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Neurobehavioral Comorbidities of Epilepsy: Lessons from Animal Models

  • Chapter
Neuropsychiatric Symptoms of Epilepsy

Part of the book series: Neuropsychiatric Symptoms of Neurological Disease ((NSND))

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Abstract

Animal models can afford useful insights into the mechanisms of neurobehavioral comorbidities of epilepsy. However, clinical relevance and value of the information that can be extracted from animal studies depend on many factors, including choice of proper models of epilepsy, choice of proper behavioral tasks, and accounting for the presence of multiple concurrent neurobehavioral disorders in the same epileptic animal. This chapter offers an overview of approaches used to examine selected neurobehavioral comorbidities in animal models of epilepsy. Assays used to study spatial and object memory, depression, anxiety, attention deficit/hyperactivity disorder, psychosis, and autism are described. First, the approaches are presented from a standpoint of single comorbidity, and mechanisms underlying respective epilepsy-associated neurobehavioral abnormalities are discussed. Further, examples are given as to how concurrent neurobehavioral perturbations may influence one another, and therefore how this may affect outcome measures and interpretation of the obtained data. It is suggested that systemic approach, rather than more commonly used isolated approach, offers more clinical-relevant and complete description of multifactorial systems that underlie neurobehavioral comorbidities of epilepsy.

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Acknowledgments

The author wishes to thank Ms. Katherine Shin, Mr. Nathaniel Shin, and Mr. Don Shin for their creative assistance.

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  1. Neurology Division, Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, 10833 LeConte Avenue, MDCC 220474, Los Angeles, CA, 90095, USA

    Andrey Mazarati MD, PhD

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  1. Andrey Mazarati MD, PhD
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Correspondence to Andrey Mazarati MD, PhD .

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  1. Atkinson Morley Regional Neuroscience Centre, Epilepsy Group, St George’s University Hospitals NHS Foundation Trust, London, United Kingdom

    Marco Mula

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Mazarati, A. (2016). Neurobehavioral Comorbidities of Epilepsy: Lessons from Animal Models. In: Mula, M. (eds) Neuropsychiatric Symptoms of Epilepsy. Neuropsychiatric Symptoms of Neurological Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-22159-5_1

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  • DOI: https://doi.org/10.1007/978-3-319-22159-5_1

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