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Epilepsy and Sleep: Close Connections and Reciprocal Influences

  • Chapter
Neuropsychiatric Symptoms of Epilepsy

Abstract

Epilepsy and epileptic seizures affect every aspect of a patient’s cognitive, social, and emotional well-being. Also sleep disorders have an adverse impact on daily living for both patients and their caregivers. This chapter is devoted to the relationship between epilepsy and sleep and its disorders. The effects of epilepsy on sleep architecture and the quality of sleep are reviewed discussing how sleep may affect epilepsy and the role of antiepileptic therapy on sleep structure. Evidence on the relation between epilepsy and sleep disorders is summarized with a brief discussion highlighting the differences between these disturbances. This chapter ends with an outline of the evaluation and treatment of epileptic patients with a sleep disorder.

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References

  1. Carney PR, Berry RB, Geyer JD. Clinical sleep disorders. 1st ed. Philadelphia: Lippincott Williams Wilkins; 2005.

    Google Scholar 

  2. Tinuper P, Bisulli F, Provini F, Geyer JD, Carney PR. Treating epilepsy in the presence of sleep disorders. In: Pediatric epilepsy. New York: McGraw Hill Medical; 2012. p. 343–61.

    Google Scholar 

  3. Rosen I, Blennow G, Risberg AM, Ingvar DH. Quantitative evaluation of nocturnal sleep in epileptic children. In: Sterman MB, Shouse MN, Passouant P, editors. Sleep and epilepsy. New York: Academic; 1982. p. 397–409.

    Google Scholar 

  4. Horita H, Khumagai K, Mackawa K. Overnight polygraphic study of Lennox—Gastaut syndrome. Brain Dev. 1987;9:627–35.

    Article  CAS  PubMed  Google Scholar 

  5. Tassinari CA, Rubboli G, Volpi L, Billard C, Bureau M. Electrical status epilepsticus during slow sleep (ESES or CSWS) including acquired apileptic aphasia (Landau-Klefner syndrome): chapter 18. In: Roger J, Bureau M, Dravet C, Genton P, Tassinari CA, Wolf P, editors. Epileptic syndromes in infancy, childhood and adolescence. 4th ed. London: John Libbey; 2005. p. 295–314.

    Google Scholar 

  6. Clemens B, Olah R. Sleep studies in benign epilepsy of childhood with rolandic spikes. Epilepsia. 1987;28:20–3.

    Article  CAS  PubMed  Google Scholar 

  7. Shouse MN, Martins da Silva A, Sammaritano M. Circadian rhythm, sleep and epilepsy. J Clin Neurophysiol. 1996;13:32–50.

    Article  CAS  PubMed  Google Scholar 

  8. Cortessi F, Gionnotti F, Ottaviano S. Sleep problems and behavior in childhood idiopathic epilepsy. Epilepsia. 1999;40:1557–65.

    Article  Google Scholar 

  9. Manni R, Tartara A. Evaluation of sleepiness in epilepsy. Clin Neurophysiol. 2000;111 Suppl 2:S111–4.

    Article  PubMed  Google Scholar 

  10. Provini F, Plazzi G, Tinuper P, Vandi S, Lugaresi E, Montagna P. Nocturnal frontal lobe epilepsy. A clinical and polygraphic overview of 100 consecutive cases. Brain. 1999;122(Pt 6):1017–31.

    Article  PubMed  Google Scholar 

  11. Oldani A, Zucconi M, Castronovo C, Ferini-Strambi L. Nocturnal frontal lobe epilepsy misdiagnosed as sleep apnea syndrome. Acta Neurol Scand. 1998;98:67–71.

    Article  CAS  PubMed  Google Scholar 

  12. Zucconi M, Oldani A, Smirne S, Ferini-Strambi L. The macrostructure and microstructure of sleep in patients with autosomal dominant nocturnal frontal lobe epilepsy. J Clin Neurophysiol. 2000;17:77–86.

    Article  CAS  PubMed  Google Scholar 

  13. Nobili L, Francione S, Mai R, Tassi L, Cardinale F, Castagna L, et al. Nocturnal frontal lobe epilepsy: intracerebral recordings of paroxysmal motor attacks with increasing complexity. Sleep. 2003;26:883–6.

