Advertisement

Graves’ Disease

  • Luca GiovanellaEmail author
Chapter
  • 1.3k Downloads

Abstract

Graves’ disease is a thyroid-specific autoimmune disorder in which autoantibodies to the thyroid-stimulating hormone receptor (TSH-R) bind to TSH-R acting as agonists and stimulating more hormones to be released leading to hyperthyroidism and goiter.

This chapter provides a brief summary on Graves’ disease, including some diagnostic and therapeutic aspects. Furthermore typical diagnostic images of Graves’ disease are showed.

Keywords

Graves Basedow Hyperthyroidism Thyroid Autoimmunity Autoantibodies 

References

  1. 1.
    Giovanella L, Ceriani L, Garancini S (2001) Clinical applications of the 2nd generation assay for anti-TSH receptor antibodies in Graves’ disease. Evaluation in patients with negative 1st generation test. Clin Chem Lab Med 39:25–28CrossRefPubMedGoogle Scholar
  2. 2.
    Brent GA (2008) Graves’ disease. N Engl J Med 358:2594–2605CrossRefPubMedGoogle Scholar
  3. 3.
    Giovanella L, Ceriani L, Ghelfo A (2008) Second-generation thyrotropin receptor antibodies assay and quantitative scintigraphy in autoimmune hyperthyroidism. Horm Metab Res 40:484–486CrossRefPubMedGoogle Scholar
  4. 4.
    Meller J, Becker W (2002) The continuing importance of thyroid scintigraphy in the era of high-resolution ultrasound. Eur J Nucl Med 29(Suppl 2):425–438CrossRefGoogle Scholar
  5. 5.
    Bahn RS, Burch HB, Cooper DS et al (2011) Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Endocr Pract 17:456–520CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of Nuclear Medicine, Thyroid and PET/CT CenterOncology Institute of Southern SwitzerlandBellinzona and LuganoSwitzerland

Personalised recommendations