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Abstract

Early postoperative negative behaviour (e-PONB) and long-term negative behaviour changes affect young children after general anaesthesia. The aetiology and physiopathological mechanism are currently unclear. For clinicians, the more relevant components of e-PONB are pain, emergence delirium and emergence agitation. The recognition of the different aspects of e-PONB remains challenges, even for expert nurses and doctors. Several risk factors were described, but none clear indication for clinical practice is available due to the lack of consensus on definition, validated tools and gold standard management.

Actually, suggested management of e-PONB includes total intravenous general anaesthesia, prevention of preoperative anxious, accurate assessment of e-PONB during early period after awakening, adequate parental information and pharmacologic management of selected cases.

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References

  1. Aouad MT, Nasr VG (2005) Emergence agitation in children: an update. Curr Opin Anaesthesiol 18(6):614–619

    Article  PubMed  Google Scholar 

  2. Aouad MT, Kanazi GE, Siddik-Sayyid SM et al (2005) Preoperative caudal block prevents emergence agitation in children following sevoflurane anesthesia. Acta Anaesthesiol Scand 49:300–304

    Article  CAS  PubMed  Google Scholar 

  3. Aouad MT, Yazbeck-Karam VG, Nasr VG et al (2007) A single dose of propofol at the end of surgery for the prevention of emergence agitation in children undergoing strabismus surgery during sevoflurane anesthesia. Anesthesiology 107(5):733–738

    Article  CAS  PubMed  Google Scholar 

  4. Bajwa SA, Costi D, Cyna AM (2010) A comparison of emergence delirium scales following general anesthesia in children. Pediatr Anesth 20:704–711

    Article  Google Scholar 

  5. Banchs RJ, Lerman J (2014) Preoperative anxiety management, emergence delirium, and postoperative behavior. Anesthesiol Clin 32(1):1–23

    Article  PubMed  Google Scholar 

  6. Beringer RM, Greenwood R, Kilpatrick N (2010) Development and validation of the Pediatric Anesthesia Behavior score – an objective measure of behavior during induction of anesthesia. Paediatr Anaesth 24(2):196–200

    Article  Google Scholar 

  7. Bong CL, Lim E, Allen JC et al (2015) A comparison of single-dose dexmedetomidine or propofol on the incidence of emergence delirium in children undergoing general anaesthesia for magnetic resonance imaging. Anaesthesia 70(4):393–399

    Article  CAS  PubMed  Google Scholar 

  8. Bortone L, Bertolizio G, Engelhardt T et al (2014) The effect of fentanyl and clonidine on early postoperative negative behavior in children: a double-blind placebo controlled trial. Paediatr Anaesth 24(6):614–619

    Article  PubMed  Google Scholar 

  9. Bryan YF, Hoke LK, Taghon TA et al (2009) A randomized trial comparing sevoflurane and propofol in children undergoing MRI scans. Paediatr Anesth 19(7):672–681

    Article  Google Scholar 

  10. Chuo EJ, Yoon SZ, Cho JE et al (2014) Comparison of the effect of 0.03 and 0.05 mg/kg midazolam with placebo on prevention of emergence agitation in children having strabismus surgery. Anesthiology 120(6):1354–1361

    Article  Google Scholar 

  11. Cohen IT et al (2002) Propofol or midazolam does no reduce emergence delirium in pediatric patients. Paediatr Anesth 12:604–609

    Article  Google Scholar 

  12. Cohen IT, Finkel JC, Hannallah RS et al (2002) The effect of fentanyl on the emergence characteristics after desflurane or sevoflurane anesthesia in children. Anesth Analg 94(5):1178–1181

    Article  CAS  PubMed  Google Scholar 

  13. Cohen IT, Finkel JC, Hannallah RS et al (2003) Rapid emergence does not explain agitation following sevoflurane anaesthesia in infants and children: a comparison with propofol. Paediatr Anesth 13(1):63–67

    Article  Google Scholar 

  14. Cohen IT, Finkel JC, Hannallah RS et al (2004) Clinical and biochemical effects of propofol EDTA vs sevoflurane in healthy infants and young children. Paediatr Anesth 14(2):135–142

    Article  Google Scholar 

  15. Costi D, Cyna AM, Ahmed S et al (2014) Effects of sevoflurane versus other general anaesthesia on emergence agitation in children. Cochrane Database Syst Rev;(9):CD007084

    Google Scholar 

  16. Costi D, Ellwood J, Wallace A et al (2015) Transition to propofol after sevoflurane anesthesia to prevent emergence agitation: a randomized controlled trial. Paediatr Anaesth 25(5):517–523. doi:10.1111/pan.12617

