS, Michurina T, Encinas JM et al (2008) Genetic approaches identify adult pituitary stem cells. Proc Natl Acad Sci U S A 105(17):6332–6337

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gökalp HZ, Mertol T (1990) Cerebellopontine angle craniopharyngioma. Neurochirurgia (Stuttg) 33(1):20–21

    Google Scholar 

  • Gokden M, Mrak RE (2009) Pituitary adenoma with craniopharyngioma component. Hum Pathol 40(8):1189–1193

    Article  PubMed  Google Scholar 

  • Goldberg GM, Eshbaugh DE (1960) Squamous cell nests of the pituitary gland as related to the origin of craniopharyngiomas: a study of their presence in the newborn and infants up kato age four. Arch Pathol 70:293–299

    CAS  PubMed  Google Scholar 

  • Gong J, Zhang H, Xing S et al (2014) High expression levels of CXCL12 and CXCR4 predict recurrence of adamantinomatous craniopharyngiomas in children. Cancer Biomark 14(4):241–251

    PubMed  Google Scholar 

  • Gorski GK, McMorrow LE, Donaldson MH, Freed M (1992) Multiple chromosomal abnormalities in a case of craniopharyngioma. Cancer Genet Cytogenet 60:212–213

    Article  CAS  PubMed  Google Scholar 

  • Griffin CA, Long PP, Carson BS, Brem H (1992) Chromosome abnormalities in low-grade central nervous system tumors. Cancer Genet Cytogenet 60(1):67–73

    Article  CAS  PubMed  Google Scholar 

  • Guaraldi F, Prencipe N, di Giacomo V et al (2013) Association of craniopharyngioma and pituitary adenoma. Endocrine 44(1):59–65

    Article  CAS  PubMed  Google Scholar 

  • Gupta K, Kuhn MJ, Shevlin DW, Wacaser LE (1999) Metastatic craniopharyngioma. AJNR Am J Neuroradiol 20(6):1059–1060

    CAS  PubMed  Google Scholar 

  • Gupta DK, Ojha BK, Sarkar C et al (2006) Recurrence in craniopharyngiomas: analysis of clinical and histological features. J Clin Neurosci 13(4):438–442

    Article  PubMed  Google Scholar 

  • Han SJ, Rolston JD, Jahangiri A, Aghi MK (2014) Rathke’s cleft cysts: review of natural history and surgical outcomes. J Neurooncol 117(2):197–203

    Article  PubMed  Google Scholar 

  • Harris BT, Horoupian DS, Tse V, Herrick MK (1999) Melanotic craniopharyngioma: a report of two cases. Acta Neuropathol 98(4):433–436

    Article  CAS  PubMed  Google Scholar 

  • Harrison MJ, Morgello S, Post KD (1994) Epithelial cystic lesions of the sellar and parasellar region: a continuum of ectodermal derivatives? J Neurosurg 80(6):1018–1025

    Article  CAS  PubMed  Google Scholar 

  • He TC, Sparks AB, Rago C et al (1998) Identification of c-MYC as a target of the APC pathway. Science 281(5382):1509–1512

    Article  CAS  PubMed  Google Scholar 

  • Herbst RS (2004) Review of epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys 59(2 Suppl):21–26

    Article  CAS  PubMed  Google Scholar 

  • Herbst RS, Fukuoka M, Baselga J (2004) Gefitinib – a novel targeted approach to treating cancer. Nat Rev Cancer 4(12):956–965

    Article  CAS  PubMed  Google Scholar 

  • Hofmann BM, Kreutzer J, Saeger W et al (2006) Nuclear beta-catenin accumulation as reliable marker for the differentiation between cystic craniopharyngiomas and rathke cleft cysts: a clinico-pathologic approach. Am J Surg Pathol 30(12):1595–1603

    Article  PubMed  Google Scholar 

  • Holsken A, Kreutzer J, Hofmann BM et al (2009) Target gene activation of the Wnt signaling pathway in nuclear beta-catenin accumulating cells of adamantinomatous craniopharyngiomas. Brain Pathol 19(3):357–364

    Article  PubMed  CAS  Google Scholar 

  • Holsken A, Gebhardt M, Buchfelder M et al (2011) EGFR signaling regulates tumor cell migration in craniopharyngiomas. Clin Cancer Res 17(13):4367–4377

    Article  PubMed  CAS  Google Scholar 

  • Holsken A, Stache C, Schlaffer SM et al (2014) Adamantinomatous craniopharyngiomas express tumor stem cell markers in cells with activated Wnt signaling: further evidence for the existence of a tumor stem cell niche? Pituitary 17(6):546–556