    PubMed  Google Scholar 

  14. Vignatelli L, Bisulli F, Naldi I, Ferioli S, Pittau F, Provini F, et al. Excessive daytime sleepiness and subjective sleep quality in patients with nocturnal frontal lobe epilepsy: a case-control study. Epilepsia. 2006;47 Suppl 5:73–7.

    Google Scholar 

  15. Shouse MN, Martins da Silva A. Chronobiology. In: Engel J, Pedley TA, editors. Epilepsy: a comprehensive textbook. Philadelphia: Lippincott-Raven; 1997. p. 1917–27.

    Google Scholar 

  16. Bazil CW, Walczak TS. Effect of sleep and sleep stage on epileptic and non epileptic seizures. Epilepsia. 1997;38:56–62.

    Article  CAS  PubMed  Google Scholar 

  17. Janz D. The grand mal epilepsies and the sleeping-waking cycle. Epilepsia. 1962;3:69–109.

    Article  CAS  PubMed  Google Scholar 

  18. Janz D. Epilepsy with impulsive petit mal (juvenile myoclonic epilepsy). Acta Neurol Scand. 1985;72:449–59.

    Article  CAS  PubMed  Google Scholar 

  19. Loiseau P, Beaussart M. The seizures of benign childhood epilepsy with rolandic paroxysmal discharges. Epilepsia. 1973;14:381–9.

    Article  CAS  PubMed  Google Scholar 

  20. Gastraut H, Roger J, Soulayrol R, Tassinari CA, Régis H, Dravet C, Bernard R, Pinsard N, Saint-Jean M, et al. Childhood epileptic encephalopathy with diffuse slow spike–waves (otherwise known as “petit mal variant”) or Lennox syndrome. Epilepsia. 1966;7:139–79.

    Article  CAS  PubMed  Google Scholar 

  21. American Academy of Sleep Medicine. International classification of sleep disorders. 3rd ed. Darien: American Academy of Sleep Medicine; 2014.

    Google Scholar 

  22. Craske MG, Tsao JCI. Assessment and treatment of nocturnal panic attacks. Sleep Med Rev. 2005;9:173–84.

    Article  PubMed  Google Scholar 

  23. Guilleminault C, Billiard M, Montplaisir J, Demerit WC. Altered states of consciousness in disorders of daytime sleepiness. J Neurol Sci. 1976;26:377–93.

    Article  Google Scholar 

  24. Manni R, Terzaghi M. Comorbidity between epilepsy and sleep disorders. Epilepsy Res. 2010;90(9):171–7.

    Article  PubMed  Google Scholar 

  25. Chiorek AM, Abou-Khalil B, Malow BA. Obstructive sleep apnea is associated with seizure occurrence in older adults with epilepsy. Neurology. 2007;69:1823–7.

    Article  Google Scholar 

  26. Manni R, Terzaghi M, Arbasino C, et al. Obstructive sleep apnea in a clinical series of adult epilepsy patients: frequency and features of the comorbidity. Epilepsia. 2003;44:836–40.

    Article  PubMed  Google Scholar 

  27. Hollinger P, Khatami R, Gugger M, et al. Epilepsy and obstructive sleep apnea. Eur Neurol. 2006;55:74–9.

    Article  PubMed  Google Scholar 

  28. Malow BA, Weatherwax KJ, Chervin RD, Hoban TF, Marzec ML, Martin C, Binns LA. Identification and treatment of obstructive sleep apnea in adults and children with epilepsy: a prospective pilot study. Sleep Med. 2003;4:509–15.

    Article  PubMed  Google Scholar 

  29. Vetrugno R, Provini F, Plazzi G, Vignatelli L, Lugaresi E, Montagna P. Catathrenia (nocturnal groaning): a new type of parasomnia. Neurology. 2001;56:681–3.

    Article  CAS  PubMed  Google Scholar 

  30. DeRoeck J, Van Hoof E, Cluydts R. Sleep-related expiratory groaning: a case report. Sleep Res. 1983;12:237.

    Google Scholar 

  31. Pevernagie D, Boon P, Mariman A, Verhaeghen D, Pauwels R. Vocalization during episodes of prolonged expiration: a parasomnia related to REM sleep. Sleep Med. 2001;2:19–30.