    Article  PubMed  Google Scholar 

  17. Dahmani S, Stany I, Brasher C et al (2010) Pharmacological prevention of sevoflurane- and desflurane-related emergence agitation in children: a meta-analysis of published studies. Br J Anaesth 104(2):216–223

    Article  CAS  PubMed  Google Scholar 

  18. Dahmani S, Delivet H, Hilly J (2014) Emergence delirium in children: an update. Curr Opin Anaesthesiol 27(3):309–315

    Article  CAS  PubMed  Google Scholar 

  19. Davis PJ, Greenberg JA, Gendelman M et al (1999) Recovery characteristics of sevoflurane and halothane in preschool-aged children undergoing bilateral myringotomy and pressure equalization tube insertion. Anesth Analg 88:34–38

    CAS  PubMed  Google Scholar 

  20. Eckenhoff JE (1958) Relationship of anesthesia to postoperative personality changes in children. Am J Dis Child 86:587–591

    Google Scholar 

  21. Eckenhoff JE, Kneale DH, Dripps RD (1961) The incidence and etiology of postanesthetic excitement. A clinical survey. Anesthesiology 22:667–673

    Article  CAS  PubMed  Google Scholar 

  22. Faulk DJ, Twite MD, Zuk J et al (2010) Hypnotic depth and the incidence of emergence agitation and negative postoperative behavioral changes. Paediatr Anaesth 20(1):72–81

    Article  PubMed Central  PubMed  Google Scholar 

  23. Finkel JC, Cohen IT, Hannallah RS et al (2001) The effect of intranasal fentanyl on the emergence characteristics after sevoflurane anesthesia in children undergoing surgery for bilateral myringotomy tube placement. Anesth Analg 92:1164–1168

    Article  CAS  PubMed  Google Scholar 

  24. Fortier MA, Del Rosario AM, Rosenbaum A et al (2010) Beyond pain: predictors of postoperative maladaptive behavior change in children. Paediatr Anaesth 20(5):445–453

    Article  PubMed  Google Scholar 

  25. Fortier MA, Tan ET, Mayes LC et al (2013) Ethnicity and parental report of postoperative behavioral changes in children. Paediatr Anaesth 23(5):422–428

    Article  PubMed  Google Scholar 

  26. Galinkin JL, Fazi LM, Cuy RM et al (2000) Use of intranasal fentanyl in children undergoing myringotomy and tube placement during halothane and sevoflurane anesthesia. Anesthesiology 93(6):1378–1383

    Article  CAS  PubMed  Google Scholar 

  27. Gupta A, Stierer T, Zuckerman R et al (2004) Comparison of recovery profile after ambulatory anesthesia with propofol, isoflurane, sevoflurane and desflurane: a systematic review. Anesth Analg 98(3):632–641

    Article  CAS  PubMed  Google Scholar 

  28. Ingelmo PM, Somaini M, Marzorati C et al (2013) A comparison of observational scales to assess pain and Emergence Delirium in recovery. In: Poster presented on the ASA congress A3115 – San Francisco, USA Oct 2013

    Google Scholar 

  29. Johr M (2002) Postanaesthesia excitation. Paediatr Anaesth 12:293–295

    Article  PubMed  Google Scholar 

  30. Kain ZN (1995) Parental presence during induction of anaesthesia. Paediatr Anaesth 5:209–212

    Article  CAS  PubMed  Google Scholar 

  31. Kain ZN, Mayes LC, O’Connor TZ et al (1996) Preoperative anxiety in children, predictors and outcomes. Arch Pediatr Adolesc Med 150:1238–1245

    Article  CAS  PubMed  Google Scholar 

  32. Kain ZN, Mayes LC, Cicchetti DV et al (1997) The Yale Preoperative Anxiety Scale: how does it compare with a “gold standard”? Anesth Analg 85:783–788

    CAS  PubMed  Google Scholar 

  33. Kain ZN, Mayes LC, Wang SM et al (1998) Parental presence during induction of anesthesia versus sedative premedication: which intervention is more effective? Anesthesiology 89:1147–1156

    Article  CAS  PubMed  Google Scholar 

  34. Kain ZN, Mayes LC, Wang SM et al (1999) Postoperative behavioral outcomes in children: effects of sedative premedication. Anesthesiology 90:758–765

    Article  CAS  PubMed  Google Scholar 

  35. Kain ZN, Wang SM, Mayes LC et al (1999) Distress during the induction of anesthesia and postoperative behavioral outcomes. Anesth Analg 88:1042–1047

    CAS  PubMed  Google Scholar 

  36. Kain ZN, Mayes LC, Wang SM et al (2000) Parental presence and a sedative premedicant for children undergoing surgery: a hierarchical study. Anesthesiology 92:939–946