    Article  PubMed  CAS  Google Scholar 

  • Honegger J, Renner C, Fahlbusch R, Adams EF (1997) Progesterone receptor gene expression in craniopharyngiomas and evidence for biological activity. Neurosurgery 41:1359–1364

    Article  CAS  PubMed  Google Scholar 

  • Hunter IJ (1955) Squamous metaplasia of cells of the anterior pituitary gland. J Pathol Bacteriol 69:141–145

    Article  CAS  PubMed  Google Scholar 

  • Hussain I, Eloy JA, Carmel PW, Liu JK (2013) Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies. J Neurosurg 119(1):106–112

    Article  CAS  PubMed  Google Scholar 

  • Inenaga C, Kakita A, Iwasaki Y, Yamatani K, Takahashi H (2004) Autopsy findings of a craniopharyngioma with a natural course over 60 years. Surg Neurol 61(6):536–540

    Article  PubMed  Google Scholar 

  • Ingham PW, Placzek M (2006) Orchestrating ontogenesis: variations on a theme by sonic hedgehog. Nat Rev Genet 7(11):841–850

    Article  CAS  PubMed  Google Scholar 

  • Ito M, Jamshidi J, Yamanaka K (2001) Does craniopharyngioma metastasize? Case report and review of the literature. Neurosurgery 48(4):933–935

    CAS  PubMed  Google Scholar 

  • Izumoto S, Suzuki T, Kinoshita M et al (2005) Immunohistochemical detection of female sex hormone receptors in craniopharyngiomas: correlation with clinical and histologic features. Surg Neurol 63(520–525):2005

    Google Scholar 

  • Jayakody SA, Andoniadou CL, Gaston-Massuet C et al (2012) SOX2 regulates the hypothalamic-pituitary axis at multiple levels. J Clin Invest 122(10):3635–3646

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jho EH, Zhang T, Domon C et al (2002) Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol 22(4):1172–1183

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jiang RS, Wu CY, Jan YJ, Hsu CY (1998) Primary ethmoid sinus craniopharyngioma: a case report. J Laryngol Otol 112(4):403–405

    Article  CAS  PubMed  Google Scholar 

  • Jin G, Hao S, Xie J, Mi R, Liu F (2013) Collision tumors of the sella: coexistence of pituitary adenoma and craniopharyngioma in the sellar region. World J Surg Oncol 7(11):178

    Article  Google Scholar 

  • Jones RT, Abedalthagafi MS, Brahmandam M et al (2015) Cross-reactivity of the BRAF VE1 antibody with epitopes in axonemal dyneins leads to staining of cilia. Mod Pathol 28(4):596–606

    Article  CAS  PubMed  Google Scholar 

  • Karavitaki N, Brufani C, Warner JT et al (2005) Craniopharyngiomas in children and adults: systematic analysis of 121 cases with long-term follow-up. Clin Endocrinol (Oxf) 62:397–409

    Article  CAS  Google Scholar 

  • Karavitaki N, Scheithauer BW, Watt J et al (2008) Collision lesions of the sella: coexistence of craniopharyngioma with gonadotroph adenoma and of Rathke’s cleft cyst with corticotroph adenoma. Pituitary 11:317–323

    Article  CAS  PubMed  Google Scholar 

  • Karnes PS, Tran TN, Cui MY et al (1992) Cytogenetic analysis of 39 pediatric central nervous system tumors. Cancer Genet Cytogenet 59:12–19

    Article  CAS  PubMed  Google Scholar 

  • Kasai H, Hirano A, Llena JF, Kawamoto K (1997) A histopathological study of craniopharyngioma with special reference to its stroma and surrounding tissue. Brain Tumor Pathol 14(1):41–45

    Article  CAS  PubMed  Google Scholar 

  • Kato K, Nakatani Y, Kanno H et al (2004) Possible linkage between specific histological structures and aberrant reactivation of the Wnt pathway in adamantinomatous craniopharyngioma. J Pathol 203(3):814–821

    Article  CAS  PubMed  Google Scholar 

  • Kawamata T, Kubo O, Kamikawa S, Hori T (2002) Ectopic clival craniopharyngioma. Acta Neurochir (Wien) 144(11):1221–1224

    Article  CAS  Google Scholar 

  • Kawamata T, Kubo O, Hori T (2005) Histological findings at the boundary of craniopharyngiomas. Brain Tumor Pathol 22(2):75–78