    Article  PubMed  Google Scholar 

  32. Ohayon MM, Ferini-Strambi L, Plazzi G, Smirne S, Castronovo V. How age influences the expression of narcolepsy. J Psychosom Res. 2005;59:399–405.

    Article  PubMed  Google Scholar 

  33. Aran A, Einen M, Lin L, Plazzi G, Nishino S, Mignot E. Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children. Sleep. 2010;33:1457–64.

    PubMed Central  PubMed  Google Scholar 

  34. Pizza F, Franceschini C, Peltola H, Vandi S, Finotti E, Ingravallo F, et al. Clinical and polysomnographic course of childhood narcolepsy with cataplexy. Brain. 2013;136:3787–95.

    Article  PubMed Central  PubMed  Google Scholar 

  35. Challamel MJ, Mazzola ME, Nevismalova S, et al. Narcolepsy in children. Sleep. 1994;17:S17–20.

    CAS  PubMed  Google Scholar 

  36. Luca G, Haba-Rubio J, Dauvilliers Y, Lammers GJ, Overeem S, Donjacour CE, et al. European Narcolepsy Network. European Narcolepsy Network. Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study. J Sleep Res. 2013;22:482–95.

    Google Scholar 

  37. Zeman A, Douglas N, Aylward R. Narcolepsy mistaken for epilepsy. BMJ. 2001;322:216–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  38. Macleod S, Ferrie C, Zuberi SM. Symptoms of narcolepsy in children misinterpreted as epilepsy. Epileptic Disord. 2005;7:13–7.

    PubMed  Google Scholar 

  39. Stores G. The protean manifestations of childhood narcolepsy and their misinterpretation. Dev Med Child Neurol. 2006;48:307–10.

    Article  PubMed  Google Scholar 

  40. Mignot E, Chen W, Black J. On the value of measuring CSF hypocretin 1 in diagnosing narcolepsy. Sleep. 2003;26:646–9.

    PubMed  Google Scholar 

  41. Ohayon MM, Guilleminault C, Priest RG. Night terrors, sleepwalking, and confusional arousals in the general population: their frequency and relationship to other sleep and mental disorders. J Clin Psychiatry. 1999;60:268–76.

    Article  CAS  PubMed  Google Scholar 

  42. Broughton R, Tolentino MA. Fragmentary pathological myoclonus in NREM sleep. Electroencephalogr Clin Neurophysiol. 1984;57:303–9.

    Article  CAS  PubMed  Google Scholar 

  43. Guilleminault C, Palombini L, Pelayo R, Chervin RD. Sleepwalking and sleep terrors in prepubertal children: what triggers them? Pediatrics. 2003;111:17–25.

    Article  Google Scholar 

  44. Derry CP, Harvey AS, Walker MC, Duncan JS, Berkovic SF. NREM arousal parasomnias and their distinction from nocturnal frontal lobe epilepsy: a video EEG analysis. Sleep. 2009;32(12):1637–44.

    PubMed Central  PubMed  Google Scholar 

  45. Tinuper P, Provini F, Bisulli F, Vignatelli L, Plazzi G, Vetrugno R, et al. Movement disorders in sleep: guidelines for differentiating epileptic from non-epileptic motor phenomena arising from sleep. Sleep Med Rev. 2007;11:255–67.

    Article  PubMed  Google Scholar 

  46. Kushida CA, Littner MR, Morgenthaler T, Alessi CA, Bailey D, Coleman Jr J, et al. Practice parameters for the indications for polysomnography and related procedures: an update for 2005. Sleep. 2005;28:499–521.

    PubMed  Google Scholar 

  47. Bisulli F, Vignatelli L, Naldi I, Licchetta L, Provini F, Plazzi G, et al. Increased frequency of arousal parasomnias in families with nocturnal frontal lobe epilepsy: a common mechanism? Epilepsia. 2010;51(9):1852–60.

    Article  PubMed  Google Scholar 

  48. Schenck CH, Bundlie SR, Ettinger MG, Mahowald MW. Chronic behavioral disorders of REM sleep: a new category of parasomnia. Sleep. 1986;9:293–308.