    Article  CAS  PubMed  Google Scholar 

  37. Kain ZN, Caldwell-Andrews AA, Weinberg ME et al (2005) Sevoflurane versus halothane: postoperative maladaptive behavioral changes: a randomized, controlled trial. Anesthesiology 102(4):720–726

    Article  CAS  PubMed  Google Scholar 

  38. Kain ZN, Caldwell-Andrews AA, Mayes LC et al (2007) Family-centered preparation for surgery improves perioperative outcomes in children: a randomized controlled trial. Anesthesiology 106:65–74

    Article  PubMed  Google Scholar 

  39. Kim HS, Kim CS, Kim SD et al (2011) Fascia iliaca compartment block reduces emergence agitation by providing effective analgesic properties in children. J Clin Anesth 23(2):119–123

    Article  PubMed  Google Scholar 

  40. Kim MS, Moon BE, Kim H et al (2013) Comparison of propofol and fentanyl administered at the end of anaesthesia for prevention of emergence agitation after sevoflurane anaesthesia in children. Br J Anaesth 110(2):274–280

    Article  CAS  PubMed  Google Scholar 

  41. Kim D, Doo AR, Lim H et al (2013) Effect of ketorolac on the prevention of emergence agitation in children after sevoflurane anesthesia. Korean J Anesthesiol 64(3):240–245

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  42. Ko YP, Huang CJ, Hung YC et al (2001) Premedication with low-dose oral midazolam reduces the incidence and severity of emergence agitation in pediatric patients following sevoflurane anesthesia. Acta Anaesthesiol Sin 39(4):169–177

    CAS  PubMed  Google Scholar 

  43. Lapin SL, Auden SM, Goldsmith LJ et al (1999) Effects of sevoflurane anaesthesia on recovery in children: a comparison with halothane. Paediatr Anaesth 9(4):299–304

    Article  CAS  PubMed  Google Scholar 

  44. Lardner DR, Dick BD, Psych R et al (2010) The effects of parental presence in the postanesthetic care unit on children’s postoperative behavior: a prospective, randomized, controlled study. Anesth Analg 110:1102–1108

    PubMed  Google Scholar 

  45. Li Y, van den Pol AN (2008) Mu-opioid receptor-mediated depression of the hypothalamic hypocretin/orexin arousal system. J Neurosci: Off J Soc Neurosci 28(11):2814–2819

    Article  CAS  Google Scholar 

  46. Locatelli BG, Ingelmo PM, Emre S et al (2013) Emergence delirium in children: a comparison of sevoflurane and desflurane anesthesia using the Paediatric Anesthesia Emergence Delirium scale. Paediatr Anaesth 23(4):301–308

    Article  PubMed  Google Scholar 

  47. Lumley MA, Melamed BG, Abeles LA (1993) Predicting children’s presurgical anxiety and subsequent behavior changes. J Pediatr Psychol 18:481–497

    Article  CAS  PubMed  Google Scholar 

  48. Malarbi S, Stargatt R, Howard K et al (2011) Characterizing the behavior of children emerging with delirium from general anesthesia. Paediatr Anaesth 21(9):942–950

    Article  PubMed  Google Scholar 

  49. Margolis JO, Ginsberg B, Dear GL et al (1998) Paediatric preoperative teaching: effects at induction and postoperatively. Paediatr Anaesth 8:17–23

    Article  CAS  PubMed  Google Scholar 

  50. McGraw T (1994) Preparing children for the operating room: psychological issues. Can J Anaesth 41:1094–1103

    Article  CAS  PubMed  Google Scholar 

  51. Merkel S, Voepel-Lewis T, Shayevitz JR et al (1997) The FLACC: a behavioral scale for scoring postoperative pain in young children. Pediatr Nurs 23(3):293–297

    CAS  PubMed  Google Scholar 

  52. Mikawa K, Nishina K, Shiga M (2002) Prevention of sevoflurane-induced agitation with oral clonidine premedication. Anesth Analg 94(6):1675–1676

    PubMed  Google Scholar 

  53. Olsen RW, Yang J, King RG et al (1986) Barbiturate and benzodiazepine modulation of GABA receptor binding and function. Life Sci 39:1969–1976

    Article  CAS  PubMed  Google Scholar 

  54. Pickard A, Davies P, Birnie K et al (2014) Systematic review and meta-analysis of the effect of intraoperative α-adrenergic agonists on postoperative behaviour in children. Br J Anaesth 112(6):982–990