    Article  PubMed  Google Scholar 

  • Kayaselçuk F, Zorludemir S, Gümürdühü D et al (2002) PCNA and Ki-67 in central nervous system tumors: correlation with the histological type and grade. J Neurooncol 57(2):115–121

    Article  PubMed  Google Scholar 

  • Kelberman D, de Castro SC, Huang S et al (2008) SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development. J Clin Endocrinol Metab 93(5):1865–1873

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kepes JJ (1978) Transitional cell tumor of the pituitary gland developing from a Rathke’s cleft cyst. Cancer 41:337–343

    Article  CAS  PubMed  Google Scholar 

  • Kikuchi K, Ito S, Inoue H, González-Alva P et al (2012) Immunohistochemical expression of podoplanin in so-called hard α-keratin-expressing tumors, including calcifying cystic odontogenic tumor, craniopharyngioma, and pilomatrixoma. J Oral Sci 54(2):165–175

    Article  PubMed  Google Scholar 

  • Kim SK, Wang KC, Shin SH et al (2001) Radical excision of pediatric craniopharyngioma: recurrence pattern and prognostic factors. Childs Nerv Syst 17(9):531–536; discussion 537

    Article  CAS  PubMed  Google Scholar 

  • Kim JS, Crooks H, Dracheva T et al (2002) Oncogenic beta-catenin is required for bone morphogenetic protein 4 expression in human cancer cells. Cancer Res 62(10):2744–2748

    CAS  PubMed  Google Scholar 

  • Kim MS, Kim YS, Lee HK et al (2014) Primary intracranial ectopic craniopharyngioma in a patient with probable Gardner’s syndrome. J Neurosurg 120(2):337–341

    Article  PubMed  Google Scholar 

  • Kim JH, Paulus W, Heim S (2015) BRAF V600E mutation is a useful marker for differentiating Rathke’s cleft cyst with squamous metaplasia from papillary craniopharyngioma. J Neurooncol 123(1):189–191

    Article  PubMed  Google Scholar 

  • Kode A, Manavalan JS, Mosialou I et al (2014) Leukaemogenesis induced by an activating beta-catenin mutation in osteoblasts. Nature 506(7487):240–244

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kristopaitis T, Thomas C, Petruzzelli GJ, Lee JM (2000) Malignant craniopharyngioma. Arch Pathol Lab Med 124(9):1356–1360

    CAS  PubMed  Google Scholar 

  • Kurosaki M, Saeger W, Lüdecke DK (2001) Immunohistochemical localisation of cytokeratins in craniopharyngioma. Acta Neurochir (Wien) 143(2):147

    Article  CAS  Google Scholar 

  • Kusama K, Katayama Y, Oba K et al (2005) Expression of hard alpha-keratins in pilomatrixoma, craniopharyngioma, and calcifying odontogenic cyst. Am J Clin Pathol 123(3):376–381

    Article  PubMed  Google Scholar 

  • Larkin SJ, Ansorge O (2013) Pathology and pathogenesis of craniopharyngiomas. Pituitary 16(1):9–17

    Article  PubMed  Google Scholar 

  • Larkin SJ, Preda V, Karavitaki N et al (2014) BRAF V600E mutations are characteristic for papillary craniopharyngioma and may coexist with CTNNB1-mutated adamantinomatous craniopharyngioma. Acta Neuropathol 127(6):927–929. doi: 10.1007/s00401-014-1270-6. Epub 2014 Apr 9. PubMed PMID: 24715106; PubMed Central PMCID: PMC4024131

    Google Scholar 

  • Laurent-Puig P, Lievre A, Blons H (2009) Mutations and response to epidermal growth factor receptor inhibitors. Clin Cancer Res 15(4):1133–1139

    Article  CAS  PubMed  Google Scholar 

  • Lauriola L, Doglietto F, Novello M et al (2011) De novo malignant craniopharyngioma: case report and literature review. J Neurooncol 103(2):381–386

    Article  PubMed  Google Scholar 

  • Le BH, Towfighi J, Kapadia SB, Lopes MB (2007) Comparative immunohistochemical assessment of craniopharyngioma and related lesions. Endocr Pathol 18(1):23–30

    Article  CAS  PubMed  Google Scholar 

  • Lee DK, Jung HW, Kim DG et al (2001) Postoperative spinal seeding of craniopharyngioma. Case report. J Neurosurg 94(4):617–620