    CAS  PubMed  Google Scholar 

  49. Olson EJ, Boeve BF, Silber MH. Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases. Brain. 2000;123:33139.

    Article  Google Scholar 

  50. Boeve BF. REM sleep behavior disorder: Updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions. Ann N Y Acad Sci. 2010;1184:15–54.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  51. Mahowald MW, Schenck CH. Insights from studying human sleep disorders. Nature. 2005;43:1279–85.

    Article  Google Scholar 

  52. Silber MH. REM sleep behaviour disorder associated with barbiturate withdrawal. Sleep Res. 1996;25:371.

    Google Scholar 

  53. Plazzi G, Montagna P, Meletti S, Lugaresi E. Polysomnographic study of sleeplessness and oneiricisms in the alcohol withdrawal syndrome. Sleep Med. 2002;3:279–82.

    Article  PubMed  Google Scholar 

  54. Schenck CH, Bundie SR, Mahovald MW. Delayed emergence of a parkinsonian disorder in 38% of 29 older males initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder. Neurology. 1996;46:388–93.

    Article  CAS  PubMed  Google Scholar 

  55. Plazzi G, Corsini R, Provini F, Pierangeli G, Martinelli P, Montagna P, et al. REM sleep behaviour disorders in multiple system atrophy. Neurology. 1997;48:1094–7.

    Article  CAS  PubMed  Google Scholar 

  56. Vetrugno R, Provini F, Cortelli P, Plazzi G, Lotti EM, Pierangeli G, et al. Sleep disorders in multiple system atrophy: a correlative video-polysomnographic study. Sleep Med. 2004;5:21–30.

    Article  PubMed  Google Scholar 

  57. Postuma RB, Iranzo A, Hogl B, Arnulf I, Ferini-Strambi L, Manni R, et al. Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: a multicenter study. Ann Neurol. 2015;77(5):830–9.

    Article  PubMed  Google Scholar 

  58. Manni R, Terzaghi M, Zambrelli E, Pacchetti C. Interictal, potentially misleading, epileptiform EEG abnormalities in REM sleep behavior disorder. Sleep. 2006;29:934–7.

    PubMed  Google Scholar 

  59. Leung AK, Robson WL. Nightmares. J Natl Med Assoc. 1993;85:233–5.

    PubMed Central  CAS  PubMed  Google Scholar 

  60. Levin R, Fireman G. Nightmare prevalence, nightmare distress, and self-reported psychological disturbance. Sleep. 2002;25:205–12.

    PubMed  Google Scholar 

  61. Koran LM, Raghavan S. Fluoxetine for isolated sleep paralysis. Psychosomatics. 1993;34:184–7.

    Article  CAS  PubMed  Google Scholar 

  62. Lottmann HB, Alova I. Primary monosymptomaic nocturnal enuresis in children and adolescents. Int J Clin Pract Suppl. 2007;155:8–16.

    Article  PubMed  Google Scholar 

  63. Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, et al. International Restless Legs Syndrome Study Group. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria – history, rationale, description, and significance. Sleep Med. 2014;15(8):860–73.

    Google Scholar 

  64. Walters A, Picchietti DL, Ehrenberg B. Restless leg syndrome in childhood and adolescence. Pediatr Neurol. 1994;11:241–5.

    Article  CAS  PubMed  Google Scholar 

  65. Kato T, Thie N, Montplaisir J, Lavigne G. Bruxism and orofacial movements during sleep. Dent Clin North Am. 2001;45:657–84.

    CAS  PubMed  Google Scholar 

  66. Meletti S, Cantalupo G, Volpi L, Rubboli G, Magaudda A, Tassinari CA. Rhythmic teeth grinding induced by temporal lobe seizures. Neurology. 2004;62:2306–9.

    Article  CAS  PubMed  Google Scholar 

  67. Bader G, Lavigne G. Sleep bruxism; an overview of an oromandibular sleep movement disorder. Sleep Med Rev. 2000;4:27–43.

    Article  PubMed  Google Scholar 

  68. Vetrugno R, Provini F, Plazzi G, Lombardi C, Liguori R, Lugaresi E, Montagna P. Familial nocturnal facio-mandibular myoclonus mimicking sleep bruxism. Neurology. 2002;58:644–7.

    Article  CAS  PubMed  Google Scholar 

  69. Chisholm T, Morehouse RL. Adult headbanging: sleep studies and treatment. Sleep. 1996;19:343–6.

    CAS  PubMed  Google Scholar 

  70. Manni R, Terzaghi M. Rhythmic movements during sleep: a physiological and pathological profile. Neurol Sci. 2005;26:s181–5.