    Article  CAS  PubMed  Google Scholar 

  55. Seiden SC, McMullan S, Sequera-Ramos L et al (2014) Tablet-based Interactive Distraction (TBID) vs oral Midazolam to minimize perioperative anxiety in pediatric patients: a noninferiority randomized trial. Paediatr Anaesth 24(12):1217–1223

    Article  PubMed  Google Scholar 

  56. Sikich N, Lerman J (2004) Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale. Anesthesiology 100(5):1138–1145

    Article  PubMed  Google Scholar 

  57. Smessaert A, Schehr CA, Artusio JF (1960) Observations in the immediate postanaesthesia period. II Mode of recovery. Br J Anaesth 32:181–185

    Article  CAS  PubMed  Google Scholar 

  58. Somaini M, Sahillioğlu E, Marzorati C et al (2015) Emergence delirium, pain or both? a challenge for clinicians. Paediatr Anaesth 25(5):524–529

    Article  PubMed  Google Scholar 

  59. Stargatt R, Davidson AJ, Huang GH et al (2006) A cohort study of the incidence and risk factors for negative behavior changes in children after general anesthesia. Paediatr Anaesth 16(8):846–859

    PubMed  Google Scholar 

  60. Stipic SS, Carev M, Kardum G et al (2015) Are postoperative behavioural changes after adenotonsillectomy in children influenced by the type of anaesthesia?: A prospective, randomised clinical study. Eur J Anaesthesiol 32(5):311–319

    Article  CAS  PubMed  Google Scholar 

  61. Tesoro S, Mezzetti D, Marchesini L et al (2005) Clonidine treatment for agitation in children after sevoflurane anesthesia. Anesth Analg 101:1619–1622

    Article  CAS  PubMed  Google Scholar 

  62. Uezono S, Goto T, Terui K et al (2000) Emergence agitation after sevoflurane versus propofol in pediatric patients. Anesth Analg 91(3):563–566

    Article  CAS  PubMed  Google Scholar 

  63. Uezono S, Goto T, Terui K et al (2002) Emergence agitation after sevoflurane versus propofol in pediatric patients. Anesth Analg 91(3):563–566

    Article  Google Scholar 

  64. Valley RD, Freid EB, Bailey AG et al (2003) Tracheal extubation of deeply anesthetized pediatric patients: a comparison of desflurane and sevoflurane. Anesth Analg 96:1320–1324

    Article  CAS  PubMed  Google Scholar 

  65. Vlajkovic GP, Sindjelic RP (2007) Emergence delirium in children: many questions, few answers. Anesth Analg 104(1):84–91

    Article  PubMed  Google Scholar 

  66. Voepel-Lewis T, Malviya S, Tait AR (2003) A prospective cohort study of emergence agitation in the pediatric postanesthesia care unit. Anesth Analg 96:1625–1630

    Article  PubMed  Google Scholar 

  67. Watcha MF, Ramirez-Ruiz M, White PF et al (1992) Perioperative effects of oral ketorolac and acetominophen in children undergoing bilateral myringotomy. Can J Anaesth 39:649–654

    Article  CAS  PubMed  Google Scholar 

  68. Welborn LG, Hannallah RS, Norden JM et al (1996) Comparison of emergence and recovery characteristics of sevoflurane, desflurane, and halothane in pediatric ambulatory patients. Anesth Analg 83:917–920

    CAS  PubMed  Google Scholar 

  69. Wells LT, Rasch DK (1999) Emergence “delirium” after sevoflurane anesthesia: a paranoid delusion? Anesth Analg 88(6):1308–1310

    CAS  PubMed  Google Scholar 

  70. Wennstrom B, Tornhage CJ, Nasic S et al (2011) The perioperative dialogue reduces postoperative stress in children undergoing day surgery as confirmed by salivary cortisol. Paediatr Anaesth 21:1058–1065

    Article  PubMed  Google Scholar 

  71. Yao Y, Qian B, Lin Y et al (2015) Intranasal dexmedetomidine premedication reduces minimum alveolar concentration of sevoflurane for laryngeal mask insertion and emergence delirium in children: a prospective, randomized, double-blind, placebo-controlled trial. Paediatr Anaesth 25(5):492–498

    Article  PubMed  Google Scholar 

  72. Yip P, Middleton P, Cyna AM et al (2009) Nonpharmacological interventions for assisting the induction of anaesthesia in children. Cochrane Database Syst Rev CD006447

    Google Scholar 

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Somaini, M., Ingelmo, P.M. (2016). Negative Behaviour After Surgery. In: Astuto, M., Ingelmo, P. (eds) Perioperative Medicine in Pediatric Anesthesia. Anesthesia, Intensive Care and Pain in Neonates and Children. Springer, Cham. https://doi.org/10.1007/978-3-319-21960-8_22

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