    Article  CAS  PubMed  Google Scholar 

  • Lee YH, Kim SD, Lim DJ et al (2009) Isolated petroclival craniopharyngioma with aggressive skull base destruction. Yonsei Med J 50(5):729–731

    Article  PubMed  PubMed Central  Google Scholar 

  • Lefranc F, Chevalier C, Vinchon M et al (2003) Characterization of the levels of expression of retinoic acid receptors, galectin-3, macrophage migration inhibitory factor and p53 in 51 adamantinomatous craniopharyngiomas. J Neurosurg 98:145–153

    Article  CAS  PubMed  Google Scholar 

  • Lefranc F, Mijatovic T, Decaestecker C et al (2005) Monitoring the expression profiles of integrins and adhesion/growth-regulatory galectins in adamantinomatous craniopharyngiomas: their ability to regulate tumor adhesiveness to surrounding tissue and their contribution to prognosis. Neurosurgery 56(4):763–776

    Article  PubMed  Google Scholar 

  • Lepore DA, Roeszler K, Wagner J et al (2005) Identification and enrichment of colony-forming cells from the adult murine pituitary. Exp Cell Res 308(1):166–176

    Article  CAS  PubMed  Google Scholar 

  • Lindholm J, Nielsen EH (2009) Craniopharyngioma: historical notes. Pituitary 12(4):352–359

    Article  CAS  PubMed  Google Scholar 

  • Losa M, Vimercati A, Acerno S et al (2004) Correlation between clinical characteristics and proliferative activity in patients with craniopharyngioma. J Neurol Neurosurg Psychiatry 75(6):889–892

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lubansu A, Ruchoux MM, Brotchi J et al (2003) Cathepsin B, D and K expression in adamantinomatous craniopharyngiomas relates to their levels of differentiation as determined by the patterns of retinoic acid receptor expression. Histopathology 43:563–572

    Article  CAS  PubMed  Google Scholar 

  • Lujambio A, Akkari L, Simon J et al (2013) Non-cell-autonomous tumor suppression by p53. Cell 153(2):449–460

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Malik JM, Cosgrove GR, VandenBerg SR (1992) Remote recurrence of craniopharyngioma in the epidural space. Case report. J Neurosurg 77(5):804–807

    Article  CAS  PubMed  Google Scholar 

  • Matsushima T, Fukui M, Ohta M et al (1980) Ciliated and goblet cells in craniopharyngioma. Acta Neuropathol 50:199–205

    Article  CAS  PubMed  Google Scholar 

  • Mendelsohn J, Baselga J (2000) The EGF receptor family as targets for cancer therapy. Oncogene 19(56):6550–6565

    Article  CAS  PubMed  Google Scholar 

  • Moshkin O, Scheithauer BW, Syro LV et al (2009) Collision tumors of the sella: craniopharyngioma and silent pituitary adenoma subtype 3: case report. Endocr Pathol 20(1):50–55

    Article  PubMed  Google Scholar 

  • Mott FW, Barrett JOW (1899) Three cases of tumor of the third ventricle. Arch Neurol (Lond) 1:417–440

    Google Scholar 

  • Mukherjee JJ, Islam N, Kaltsas G et al (1997) Clinical, radiological and pathological features of patients with Rathke’s cleft cysts: tumors that may recur. J Clin Endocrinol Metab 82:2357–2362

    CAS  PubMed  Google Scholar 

  • Müller HL (2014) Craniopharyngioma. Endocr Rev 35(3):513–543

    Article  PubMed  CAS  Google Scholar 

  • Müller HL, Gebhardt U, Schröder S et al (2010) Analyses of treatment variables for patients with childhood craniopharyngioma–results of the multicenter prospective trial KRANIOPHARYNGEOM 2000 after three years of follow-up. Horm Res Paediatr 73:175–180

    Article  PubMed  CAS  Google Scholar 

  • Musani V, Gorry P, Basta-Juzbasic A et al (2006) Mutation in exon 7 of PTCH deregulates SHH/PTCH/SMO signaling: possible linkage to WNT. Int J Mol Med 17(5):755–759

    CAS  PubMed  Google Scholar 

  • Nelson GA, Bastian FO, Schlitt M, White RL (1988) Malignant transformation in craniopharyngioma. Neurosurgery 22(2):427–429

    Article  CAS  PubMed  Google Scholar 

  • Netsky MG (1988) Epidermoid tumors. Review of the literature. Surg Neurol 29(6):477–483