    Article  PubMed  Google Scholar 

  71. Mayer G, Wilde-Frenz J, Kurella B. Sleep related rhythmic movement disorder revisited. J Sleep Res. 2007;16:110–6.

    Article  PubMed  Google Scholar 

  72. Manni R, Tartara A. Clonazepam treatment of rhythmic movement disorders. Sleep. 1997;20:812.

    CAS  PubMed  Google Scholar 

  73. Resnick TJ, Moshe SL, Perotta L, Chambers HJ. Benign neonatal sleep myoclonus: relation to sleep state. Arch Neurol. 1986;43:266–8.

    Article  CAS  PubMed  Google Scholar 

  74. Coulter DL, Allen RJ. Benign neonatal sleep myoclonus. Arch Neurol. 1982;39:191–2.

    Article  CAS  PubMed  Google Scholar 

  75. Di Capua M, Fusco L, Ricci S, Vigevano F. Benign neonatal sleep myoclonus: clinical features and video-polygraphic recordings. Mov Disord. 1993;8:191–4.

    Article  PubMed  Google Scholar 

  76. Alfonso I, Papazian O, Aicardi J, Jeffries HE. A simple maneuver to provoke benign neonatal sleep myoclonus. Pediatrics. 1995;96:1161–3.

    CAS  PubMed  Google Scholar 

  77. Cohen R, Shuper A, Straussberg R. Familial benign neonatal sleep myoclonus. Pediatr Neurol. 1996;5:334–7.

    Google Scholar 

  78. Brown P, Thompson PD, Rothwell JC, Day BL, Marsden CD. Axial myoclonus of propriospinal origin. Brain. 1991;114:197–214.

    PubMed  Google Scholar 

  79. Montagna P, Provini F, Plazzi G, Liguori R, Lugaresi E. Propriospinal myoclonus upon relaxation and drowsiness. A cause of severe insomnia. Mov Disord. 1997;12:66–72.

    Article  CAS  PubMed  Google Scholar 

  80. Vetrugno R, Plazzi G, Provini F, Liguori R, Lugaresi E, Montagna P. Excessive fragmentary hypnic myoclonus: clinical and neurophysiologic findings. Sleep Med. 2002;3:73–6.

    Article  PubMed  Google Scholar 

  81. Richter JE. Extraesophageal presentations of gastroesophageal reflux disease. Semin Gastrointest Dis. 1997;8:75–89.

    CAS  PubMed  Google Scholar 

  82. Foldary-Schaefer N. Sleep complaints and epilepsy: the role of seizures, antiepileptic drugs and sleep disorders. J Clin Neurophysiol. 2002;19:514–21.

    Article  Google Scholar 

  83. Bazil CW, Castro LHM, Walczak TS. Reduction of rapid eye movement sleep by diurnal and nocturnal seizures in temporal lobe epilepsy. Arch Neurol. 2000;57:363–8.

    Article  CAS  PubMed  Google Scholar 

  84. Carney PR, Kohrman MH. Relation between epilepsy and sleep during infancy and childhood. In: Bazil CW, Malow BA, Sammaritano MR, editors. Sleep and epilepsy: the clinical spectrum. Amsterdam: Elsevier Science BV; 2002. p. 359–72.

    Google Scholar 

  85. Koh S, Ward SL, Lin M, Chen LS. Sleep apnea treatment improves seizure control in children with neurodevelopmental disorders. Pediatr Neurol. 2000;22:36–9.

    Article  CAS  PubMed  Google Scholar 

  86. Foldvary N, Perry M, Lee J, Dinner D, Morris HH. The effects of lamotrigine on sleep in patients with epilepsy. Epilepsia. 2001;42(12):1569–73.

    Article  CAS  PubMed  Google Scholar 

  87. Rodriguez AJ. Pediatric sleep and epilepsy. Curr Neurol Neurosci Rep. 2007;7:342–7.

    Article  PubMed  Google Scholar 

  88. Giannotti F, Cortesi F, Bruni O. Sleep habitus in children with idiopathic epilepsy. Sleep Res. 1994;23:361 [abstract].

