Medullary Thyroid Carcinoma

  • Pierpaolo Trimboli
  • Luca GiovanellaEmail author


Medullary thyroid carcinoma (MTC) is an infrequent thyroid malignancy deriving from parafollicular thyroid C cells.

This chapter provides a brief summary on MTC, including some diagnostic and therapeutic aspects. Furthermore typical diagnostic images of medullary thyroid carcinoma are discussed.


Medullary thyroid carcinoma Calcitonin Thyroid Cancer Neuroendocrine 


  1. 1.
    American Thyroid Association Guidelines Task Force, Kloos RT, Eng C, Evans DB et al (2009) Medullary thyroid cancer: management guidelines of the American Thyroid Association. Thyroid 19:565–612CrossRefGoogle Scholar
  2. 2.
    Elisei R, Bottici V, Luchetti F et al (2004) Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: experience in 10,864 patients with nodular thyroid disorders. J Clin Endocrinol Metab 89:163–168CrossRefPubMedGoogle Scholar
  3. 3.
    Trimboli P, Giovanella L (2015) Serum calcitonin negative medullary thyroid carcinoma: systematic review of the literature. Clin Chem Lab Med 53: 1507–1514CrossRefPubMedGoogle Scholar
  4. 4.
    Trimboli P, Treglia G, Guidobaldi L et al (2015) Detection rate of FNA cytology in medullary thyroid carcinoma: a meta-analysis. Clin Endocrinol 82:280–285CrossRefGoogle Scholar
  5. 5.
    Pusztaszeri MP, Bongiovanni M, Faquin WC (2014) Update on the cytologic and molecular features of medullary thyroid carcinoma. Adv Anat Pathol 21:26–35CrossRefPubMedGoogle Scholar
  6. 6.
    Trimboli P, Giovanella L, Crescenzi A et al (2014) Medullary thyroid cancer diagnosis: an appraisal. Head Neck 36:1216–1223CrossRefPubMedGoogle Scholar
  7. 7.
    Trimboli P, Seregni E, Treglia G et al (2015) Procalcitonin for detecting medullary thyroid carcinoma: a systematic review. Endocr Relat Cancer 22:R157–R164CrossRefPubMedGoogle Scholar
  8. 8.
    Treglia G, Rufini V, Salvatori M et al (2012) PET imaging in recurrent medullary thyroid carcinoma. Int J Mol Imaging 2012:324686PubMedCentralPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Section of Endocrinology and DiabetologyOspedale Israelitico of RomeRomeItaly
  2. 2.Department of Nuclear Medicine, Thyroid and PET/CT CentreOncology Institute of Southern SwitzerlandBellinzona and LuganoSwitzerland

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