    Article  CAS  PubMed  Google Scholar 

  • Nguyen LV, Vanner R, Dirks P, Eaves CJ (2012) Cancer stem cells: an evolving concept. Nat Rev Cancer 12(2):133–143

    CAS  PubMed  Google Scholar 

  • Nicolas M, Wolfer A, Raj K et al (2003) Notch1 functions as a tumor suppressor in mouse skin. Nat Genet 33(3):416–421

    Article  CAS  PubMed  Google Scholar 

  • Nishi T, Kuratsu J, Takeshima H et al (1999) Prognostic significance of the MIB-1 labeling index for patients with craniopharyngiomas. Int J Mol Med 3:157–161

    CAS  PubMed  Google Scholar 

  • Nishio S, Mizuno J, Barrow DL et al (1987) Pituitary tumors composed of adenohypophysial adenoma and Rathke’s cleft cyst elements: a clinicopathological study. Neurosurgery 21(3):371–377

    Article  CAS  PubMed  Google Scholar 

  • Novegno F, Di Rocco F, Colosimo C Jr et al (2002) Ectopic recurrences of craniopharyngioma. Childs Nerv Syst 18(9–10):468–473

    PubMed  Google Scholar 

  • Oikonomou E, Barreto DC, Soares B et al (2005) Beta-catenin mutations in craniopharyngiomas and pituitary adenomas. J Neurooncol 73(3):205–209

    Article  CAS  PubMed  Google Scholar 

  • Oka H, Kawano N, Yagishita S et al (1997) Ciliated craniopharyngioma indicates histogenetic relationship to Rathke cleft epithelium. Clin Neuropathol 16(2):103–106. PubMed PMID: 9101113

    Google Scholar 

  • Okada T, Fujitsu K, Miyahara K et al (2010) Ciliated craniopharyngioma – case report and pathological study. Acta Neurochir (Wien) 152(2):303–306 discussion 307. doi:10.1007/s00701-009-0448-5. Epub 2009 Jul 21. PubMed PMID: 19626269

    Google Scholar 

  • Ono M, Kuwano M (2006) Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs. Clin Cancer Res 12(24):7242–7251

    Article  CAS  PubMed  Google Scholar 

  • Ortega-Porcayo LA, Ponce-Gómez JA, Martínez-Moreno M et al (2015) Primary ectopic frontotemporal craniopharyngioma. Int J Surg Case Rep 9:57–60

    Article  PubMed  PubMed Central  Google Scholar 

  • Pascual JM, Rosdolsky M, Prieto R et al (2015) Jakob Erdheim (1874–1937): father of hypophyseal-duct tumors (craniopharyngiomas). Virchows Arch 467(4):459–469

    Article  PubMed  Google Scholar 

  • Paulus W, Stöckel C, Krauss J et al (1997) Odontogenic classification of craniopharyngiomas: a clinicopathological study of 54 cases. Histopathology 30(2):172–176

    Article  CAS  PubMed  Google Scholar 

  • Paulus W, Honegger J, Keyvani K, Fahlbusch R (1999) Xanthogranuloma of the sellar region: a clinicopathological entity different from adamantinomatous craniopharyngioma. Acta Neuropathol 97(4):377–382

    Article  CAS  PubMed  Google Scholar 

  • Petito CK, DeGirolami U, Earle KM (1976) Craniopharyngiomas: a clinical and pathological review. Cancer 37:1944–1952

    Article  CAS  PubMed  Google Scholar 

  • Powers CJ, New KC, McLendon RE, Friedman AH, Fuchs HE (2007) Cerebellopontine angle craniopharyngioma: case report and literature review. Pediatr Neurosurg 43(2):158–163

    Article  PubMed  Google Scholar 

  • Prabhakar V, Rao BD, Subramanyam MV (1971) Pituitary adenoma associated with craniopharyngioma. J Pathol 103:185–187

    Article  CAS  PubMed  Google Scholar 

  • Prieto R, Pascual JM, Subhi-Issa I et al (2013) Predictive factors for craniopharyngioma recurrence: a systematic review and illustrative case report of a rapid recurrence. World Neurosurg 79(5–6):733–749

    Article  PubMed  Google Scholar 

  • Proescholdt M, Merrill M, Stoerr EM et al (2011) Expression of carbonic anhydrase IX in craniopharyngiomas. J Neurosurg 115(4):796–801

    Article  CAS  PubMed  Google Scholar 

  • Qi ST, Zhou J, Pan J et al (2012) Epithelial-mesenchymal transition and clinicopathological correlation in craniopharyngioma. Histopathology 61(4):711–725