    Google Scholar 

  89. Touchon J, Baldy-Moulinier M, Billiard M, Besset A, Cadilhac J. Sleep organization and epilepsy. In: Degen R, Rodin EA, editors. Epilepsy, sleep and sleep deprivation. Amsterdam: Elsevier; 1991. p. 73–81.

    Google Scholar 

  90. Kellaway P, Frost JD, Mizrabi EM. Ethosuximide effect on thalamic oscillation mechanisms, spindles and generalized 3-Hz spike-and wave bursts [abstract]. Ann Neurol. 1991;30:293.

    Google Scholar 

  91. Declerck AC, Wauquier A. Influence of antiepileptic drugs on sleep patterns. In: Degen R, Rodin EA, editors. Epilepsy, sleep and sleep deprivation. 2nd ed. Amsterdam: Elsevier; 1991. p. 153–62.

    Google Scholar 

  92. Wolf P, Röder–Wanner UU, Brede M. Influence of therapeutic phenobarbital and phenytoin medication on the polygraphic sleep of patients with epilepsy. Epilepsia. 1984;25:467–75.

    Article  CAS  PubMed  Google Scholar 

  93. Manni R, Galimberti CA, Zucca C, Parietti L, Tartara A. Sleep patterns in patients with late onset partial epilepsy receiving chronic carbamazepine therapy. Epilepsy Res. 1990;7(1):72–6.

    Article  CAS  PubMed  Google Scholar 

  94. Obermayer WH, Benca RM. Effects of drugs on sleep. Neurol Clin. 1996;14:827–40.

    Article  Google Scholar 

  95. Findji J, Catani P. The effects of valproic acid on sleep parameters in epileptic children: clinical note. In: Sterman MB, Shouse MN, Passouant P, editors. Sleep and epilepsy. New York: Academic; 1982. p. 395–6.

    Google Scholar 

  96. Barzaghi N, Gatti G, Manni R, Galimberti CA, Zucca C, Tartara A, Perucca E. Time-dependent pharmacodynamic effects of phenobarbital in humans. Ther Drug Monit. 1990;11:661–6.

    Article  Google Scholar 

  97. Ehrenberg B. Importance of sleep restoration in co-morbid disease: effect of anticonvulsants. Neurology. 2000;54 suppl 1:S33–7.

    CAS  PubMed  Google Scholar 

  98. Placidi F, Diomedi M, Scalise A, Marciani MG, Romigi A, Gigli GL. Effect of anticonvulsants on nocturnal sleep in epilepsy. Neurology. 2000;54 suppl 1:S25–32.

    CAS  PubMed  Google Scholar 

  99. Adler M. Lamotrigine associated with insomnia. Epilepsia. 1999;40(3):322–5.

    Article  Google Scholar 

  100. Placidi F, Diomedi M, Scalise A, Silvestri G, Marciani MD, Gigli GL. Effect of long-term treatment with gabapentin on nocturnal sleep in epilepsy. Epilepsia. 1997;38 suppl 8:179–80.

    Google Scholar 

  101. Bonanni E, Massetani R, Galli R, Gneri C, Petri M, Iudice A, Murri L. A quantitative study of daytime sleepiness induced by carbamazepine and add-on vigabatrin in epileptic patients. Acta Neurol Scand. 1997;95:193–6.

    Article  CAS  PubMed  Google Scholar 

  102. Malow BA, Edwards J, Marzec M, Sagher O, Fromes G. Effects of vagus nerve stimulation on respiration during sleep: a pilot study. Neurology. 2000;55:1450–4.

    Article  CAS  PubMed  Google Scholar 

  103. Malow BA, Edwards J, Marzec M, Sagher O, Ross D, Fromes G. Vagus nerve stimulation reduces daytime sleepiness in epilepsy patients. Neurology. 2001;57:879–84.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

We thank the IRCCS Sleep Laboratory. We thank Mrs. Elena Zoni for graphic production and Anne Collins for editing the manuscript.

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Tinuper, P., Bisulli, F., Provini, F. (2016). Epilepsy and Sleep: Close Connections and Reciprocal Influences. In: Mula, M. (eds) Neuropsychiatric Symptoms of Epilepsy. Neuropsychiatric Symptoms of Neurological Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-22159-5_8

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