    PubMed  Google Scholar 

  • Raghavan R, Dickey WT Jr et al (2000) Proliferative activity in craniopharyngiomas: clinicopathological correlations in adults and children. Surg Neurol 54(3):241–247; discussion 248

    Article  CAS  PubMed  Google Scholar 

  • Ren X, Lin S, Wang Z et al (2012) Clinical, radiological, and pathological features of 24 atypical intracranial epidermoid cysts. J Neurosurg 116(3):611–621

    Article  PubMed  Google Scholar 

  • Ribas A, Flaherty KT (2011) BRAF targeted therapy changes the treatment paradigm in melanoma. Nat Rev Clin Oncol 8:426–433

    Article  CAS  PubMed  Google Scholar 

  • Rickert CH, Paulus W (2003) Lack of chromosomal imbalances in adamantinomatous and papillary craniopharyngiomas. J Neurol Neurosurg Psychiatry 74(2):260–261

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rienstein S, Adams EF, Pilzer D et al (2003) Comparative genomic hybridization analysis of craniopharyngiomas. J Neurosurg 98:162–164

    Article  CAS  PubMed  Google Scholar 

  • Rizzoti K, Akiyama H, Lovell-Badge R (2013) Mobilized adult pituitary stem cells contribute to endocrine regeneration in response to physiological demand. Cell Stem Cell 13(4):419–432

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rodriguez FJ, Scheithauer BW, Tsunoda S et al (2007) The spectrum of malignancy in craniopharyngioma. Am J Surg Pathol 31(7):1020–1028

    Article  PubMed  Google Scholar 

  • Romer JT, Kimura H, Magdaleno S et al (2004) Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/−)p53(−/−) mice. Cancer Cell 6(3):229–240

    Article  CAS  PubMed  Google Scholar 

  • Rubin LL, de Sauvage FJ (2006) Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov 5(12):1026–1033

    Article  CAS  PubMed  Google Scholar 

  • Rudin CM, Hann CL, Laterra J et al (2009) Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 361(12):1173–1178

    Article  CAS  PubMed  Google Scholar 

  • Rushing EJ, Giangaspero F, Paulus W, Burger PC (2007) Craniopharyngioma. In: Louis DN, Ohgaki H, Wiestler OD, Webster KC (eds) WHO classification of tumours of the central nervous system, 3rd edn. World Health Organization Press, Geneva, pp 238–240

    Google Scholar 

  • Salyer D, Carter D (1973) Squamous carcinoma arising in the pituitary gland. Cancer 31(3):713–718

    Article  CAS  PubMed  Google Scholar 

  • Sargis RM, Wollmann RL, Pytel P (2009) A 59 year-old man with sellar lesion. Brain Pathol 19(1):161–162

    Article  PubMed  Google Scholar 

  • Sarubi JC, Bei H, Adams EF et al (2001) Clonal composition of human adamantinomatous craniopharyngiomas and somatic mutation analyses of the patched (PTCH), Gsalpha and Gi2alpha genes. Neurosci Lett 310:5–8

    Article  CAS  PubMed  Google Scholar 

  • Schittenhelm J, Psaras T, Meyermann R et al (2010) Pituitary adenomas and craniopharyngiomas are CDX2 negative neoplasms. Folia Neuropathol 48:75–80

    PubMed  Google Scholar 

  • Schweizer L, Capper D, Hölsken A et al (2015) BRAF V600E analysis for the differentiation of papillary craniopharyngiomas and Rathke's cleft cysts. Neuropathol Appl Neurobiol 41(6):733–742. doi: 10.1111/nan.12201. Epub 2015 May 2. PubMed PMID: 25442675.

    Google Scholar 

  • Seemayer TA, Blundell JS, Wiglesworth FW (1972) Pituitary craniopharyngioma with tooth formation. Cancer 29:423–430

    Article  CAS  PubMed  Google Scholar 

  • Sekine S, Shibata T, Kokubu A et al (2002) Craniopharyngiomas of adamantinomatous type harbor beta-catenin gene mutations. Am J Pathol 161(6):1997–2001

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sekine S, Takata T, Shibata T et al (2004) Expression of enamel proteins and LEF1 in adamantinomatous craniopharyngioma: evidence for its odontogenic epithelial differentiation. Histopathology 45(6):573–579

    Article  CAS  PubMed  Google Scholar 

  • Shah GB, Bhaduri AS, Misra BK (2007) Ectopic craniopharyngioma of the fourth ventricle: case report. Surg Neurol 68(1):96–98

    Article  PubMed  Google Scholar 

  • Shapiro K, Till K, Grant DN. (1979) Craniopharyngiomas in childhood. A rational approach to treatment. J Neurosurg. 50(5):617–23. PubMed PMID: 430156

    Google Scholar 

  • Shin JL, Asa SL, Woodhouse LJ et al (1999) Cystic lesions of the pituitary: clinicopathological features distinguishing craniopharyngioma, Rathke’s cleft cyst, and arachnoid cyst. J Clin Endocrinol Metab 84(11):3972–3982. PubMed PMID: 10566636

    Google Scholar 

  • Shin K, Lee J, Guo N et al (2011) Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature 472(7341):110–114

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sofela AA, Hettige S, Curran O, Bassi S (2014) Malignant transformation in craniopharyngiomas. Neurosurgery 75(3):306–314

    Article  PubMed  Google Scholar 

  • Solarski A, Panke ES, Panke TW (1978) Craniopharyngioma in the pineal gland. Arch Pathol Lab Med 102(9):490–491

    CAS  PubMed  Google Scholar 

  • Stache C, Hölsken A, Fahlbusch R et al (2014) Tight junction protein claudin-1 is differentially expressed in craniopharyngioma subtypes and indicates invasive tumor growth. Neuro Oncol 16(2):256–264

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stache C, Hölsken A, Schlaffer SM et al (2015) Insights into the infiltrative behavior of adamantinomatous craniopharyngioma in a new xenotransplant mouse model. Brain Pathol 25(1):1–10. doi: 10.1111/bpa.12148. Epub 2014 May 19. PubMed PMID:24716541

    Google Scholar 

  • Sumida M, Uozumi T, Mukada K et al (1994) Rathke cleft cysts: correlation of enhanced MR and surgical findings. AJNR Am J Neuroradiol 15(3):525–532

    CAS  PubMed  Google Scholar 

  • Sun HI, Akgun E, Bicer A et al (2010) Expression of angiogenic factors in craniopharyngiomas: implications for tumor recurrence. Neurosurgery 66(4):744–750; discussion 750

    Article  PubMed  Google Scholar 

  • Szeifert GT, Julow J, Slowik F et al (1990) Pathological changes in cystic craniopharyngiomas following intracavital 90yttrium treatment. Acta Neurochir (Wien) 102(1–2):14–18. PubMed PMID: 1689531

    Google Scholar 

  • Tateyama H, Tada T, Okabe M et al (2001) Different keratin profiles in craniopharyngioma subtypes and ameloblastomas. Pathol Res Pract 197(11):735–742

    Article  CAS  PubMed  Google Scholar 

  • Tena-Suck ML, Salinas-Lara C, Arce-Arellano RI et al (2006) Clinico-pathological and immunohistochemical characteristics associated to recurrence/regrowth of craniopharyngiomas. Clin Neurol Neurosurg 108(7):661–669

    Article  PubMed  Google Scholar 

  • Tetsu O, McCormick F (1999) Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398(6726):422–426

    Article  CAS  PubMed  Google Scholar 

  • Thapar K, Stefaneanu L, Kovacs K et al (1994) Estrogen receptor gene expression in craniopharyngiomas: an in situ hybridization study. Neurosurgery 35:1012–1017

    Article  CAS  PubMed  Google Scholar 

  • Theunissen JW, de Sauvage FJ (2009) Paracrine Hedgehog signaling in cancer. Cancer Res 69(15):6007–6010

    Article  CAS  PubMed  Google Scholar 

  • Vankelecom H (2012) Pituitary stem cells drop their mask. Curr Stem Cell Res Ther 7(1):36–71

    Article  CAS  PubMed  Google Scholar 

  • Vaquero J, Zurita M, de Oya S et al (1999) Expression of vascular permeability factor in craniopharyngioma. J Neurosurg 91(5):831–834

    Article  CAS  PubMed  Google Scholar 

  • Vidal S, Kovacs K, Lloyd RV et al (2002) Angiogenesis in patients with craniopharyngiomas: correlation with treatment and outcome. Cancer 94:738–745

    Article  PubMed  Google Scholar 

  • Virik K, Turner J, Garrick R, Sheehy JP (1999) Malignant transformation of craniopharyngioma. J Clin Neurosci 6(6):527–530

    Article  CAS  PubMed  Google Scholar 

  • Visvader JE, Lindeman GJ (2012) Cancer stem cells: current status and evolving complexities. Cell Stem Cell 10(6):717–728

    Article  CAS  PubMed  Google Scholar 

  • Wang W, Chen XD, Bai HM et al (2015) Malignant transformation of craniopharyngioma with detailed follow-up. Neuropathology 35(1):50–55

    Article  CAS  PubMed  Google Scholar 

  • Weiner HL, Wisoff JH, Rosenberg ME et al (1994) Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcome. Neurosurgery 35(6):1001–1010

    Article  CAS  PubMed  Google Scholar 

  • Wheatley T, Clark JD, Stewart S (1986) Craniopharyngioma with hyperprolactinaemia due to a prolactinoma. J Neurol Neurosurg Psychiatry 49:1305–1307

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xia Z, Liu W, Li S et al (2011) Expression of matrix metalloproteinase-9, type IV collagen and vascular endothelial growth factor in adamantinous craniopharyngioma. Neurochem Res 36(12):2346–2351

    Article  CAS  PubMed  Google Scholar 

  • Xin W, Rubin MA, McKeever PE (2002) Differential expression of cytokeratins 8 and 20 distinguishes craniopharyngioma from rathke cleft cyst. Arch Pathol Lab Med 126(10):1174–1178

    CAS  PubMed  Google Scholar 

  • Xu J, You C, Zhang S et al (2006) Angiogenesis and cell proliferation in human craniopharyngioma xenografts in nude mice. J Neurosurg 105(Suppl 4):306–310

    PubMed  Google Scholar 

  • Xu J, Zhang S, You C et al (2007) Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor. J Neurooncol 83(2):183–189. Epub 2007 Apr 5. PubMed PMID: 17410335

    Google Scholar 

  • Yan Y, Tang WY, Yang G, Zhong D (2009) Isolated cerebellopontine angle craniopharyngioma. J Clin Neurosci 16(12):1655–1657

    Article  PubMed  Google Scholar 

  • Yauch RL, Gould SE, Scales SJ et al (2008) A paracrine requirement for hedgehog signalling in cancer. Nature 455(7211):406–410

    Article  CAS  PubMed  Google Scholar 

  • Yoshida A, Sen C, Asa SL, Rosenblum MK (2008) Composite pituitary adenoma and craniopharyngioma?: an unusual sellar neoplasm with divergent differentiation. Am J Surg Pathol 32(11):1736–1741

    Article  PubMed  Google Scholar 

  • Yoshimoto M, de Toledo SR, da Silva NS et al (2004) Comparative genomic hybridization analysis of pediatric adamantinomatous craniopharyngiomas and a review of the literature. J Neurosurg 101(1 Suppl):85–90

    PubMed  Google Scholar 

  • Zada G, Lin N, Ojerholm E et al (2010) Craniopharyngioma and other cystic epithelial lesions of the sellar region: a review of clinical, imaging, and histopathological relationships. Neurosurg Focus 28(4):E4

    Article  PubMed  Google Scholar 

  • Zhu L, Gibson P, Currle DS et al (2009) Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature 457(7229):603–607

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zuhur SS, Müslüman AM, Tanık C et al (2011) MGMT immunoexpression in adamantinomatous craniopharyngiomas. Pituitary 14(4):323–327

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

Dr. Cynthia Andoniadou is acknowledged for her comments on this manuscript and for preparing Fig. 2.11.

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Authors and Affiliations

  1. Institute of Brain, Behaviour and Mental Health, The University of Manchester, Manchester, UK

    Federico Roncaroli

  2. Birth Defects Research Centre, UCL Institute of Child Health, London, UK

    Juan Pedro Martinez-Barbera

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  1. Federico Roncaroli
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Correspondence to Federico Roncaroli .

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  1. Department of Biomedical Sciences, Humanitas University, Rozzano, Italy

    Andrea Lania

  2. DISCO Department Endocrinology and Diabetology Unit, University of Milan IRCCS Fondazione Policlinico Milano, Milan, Italy

    Anna Spada

  3. Neurosurgery Department, Istituto Clinico Humanitas, Rozzano (MI), Italy

    Giovanni Lasio

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Roncaroli, F., Martinez-Barbera, J.P. (2016). Craniopharyngioma: Pathological and Molecular Aspects. In: Lania, A., Spada, A., Lasio, G. (eds) Diagnosis and Management of Craniopharyngiomas. Springer, Cham. https://doi.org/10.1007/978-3-319-22297-4_2

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